Abstract:
Introduction:Bone mass density (BMD) is still the gold standard for the diagnosis of osteoporosis, but bone turnover markers (BTMs) can provide helpful information regarding the bone remodeling process. The aim of this study was to determine the correlations between BMD and serum levels of BTMs (tartrate-resistant acid phosphatase-5b [TRAP-5b]), bone-specific alkaline phosphatase (BSAP), estradiol (E2), and magnesium (Mg[2+]) ion concentrations in postmenopausal osteoporotic women as compared to healthy postmenopausal subjects. Materials and methods:The study included 132 women with postmenopausal osteoporosis and 81 healthy postmenopausal women without osteoporosis. Dual-energy X-ray absorptiometry scan assessed BMD at different skeleton sites. Serum levels of E2, BSAP, and TRAP-5b were measured by enzyme linked immunosorbent assay. Serum levels of Mg(2+) were determined using the colorimetric spectrometry technique. Results:Serum levels of BTMs were significantly higher in osteoporotic women than in controls. BSAP has a moderate sensitivity (76.5%) and specificity (84.3%) (cutoff point 21.27 U/L). At a cutoff point of 3.45 U/L, TRAP-5b presented a sensitivity of 86.3% and a higher specificity of 90.6%. Osteoporotic patients showed significantly lower concentrations of serum Mg(2+) than the control group. Mg(2+) levels correlated positively with BMD values (r=0.747, P<0.0001). Furthermore, Mg(2+) concentrations correlated positively with E2 levels (r=0.684, P<0.0001). Spine BMD correlated negatively with BSAP levels (r=-0.36, P<0.0001). Conclusion:Our study showed that BMD correlates negatively with BTMs and positively with E2 and Mg(2+) levels. TRAP-5b presents a good specificity in identifying patients with postmenopausal osteoporosis.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Mederle OA,Balas M,Ioanoviciu SD,Gurban CV,Tudor A,Borza Cdoi
10.2147/CIA.S170111subject
Has Abstractpub_date
2018-08-03 00:00:00pages
1383-1389eissn
1176-9092issn
1178-1998pii
cia-13-1383journal_volume
13pub_type
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S162946
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2147/CIA.S141163
更新日期:2017-12-14 00:00:00
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journal_title:Clinical interventions in aging
pub_type:
doi:10.2147/CIA.S277762
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Clinical interventions in aging
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更新日期:2016-04-22 00:00:00
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更新日期:2016-02-12 00:00:00
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pub_type: 杂志文章
doi:10.2147/CIA.S42229
更新日期:2013-01-01 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
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更新日期:2016-09-22 00:00:00
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