Abstract:
PURPOSE:Osteoarthritis (OA) is a degenerative disease characterized by a progressive loss of articular cartilage extracellular matrix and is due to functional impairments occurring in chondrocytes. In previous works, we highlighted that Regenerative Tissue Optimization (TO-RGN) treatment with radioelectric asymmetric conveyer (REAC) technology influenced the gene expression profiles controlling stem cell differentiation and the pluripotency of human skin-derived fibroblasts in vitro. Since interleukin-1 beta signaling has been implicated in the induction and progression of this disease (through metalloproteinase-3 synthesis and nitric oxide production), we investigated whether REAC TO-RGN might influence the biochemical and morphological changes induced by interleukin-1 beta in normal and OA chondrocytes. METHODS:The induction of metalloproteinase-3 and proteoglycan synthesis was evaluated by a solid-phase enzyme-amplified sensitivity immunoassay, and nitric oxide production was evaluated with the Griess method. Ultrastructural features were observed by transmission electron microscopy. RESULTS:REAC TO-RGN treatment decreased nitric oxide and metalloproteinase-3 production in normal and OA chondrocytes, while inducing an increase in proteoglycan synthesis. OA chondrocytes were more affected by REAC TO-RGN treatment than were normal chondrocytes. Ultrastructural changes confirmed that REAC TO-RGN may counteract the negative effects of interleukin-1 beta incubation. CONCLUSION:The results of this in vitro study suggest that REAC TO-RGN treatment may represent a new, promising approach for the management of OA.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Collodel G,Fioravanti A,Pascarelli NA,Lamboglia A,Fontani V,Maioli M,Santaniello S,Pigliaru G,Castagna A,Moretti E,Iacoponi F,Rinaldi S,Ventura Cdoi
10.2147/CIA.S42229subject
Has Abstractpub_date
2013-01-01 00:00:00pages
309-16eissn
1176-9092issn
1178-1998pii
cia-8-309journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Atrial fibrillation (AF) disproportionately affects older adults. However, direct comparison of clinical features, medical therapy, and outcomes in AF patients aged 65-74 and ≥ 75 years is rare. The objective of the present study was to evaluate the differences in clinical characteristics and prognosis in th...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,多中心研究
doi:10.2147/CIA.S67123
更新日期:2014-08-12 00:00:00
abstract::Dementia is one of the most important public health problems as a result of the rapid increase in the number of elderly persons worldwide. Improvement of prevention strategies and caring for people with dementia should be undertaken. We performed a door-to-door study to screen all subjects aged 50 years and older (n=4...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S48325
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Age is an important determinant of outcome in acute myocardial infarction (AMI). However, in clinical settings, there is an occasional mismatch between chronological age and physical age. We evaluated whether activities of daily living (ADL), which reflect physical age, also predict complications and prognos...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S107136
更新日期:2016-08-24 00:00:00
abstract:Background:The study aimed to investigate the potential association of trunk skeletal muscle mass (tSM) and phase angle measured by bioelectrical impedance analysis (BIA) with the chance of femoral neck fractures in very elderly people. Patients and Methods:This case-control study enrolled 78 femoral neck fracture pat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S250629
更新日期:2020-06-12 00:00:00
abstract::Alzheimer's disease (AD) is the most common cause of dementia affecting nearly 18 million people around the world and 4.5 million in the US. It is a progressive neurodegenerative condition that is estimated to dramatically increase in prevalence as the elderly population continues to grow. As the cognitive and neurops...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/ciia.2006.1.2.131
更新日期:2006-01-01 00:00:00
abstract:Background:Depression in the elderly is a serious and often underdiagnosed psychiatric disorder that has been linked to adverse outcomes in the hospital setting. This study aims to evaluate the prevalence of depressive symptoms and associated factors among elderly hospital inpatients. Methods:The cross-sectional study...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S170346
更新日期:2018-09-13 00:00:00
abstract::The purpose of this study was to determine the test-retest reliability of the International Physical Activity Questionnaire (IPAQ) for older adults in Serbia. Six hundred and sixty older adults (352 men, 53%; 308 women, 47%; mean age 67.65±5.76 years) participated in the study. To examine test-retest reliability, the ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S57379
更新日期:2014-04-07 00:00:00
abstract::The objective of this article is to review the current and emerging treatments of CKD prior to dialysis in the elderly. Worldwide, there are increasing numbers of people who are aged over 65 years. In parallel, there are increasing numbers of elderly patients presenting with chronic kidney disease (CKD), particularly ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S39763
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:Visual impairment is more prevalent in the elderly and depression is common in this population. Although many studies have investigated depression or quality of life (QOL) in older adults with visual impairment, few have looked at the association between these two concepts for this population. The aim of thi...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S27717
更新日期:2013-01-01 00:00:00
abstract::The evaluation of pain and the subsequent issue of pain control is a clinical challenge that all healthcare providers face. Pain in the elderly population is especially difficult given the myriad of physiological, pharmacological, and psychological aspects of caring for the geriatric patient. Opiates are the mainstay ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s1847
更新日期:2008-01-01 00:00:00
abstract:Purpose:The role of biomarkers in the prediction of acute ischemic stroke (AIS) outcome or response to thrombolytic therapy (with recombinant tissue plasminogen activator [rt-PA]) remains limited. The aim of this study was to evaluate whether mean platelet volume (MPV) could predict short-term functional outcome in pat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S195451
更新日期:2019-02-27 00:00:00
abstract:Background:Aging leads to structural and functional changes in the vasculature characterized by arterial endothelial dysfunction and stiffening of large elastic arteries and is a predominant risk factor for cardiovascular disease, the leading cause of morbidity and mortality in modern societies. Although exercise reduc...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S220283
更新日期:2019-09-02 00:00:00
abstract:Purpose:The study aimed to investigate the association between body composition and frailty in elder inpatients. Patients and Methods:This is a cross-sectional study including 656 elder inpatients (275 females and 381 males) aged ≥65 years, from department of geriatrics of Zhejiang Hospital between January 2018 and Ma...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S243211
更新日期:2020-03-04 00:00:00
abstract:OBJECTIVE:This cross-sectional study compared three tools for predicting painful new osteoporotic vertebral fractures (PNOVFs) in older Chinese men: bone mineral density (BMD), the Osteoporosis Self-Assessment Tool for Asians (OSTA), and the World Health Organization fracture risk assessment tool (FRAX) (without BMD). ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S101078
更新日期:2016-04-22 00:00:00
abstract:BACKGROUND:One of the key clinical features of Alzheimer's disease (AD) is impairment in daily functioning. Patients with mild cognitive impairment (MCI) also commonly have mild problems performing complex tasks. Information and communication technology (ICT), particularly techniques involving imaging and video process...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S36297
更新日期:2012-01-01 00:00:00
abstract::Bone remodeling requires a precise balance between resorption and formation. It is a complex process that involves numerous factors: hormones, growth factors, vitamins, and cytokines, and notably osteoprotegerin (OPG) and receptor activator for nuclear factor-κB (RANK) ligand. The signaling pathway OPG/RANK/RANKL is k...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S10153
更新日期:2010-11-19 00:00:00
abstract::Heart failure is a common and disabling condition with morbidity and mortality that increase dramatically with advancing age. Large observational studies, retrospective subgroup analyses and meta-analyses of clinical trials in systolic heart failure, and recently published randomized studies have provided data support...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S4482
更新日期:2010-12-03 00:00:00
abstract:PURPOSE:We evaluated the short- to midterm outcomes of metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty (total joint replacement [TJR]) as surgical treatments for advanced-stage hallux rigidus (HR). PATIENTS AND METHODS:From 2012 to 2014, all data from patients who underwen...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S110865
更新日期:2016-12-13 00:00:00
abstract:Background:Care transitions programs are increasingly used to improve care and reduce re-admission of patients after hospitalization. To learn from the experience of patients who have participated in the Mayo Clinic Care Transitions (MCCT) program and to understand the patient experience, we sought perspectives of pati...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S183893
更新日期:2018-12-19 00:00:00
abstract:Introduction:The clinical benefit of invasive therapy in elderly patients with acute coronary syndrome (ACS) remains unclear. Furthermore, the decision-making process to treat this growing patient group is also debatable. The purpose of this study was to assess the association between elderly ACS patients, the treatmen...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S249017
更新日期:2020-05-25 00:00:00
abstract:BACKGROUND:Satisfaction with treatment is considered a relevant factor for assessing results in clinical practice. However, when assessing satisfaction in dependent patients, the opinion of their caregivers becomes crucial, since implicit in satisfaction is the degree of caregiver involvement, of adherence to treatment...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S83086
更新日期:2015-06-17 00:00:00
abstract::Endoscopic surgical treatment has become an option to treat benign prostate hyperplasia. We evaluated the safety and effectiveness of photoselective vaporization of the prostate (PVP) in patients. We evaluated preoperative and perioperative parameters, functional outcomes, and adverse events up to 12 months postoperat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S41270
更新日期:2013-01-01 00:00:00
abstract::Digital ulcers (DUs) are a severe and frequent clinical feature of patients with systemic sclerosis (SSc). The presence of DUs may cause severe pain and often lead to impairment of patient's functional activities and health-related quality of life. Moreover, poor patient cooperation during the wound care procedure due...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S102577
更新日期:2016-03-14 00:00:00
abstract::Sensorimotor functions decrease in old age. The well-documented loss of tactile acuity in elderly is accompanied by deterioration ofhaptic performance and fine manipulative movements. Physical training and exercise can maintain sensorimotor fitness into high age. However, regular schedules of training require discipli...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/cia.s3174
更新日期:2008-01-01 00:00:00
abstract:Purpose:The aim of this study was to investigate the relationship between obesity and cognitive impairment in the Chinese elderly. Patients and methods:Patients aged 60 years or above were enrolled from the Department of Geriatrics of The First Affiliated Hospital of Chongqing Medical University from March 2013 to May...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S192050
更新日期:2019-02-15 00:00:00
abstract::Prevention of dementia is a public health priority. Physical activity (PA) can reduce the risk of dementia, but the majority of people remain sedentary. We conducted a multicenter controlled study with older adults (60+ years). We hypothesized that an evidence-based PA intervention - GEhen, Spielen und Tanzen Als Lebe...
journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2147/CIA.S141163
更新日期:2017-12-14 00:00:00
abstract::Apligraf (Organogenesis, Canton, MA) is a bi-layered bioengineered skin substitute and was the first engineered skin US Food and Drug Administration (FDA)-approved to promote the healing of ulcers that have failed standard wound care. Constructed by culturing human foreskin-derived neonatal fibroblasts in a bovine typ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/ciia.2007.2.1.93
更新日期:2007-01-01 00:00:00
abstract:Background:Aging decreases osteogenic ability, inducing harmful effects on the bone extracellular matrix (ECM), while exercise training has been indicated as a tool to counteract bone disorders related to advancing age. The modulation of bone ECM is regulated by several types of matrix metalloproteinase (MMP); however,...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S276518
更新日期:2021-01-08 00:00:00
abstract:Purpose:The post-stroke elderly was increased caused by increasing stroke and advanced medical. However, ankle-foot orthoses (AFOs) can be uncomfortable for hemiplegic patients; therefore, the usability is not good. In this study, we analyzed ankle and knee joint angles in post-stroke elderly patients to assess the fun...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S222087
更新日期:2019-12-05 00:00:00
abstract:BACKGROUND:The purpose of this work was to study the performance and reliability of a test of fast alternating forearm movements and its relationship with measures of lower extremity function in older women with dementia. METHODS:Fast alternating movements was studied in 26 female patients (mean age 81.7 ± 5.9 years) ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S37733
更新日期:2013-01-01 00:00:00