Receptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss.

Abstract:

:Bone remodeling requires a precise balance between resorption and formation. It is a complex process that involves numerous factors: hormones, growth factors, vitamins, and cytokines, and notably osteoprotegerin (OPG) and receptor activator for nuclear factor-κB (RANK) ligand. The signaling pathway OPG/RANK/RANKL is key to regulation for maintaining the balance between the activity of osteoblasts and osteoclasts in order to prevent bone loss and ensure a normal bone turnover. In this review, the RANK/RANKL/OPG pathway is described. The multiple interactions of various factors (hormones, cytokines, growth factors, and vitamins) with the OPG/RANK/RANKL pathway are also commented on. Finally, the effects of denosumab, a human monoclonal antibody that binds to RANKL and thereby inhibits the activation of osteoclasts, and of strontium ranelate are also described. Indeed, these two new drugs afford appreciable assistance in daily care practice, helping to prevent bone loss in patients with osteoporosis.

journal_name

Clin Interv Aging

authors

Trouvin AP,Goëb V

doi

10.2147/CIA.S10153

subject

Has Abstract

pub_date

2010-11-19 00:00:00

pages

345-54

eissn

1176-9092

issn

1178-1998

journal_volume

5

pub_type

杂志文章,评审
  • Association Between Active Gait Training for Severely Disabled Patients with Nasogastric Tube Feeding or Gastrostoma and Recovery of Oral Feeding: A Retrospective Cohort Study.

    abstract:Purpose:This study evaluates the effect of introducing active gait training (AGT) to patients who are severely disabled with nasogastric tube feeding or gastrostoma on the recovery of oral feeding. Patients and Methods:We conducted a historical cohort study at a single rehabilitation center in Japan between January 20...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S270277

    authors: Arai H,Takeuchi J,Nozoe M,Fukuoka T,Matsumoto S,Morimoto T

    更新日期:2020-10-13 00:00:00

  • Age-associated alterations in cholesterol homeostasis: evidence from a cross-sectional study in a Northern Italy population.

    abstract:BACKGROUND:The modifications of cholesterol metabolism associated with aging are ill-defined. The objective of this study was to define age-associated alterations of the different metabolic pathways controlling cholesterol homeostasis by analyzing circulating sterols. METHODS:We analyzed serum samples collected from 2...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S57714

    authors: Bertolotti M,Mussi C,Pellegrini E,Magni A,Del Puppo M,Ognibene S,Carulli L,Anzivino C,Baldelli E,Loria P,Carulli N

    更新日期:2014-03-17 00:00:00

  • Beneficial effects of multisensory and cognitive stimulation in institutionalized elderly: 12-months follow-up.

    abstract::We previously demonstrated the beneficial effects of a multisensory and cognitive stimulation program, consisting of 48 sessions, twice a week, to improve the cognition of elderly subjects living either in long-term care institutions (institutionalized - I) or in communities with their families (noninstitutionalized -...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S80997

    authors: de Macedo LD,De Oliveira TC,Soares FC,Bento-Torres J,Bento-Torres NV,Anthony DC,Picanço-Diniz CW

    更新日期:2015-08-19 00:00:00

  • Wearable Technology To Reduce Sedentary Behavior And CVD Risk In Older Adults: A Pilot Randomized Clinical Trial.

    abstract:Background:Physical exercise is associated with decreased cardiovascular disease (CVD) risk, but recent large-scale trials suggest that exercise alone is insufficient to reduce CVD events in high-risk older adults. Purpose:This pilot randomized clinical trial aimed to collect critical data on feasibility, safety, and ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,随机对照试验

    doi:10.2147/CIA.S222655

    authors: Roberts LM,Jaeger BC,Baptista LC,Harper SA,Gardner AK,Jackson EA,Pekmezi D,Sandesara B,Manini TM,Anton SD,Buford TW

    更新日期:2019-10-23 00:00:00

  • Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review.

    abstract::Cognitive frailty, defined as the coexistence of mild cognitive impairment symptoms and physical frailty phenotype in older persons, is increasingly considered the main geriatric condition predisposing to dementia. Recent studies have demonstrated that gut microbiota may be involved in frailty physiopathology by promo...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S139163

    authors: Ticinesi A,Tana C,Nouvenne A,Prati B,Lauretani F,Meschi T

    更新日期:2018-08-29 00:00:00

  • Different types of atrial fibrillation, renal function, and mortality in elderly Chinese patients with coronary artery disease.

    abstract:BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia in patients with chronic kidney disease (CKD), and the combined prevalence of these two disorders increases as the population ages. Both AF and CKD have risk factors for development of each other and eventual mortality. However, the relationship between ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S55972

    authors: Fu S,Liu T,Luo L,Ye P

    更新日期:2014-02-14 00:00:00

  • Population-based health promotion perspective for older driver safety: conceptual framework to intervention plan.

    abstract::The topic of motor vehicle crashes among the elderly is dynamic and multi-faceted requiring a comprehensive and synergistic approach to intervention planning. This approach must be based on the values of a given population as well as health statistics and asserted through community, organizational and policy strategie...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:

    authors: Classen S,Lopez ED,Winter S,Awadzi KD,Ferree N,Garvan CW

    更新日期:2007-01-01 00:00:00

  • The embodied and relational nature of the mind: implications for clinical interventions in aging individuals and populations.

    abstract::Considerable research over the past decade has garnered support for the notion that the mind is both embodied and relational. Jointly, these terms imply that the brain, physical attributes of the self, and features of our interpersonal relationships and of the environments in which we live jointly regulate energy and ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S44797

    authors: Rejeski WJ,Gauvin L

    更新日期:2013-01-01 00:00:00

  • A comparison between metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty as surgical treatments for hallux rigidus: a retrospective study with short- to midterm follow-up.

    abstract:PURPOSE:We evaluated the short- to midterm outcomes of metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty (total joint replacement [TJR]) as surgical treatments for advanced-stage hallux rigidus (HR). PATIENTS AND METHODS:From 2012 to 2014, all data from patients who underwen...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S110865

    authors: Mermerkaya MU,Adli H

    更新日期:2016-12-13 00:00:00

  • Development, validation, and administration of a treatment-satisfaction questionnaire for caregivers of dependent type 2 diabetic patients.

    abstract:BACKGROUND:Satisfaction with treatment is considered a relevant factor for assessing results in clinical practice. However, when assessing satisfaction in dependent patients, the opinion of their caregivers becomes crucial, since implicit in satisfaction is the degree of caregiver involvement, of adherence to treatment...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S83086

    authors: García-Aparicio J,Herrero-Herrero JI

    更新日期:2015-06-17 00:00:00

  • Prevalence and pattern of the elongated styloid process among geriatric patients in Saudi Arabia.

    abstract:OBJECTIVE:The objectives of this study were to assess the elongation of the styloid process on digital panoramic radiographs and to evaluate the prevalence of the elongation according to age, sex and types. PATIENTS AND METHODS:Digital panoramic radiographs of 198 geriatric edentulous patients were analyzed. The radio...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S129818

    authors: AlZarea BK

    更新日期:2017-03-30 00:00:00

  • Tongue-pressure resistance training improves tongue and suprahyoid muscle functions simultaneously.

    abstract:Purpose:Producing tongue pressure (TP) by pushing the tongue against the palate consists of lifting the tongue muscles and elevating the floor of the mouth via suprahyoid muscle contraction. Though studies have shown that tongue-pressure resistance training (TPRT) increases tongue function, none have focused on suprahy...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S194808

    authors: Namiki C,Hara K,Tohara H,Kobayashi K,Chantaramanee A,Nakagawa K,Saitou T,Yamaguchi K,Yoshimi K,Nakane A,Minakuchi S

    更新日期:2019-03-22 00:00:00

  • Care pathways for dementia: current perspectives.

    abstract::Uncertainty appears to typify the experience of living with dementia. With an uncertain illness trajectory and unpredictable levels of deterioration and stability in symptoms, people with a diagnosis of dementia may live with uncertainty and anxiety and find it hard to make plans or decisions for their future. People ...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/CIA.S70628

    authors: Samsi K,Manthorpe J

    更新日期:2014-11-27 00:00:00

  • Elderly quality of life impacted by traditional Chinese medicine techniques.

    abstract:BACKGROUND:The shift in age structure is having a profound impact, suggesting that the aged should be consulted as reporters on the quality of their own lives. OBJECTIVES:The aim of this research was to establish the possible impact of traditional Chinese medicine (TCM) techniques on the quality of life (QOL) of the e...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S10615

    authors: Figueira HA,Figueira OA,Figueira AA,Figueira JA,Giani TS,Dantas EH

    更新日期:2010-10-01 00:00:00

  • Association Between Body Composition and Frailty in Elder Inpatients.

    abstract:Purpose:The study aimed to investigate the association between body composition and frailty in elder inpatients. Patients and Methods:This is a cross-sectional study including 656 elder inpatients (275 females and 381 males) aged ≥65 years, from department of geriatrics of Zhejiang Hospital between January 2018 and Ma...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S243211

    authors: Xu L,Zhang J,Shen S,Hong X,Zeng X,Yang Y,Liu Z,Chen L,Chen X

    更新日期:2020-03-04 00:00:00

  • Efficacy and safety of stenting for elderly patients with severe and symptomatic carotid artery stenosis: a critical meta-analysis of randomized controlled trials.

    abstract:OBJECTIVE:To investigate both short-term and long-term therapeutic efficacy and safety of carotid artery stenting (CAS) and carotid artery endarterectomy (CEA) for elderly patients with severe and symptomatic carotid artery stenosis. METHODS:PubMed, EMBASE, Cochrane Library, Clinical Trials Register Centers, and Googl...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,meta分析

    doi:10.2147/CIA.S91721

    authors: Ouyang YA,Jiang Y,Yu M,Zhang Y,Huang H

    更新日期:2015-10-28 00:00:00

  • Effects of different resistance training frequencies on flexibility in older women.

    abstract:OBJECTIVE:The main purpose of the investigation reported here was to analyze the effect of resistance training (RT) performed at different weekly frequencies on flexibility in older women. PARTICIPANTS AND METHODS:Fifty-three older women (≥60 years old) were randomly assigned to perform RT either two (n=28; group "G2x...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,随机对照试验

    doi:10.2147/CIA.S77433

    authors: Carneiro NH,Ribeiro AS,Nascimento MA,Gobbo LA,Schoenfeld BJ,Achour Júnior A,Gobbi S,Oliveira AR,Cyrino ES

    更新日期:2015-03-05 00:00:00

  • Screening and Identification of Potential Hub Genes in Myocardial Infarction Through Bioinformatics Analysis.

    abstract:Background:Myocardial infarction (MI) is a common cause of death worldwide. It is characterized by coronary artery occlusion that causes ischemia and hypoxia of myocardial cells, leading to irreversible myocardial damage. Materials and Methods:To explore potential targets for treatment of MI, we reorganized and analyz...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S281290

    authors: Yu YW,Xue YJ,Qian LL,Chen Z,Que JQ,Huang KY,Liu S,Weng YB,Rong FN,Ji KT,Zeng JN

    更新日期:2020-12-01 00:00:00

  • The relationship between cholesterol and cognitive function is homocysteine-dependent.

    abstract:INTRODUCTION:Previous studies have identified hyperlipidemia as a potential risk factor for dementia and Alzheimer's disease. However, studies on cholesterol measured in late-life and cognitive function have been inconsistent. Few studies have explored nonlinear relationships or considered interactions with other bioma...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S64766

    authors: Cheng Y,Jin Y,Unverzagt FW,Su L,Yang L,Ma F,Hake AM,Kettler C,Chen C,Liu J,Bian J,Li P,Murrell JR,Hendrie HC,Gao S

    更新日期:2014-10-23 00:00:00

  • Kidney function and cognitive decline in an oldest-old Chinese population.

    abstract:BACKGROUND:Early-stage chronic kidney disease has been suggested to be correlated with cognitive decline, but the association has rarely been explored in the oldest old. SUBJECTS AND METHODS:This prospective study included 284 Chinese participants aged 80 years or older with serum creatinine levels <150 µmol/L. The me...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S134205

    authors: Bai K,Pan Y,Lu F,Zhao Y,Wang J,Zhang L

    更新日期:2017-07-04 00:00:00

  • Assessment and management of nutrition in older people and its importance to health.

    abstract::Nutrition is an important element of health in the older population and affects the aging process. The prevalence of malnutrition is increasing in this population and is associated with a decline in: functional status, impaired muscle function, decreased bone mass, immune dysfunction, anemia, reduced cognitive functio...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/cia.s9664

    authors: Ahmed T,Haboubi N

    更新日期:2010-08-09 00:00:00

  • A review of tazarotene in the treatment of photodamaged skin.

    abstract::Chronic sun exposure leads to photodamage, which is characterized clinically by fine and coarse wrinkles, dyspigmentation, telangiectasia, laxity, roughness and a sallow appearance. Many treatments claim to reduce the signs of photodamage, however evidence from randomized controlled trials (RCT) to support these claim...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章,评审

    doi:10.2147/cia.s1101

    authors: Ogden S,Samuel M,Griffiths CE

    更新日期:2008-01-01 00:00:00

  • Myocardial infarction in patients over 90 years of age.

    abstract:BACKGROUND:The aim of this study was to examine the trend in increasing life expectancy in relation to heart attack and cardiac catheterization. METHODS:A retrospective study of very elderly patients over 90 years of age (study group) and between 70 and 79 years of age (control group) with myocardial infarction and ac...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S29045

    authors: Yayan J

    更新日期:2012-01-01 00:00:00

  • Discharge destination from an acute care for the elderly (ACE) unit.

    abstract::Older adults age 65 and over account for a disproportional number of hospital stays and discharges compared to other age groups. The objective of this paper is to describe placement and characteristics of older patients discharged from an acute care for the elderly (ACE) unit. The study sample consists of 1,351 men an...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:

    authors: Amador LF,Reyes-Ortiz CA,Reed D,Lehman C

    更新日期:2007-01-01 00:00:00

  • Predicting hemorrhage and obstruction in the elderly population using thromboelastographic indices.

    abstract:OBJECTIVE:To estimate the value of the different thromboelastogram indices for predicting hemorrhage and vascular obstruction in an elderly population. METHODS:This was a prospective cohort study of patients 65 years and older without hemato-logic disorders who received thromboelastography (TEG) examination at the Chi...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S49478

    authors: Zheng Q,Fu S,Chen D,Li X,Li Y,Li Y,Yu J,Gong M,Bai J

    更新日期:2013-01-01 00:00:00

  • Polypharmacy: misleading, but manageable.

    abstract::The percentage of the population described as elderly is growing, and a higher prevalence of multiple, chronic disease states must be managed concurrently. Healthcare practitioners must appropriately use medication for multiple diseases and avoid risks often associated with multiple medication use such as adverse effe...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/cia.s2468

    authors: Bushardt RL,Massey EB,Simpson TW,Ariail JC,Simpson KN

    更新日期:2008-01-01 00:00:00

  • Efficiency of individual dosage of digoxin with calculated concentration.

    abstract:BACKGROUND:Digoxin is a frequently prescribed drug, particularly in the elderly population, in which there is an increased prevalence of atrial fibrillation and cardiac failure. With its complex pharmacokinetic profile and narrow therapeutic index, use of digoxin requires regular monitoring of blood levels. Recent evid...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S63596

    authors: Zhao L,Yang P,Li P,Wang X,Qin W,Zhang X

    更新日期:2014-07-22 00:00:00

  • Changing from bevacizumab to ranibizumab in age-related macular degeneration. Is it safe?

    abstract:OBJECTIVE:To report our experiences in changing from intravitreal bevacizumab to ranibizumab in age-related macular degeneration (AMD). DESIGN:Retrospective case series. PARTICIPANTS AND METHODS:We retrospectively reviewed the records of 34 patients (36 eyes) who were treated with monthly injections of intravitreal b...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/cia.s8367

    authors: Karagiannis DA,Ladas ID,Parikakis E,Georgalas I,Kotsolis A,Amariotakis G,Soumplis V,Mitropoulos P

    更新日期:2009-01-01 00:00:00

  • Dementia and delirium, the outcomes in elderly hip fracture patients.

    abstract:BACKGROUND:Delirium in hip fractured patients is a frequent complication. Dementia is an important risk factor for delirium and is common in frail elderly. This study aimed to extend the previous knowledge on risk factors for delirium and the consequences. Special attention was given to patients with dementia and delir...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S115945

    authors: Mosk CA,Mus M,Vroemen JP,van der Ploeg T,Vos DI,Elmans LH,van der Laan L

    更新日期:2017-03-10 00:00:00

  • Prevalence of dementia in Al-Quseir city, Red Sea Governorate, Egypt.

    abstract::Dementia is one of the most important public health problems as a result of the rapid increase in the number of elderly persons worldwide. Improvement of prevention strategies and caring for people with dementia should be undertaken. We performed a door-to-door study to screen all subjects aged 50 years and older (n=4...

    journal_title:Clinical interventions in aging

    pub_type: 杂志文章

    doi:10.2147/CIA.S48325

    authors: El Tallawy HN,Farghly WM,Badry R,Rageh TA,Shehata GA,Hakeem M NA,Abd El Hamed M,Sayd MA,Hamed Y,Kandil MR

    更新日期:2014-01-01 00:00:00