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Age-associated alterations in cholesterol homeostasis: evidence from a cross-sectional study in a Northern Italy population.

Abstract：

BACKGROUND:The modifications of cholesterol metabolism associated with aging are ill-defined. The objective of this study was to define age-associated alterations of the different metabolic pathways controlling cholesterol homeostasis by analyzing circulating sterols. METHODS:We analyzed serum samples collected from 201 adult (75 male, 126 female) subjects within the epidemiological MICOL study (Multicentrica Italiana Colelitiasi). The age range was 38-79 years; 103 had evidence of gallstones. The concentrations of the different sterols, recognized as markers of the main pathways of cholesterol homeostasis, were analyzed by gas chromatography-mass spectrometry, including lathosterol (synthesis), campesterol and sitosterol (absorption), and 7α-hydroxy-4-cholesten-3-one (degradation to bile acids). RESULTS:A significant direct correlation was detected between age and cholesterol levels (r =0.34, P<0.01). The lathosterol/cholesterol ratio was lower in older age quartiles (P<0.05 by analysis of variance), with an inverse correlation between the lathosterol/cholesterol ratio and age (r=-0.32, P<0.01). Such correlation was particularly evident in females. The campesterol/cholesterol and sitosterol/cholesterol ratios were inversely correlated with aging in control, but not in gallstone patients. The levels of 7α-hydroxy-4-cholesten-3-one were not correlated with age. CONCLUSION:These data show a reduction of cholesterol synthesis with aging which is associated with increased circulating cholesterol levels. The finding might be related to a reduced metabolic need for cholesterol in advancing age, leading to a downregulation of the main mechanisms of cholesterol intake in the liver. A different age-related behavior was observed in gallstone-free versus gallstone patients regarding cholesterol absorption. The possible implications in terms of the pharmacological management of hypercholesterolemia in the elderly remain to be defined.

journal_name

Clin Interv Aging

journal_title

Clinical interventions in aging

authors

Bertolotti M,Mussi C,Pellegrini E,Magni A,Del Puppo M,Ognibene S,Carulli L,Anzivino C,Baldelli E,Loria P,Carulli N

doi

10.2147/CIA.S57714

subject

Has Abstract

pub_date

2014-03-17 00:00:00

pages

425-32

eissn

1176-9092

issn

1178-1998

pii

cia-9-425

journal_volume

pub_type

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Age-associated alterations in cholesterol homeostasis: evidence from a cross-sectional study in a Northern Italy population.