Abstract:
:Age remains the most powerful prognostic factor among glioblastoma (GBM) patients. Half of all patients with GBM are aged 65 years or older at the time of diagnosis, and the incidence rate of GBM in patients aged over 65 years is increasing rapidly. Median survival for elderly GBM patients is less than 6 months and reflects less favorable tumor biologic factors, receipt of less aggressive care, and comorbid disease. The standard of care for elderly GBM patients remains controversial. Based on limited data, extensive resection appears to be more beneficial than biopsy. For patients with favorable Karnofsky performance status (KPS), adjuvant radiotherapy (RT) has a demonstrated survival benefit with no observed decrement in quality of life. Concurrent and adjuvant temozolomide (TMZ) along with RT to 60 Gy have not been prospectively studied among patients aged over 70 years but should be considered for patients aged 65-70 years with excellent KPS. Based on the recent NOA-08 and Nordic randomized trials, testing for O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation should be performed routinely immediately after surgery to aid in adjuvant treatment decisions. Patients aged over 70 years with favorable KPS, or patients aged 60-70 years with borderline KPS, should be considered for monotherapy utilizing standard TMZ dosing for patients with MGMT-methylated tumors, and hypofractionated RT (34 Gy in ten fractions or 40 Gy in 15 fractions) for patients with MGMT-unmethylated tumors. The ongoing European Organisation for Research and Treatment of Cancer/National Cancer Institute of Canada trial will help clarify the role for concurrent TMZ with hypofractionated RT. For elderly patients with poor KPS, reasonable options include best supportive care, TMZ alone, hypofractionated RT alone, or whole brain RT for symptomatic patients needing to start treatment urgently. Given the balance between short survival and quality of life in this patient population, optimal management of elderly GBM patients must be made individually according to patient age, MGMT methylation status, performance score, and patient preferences.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Arvold ND,Reardon DAdoi
10.2147/CIA.S44259subject
Has Abstractpub_date
2014-02-21 00:00:00pages
357-67eissn
1176-9092issn
1178-1998pii
cia-9-357journal_volume
9pub_type
杂志文章,评审abstract:BACKGROUND:Sarcopenia is strongly associated with an inadequate intake of dietary protein. Dietary protein supplementation boosts muscle-protein synthesis and increases muscle mass in the elderly. This study tested whether adding a protein-rich food, ricotta cheese, to the habitual diet increased total appendicular ske...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S32356
更新日期:2012-01-01 00:00:00
abstract::We previously demonstrated the beneficial effects of a multisensory and cognitive stimulation program, consisting of 48 sessions, twice a week, to improve the cognition of elderly subjects living either in long-term care institutions (institutionalized - I) or in communities with their families (noninstitutionalized -...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S80997
更新日期:2015-08-19 00:00:00
abstract:Purpose:The aim of the study was to evaluate the impact of inertial training on upper and lower extremity strength in the elderly. The study also assessed the influence of inertial training on their independence, balance, and speed and quality of gait. Methods:Twenty physically inactive older residents of a nursing ho...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S234299
更新日期:2020-02-07 00:00:00
abstract:Background:Aging leads to structural and functional changes in the vasculature characterized by arterial endothelial dysfunction and stiffening of large elastic arteries and is a predominant risk factor for cardiovascular disease, the leading cause of morbidity and mortality in modern societies. Although exercise reduc...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S220283
更新日期:2019-09-02 00:00:00
abstract::The objective of this study was to evaluate cardiac autonomic control and muscle vasodilation response during isometric exercise in sedentary and physically active older adults. Twenty healthy participants, 10 sedentary and 10 physically active older adults, were evaluated and paired by gender, age, and body mass inde...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S120876
更新日期:2017-06-28 00:00:00
abstract:PURPOSE:We evaluated the short- to midterm outcomes of metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty (total joint replacement [TJR]) as surgical treatments for advanced-stage hallux rigidus (HR). PATIENTS AND METHODS:From 2012 to 2014, all data from patients who underwen...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S110865
更新日期:2016-12-13 00:00:00
abstract::Sensorimotor functions decrease in old age. The well-documented loss of tactile acuity in elderly is accompanied by deterioration ofhaptic performance and fine manipulative movements. Physical training and exercise can maintain sensorimotor fitness into high age. However, regular schedules of training require discipli...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/cia.s3174
更新日期:2008-01-01 00:00:00
abstract::Atrial fibrillation (AF) is associated with an increased incidence and severity of strokes. The burden of AF-related stroke is expected to increase in parallel with the aging of the population. Oral anticoagulation with warfarin has been the pharmacologic standard for stroke risk reduction in patients with AF. When us...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S37818
更新日期:2013-01-01 00:00:00
abstract:Background:When considering the "joint as an organ", the tissues in a joint act as complementary components of an organ, and the "set point" is the cellular activity for homeostasis of the joint tissues. Even in the absence of injury, joint tissues have adaptive responses to processes, like aging and menopause, which r...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S151453
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:Cardiovascular diseases are the leading cause of death and disability worldwide. Among these diseases, heart failure (HF) and acute myocardial infarction (AMI) are the most common causes of hospitalization. Therefore, readmission for HF and AMI is receiving increasing attention. Several socioeconomic factors co...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S71165
更新日期:2015-01-12 00:00:00
abstract:BACKGROUND:No conventional creatinine- or cystatin C-based glomerular filtration rate (GFR) estimation equation performed consistently outstandingly in elderly Chinese in our previous studies. This research aimed to further evaluate the performance of some recently proposed estimation equations based on creatinine and ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S68801
更新日期:2014-09-11 00:00:00
abstract:PURPOSE:This paper examines the influence of age on several attributes of sensorimotor performance while performing a reaching task. Our hypothesis, based on previous studies, is that aged persons will show differences in one or more of the attributes of sensorimotor performance. PATIENTS AND METHODS:Fifty-one subject...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S45900
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article on p. 737 in vol. 13, PMID: 29731615.]. ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,已发布勘误
doi:10.2147/CIA.S172968
更新日期:2018-09-10 00:00:00
abstract:Objective:The objective involved the analysis of the efficiency of the Program of Movement Recreation of Elderly People (PMREP) exercise program expressed in terms of the stabilography measures and coactivation of muscles in women in the age group of 60-70 years. The assumption that was assumed stems from theoretical i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S167782
更新日期:2018-09-12 00:00:00
abstract:BACKGROUND:Alzheimer's disease (AD) is closely linked to cardiovascular risk factors. METHODS:Echocardiographic studies were performed, including left ventricular diastolic functions, left and right atrial conduction times, and arterial stiffness parameters, namely stiffness index, pressure-strain elastic modulus, and...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S63337
更新日期:2014-07-16 00:00:00
abstract:Purpose:DNA methylation is thought to play a role in exercise-induced gene expression. We aimed to examine changes in muscular strength and body composition in elderly patients with end-stage knee osteoarthritis before and after artificial knee arthroplasty and exercise therapy. We aimed to confirm the relationship bet...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S213154
更新日期:2019-08-07 00:00:00
abstract::The increasingly aged population worldwide means more people are living with chronic diseases, reduced autonomy, and taking various medications. Health professionals should take these into consideration when managing dermatological problems in elderly patients. Accordingly, current research is investigating the dermat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S96232
更新日期:2016-02-12 00:00:00
abstract::In the elderly population, osteoporosis is a significant clinical problem leading to disability and even death. Many patients remain untreated, despite effective therapies, because of patients' unwillingness to take current therapies or inability to tolerate the therapies. For this reason, ongoing research continues t...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::Alzheimer's disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for prevention and treatment of AD is a growing topic. In this sense, carotenoids are phytochemicals presen...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S134605
更新日期:2017-05-15 00:00:00
abstract:Purpose:The incidence of proximal humeral fractures is high in the elderly, and the superior management of these fractures remains a controversy. The study aims to compare clinical outcomes of intramedullary nails, locking plates and conservative treatment for the management of displaced proximal humeral fractures in t...
journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章
doi:10.2147/CIA.S144084
更新日期:2017-11-29 00:00:00
abstract:Introduction:Bone mass density (BMD) is still the gold standard for the diagnosis of osteoporosis, but bone turnover markers (BTMs) can provide helpful information regarding the bone remodeling process. The aim of this study was to determine the correlations between BMD and serum levels of BTMs (tartrate-resistant acid...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S170111
更新日期:2018-08-03 00:00:00
abstract::[This corrects the article on p. 1237 in vol. 13, PMID: 30034227.]. ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,已发布勘误
doi:10.2147/CIA.S182535
更新日期:2018-09-05 00:00:00
abstract::The topic of motor vehicle crashes among the elderly is dynamic and multi-faceted requiring a comprehensive and synergistic approach to intervention planning. This approach must be based on the values of a given population as well as health statistics and asserted through community, organizational and policy strategie...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract::The most compelling reason and primary goal of treating actinic keratoses is to prevent malignant transformation into invasive squamous cell carcinoma, and although there are well established guidelines outlining treatment modalities and regimens for squamous cell carcinoma, the more commonly encountered precancerous ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S31930
更新日期:2013-01-01 00:00:00
abstract::Prevention of dementia is a public health priority. Physical activity (PA) can reduce the risk of dementia, but the majority of people remain sedentary. We conducted a multicenter controlled study with older adults (60+ years). We hypothesized that an evidence-based PA intervention - GEhen, Spielen und Tanzen Als Lebe...
journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2147/CIA.S141163
更新日期:2017-12-14 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia in patients with chronic kidney disease (CKD), and the combined prevalence of these two disorders increases as the population ages. Both AF and CKD have risk factors for development of each other and eventual mortality. However, the relationship between ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S55972
更新日期:2014-02-14 00:00:00
abstract:OBJECTIVE:Routine measurement of the carotid intima-media thickness is not recommended in recent clinical practice guidelines for risk assessment of the first atherosclerotic cardiovascular disease (ASCVD) event (the definition of which includes acute coronary syndromes, a history of myocardial infarction, stable or un...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S85216
更新日期:2015-07-07 00:00:00
abstract:Purpose:This study evaluates the effect of introducing active gait training (AGT) to patients who are severely disabled with nasogastric tube feeding or gastrostoma on the recovery of oral feeding. Patients and Methods:We conducted a historical cohort study at a single rehabilitation center in Japan between January 20...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S270277
更新日期:2020-10-13 00:00:00
abstract:Background:Neuromuscular electrical stimulation with muscle contraction, administered through the skin of the neck, improves a patient's swallowing ability. However, the beneficial effects of transcutaneous electrical sensory stimulation (TESS), without muscle contraction, are controversial. We investigated the effect ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S140746
更新日期:2017-11-07 00:00:00
abstract:OBJECTIVE:To describe challenges in disseminating the Health Enhancement Program (HEP), a community-based disability prevention program for community dwelling elders, and to examine program effectiveness in geographically dispersed sites. METHODS:Within-group, pre-test-post-test comparisons of disability risk factors,...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/ciia.2006.1.3.267
更新日期:2006-01-01 00:00:00