Abstract:
:We previously demonstrated the beneficial effects of a multisensory and cognitive stimulation program, consisting of 48 sessions, twice a week, to improve the cognition of elderly subjects living either in long-term care institutions (institutionalized - I) or in communities with their families (noninstitutionalized - NI). In the present study, we evaluated these subjects after the end of the intervention and compared the rate of age-related cognitive decline of those living in an enriched community environment (NI group, n=15, 74.1±3.9 years old) with those living in the impoverished environment of long-term care institutions (I group, n=20, 75.1±6.8 years old). Both groups participated fully in our stimulation program. Over 1 year, we conducted revaluations at five time points (2 months, 4 months, 6 months, 8 months, and 12 months) after the completion of the intervention. Both elderly groups were evaluated with the mini-mental state examination and selected language tests. Progressive cognitive decline was observed in both groups over the period. Indeed, it took only 4-6 months after the end of the stimulation program for significant reductions in language test scores to become apparent. However, earlier reductions in test scores were mainly associated with I group, and linguistic prosody test scores were significantly affected by institutionalization and time, two variables that interacted and reduced these scores. Moreover, I group reduced the Montréal cognitive assessment battery language tests scores 4 months before NI group. It remains to be investigated what mechanisms may explain the earlier and more intense language losses in institutionalized elderly.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
de Macedo LD,De Oliveira TC,Soares FC,Bento-Torres J,Bento-Torres NV,Anthony DC,Picanço-Diniz CWdoi
10.2147/CIA.S80997subject
Has Abstractpub_date
2015-08-19 00:00:00pages
1351-9eissn
1176-9092issn
1178-1998pii
cia-10-1351journal_volume
10pub_type
杂志文章abstract::After more than 40 years of clinical use, levodopa (LD) remains the gold standard of symptomatic efficacy in the drug treatment of Parkinson's disease (PD). Compared with other available dopaminergic therapies, dopamine replacement with LD is associated with the greatest improvement in motor function. Long-term treatm...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s6456
更新日期:2010-09-07 00:00:00
abstract:Background:Transcutaneous electrical nerve stimulation (TENS) is a noninvasive modality which may be used to reduce acute postoperative pain. Intense perioperative pain within the first few days after hip fracture surgery is common and is related to negative consequences such as restricted and delayed ambulation. Obje...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S203658
更新日期:2019-10-29 00:00:00
abstract::Hypernatremia in the geriatric population is a common disorder associated with significant morbidity and mortality. Older people are predisposed to developing hypernatremia because of age-related physiologic changes such as decreased thirst drive, impaired urinary concentrating ability, and reduced total body water. M...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S65214
更新日期:2014-11-19 00:00:00
abstract:Purpose:The aim of the study was to evaluate the impact of inertial training on upper and lower extremity strength in the elderly. The study also assessed the influence of inertial training on their independence, balance, and speed and quality of gait. Methods:Twenty physically inactive older residents of a nursing ho...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S234299
更新日期:2020-02-07 00:00:00
abstract::Age remains the most powerful prognostic factor among glioblastoma (GBM) patients. Half of all patients with GBM are aged 65 years or older at the time of diagnosis, and the incidence rate of GBM in patients aged over 65 years is increasing rapidly. Median survival for elderly GBM patients is less than 6 months and re...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S44259
更新日期:2014-02-21 00:00:00
abstract:PURPOSE:Osteoarthritis (OA) is a degenerative disease characterized by a progressive loss of articular cartilage extracellular matrix and is due to functional impairments occurring in chondrocytes. In previous works, we highlighted that Regenerative Tissue Optimization (TO-RGN) treatment with radioelectric asymmetric c...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S42229
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Use of intensive anticoagulation and antiplatelet therapy in acute myocardial infarction (AMI) potentially increases the risk of bleeding complications during percutaneous coronary intervention via the transfemoral route. Recently, the transradial access has been intensively employed as an alternative means ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S50939
更新日期:2013-01-01 00:00:00
abstract:Purpose:The aim of our study was to explore the risk factors related to blood transfusion after intramedullary nail fixation of elderly femoral intertrochanteric fracture (FTF) and establish a nomogram prediction model. Patients and Methods:We conducted a retrospective study including elderly FTF patients treated by i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S253193
更新日期:2021-01-06 00:00:00
abstract:Background:Neuromuscular electrical stimulation with muscle contraction, administered through the skin of the neck, improves a patient's swallowing ability. However, the beneficial effects of transcutaneous electrical sensory stimulation (TESS), without muscle contraction, are controversial. We investigated the effect ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S140746
更新日期:2017-11-07 00:00:00
abstract::Alzheimer's disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for prevention and treatment of AD is a growing topic. In this sense, carotenoids are phytochemicals presen...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S134605
更新日期:2017-05-15 00:00:00
abstract::Bone remodeling requires a precise balance between resorption and formation. It is a complex process that involves numerous factors: hormones, growth factors, vitamins, and cytokines, and notably osteoprotegerin (OPG) and receptor activator for nuclear factor-κB (RANK) ligand. The signaling pathway OPG/RANK/RANKL is k...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S10153
更新日期:2010-11-19 00:00:00
abstract::Heart failure is a common and disabling condition with morbidity and mortality that increase dramatically with advancing age. Large observational studies, retrospective subgroup analyses and meta-analyses of clinical trials in systolic heart failure, and recently published randomized studies have provided data support...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S4482
更新日期:2010-12-03 00:00:00
abstract::Type 2 diabetes mellitus affects 5.9% of the world adult population, with older people and some ethnic groups disproportionately affected. Treatment of older people with diabetes differs in many ways from that in younger adults since the majority have type 2 disease and are at particular risk of macrovascular rather t...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s3142
更新日期:2009-01-01 00:00:00
abstract::Osteoporosis and fragility fractures are relevant health issues because of their impact in terms of morbidity, mortality, and socioeconomic burden. Despite this alarming scenario, both underdiagnosis and undertreatment are common features of osteoporotic patients, particularly those who have already sustained a fragil...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S242038
更新日期:2020-03-26 00:00:00
abstract::Overactive bladder (OAB) is a difficult condition to live with and is very costly to the community. OAB affects 16% of the adult population and rises with increasing age. We describe the necessary steps in evaluation and behavioral therapy prior to initiating medical therapy. There are several medications that have be...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s3414
更新日期:2008-01-01 00:00:00
abstract::Prevention of dementia is a public health priority. Physical activity (PA) can reduce the risk of dementia, but the majority of people remain sedentary. We conducted a multicenter controlled study with older adults (60+ years). We hypothesized that an evidence-based PA intervention - GEhen, Spielen und Tanzen Als Lebe...
journal_title:Clinical interventions in aging
pub_type: 临床试验,杂志文章,多中心研究
doi:10.2147/CIA.S141163
更新日期:2017-12-14 00:00:00
abstract:BACKGROUND:Gerontological research aims at understanding factors that are crucial for mediating "successful aging". This term denotes the absence of significant disease and disabilities, maintenance of high levels of physical and cognitive function, and preservation of social and productive activities. Preservation of ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S15433
更新日期:2011-01-01 00:00:00
abstract:Purpose:DNA methylation is thought to play a role in exercise-induced gene expression. We aimed to examine changes in muscular strength and body composition in elderly patients with end-stage knee osteoarthritis before and after artificial knee arthroplasty and exercise therapy. We aimed to confirm the relationship bet...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S213154
更新日期:2019-08-07 00:00:00
abstract:Background:Both aortic valve stenosis and aortic stiffness are moderators of arterio ventricular coupling and independent predictors of cardiovascular morbidity and mortality. Studies on the effect of transcatheter aortic valve implantation (TAVI) on aortic functional properties are limited. We performed a study to inv...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S211328
更新日期:2019-08-02 00:00:00
abstract:BACKGROUND:The purpose of this work was to study the performance and reliability of a test of fast alternating forearm movements and its relationship with measures of lower extremity function in older women with dementia. METHODS:Fast alternating movements was studied in 26 female patients (mean age 81.7 ± 5.9 years) ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S37733
更新日期:2013-01-01 00:00:00
abstract::Life-space mobility (LSM) is a concept for assessing patterns of functional mobility over time. LSM is gaining traction in the research of geriatric population health. Several instruments have been developed to measure LSM, such as the University of Alabama at Birmingham Life-Space Assessment (LSA) or the Nursing Home...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S196944
更新日期:2020-09-15 00:00:00
abstract:PURPOSE:This validation study aims to examine Cornell Scale for Depression in Dementia (CSDD) items in terms of the agreement found between residents and caregivers, and also to compare alternative models of the Thai version of the CSDD. PATIENTS AND METHODS:A cross-sectional study was conducted of 84 elderly resident...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S45201
更新日期:2013-01-01 00:00:00
abstract::[This corrects the article on p. 1237 in vol. 13, PMID: 30034227.]. ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,已发布勘误
doi:10.2147/CIA.S182535
更新日期:2018-09-05 00:00:00
abstract::Background and objective: Oxidative stress has been demonstrated to be a mechanism that leads to bone mass reduction, and according to many studies, serum uric acid (UA) is a strong endogenous antioxidant that can protect bone mineral density (BMD). To date, there have been no large-scale, cross-sectional studies base...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S186500
更新日期:2019-06-12 00:00:00
abstract:Purpose:The role of biomarkers in the prediction of acute ischemic stroke (AIS) outcome or response to thrombolytic therapy (with recombinant tissue plasminogen activator [rt-PA]) remains limited. The aim of this study was to evaluate whether mean platelet volume (MPV) could predict short-term functional outcome in pat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S195451
更新日期:2019-02-27 00:00:00
abstract:Purpose:The purpose of this study was to identify how changes to general health might affect the oral health of nursing-home residents over a six-month period. Materials and Methods:The study was conducted in nine nursing homes in Germany. Sociodemographic and general data were collected at baseline and after six mont...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S234938
更新日期:2020-01-09 00:00:00
abstract:Background and Aim:Caregivers in the home environment have an important role in timely detecting and responding to abuse. The aim of this review was to provide insight into both the existing tools for the assessment of and interventions for elder abuse by formal and informal caregivers in the home environment, and to c...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S261877
更新日期:2020-09-28 00:00:00
abstract:BACKGROUND:It is important to obtain knowledge about the prevalence of nutritional risk and associated factors among older home-dwelling people in order to be able to meet nutritional challenges in this group in the future and to plan appropriate interventions. The aim of this survey was to investigate the prevalence o...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S35986
更新日期:2012-01-01 00:00:00
abstract:Background:Aging is a spontaneous and inevitable phenomenon of biology, which can lead to the gradual deterioration of tissues and organs. One of the age-related deterioration processes is immunosenescence, which leads to changes in the function of immune systems, including immune cells and associated cytokines. A prop...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S237601
更新日期:2020-01-29 00:00:00
abstract:OBJECTIVE:To investigate the long-term effects of three antiarthritics, namely dexamethasone, celecoxib, and methotrexate on the histology and metabolism of intact bone tissue in rats. METHODS:Thirty-two 12-week-old healthy female Sprague Dawley rats were randomly allocated into four groups: 1) control (saline, daily)...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S85225
更新日期:2015-08-05 00:00:00