Abstract:
Background:Disc degeneration (DD) is one of the common diseases worldwide, which deeply influences normal life and leads to excruciating pain. However, an effective treatment for DD is still not identified. Method:The present study systemically examined the effect of melatonin on annulus fibrosus (AF) cells of patients with DD. Results:Melatonin had the effect of promoting proliferation, inducing autophagy, and suppressing apoptosis on AF cells of patients with DD. Moreover, melatonin contributed to the translation and transcription of autophagy-related protein ATG7 and inhibited the function of miR-106a-5p in AF cells. In addition, the results suggested that miR-106a-5p mediated the expression of ATG7 by directly binding to its 3'UTR in AF cells. Conclusion:This research not only gained a deep insight of melatonin mode of action, but also indicated its potential target signaling pathway in AF cells.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Hai B,Ma Y,Pan X,Yong L,Liang C,He G,Yang C,Zhu B,Liu Xdoi
10.2147/CIA.S193765subject
Has Abstractpub_date
2019-03-28 00:00:00pages
621-630eissn
1176-9092issn
1178-1998pii
cia-14-621journal_volume
14pub_type
杂志文章abstract:Purpose:The aim of our study was to explore the risk factors related to blood transfusion after intramedullary nail fixation of elderly femoral intertrochanteric fracture (FTF) and establish a nomogram prediction model. Patients and Methods:We conducted a retrospective study including elderly FTF patients treated by i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S253193
更新日期:2021-01-06 00:00:00
abstract:Objective:We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the efficacy of cognitive stimulation therapy (CST) of different durations for Alzheimer's disease (AD). Methods:A comprehensive search was carried out in three databases. The primary outcome was Mini-Mental...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,meta分析
doi:10.2147/CIA.S210062
更新日期:2019-07-12 00:00:00
abstract:Objective:The number of long-term care (LTC) users and the associated expenditures in Japan are increasing dramatically. The national government recommends LTC prevention through activation of communities. However, there is no clear evidence of the effect of population-based comprehensive geriatric intervention program...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S151427
更新日期:2018-05-24 00:00:00
abstract:Purpose:Sleep disorders, such as insomnia with objective short sleep duration, are associated with increased risk of hypertension. The objective of the study was to evaluate the effects of insomnia and daytime sleepiness on the quality of life (QOL) among elderly hypertensive patients. Patients and methods:This cross-...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S188499
更新日期:2019-01-15 00:00:00
abstract:BACKGROUND:The modifications of cholesterol metabolism associated with aging are ill-defined. The objective of this study was to define age-associated alterations of the different metabolic pathways controlling cholesterol homeostasis by analyzing circulating sterols. METHODS:We analyzed serum samples collected from 2...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S57714
更新日期:2014-03-17 00:00:00
abstract:Background and Aim:Caregivers in the home environment have an important role in timely detecting and responding to abuse. The aim of this review was to provide insight into both the existing tools for the assessment of and interventions for elder abuse by formal and informal caregivers in the home environment, and to c...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S261877
更新日期:2020-09-28 00:00:00
abstract:Purpose:The purpose of this study was to identify how changes to general health might affect the oral health of nursing-home residents over a six-month period. Materials and Methods:The study was conducted in nine nursing homes in Germany. Sociodemographic and general data were collected at baseline and after six mont...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S234938
更新日期:2020-01-09 00:00:00
abstract::The objective of this article is to review the current and emerging treatments of CKD prior to dialysis in the elderly. Worldwide, there are increasing numbers of people who are aged over 65 years. In parallel, there are increasing numbers of elderly patients presenting with chronic kidney disease (CKD), particularly ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S39763
更新日期:2014-01-15 00:00:00
abstract:Objective:We studied the efficacy of zoledronic acid (ZOL) infusion on radiographic and clinical outcomes after percutaneous kyphoplasty (PKP) for elderly patients with osteoporotic thoracolumbar fractures (osteoporotic vertebral compression fractures [OVCFs]). Materials and methods:We retrospectively analyzed 95 elde...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S146871
更新日期:2018-05-04 00:00:00
abstract:BACKGROUND:Older patients with acute myocardial infarction (AMI) usually have a poor prognosis, but whether this poor prognosis leads to high hospital costs remains unclear. This study investigated the clinical outcomes of and costs incurred by older patients with AMI and metabolic syndrome (MS) in hospital. METHODS A...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S70372
更新日期:2015-01-23 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S162946
更新日期:2018-03-23 00:00:00
abstract:PURPOSE:The effects of a multicomponent dyadic intervention on the mood, behavior, and physical health of people with dementia living in the community were evaluated in a randomized controlled trial. This multicomponent dyadic intervention is a translated and adapted version of an intervention that has been shown to be...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S95789
更新日期:2016-03-31 00:00:00
abstract::The percentage of the population described as elderly is growing, and a higher prevalence of multiple, chronic disease states must be managed concurrently. Healthcare practitioners must appropriately use medication for multiple diseases and avoid risks often associated with multiple medication use such as adverse effe...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/cia.s2468
更新日期:2008-01-01 00:00:00
abstract::Dementia is one of the most important public health problems as a result of the rapid increase in the number of elderly persons worldwide. Improvement of prevention strategies and caring for people with dementia should be undertaken. We performed a door-to-door study to screen all subjects aged 50 years and older (n=4...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S48325
更新日期:2014-01-01 00:00:00
abstract::The most compelling reason and primary goal of treating actinic keratoses is to prevent malignant transformation into invasive squamous cell carcinoma, and although there are well established guidelines outlining treatment modalities and regimens for squamous cell carcinoma, the more commonly encountered precancerous ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S31930
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:This paper examines the influence of age on several attributes of sensorimotor performance while performing a reaching task. Our hypothesis, based on previous studies, is that aged persons will show differences in one or more of the attributes of sensorimotor performance. PATIENTS AND METHODS:Fifty-one subject...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S45900
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:We evaluated the short- to midterm outcomes of metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty (total joint replacement [TJR]) as surgical treatments for advanced-stage hallux rigidus (HR). PATIENTS AND METHODS:From 2012 to 2014, all data from patients who underwen...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S110865
更新日期:2016-12-13 00:00:00
abstract:OBJECTIVE:To estimate the value of the different thromboelastogram indices for predicting hemorrhage and vascular obstruction in an elderly population. METHODS:This was a prospective cohort study of patients 65 years and older without hemato-logic disorders who received thromboelastography (TEG) examination at the Chi...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S49478
更新日期:2013-01-01 00:00:00
abstract::Osteoarthritis is the most common arthritis in the world. It affects millions of people with age being the greatest risk factor for developing the disease. The burden of disease will worsen with the aging of the world's population. The disease causes pain and functional disability. The direct costs of osteoarthritis i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s1632
更新日期:2007-01-01 00:00:00
abstract::Life-space mobility (LSM) is a concept for assessing patterns of functional mobility over time. LSM is gaining traction in the research of geriatric population health. Several instruments have been developed to measure LSM, such as the University of Alabama at Birmingham Life-Space Assessment (LSA) or the Nursing Home...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S196944
更新日期:2020-09-15 00:00:00
abstract:Introduction:The clinical benefit of invasive therapy in elderly patients with acute coronary syndrome (ACS) remains unclear. Furthermore, the decision-making process to treat this growing patient group is also debatable. The purpose of this study was to assess the association between elderly ACS patients, the treatmen...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S249017
更新日期:2020-05-25 00:00:00
abstract::The topic of motor vehicle crashes among the elderly is dynamic and multi-faceted requiring a comprehensive and synergistic approach to intervention planning. This approach must be based on the values of a given population as well as health statistics and asserted through community, organizational and policy strategie...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:Purpose:The aim of the study was to evaluate the impact of inertial training on upper and lower extremity strength in the elderly. The study also assessed the influence of inertial training on their independence, balance, and speed and quality of gait. Methods:Twenty physically inactive older residents of a nursing ho...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S234299
更新日期:2020-02-07 00:00:00
abstract::Alzheimer's disease (AD) is the most common cause of dementia affecting nearly 18 million people around the world and 4.5 million in the US. It is a progressive neurodegenerative condition that is estimated to dramatically increase in prevalence as the elderly population continues to grow. As the cognitive and neurops...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/ciia.2006.1.2.131
更新日期:2006-01-01 00:00:00
abstract::We previously demonstrated the beneficial effects of a multisensory and cognitive stimulation program, consisting of 48 sessions, twice a week, to improve the cognition of elderly subjects living either in long-term care institutions (institutionalized - I) or in communities with their families (noninstitutionalized -...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S80997
更新日期:2015-08-19 00:00:00
abstract::[This corrects the article on p. 1237 in vol. 13, PMID: 30034227.]. ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,已发布勘误
doi:10.2147/CIA.S182535
更新日期:2018-09-05 00:00:00
abstract::Fracture of the hip is frequently a catastrophic event in the elderly, often resulting in death within a year and of the survivors, few regain pre-fracture quality of life. Although less appreciated, fractures of the spine result in significant morbidity and are also associated with increased mortality compared with i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s241
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Osteoarthritis (OA) is a degenerative disease characterized by a progressive loss of articular cartilage extracellular matrix and is due to functional impairments occurring in chondrocytes. In previous works, we highlighted that Regenerative Tissue Optimization (TO-RGN) treatment with radioelectric asymmetric c...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S42229
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Digoxin is a frequently prescribed drug, particularly in the elderly population, in which there is an increased prevalence of atrial fibrillation and cardiac failure. With its complex pharmacokinetic profile and narrow therapeutic index, use of digoxin requires regular monitoring of blood levels. Recent evid...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S63596
更新日期:2014-07-22 00:00:00
abstract::[This corrects the article on p. 737 in vol. 13, PMID: 29731615.]. ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,已发布勘误
doi:10.2147/CIA.S172968
更新日期:2018-09-10 00:00:00