Effect of 12-week home-based cognitive training on cognitive function and brain metabolism in patients with amnestic mild cognitive impairment.

Abstract:

Purpose:We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI). Patients and methods:Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks. Results:The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed. Conclusion:The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.

journal_name

Clin Interv Aging

authors

Park J,Kim SE,Kim EJ,Lee BI,Jeong JH,Na HR,Choi SH,Kang DY,Park KW

doi

10.2147/CIA.S200269

subject

Has Abstract

pub_date

2019-06-28 00:00:00

pages

1167-1175

eissn

1176-9092

issn

1178-1998

pii

200269

journal_volume

14

pub_type

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