Abstract:
:Obesity is a global epidemic associated with aging-like cellular processes; in both aging and obesity, resistance to hormones such as insulin and leptin can be observed. Leptin is a circulating hormone/cytokine with central and peripheral effects that is released mainly by subcutaneous white adipose tissue. Centrally, leptin controls food intake, energy expenditure, and fat distribution, whereas it controls (among several others) insulin sensitivity, free fatty acids (FFAs) oxidation, and lipolysis in the periphery. Aging is associated with important changes in both the distribution and the composition of adipose tissue. Fat is redistributed from the subcutaneous to the visceral depot and increased inflammation participates in adipocyte dysfunction. This redistribution of adipose tissue in favor of visceral fat influences negatively both longevity and healthy aging as shown in numerous animal models. These modifications observed during aging are also associated with leptin resistance. This resistance blunts normal central and peripheral functions of leptin, which leads to a decrease in neuroendocrine function and insulin sensitivity, an imbalance in energy regulation, and disturbances in lipid metabolism. Here, we review how age-related leptin resistance triggers metabolic disturbances and affects the longevity of obese patients. Furthermore, we discuss the potential impacts of leptin resistance on the decline of brown adipose tissue thermogenesis observed in elderly individuals.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Carter S,Caron A,Richard D,Picard Fdoi
10.2147/CIA.S36367subject
Has Abstractpub_date
2013-01-01 00:00:00pages
829-44eissn
1176-9092issn
1178-1998pii
cia-8-829journal_volume
8pub_type
杂志文章,评审abstract:BACKGROUND:Atrial fibrillation (AF) disproportionately affects older adults. However, direct comparison of clinical features, medical therapy, and outcomes in AF patients aged 65-74 and ≥ 75 years is rare. The objective of the present study was to evaluate the differences in clinical characteristics and prognosis in th...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,多中心研究
doi:10.2147/CIA.S67123
更新日期:2014-08-12 00:00:00
abstract:PURPOSE:With longer life expectancies, the prevalence of arrhythmias is increasing; thus, there is a need for new methods to screen the older outpatient population. This population-based study describes the prevalence of arrhythmias in 200 outpatients aged ≥66 years. We also investigated the feasibility of wireless lon...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S110532
更新日期:2016-08-10 00:00:00
abstract::Background: Current surgical risk assessment tools fall short of appreciating geriatric risk factors including cognitive deficits, depressive, and frailty symptoms that may worsen outcomes post-transcatheter aortic valve implantation (TAVI). This study hypothesized that a screening tool, SMARTIE, would improve detecti...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S201615
更新日期:2019-05-08 00:00:00
abstract:Background:Transcutaneous electrical nerve stimulation (TENS) is a noninvasive modality which may be used to reduce acute postoperative pain. Intense perioperative pain within the first few days after hip fracture surgery is common and is related to negative consequences such as restricted and delayed ambulation. Obje...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S203658
更新日期:2019-10-29 00:00:00
abstract:Purpose:Define the effectiveness of teriparatide (TPTD) treatment on reducing the incidence of new vertebral compression fractures (NVCFs) and back pain and improving quality of life after percutaneous kyphoplasty (PKP). Methods:Two years of clinical follow-up data from primary osteoporotic women who had experienced i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S224663
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this work was to analyze and compare the movement kinematics of sit-to-stand (STS) and back-to-sit (BTS) transfers between frail aged adults and young subjects, as well as to determine the relationship between kinematic changes and functional capacities. METHODS:We analyzed the Timed Up and Go...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S74755
更新日期:2015-02-26 00:00:00
abstract:Objective:The number of long-term care (LTC) users and the associated expenditures in Japan are increasing dramatically. The national government recommends LTC prevention through activation of communities. However, there is no clear evidence of the effect of population-based comprehensive geriatric intervention program...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S151427
更新日期:2018-05-24 00:00:00
abstract:OBJECTIVE:To evaluate the impact of chronic obstructive pulmonary disease (COPD) on left ventricular (LV) diastolic function in hospitalized elderly patients. METHODS:This was a case-control observational study of 148 consecutive hospitalized elderly patients (≥65 years old): 73 subjects without COPD as controls and 7...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S71878
更新日期:2014-12-19 00:00:00
abstract:Background:Neuromuscular electrical stimulation with muscle contraction, administered through the skin of the neck, improves a patient's swallowing ability. However, the beneficial effects of transcutaneous electrical sensory stimulation (TESS), without muscle contraction, are controversial. We investigated the effect ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S140746
更新日期:2017-11-07 00:00:00
abstract:BACKGROUND:One of the key clinical features of Alzheimer's disease (AD) is impairment in daily functioning. Patients with mild cognitive impairment (MCI) also commonly have mild problems performing complex tasks. Information and communication technology (ICT), particularly techniques involving imaging and video process...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S36297
更新日期:2012-01-01 00:00:00
abstract::Uncertainty appears to typify the experience of living with dementia. With an uncertain illness trajectory and unpredictable levels of deterioration and stability in symptoms, people with a diagnosis of dementia may live with uncertainty and anxiety and find it hard to make plans or decisions for their future. People ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S70628
更新日期:2014-11-27 00:00:00
abstract:PURPOSE:The effects of a multicomponent dyadic intervention on the mood, behavior, and physical health of people with dementia living in the community were evaluated in a randomized controlled trial. This multicomponent dyadic intervention is a translated and adapted version of an intervention that has been shown to be...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
doi:10.2147/CIA.S95789
更新日期:2016-03-31 00:00:00
abstract:BACKGROUND:The skeletal muscle echo intensity (EI) during ultrasound imaging has been investigated to evaluate the muscle quality. However, EI fluctuates according to the scanning conditions. METHODS:The motor functions and ultrasound images of 19 elderly (73 ± 3.2 years) and 19 young (22 ± 1.5 years) individuals were...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S67820
更新日期:2014-09-05 00:00:00
abstract::Promoting health and prolonging independence in the home is a priority for older adults, caregivers, clinicians, and society at large. Rapidly developing robotics technology provides a platform for interventions, with the fields of physically and socially assistive robots expanding in recent years. However, less atten...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/CIA.S253236
更新日期:2020-07-13 00:00:00
abstract:Background:Multiple cranial dural arteriovenous fistulas (dAVFs) are considered to be an uncommon vascular condition. dAVFs usually manifest with vague symptoms, which are related to the site of occurrence of the lesion and present with complex angio-architectural features, which in turn can render treatment procedures...
journal_title:Clinical interventions in aging
pub_type:
doi:10.2147/CIA.S277762
更新日期:2020-12-08 00:00:00
abstract:Background:Myocardial infarction (MI) is a common cause of death worldwide. It is characterized by coronary artery occlusion that causes ischemia and hypoxia of myocardial cells, leading to irreversible myocardial damage. Materials and Methods:To explore potential targets for treatment of MI, we reorganized and analyz...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S281290
更新日期:2020-12-01 00:00:00
abstract::Alzheimer's disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for prevention and treatment of AD is a growing topic. In this sense, carotenoids are phytochemicals presen...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S134605
更新日期:2017-05-15 00:00:00
abstract:Purpose:The aim of our study was to explore the risk factors related to blood transfusion after intramedullary nail fixation of elderly femoral intertrochanteric fracture (FTF) and establish a nomogram prediction model. Patients and Methods:We conducted a retrospective study including elderly FTF patients treated by i...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S253193
更新日期:2021-01-06 00:00:00
abstract::Digital ulcers (DUs) are a severe and frequent clinical feature of patients with systemic sclerosis (SSc). The presence of DUs may cause severe pain and often lead to impairment of patient's functional activities and health-related quality of life. Moreover, poor patient cooperation during the wound care procedure due...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S102577
更新日期:2016-03-14 00:00:00
abstract:BACKGROUND:Older patients with acute myocardial infarction (AMI) usually have a poor prognosis, but whether this poor prognosis leads to high hospital costs remains unclear. This study investigated the clinical outcomes of and costs incurred by older patients with AMI and metabolic syndrome (MS) in hospital. METHODS A...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S70372
更新日期:2015-01-23 00:00:00
abstract:Background:Postoperative functional training for fracture or osteoarthritis is mainly focused on functional self-exercise, which aims to recover the function of the lower limbs. Purpose:To compare the function and life quality recovery in patients with fracture or arthritis treated with novel muscle training device (N...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S277118
更新日期:2020-11-18 00:00:00
abstract::Type 2 diabetes mellitus affects 5.9% of the world adult population, with older people and some ethnic groups disproportionately affected. Treatment of older people with diabetes differs in many ways from that in younger adults since the majority have type 2 disease and are at particular risk of macrovascular rather t...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
doi:10.2147/cia.s3142
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:This cross-sectional study compared three tools for predicting painful new osteoporotic vertebral fractures (PNOVFs) in older Chinese men: bone mineral density (BMD), the Osteoporosis Self-Assessment Tool for Asians (OSTA), and the World Health Organization fracture risk assessment tool (FRAX) (without BMD). ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S101078
更新日期:2016-04-22 00:00:00
abstract:OBJECTIVE:The best practice tariff (BPT) incentivizes hospitals in the England and Wales National Health Service to provide multiprofessional care to patients with hip fractures. The initial six targets included: 1) admission under consultant-led joint orthopedic-geriatric care, 2) multidisciplinary assessment protocol...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S65736
更新日期:2014-12-01 00:00:00
abstract:Background:Functional dependence (FD) and vitamin D deficiency are common conditions in older adults. However, little is known about the relationship between FD and serum vitamin D status in centenarians. The current study was designed to evaluate the prevalence of FD and examine its relationship with serum vitamin D s...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S182318
更新日期:2018-10-17 00:00:00
abstract::Endoscopic surgical treatment has become an option to treat benign prostate hyperplasia. We evaluated the safety and effectiveness of photoselective vaporization of the prostate (PVP) in patients. We evaluated preoperative and perioperative parameters, functional outcomes, and adverse events up to 12 months postoperat...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S41270
更新日期:2013-01-01 00:00:00
abstract:Purpose:The post-stroke elderly was increased caused by increasing stroke and advanced medical. However, ankle-foot orthoses (AFOs) can be uncomfortable for hemiplegic patients; therefore, the usability is not good. In this study, we analyzed ankle and knee joint angles in post-stroke elderly patients to assess the fun...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S222087
更新日期:2019-12-05 00:00:00
abstract:PURPOSE:Osteoarthritis (OA) is a degenerative disease characterized by a progressive loss of articular cartilage extracellular matrix and is due to functional impairments occurring in chondrocytes. In previous works, we highlighted that Regenerative Tissue Optimization (TO-RGN) treatment with radioelectric asymmetric c...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S42229
更新日期:2013-01-01 00:00:00
abstract:Objective:The aim of this study was to evaluate the effects of dental status and chewing efficiency on the oral-health-related quality of life (OHRQoL) of nursing-home residents. Materials and Methods:The study was conducted in nine nursing homes. All eligible participants were included, and general and medical data, ...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S273671
更新日期:2020-11-11 00:00:00
abstract:Purpose:The study aimed to investigate the association between body composition and frailty in elder inpatients. Patients and Methods:This is a cross-sectional study including 656 elder inpatients (275 females and 381 males) aged ≥65 years, from department of geriatrics of Zhejiang Hospital between January 2018 and Ma...
journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S243211
更新日期:2020-03-04 00:00:00