Abstract:
Purpose:Define the effectiveness of teriparatide (TPTD) treatment on reducing the incidence of new vertebral compression fractures (NVCFs) and back pain and improving quality of life after percutaneous kyphoplasty (PKP). Methods:Two years of clinical follow-up data from primary osteoporotic women who had experienced initial osteoporotic vertebral compression fractures (OVCFs) and received PKP plus 12-month TPTD (n=113) or basic treatment (BT) of calcium and vitamin D supplements (n=208) were retrospectively collected. The risk of NVCFs over each 6-month period in the TPTD group was evaluated and compared with the BT group using a logistic regression. Health-related quality of life (HRQoL, EQ-5D questionnaire), back pain [100 mm visual analog scale (VAS)] and bone mineral density (BMD) of the spine were analyzed using linear mixed models for repeated measures (LMMRM). Results:Logistic regression analysis adjusting for baseline characteristics showed that patients in the TPTD group had a lower risk of NVCFs compared with those receiving BT during the final three observation intervals (6-12 months, OR=0.189, 95% CI=0.030-0.681, p=0.046; 12-18 months, OR=0.009, 95% CI=0.0001-0.111, p=0.001; 18-24 months, OR=0.024, 95% CI=0.0009-0.264, p=0.009, respectively). Significant improvements in adjusted EQ-5D and back pain VAS scores were identified in the TPTD group compared with the BT group, and this improvement was sustained for at least 12 months after teriparatide treatment was discontinued (both p<0.001). The BMD of the spine also showed a higher T-value in the TPTD group compared with the BT group (p<0.001). Conclusion:In routine clinical practice, for patients with OVCFs who receive the PKP procedure, TPTD treatment may be a preferable subsequent therapy because of its ability to reduce the incidence of NVCFs and sustain a high quality of life and back pain alleviation.
journal_name
Clin Interv Agingjournal_title
Clinical interventions in agingauthors
Kong M,Zhou C,Zhu K,Zhang Y,Song M,Zhang H,Tu Q,Ma Xdoi
10.2147/CIA.S224663subject
Has Abstractpub_date
2019-10-01 00:00:00pages
1693-1703eissn
1176-9092issn
1178-1998pii
224663journal_volume
14pub_type
杂志文章abstract:PURPOSE:To evaluate whether yogurt supplemented with a probiotic strain could protect middle-aged and elderly people from acute upper respiratory tract infections (URTI) using a randomized, blank-controlled, parallel-group design. PATIENTS AND METHODS:Two hundred and five volunteers aged ≥45 years were randomly divide...
journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
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更新日期:2017-01-06 00:00:00
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
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journal_title:Clinical interventions in aging
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更新日期:2019-12-16 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S104425
更新日期:2016-05-19 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,meta分析
doi:10.2147/CIA.S210062
更新日期:2019-07-12 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S120876
更新日期:2017-06-28 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S281290
更新日期:2020-12-01 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:10.2147/CIA.S68801
更新日期:2014-09-11 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,评审
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journal_title:Clinical interventions in aging
pub_type: 杂志文章,随机对照试验
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doi:10.2147/CIA.S234299
更新日期:2020-02-07 00:00:00
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journal_title:Clinical interventions in aging
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
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journal_title:Clinical interventions in aging
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更新日期:2010-09-07 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-05-08 00:00:00
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更新日期:2018-08-29 00:00:00