abstract：:Gaps between limited health resources and expanding health service demands are emerging to be more and more prominent, which extremely generate the cost-effective strategies for scientific policy-making in the context of healthcare. As a systematic approach and solid tool to promote healthcare system more efficient an...

authors： Chen Y

更新日期：2022-03-01 00:00:00

abstract：:Patients with type 2 diabetes mellitus (T2DM) often have cognitive impairment and structural brain abnormalities. The magnetic resonance imaging (MRI)-based brain atrophy and lesion index can be used to evaluate common brain changes and their correlation with cognitive function, and can therefore also be used to refle...

authors： Zhao H,Wang F,Luo GH,Lei H,Peng F,Ren QP,Chen W,Wu YF,Yin LC,Liu JC,Pan SN

更新日期：2022-03-01 00:00:00

abstract：:Lipid droplets (LDs) are globular intracellular structures dedicated to the storage of neutral lipids. They are closely associated with the endoplasmic reticulum (ER) and are delineated by a monolayer of phospholipids that is continuous with the cytoplasmic leaflet of the ER membrane. LDs contain a specific set of pro...

authors： Cottier S,Schneiter R

更新日期：2022-03-01 00:00:00

abstract：:Membrane contact sites (MCSs) between the endoplasmic reticulum (ER) and late endosomes/lysosomes (LE/lys) are emerging as critical hubs for diverse cellular events, and changes in their extents are linked to severe neurological diseases. While recent studies show that the synaptotagmin-like mitochondrial-lipid-bindin...

authors： Gao Y,Xiong J,Chu QZ,Ji WK

更新日期：2022-03-01 00:00:00

abstract：:Data from a survey of 1478 travelers and multistep group structural equation model analysis revealed that the Health Belief Model constructs of cues to action (trust in third-party information sources), perceived severity of and susceptibility to COVID-19, and beliefs about the protection benefits of a COVID-19 vaccin...

authors： Suess C,Maddock J,Dogru T,Mody M,Lee S

更新日期：2022-02-01 00:00:00

abstract：:Fibromyalgia (FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investig...

authors： Martins CP,Paes RS,Baldasso GM,Ferrarini EG,Scussel R,Zaccaron RP,Machado-de-Ávila RA,Lock Silveira PC,Dutra RC

更新日期：2022-02-01 00:00:00

abstract：:High-frequency spinal cord stimulation (HF-SCS) has been established as an effective therapy for neuropathic pain. However, the analgesic mechanisms involved in HF-SCS remain to be clarified. In our study, adult rat neuropathic pain was induced by spinal nerve ligation. Two days after modeling, the rats were subjected...

authors： Wang ZB,Liu YD,Wang S,Zhao P

更新日期：2022-02-01 00:00:00

abstract：:The onset and mechanisms underlying neurodegenerative diseases remain uncertain. The main features of neurodegenerative diseases have been related with cellular and molecular events like neuronal loss, mitochondrial dysfunction and aberrant accumulation of misfolded proteins or peptides in specific areas of the brain....

authors： Panes JD,Wendt A,Ramirez-Molina O,Castro PA,Fuentealba J

更新日期：2022-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are considerably small yet highly important riboregulators involved in nearly all cellular processes. Due to their critical roles in posttranscriptional regulation of gene expression, they have the potential to be used as biomarkers in addition to their use as drug targets. Although computational ap...

authors： Yaylak B,Akgül B

更新日期：2022-01-01 00:00:00

abstract：:Mechanistic modeling in biology allows to investigate, based on first principles, if putative hypotheses are compatible with observations and to drive further experimental works. Along this line, polymer modeling has been instrumental in 3D genomics to better understand the impact of key mechanisms on the spatial geno...

authors： Jost D

更新日期：2022-01-01 00:00:00

abstract：:Gene regulation is of utmost importance to cell homeostasis; thus, any dysregulation in it often leads to disease. MicroRNAs (miRNAs) are involved in posttranscriptional gene regulation and consequently, their dysregulation has been associated with many diseases.MiRBase version 21 contains microRNAs from about 200 spe...

authors： Odenthal L,Allmer J,Yousef M

更新日期：2022-01-01 00:00:00

abstract：:Epigenomics studies require the combined analysis and integration of multiple types of data and annotations to extract biologically relevant information. In this context, sophisticated data visualization techniques are fundamental to identify meaningful patterns in the data in relation to the genomic coordinates. Data...

authors： Pal K,Ferrari F

更新日期：2022-01-01 00:00:00

abstract：Background:Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are genomic imprinting disorders that are mainly caused by a deletion on 15q11-q13, the uniparental disomy of chromosome 15, or an imprinting defect. We evaluated the utility of methylation-specific multiplex ligation-dependent probe amplification (MS-ML...

authors： Kim B,Park Y,Cho SI,Kim MJ,Chae JH,Kim JY,Seong MW,Park SS

更新日期：2022-01-01 00:00:00

abstract：:Studies have shown that downregulation of nuclear-enriched autosomal transcript 1 (Neat1) may adversely affect the recovery of nerve function and the increased loss of hippocampal neurons in mice. Whether Neat1 has protective or inhibitory effects on neuronal cell apoptosis after secondary brain injury remains unclear...

authors： Chai WN,Wu YF,Wu ZM,Xie YF,Shi QH,Dan W,Zhan Y,Zhong JJ,Tang W,Sun XC,Jiang L

更新日期：2022-01-01 00:00:00

abstract：:Dynamic protein-protein interactions are essential for proper cell functioning. Homo-interaction events-physical interactions between the same type of proteins-represent a pivotal subset of protein-protein interactions that are widely exploited in activating intracellular signaling pathways. Capacities of modulating p...

authors： Huang P,Zhao Z,Duan L

更新日期：2022-01-01 00:00:00

abstract：:Few validated tools exist for measuring physical activity following total knee arthroplasty (TKA) despite the importance of returning to sufficient levels of physical activity post-TKA to achieve health benefits. This study examined the validity of two clinical measures-the Fitbit, a commercially available personal ac...

authors： Jasper L,Beaupre LA,Spence JC,Jones CA

更新日期：2021-12-30 00:00:00

abstract：:FK506, a first-line immunosuppressant, is routinely administered orally and intravenously to inhibit activation and proliferation of T cells after heart transplantation (HT). Current administration route is not conducive enough to exert its efficacy in lymphatic system. Herein, we proposed that subcutaneous (SC) admin...

authors： Deng C,Jin Q,Wu Y,Li H,Yi L,Chen Y,Gao T,Wang W,Wang J,Lv Q,Yang Y,Xu J,Fu W,Zhang L,Xie M

更新日期：2021-12-01 00:00:00

abstract：:The COVID-19 epidemic and government intervention measures may have adverse effects on people's mental health. To explore the influence of pets on the intervention of people's psychological problems during the COVID-19 epidemic, an online survey was carried out between April 9 and April 29, 2020. A total of 756 partic...

authors： Xin X,Cheng L,Li S,Feng L,Xin Y,Wang S

更新日期：2021-12-01 00:00:00

abstract：:Early growth response-1 (EGR1) is a multi-domain protein and an immediate early transcription factor that is induced during liver injury and controls the expression of a variety of genes implicated in metabolism, cell proliferation, and tumorigenesis. Liver cancer (LC) is a highly malignant disease with high mortality...

authors： Zhang L,Ren R,Yang X,Ge Y,Zhang X,Yuan H

更新日期：2021-12-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) play crucial roles in human diseases. However, the detailed role of lncRNAs in hypertrophic scar fibroblasts (HSFs) is inadequately understood. This study aimed to investigate the potential role of lncRNA nuclear enriched abundant transcript 1 (NEAT1) in hypertrophic scarring. Expression...

authors： Wu Q,Chen J,Tan Z,Wang D,Zhou J,Li D,Cen Y

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:The purpose of the study was to examine the immediate-term effect of positive-word stimuli via a smartphone application on the multi-directional reach ability in standing position in young adults. METHODS:This study was an immediate-term, assessor-blinded, two-arm, parallel-group, randomized controlled tria...

authors： Azukizawa K,Hirose K,Morigami Y,Higashi N,Uchida H,Hirao K

更新日期：2021-12-01 00:00:00

abstract：:Development of chemoresistance remains a major challenge in treating patients suffering from esophageal squamous cell carcinoma (ESCC), despite treatment advances. MicroRNAs (miRNAs) have been shown to play critical roles in the regulation of ESCC cell chemoresistance. Here, we aimed to investigate the role of miR-624...

authors： Yan J,Shi L,Lin S,Li Y

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Ambrisentan is an oral endothelin-receptor antagonist (ERA). However, there is no report on the interaction between ambrisentan and shikonin. OBJECTIVE:To investigate the effect of shikonin on ambrisentan metabolism in vivo and in vitro. MATERIALS AND METHODS:This study developed an ultra-performance liquid c...

authors： Lan T,Fang P,Ye X,Lan X,Xu RA

更新日期：2021-12-01 00:00:00

abstract：:High-density lipoprotein (HDL) particles comprising heterogeneous subclasses of different functions exert anti-inflammatory effects by interacting with immune-response cells. However, the relationship of HDL subclasses with immune-response cells in metabolic unhealth/obesity has not been defined clearly. The purpose o...

authors： Tang H,Xiang Z,Li L,Shao X,Zhou Q,You X,Xiong C,Ning J,Chen T,Deng D,Zou H

更新日期：2021-12-01 00:00:00

abstract：:Colon adenocarcinoma (COAD) is one of the most common types of malignancy and accounts for >3 million deaths worldwide each year. The present study aimed to evaluate the role of notum palmitoleoyl-protein carboxylesterase (NOTUM) in in vivo and in vitro, and to identify the relationship between NOTUM and the apoptosis...

authors： Gong H,Niu Q,Zhou Y,Wang YX,Xu XF,Hou KZ

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Incremental peritoneal dialysis (iPD) can be useful in patients with residual renal function (RRF). RRF was well preserved and similar survival was shown in iPD compared to conventional PD (cPD) in previous study. However, the long-term survival of iPD remains unclear compared to cPD in diabetic patients. Th...

authors： Lee SM,Min YS,Son YK,Kim SE,An WS

更新日期：2021-12-01 00:00:00

abstract：:Seventy-five individually fed barrows averaging 35 kg were used in a series of three experiments for 6-week growth assays (25 barrows each) to determine the effects of l-tryptophan (Trp) supplementation on growth performance and to establish the lower limits of dietary crude protein (CP) levels. Corn and soybean meal ...

authors： Sato H,Miura M,Fujieda T,Taciak M,Kikusato M,Sato K,Toyomizu M

更新日期：2021-12-01 00:00:00

abstract：INTRODUCTION:Patients on maintenance hemodialysis (MHD) are highly predisposed to low bone mineral density (BMD). This study aims to assess the value of quantitative ultrasound (QUS), bioelectrical impedance analysis (BIA), and their combination in detecting high-risk patients for low BMD in MHD. METHODS:Patients' BMD...

authors： Xiang T,Zhou L,Fu P,Yan XP,Zeng XQ

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Growing prevalence of chronic diseases is a rising challenge for healthcare systems. The Primary Care Practice-Based Care Management (PraCMan) programme is a comprehensive disease management intervention in primary care in Germany aiming to improve medical care and to reduce potentially avoidable hospitalisa...

authors： Senft JD,Freund T,Wensing M,Schwill S,Poss-Doering R,Szecsenyi J,Laux G

更新日期：2021-12-01 00:00:00

abstract：:Scavenger receptors are part of a complex surveillance system expressed by host cells to efficiently orchestrate innate immune response against bacterial infections. Stabilin-1 (STAB-1) is a scavenger receptor involved in cell trafficking, inflammation, and cancer; however, its role in infection remains to be elucidat...

authors： Pombinho R,Pinheiro J,Resende M,Meireles D,Jalkanen S,Sousa S,Cabanes D

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Direct access to hospital radiology facilities by general practitioner (GP) cooperatives is known to decrease the number of emergency department referrals, but the effects on length of stay (LOS; time from patient arrival at GP cooperative till departure to home) and patient experiences are unclear. OBJECTI...

authors： Rutten MH,Giesen PHJ,Assendelft WJJ,Westert G,Smits M

更新日期：2021-12-01 00:00:00

abstract：:The location of the instantaneous helical axis (IHA) and the impact of the facet joints (FJ) on the kinematics in the thoracic spine remain inconclusive. This study aimed to examine the IHA in the functional spinal unit (FSU) T4-5 during axial rotation in intact conditions and after bilateral facetectomy. Four human T...

authors： Roch PJ,Saul D,Wüstefeld N,Spiering S,Lehmann W,Weiser L,Wachowski MM

更新日期：2021-12-01 00:00:00

abstract：:The growth and morphology of rumen methanogenic archaea (15 strains of 10 species in 5 genera, including 7 strains newly isolated in the present study) and bacteria (14 species in 12 genera) were investigated using unsupplemented in vitro pure cultures and cultures supplemented with cashew nut shell liquid (CNSL) and ...

authors： Wakai M,Hayashi S,Chiba Y,Koike S,Nagashima K,Kobayashi Y

更新日期：2021-12-01 00:00:00

abstract：:The competence centre for Residency Training in Family Medicine Bavaria (CCRTB) was established to improve the quality of postgraduate medical education by offering training and mentoring programmes for residents, and by providing train-the-trainer and mentoring courses for supervisors. Beyond that, regional Residency...

authors： Olm M,Roos M,Hapfelmeier A,Schneider D,Gensichen J,Berberat PO,Schneider A

更新日期：2021-12-01 00:00:00

abstract：:With the outbreak of COVID-19, online sharing of rumors about the disease is of growing concern worldwide. Drawing on the stimulus-organism-response (S-O-R) framework, this study aims to explore the impacts of peer condition and peer communication on fear of COVID-19, and the impact of fear of COVID-19 on online rumor...

authors： Luo P,Wang C,Guo F,Luo L

更新日期：2021-12-01 00:00:00

abstract：:MicroRNA 200a (miR-200a) can inhibit the activation and proliferation of hepatic stellate cells (HSCs) through the transforming growth factor-β (TGF-β) signaling pathway, and improve fibrotic lesions. However, to date, there is no study exploring the role of miR-200a in schistosomiasis liver fibrosis (SLF). In this st...

authors： Xu A,Zhong G,Wang J,Liu C,Liu Y,Wang W

更新日期：2021-12-01 00:00:00

abstract：:There are few studies on the role of iron metabolism genes in predicting the prognosis of lung adenocarcinoma (LUAD). Therefore, our research aims to screen key genes and to establish a prognostic signature that can predict the overall survival rate of lung adenocarcinoma patients. RNA-Seq data and corresponding clini...

authors： Qin J,Xu Z,Deng K,Qin F,Wei J,Yuan L,Sun Y,Zheng T,Li S

更新日期：2021-12-01 00:00:00

abstract：:Aim: Colorectal cancer (CRC) is one of the leading cancers in the world. Even though its mortality and pathophysiology are well documented in the US and the European countries, it is seldom studied in North African population. Recent studies have shown link of HER2 overexpression in oesophageal and gastric cancers. Th...

authors： Abdul Razzaq EA,Venkatachalam T,Bajbouj K,Rahmani M,Mahdami A,Rawat S,Mansuri N,Alhashemi H,Hamoudi RA,Bendardaf R

更新日期：2021-12-01 00:00:00

abstract：:The rumen microbiota comprises a vast range of bacterial taxa, which may affect the production of high-quality meat in Japanese Black cattle. The aim of this study was to identify core rumen microbiota in rumen fluid samples collected from 74 Japanese Black cattle raised under different dietary conditions using 16S rR...

authors： Miura H,Hashimoto T,Kawanishi Y,Kawauchi H,Inoue R,Shoji N,Saito K,Sekiya M,Saito Y,Yasuda J,Yonezawa C,Endo T,Kasuya H,Suzuki Y,Kobayashi Y,Koike S

更新日期：2021-12-01 00:00:00

abstract：Background:In December 2019, a global pandemic of Coronavirus 2019 (COVID-19) has invaded entire the world. The virus associated with the COVID-19 infections is SARS-CoV-2; the infections are mainly pulmonary manifesting as severe respiratory complications such as acute respiratory distress syndrome. However, there are...

authors： Azab MA,Hasaneen SF,Hanifa H,Azzam AY

更新日期：2021-12-01 00:00:00