Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS.

abstract：:Pergularia daemia (Forsk.) Chiov. (Asclepiadaceae) is used traditionally as an anthelmintic, laxative, antipyretic, and expectorant, and also used to treat malarial intermittent fever. But the scientific parameters are not yet available to identify the true plant material. In the present investigation, various pharmac...

journal_title：Pharmaceutical biology

authors： Bhaskar VH,Balakrishnan N

更新日期：2010-04-01 00:00:00

abstract：:The root extract of Hemidesmus indicus (Linn.) R. Br. (Asclepiadaceae) (HI) was studied for its cardioprotective effect in Langendorff-perfused rat hearts. HI was perfused for 15 min at a concentration of 0.09 g/L prior to 30 min global ischemia/120 min reperfusion (I/R). Recovery of functional parameters, reperfusion...

journal_title：Pharmaceutical biology

authors： Khandelwal VK,Balaraman R,Ondrejcáková M,Pancza D,Ravingerová T

更新日期：2010-06-01 00:00:00

abstract：:Clematis brachiata Thunb. (Ranunculaceae) is used as a folk remedy for the treatment of pain, fever and inflammatory ailments. Aqueous extract of Clematis brachiata leaf was screened for its phytochemical constituents. The anti-inflammatory investigations were carried out using carrageenan and histamine-induced edema ...

journal_title：Pharmaceutical biology

authors： Mostafa M,Appidi JR,Yakubu MT,Afolayan AJ

更新日期：2010-06-01 00:00:00

abstract：:Guava [Psidium guajava L. (Myrtaceae)] budding leaf extract (PE) has shown tremendous bioactivities. Previously, we found seven major compounds in PE, i.e., gallic acid, catechin, epicatechin, rutin, quercetin, naringenin, and kaempferol. PE showed a potentially active antiglycative effect in an LDL (low density lipop...

journal_title：Pharmaceutical biology

authors： Chen KC,Chuang CM,Lin LY,Chiu WT,Wang HE,Hsieh CL,Tsai T,Peng RY

更新日期：2010-01-01 00:00:00

abstract：:Vinca minor L. (Apocynaceae) is a medicinal plant that has long been used to treat cerebral and memory disorders in European folk medicine. Furthermore, it contains more than 50 alkaloids, some of them having bisindole structure such as the antineoplastic alkaloids present in Catharanthus roseus (L.) G. Don (Apocynace...

journal_title：Pharmaceutical biology

authors： Khanavi M,Pourmoslemi S,Farahanikia B,Hadjiakhoondi A,Ostad SN

更新日期：2010-01-01 00:00:00

abstract：:The epicarp and seed of Persea Americana Mill. var. Hass (Lauraceae), Persea Americana Mill. var. Shepard, and Persea americana Mill. var Fuerte cultivars of mature avocados (n = 3) were ground separately and extracted with both absolute ethanol and distilled water. Extracts were analyzed for antimicrobial activity us...

journal_title：Pharmaceutical biology

authors： Raymond Chia TW,Dykes GA

更新日期：2010-07-01 00:00:00

abstract：:Earthworm fibrinolytic enzymes (EFEs), an ideal drug for cardiovascular diseases, have a very low oral bioavailability. In order to improve the absorption of EFEs, six different enhancers were selected to increase the intestinal absorption of EFEs. In vitro (Caco-2 monolayers) and in vivo (mice) experiments were carri...

journal_title：Pharmaceutical biology

authors： Yu Q,Li P,Yang Q

更新日期：2010-07-01 00:00:00

abstract：:Herba Cistanche, a Chinese herb derived from the whole plant of Cistanche deserticola Y.C. Ma (Orobanchaceae), has been shown to enhance mitochondrial ATP generation and to protect against myocardial ischemia/reperfusion (I/R) injury ex vivo in rats. To define the role of mitochondria in the cardioprotective action of...

journal_title：Pharmaceutical biology

authors： Siu AH,Ko KM

更新日期：2010-05-01 00:00:00

abstract：:Urtica cannabina L. (Urticaceae) is a perennial herb that grows in Xinjiang Uighur Autonomous Region (northwest China). Two megastigmanes (1, 2) and five flavonoid glycosides (3-7) were isolated from its fruit. Compound 1 was determined by spectroscopic analysis to be (+)-blumenol A, and its absolute stereochemistry w...

journal_title：Pharmaceutical biology

authors： Aishan H,Baba M,Iwasaki N,Kuang H,Okuyama T

更新日期：2010-05-01 00:00:00

abstract：:Aristolochia baetica L. (Aristolochiaceae) and Origanum compactum Benth. (Lamiaceae) are native plants of Morocco used in traditional medicine. In order to systematically evaluate their potential activity on human breast cancer, four different polarity extracts from each plant were assessed in vitro for their antiprol...

journal_title：Pharmaceutical biology

authors： Chaouki W,Leger DY,Eljastimi J,Beneytout JL,Hmamouchi M

更新日期：2010-03-01 00:00:00

abstract：:No phytochemical investigation regarding Scrophularia striata Boiss. (Scrophulariaceae) has been performed, although several reports about other Scrophularia species have been published. The inhibitory effects of aerial parts of S. striata on matrix metalloproteinase expression elaborate a new approach to treat variet...

journal_title：Pharmaceutical biology

authors： Monsef-Esfahani HR,Hajiaghaee R,Shahverdi AR,Khorramizadeh MR,Amini M

更新日期：2010-03-01 00:00:00

abstract：:Four quaternary isoquinoline alkaloids, dehydrocorydalmine, jatrorrhizine, columbamine, and oxyberberine, have been isolated from the whole plant of Argemone mexicana Linn. (Papaveraceae) and their structures established by spectral evidence. This is the first report of these alkaloids (dehydrocorydalmine, jatrorrhizi...

journal_title：Pharmaceutical biology

authors： Singh S,Singh TD,Singh VP,Pandey VB

更新日期：2010-02-01 00:00:00

abstract：:Gloriosa superba L. (Liliaceae) seeds, known as "kalihari" (Hindi), were phytochemically investigated for colchicine (well known for gout treatment) and other related alkaloid content. Colchicine, 2- demethylcolchicine, 3-demethylcolchicine, and N-formyl-N-deacetylcolchicine were alkaloids isolated from the seeds. The...

journal_title：Pharmaceutical biology

authors： Joshi CS,Priya ES,Mathela CS

更新日期：2010-02-01 00:00:00

abstract：:Alpinia conchigera Griff. (Zingiberaceae), locally known to the Malays as "lengkuas ranting", is native to Peninsular Malaysia. The Malays traditionally used it to treat infection and rashes, and as a health drink. This study evaluated the analgesic and anti-inflammatory activities of the ethanol extract of A. conchig...

journal_title：Pharmaceutical biology

authors： Sulaiman MR,Zakaria ZA,Mohamad AS,Ismail M,Hidayat MT,Israf DA,Adilius M

更新日期：2010-08-01 00:00:00

abstract：CONTENT:Vascular smooth muscle cells (VSMCs) play a major role in the pathogenesis of atherosclerosis and restenosis, and thus the excessive proliferation of VSMCs contributes to neointimal thickening during atherosclerosis and restenosis. PMC (2,2,5,7,8-pentamethyl-6-hydroxychromane) is the most potent hydrophilic der...

journal_title：Pharmaceutical biology

authors： Chang CC,Lee JJ,Chiang CW,Jayakumar T,Hsiao G,Hsieh CY,Sheu JR

更新日期：2010-08-01 00:00:00

abstract：CONTEXT:The roots of Plumbago zeylanica Linn. (Plumbaginaceae) are reputed to have a wide spectrum of therapeutic properties in the Ayurvedic system of medicine. They are useful in curing many ailments such as skin diseases, diarrhea, plague and leprosy. OBJECTIVE:The study was aimed at isolating, separating and evalu...

journal_title：Pharmaceutical biology

authors： Jetty A,Subhakar C,Rajagopal D,Jetty M,Subramanyam M,Marthanda Murthy M

更新日期：2010-09-01 00:00:00

abstract：CONTEXT:Stachyss species have been used as a medicine for centuries throughout the world. Stachys lavandulifolia Vahl. var. lavandulifolia (Lamiaceae) is of interest to researchers because the constituents such as betulinic acid, oleanolic acid, rosmarinic acid, and ursolic acid are similar to other Stachys species com...

journal_title：Pharmaceutical biology

authors： Altun D,Ayar A,Uysal H,Kara AA,Unal EL

更新日期：2010-11-01 00:00:00

abstract：AIM:Growing evidence indicates that the glutamatergic system, especially the abnormalities of glutamate and N-methyl-D-aspartate (NMDA) receptors contribute to the pathophysiology and possibly the pathogenesis of major depressive disorders. This study is to evaluate the effect of gan mai da zao (GMDZ) decoction on glut...

journal_title：Pharmaceutical biology

authors： Lou JS,Li CY,Yang XC,Fang J,Yang YX,Guo JY

更新日期：2010-12-01 00:00:00

abstract：CONTEXT: Allanblackia floribunda Oliver (Guttiferae) is an African medicinal plant used traditionally to treat a variety of ailments. OBJECTIVE: We investigated the antitumor, radical scavenging, antimycobacterial, antibacterial and antifungal activities of the root bark extract of A. floribunda and three isolated phe...

journal_title：Pharmaceutical biology

authors： Kuete V,Azebaze AG,Mbaveng A,Nguemfo EL,Tshikalange ET,Chalard P,Nkengfack AE

更新日期：2011-01-01 00:00:00

abstract：CONTEXT:Cinnamomum osmophloeum Kaneh. (Lauraceae) is one of the indigenous tree species in Taiwan. This tree species has been of interest to researchers because the chemical constituents of its essential oil are similar to those of Cinnamomum cassia Presl. bark oil, known as cinnamon oil, which is commonly used in food...

journal_title：Pharmaceutical biology

authors： Tung YT,Yen PL,Lin CY,Chang ST

更新日期：2010-10-01 00:00:00

abstract：CONTEXT:Capparis ovata Desf. (Capparaceae) grows widely in Turkey. Flower buds and fruits of the plant are used in folk medicine for their analgesic, antirheumatismal, and diuretic effects. OBJECTIVE:This study evaluated the possible antinociceptive effect of the methanol extract of C. ovata (CME) in mice. MATERIALS:...

journal_title：Pharmaceutical biology

authors： Arslan R,Bektas N

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Fruits of Bunium persicum (Boiss.) B. Fedtsh. (Apiaceae) are widely used in Iranian folkloric medicine for controlling colic pain and dysmenorrhea. This study was aimed to evaluate the anti-inflammatory and analgesic effects of the plant fruits and analyzing its essential oil. MATERIALS AND METHODS:Hydroalco...

journal_title：Pharmaceutical biology

authors： Hajhashemi V,Sajjadi SE,Zomorodkia M

更新日期：2011-02-01 00:00:00

abstract：CONTEXT:Penstemon gentianoides (Kunth) Poir. and Penstemon campanulatus (Cav.) Willd. (Plantaginaceae) are important medicinal plants in Mexico used by indigenous people for their anti-inflammatory effects and to also reduce rheumatic pains. OBJECTIVE:In addition to radical scavenging activity, the anti-inflammatory a...

journal_title：Pharmaceutical biology

authors： Domínguez M,Avila JG,Nieto A,Céspedes CL

更新日期：2011-02-01 00:00:00

abstract：CONTEXT:Macrotyloma uniflorum (Lam.) Verdc. (Leguminosae) seeds, known as the poor man's pulse crop in India, have been used as a food and also used in the traditional method for treatment of kidney stones, diabetes, obesity, etc. OBJECTIVE:To investigate the antidiabetic effect of α-amylase inhibitor isolated from th...

journal_title：Pharmaceutical biology

authors： Gupta LH,Badole SL,Bodhankar SL,Sabharwal SG

更新日期：2011-02-01 00:00:00

abstract：CONTEXT:Sansevieria roxburghiana Schult. & Schult. f. (Agavaceae) is a herbaceous perennial plant traditionally used for coughs, rheumatism; as an expectorant, febrifuge, purgative, and tonic. OBJECTIVE:To evaluate the hydroalcoholic extract of S. roxburghiana rhizome (HASR) for antitumor activity against Ehrlich asci...

journal_title：Pharmaceutical biology

authors： Haldar PK,Kar B,Bala A,Bhattacharya S,Mazumder UK

更新日期：2010-12-01 00:00:00

abstract：:The cytogenetic effects of aqueous extracts of Chenopodium multifidum L. (Paico) were determined by addition of the extracts and fractions to human lymphocyte cultures. Toxicity was evaluated by analysis of chromosomal aberrations (CA), sister chromatid exchange (SCE), mitotic (MI) and replication (RI) indexes. The re...

journal_title：Pharmaceutical biology

authors： Gadano A,Gurni A,Nigro López M,López P,Gratti A,van Baren C,Ferraro G,Carballo M

更新日期：2000-01-01 00:00:00

abstract：:A survey on the utilization of medicinal plants used by Thai people at Khao Kho District, Petchabun Province was carried out by interviewing herbalists followed by collecting plant specimens and identifying the specimens. In addition, the plant specimens were compared with the authentic specimens at two herbaria: the ...

journal_title：Pharmaceutical biology

authors： Chuakul W

更新日期：2000-01-01 00:00:00

abstract：:This paper is a synthesis of local traditional knowledge of plants used as medicine and western biological science. In many areas women are responsible for curing their family members and others for various illness. Ethnomedical uses of 51 plants by women in hamlets/villages of Jawhar and Mokhada talukas in Thane dist...

journal_title：Pharmaceutical biology

authors： Natarajan B,Paulsen BS

更新日期：2000-01-01 00:00:00

abstract：:Folk medicines are gaining great importance as information sources on traditional medicinal plants. The aim of this paper is the study of a plant traditionally employed by the Puna inhabitants: Werneria poposa Phil. Morphology of its secretory tissue and other histological diagnostic features, as well as the chemical ...

journal_title：Pharmaceutical biology

authors： Abella L,Cortella AR,Velasco-Negueruela A,Pérez-Alonso MJ

更新日期：2000-01-01 00:00:00

abstract：:A new triterpenoid glycoside 3-O-[a-L-arabinopyranosyl] 2 a, 3 ß , 6 ß , 23-a tetrahydroxyurs-12-ene-28-oic acid ( 1 ) accompanied by 6ß-hydroxyasiatic acid and asiatic acid were isolated from Centella asiatica . The structure of 1 was established by physicochemical data. Compound 1 exhibited dose-dependent growth inh...

journal_title：Pharmaceutical biology

authors： Shukla YN,Srivastava R,Tripathi AK,Prajapati V

更新日期：2000-01-01 00:00:00