Abstract:
:Dynamic protein-protein interactions are essential for proper cell functioning. Homo-interaction events-physical interactions between the same type of proteins-represent a pivotal subset of protein-protein interactions that are widely exploited in activating intracellular signaling pathways. Capacities of modulating protein-protein interactions with spatial and temporal resolution are greatly desired to decipher the dynamic nature of signal transduction mechanisms. The emerging optogenetic technology, based on genetically encoded light-sensitive proteins, provides promising opportunities to dissect the highly complex signaling networks with unmatched specificity and spatiotemporal precision. Here we review recent achievements in the development of optogenetic tools enabling light-inducible protein-protein homo-interactions and their applications in optical activation of signaling pathways.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Huang P,Zhao Z,Duan Ldoi
10.4103/1673-5374.314293keywords:
["cryptochrome 2","homo-interaction","intracellular signaling","light","light-induced protein-protein interaction","light-oxygen-voltage-sensing domain","light-sensitive proteins","optogenetics","phytochrome","signal transduction"]subject
Has Abstractpub_date
2022-01-01 00:00:00pages
25-30issue
1eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2022_17_1_25_314293journal_volume
17pub_type
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