Effects of FR139317 on renal responses to acute nitric oxide blockade in anaesthetized rats.

abstract：:1. In order to investigate further whether the increased sensitivity to inhibition by nifedipine of the responses to noradrenaline of aortae from spontaneously hypertensive stroke-prone (SHRSP) rats is related to the development of the hypertension, we have compared the sensitivity to noradrenaline, potassium chloride...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang GC,Iwanov V,Moulds RF

更新日期：1995-01-01 00:00:00

abstract：:KISS1 and KISS1R, a novel pair of metastasis suppressors, are likely to be associated with the prognosis of colorectal cancer (CRC). Here, a meta-analysis was performed to study the role of KISS1 and KISS1R in CRC. Heterogeneity, stability and publication bias were all estimated. Six publications describing a total of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang XQ,Fang PF,Zhang C,Xu YY,Song XB,Liang J,Xia QR

更新日期：2019-07-01 00:00:00

abstract：:1. The concentration of methylguanidine and guanidinosuccinic acid has been measured in normal human plasma and discrepancies between various published methods for measuring methylguanidine have been resolved. Previous methods have been modified to allow these guanidines, together with guanidinoacetic acid and creatin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lazdins I,Dawborn JK

更新日期：1978-01-01 00:00:00

abstract：:1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reith D,Medlicott NJ,Kumara De Silva R,Yang L,Hickling J,Zacharias M

更新日期：2009-01-01 00:00:00

abstract：:1. The alpha-adrenoceptor antagonist, phentolamine, was administered intravenously, to conscious or anaesthetized rats, before or after the beta-adrenoceptor antagonist, propanolol. 2. The bradycardia which followed the combined administration of propranolol and phentolamine exceeded that induced by propranolol alone,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oates HF,Stoker LM

更新日期：1980-03-01 00:00:00

abstract：:1. Changes in membrane fluidity have been proposed to contribute to the pathogenesis of ethanol-induced hypertension possibly through changes in membrane lipid patterns, but reports are inconsistent. 2. In a controlled trial we documented ethanol-induced changes in blood pressure and composition of membrane lipids in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Puddey IB,Burke V,Croft K,Beilin LJ

更新日期：1995-09-01 00:00:00

abstract：:This study explored the effects and mechanisms of dopamine D1 receptors (DR1) activation on the apoptosis of osteosarcoma cells (OS732).The DR1 agonist SKF-38393 decreased the viability of OS732 cells and increased their rate of apoptosis, whereas the DR1 antagonist SCH-23390 abolished the effects of SKF-38393. In OS7...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gao J,Gao F

更新日期：2017-11-01 00:00:00

abstract：:1. The distribution of binding sites for [125I]-labelled endothelin-1 ([125I]-ET-1) and [125I]-labelled sarafotoxin S6B ([125I]-SRT) was visualized in rat tissues using in vitro autoradiography. 2. A high density of endothelin-1 (ET-1) binding was found in the heart. In the kidney, ET-1 binding occurred in association...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kohzuki M,Johnston CI,Abe K,Chai SY,Casley DJ,Yasujima M,Yoshinaga K,Mendelsohn FA

更新日期：1991-07-01 00:00:00

abstract：:1. The Type 2C protein phosphatases (PP2C) represent a highly conserved gene family in the mammalian genome. Recent studies have revealed that PP2C isoforms possess unique patterns of tissue and subcellular distribution associated with diverse functionalities. 2. The functional importance of PP2C isoforms has been sho...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lu G,Wang Y

更新日期：2008-02-01 00:00:00

abstract：:1. The effects of volume depletion and NaHCO(3) loading on the expression of Na(+)/H(+) exchanger isoform 3 (NHE3), Na(+) : HCO(3)(-) cotransporter type 1 (NBC1) and neuronal (n) and inducible (i) isoforms of nitric oxide synthase (NOS) were determined in rat kidney. 2. Adult male Sprague-Dawley rats were used. Rats w...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ma SK,Kang JS,Bae EH,Choi C,Lee J,Kim SH,Choi KC,Kim SW

更新日期：2008-03-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a progressively fatal form of cancer originating from the malignant transformation of hepatic biliary cholangiocytes. The present study reports for the first time in vitro growth inhibitory activities of β-eudesmol, the bioactive sesquiterpenoid present in the rhizome of Atractylodes lancea...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mathema VB,Chaijaroenkul W,Karbwang J,Na-Bangchang K

更新日期：2017-11-01 00:00:00

abstract：:The anti-acetylcholinesterase (AChEase) activity of 15 opioids, namely morphine, nalorphine, oxymorphone, naloxone, naltrexone, N-methylnaloxone, levorphanol, levallophan, dextrorphan, dextrallophan, levo-methadone, dextro-methadone, pethidine, leu-enkephalin and U-50,488H was investigated. Among the opioids, the morp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sim MK,Chua ME

更新日期：1986-02-01 00:00:00

abstract：:This study evaluates the association between the long noncoding RNA GAS5 levels and the anti-proliferative effect of the glucocorticoid (GC) methylprednisolone (MP) alone and in combination with rapamycin in peripheral blood mononuclear cells (PBMCs) obtained from healthy donors. The effect of MP, rapamycin, and MP pl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lucafò M,Bravin V,Tommasini A,Martelossi S,Rabach I,Ventura A,Decorti G,De Iudicibus S

更新日期：2016-06-01 00:00:00

abstract：:1. The effects of reserpine pretreatment on neurotransmission in the guinea-pig vas deferens have been re-examined with a view to study the role of noradrenaline (NA) in mediating postjunctional electrical responses and, in particular, excitatory junction potentials (EJP). 2. Reserpine (5 mg/kg, i.p.) caused almost to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cunnane TC,Manchanda R

更新日期：1989-06-01 00:00:00

abstract：:Accumulating reports have demonstrated that long non-coding RNAs (lncRNAs) play critical roles in the occurrence and metastasis of cholangiocarcinoma (CCA). LncRNA myocardial infarction associated transcript (MIAT) has been widely reported in hepatocellular carcinoma, pancreatic cancer and colorectal cancer, but the r...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chang W,Wang Y,Li W,Geng Z

更新日期：2020-06-01 00:00:00

abstract：:1. There are hundreds of commercially available microcomputer statistics packages, ranging from the very cheap and elementary to the very expensive and complex, and from the very general to the very specialized. This review covers only those that appear to be popular with biomedical investigators who deal with fairly ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J

更新日期：1995-12-01 00:00:00

abstract：:The possibility that serotonin (5HT) nerve endings in the dorsomedial medulla oblongata participate in the control of blood pressure was investigated in stroke-prone hypertensive rats and in normotensive rats. 5HT nerves were destroyed by injecting 5,7-dihydroxytryptamine bilaterally into the solitary tract nucleus. I...

journal_title：Clinical and experimental pharmacology & physiology

authors： Howe PR,Rogers PF,King RA,Smith RM

更新日期：1983-05-01 00:00:00

abstract：:In the present study, we investigated whether mood stabilizer lithium (Li) protects against d-amphetamine (AMP)-induced mania-like behaviours via modulating the novel proinflammatory potential. Repeated treatment with AMP resulted in significant increases in proinflammatory cyclooxygenase-2 (COX-2) and indolemaine-2,3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Phan DH,Shin EJ,Jeong JH,Tran HQ,Sharma N,Nguyen BT,Jung TW,Nah SY,Saito K,Nabeshima T,Kim HC

更新日期：2020-05-01 00:00:00

abstract：:1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their plasma kininogen level, 9.2 +/- 0.7 microgram bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 +/- 0.5 microgram/ml). 2. When the rheumatoid pati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sharma JN,Zeitlin IJ,Brooks PM,Buchanan WW,Dick WC

更新日期：1980-07-01 00:00:00

abstract：:1. The present paper reviews the toxic dinoflagellates found in Singapore waters that produce toxins that can accumulate through marine food chains to cause seafood poisonings. 2. Singapore waters contain dinoflagellate species linked to three types of seafood poisoning: paralytic shellfish poisoning, diarrhetic shell...

journal_title：Clinical and experimental pharmacology & physiology

authors： Holmes MJ,Teo SL

更新日期：2002-09-01 00:00:00

abstract：:1. Two aspects of cholesterol absorption; (a) the importance of solubilization and (b) the effects of different bile salts on the mucosal metabolism and lymphatic output of cholesterol, have been investigated using two different in vivo techniques. 2. Bile diverted lymph fistula rats were infused intraduodenally at a ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Watt SM,Simmonds WJ

更新日期：1976-07-01 00:00:00

abstract：:1. We have examined the question asked in the title by studying: the carotid baroreceptor reflex in man with a variable-pressure neck chamber; the carotid baroreceptor reflex in conscious rabbits with a variable-pressure capsule around the carotid bifurcation; and the barorecptor-heart rate reflex. 2. At rest, the ass...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J,Mancia G,Zanchetti A

更新日期：1980-09-01 00:00:00

abstract：:This in vivo study tested the hypothesis that the modulation of acetylcholine (ACh) release by the M1 muscarinic receptor (mAChR) in the neuromuscular junction of disused muscles may affect the tensions of the muscles during the neuromuscular monitoring of a rocuronium-induced neuromuscular block and compared the resu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kim YB,Yang HS,Kim HJ,Choi HR,In J,Yoon SY,Ro YJ

更新日期：2018-12-01 00:00:00

abstract：:1. Indices quantifying blood pressure (BP) and heart rate (HR) variability have been recently developed and may be used to assess the contribution of the autonomic nervous system to cardiovascular fluctuations. 2. Cardiovascular variables were measured in eight conscious mice equipped with a BP telemetric device. Each...

journal_title：Clinical and experimental pharmacology & physiology

authors： Laude D,Baudrie V,Elghozi JL

更新日期：2008-04-01 00:00:00

abstract：:1. An antisense oligonucleotide (ASO) is a short strand of deoxyribonucleotide analogue that hybridizes with the complementary mRNA in a sequence-specific manner via Watson-Crick base pairing. Formation of the ASO-mRNA heteroduplex either triggers RNase H activity, leading to mRNA degradation, induces translational ar...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chan JH,Lim S,Wong WS

更新日期：2006-05-01 00:00:00

abstract：:1. Trophoblast invasion during embryo implantation in some aspects resembles tumour cell invasion but, unlike tumour cells, trophoblast cells are able to differentiate and establish a placenta. Because direct cell-cell communication is believed to be involved in growth control and differentiation, we have investigated...

journal_title：Clinical and experimental pharmacology & physiology

authors： Winterhager E,Reuss B,Hellmann P,Spray DC,Gruemmer R

更新日期：1996-12-01 00:00:00

abstract：:1. Ethamsylate (diethylammonium 2,5-dihydroxybenzene sulfonate, Dicynene), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti-inflammatory activity using the carrageenan-induced rat paw oedema test. 2. Ethamsylate was shown to be an effective anti-inflammatory agent with a time cours...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gard PR,Trigger DJ

更新日期：1990-12-01 00:00:00

abstract：:1. Using a nested case-control study of 661 non-institutionalized elderly (> or = 60 years) residents of Dubbo, New South Wales, Australia, the aim of this study is to determine whether the A1166C polymorphism of the angiotensin II type I (AT1) receptor gene is associated with hypertension in the elderly. 2. Individua...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liyou N,Davis D,James K,Simons L,Friedlander Y,Simons J,McCallum J,Johnson A

更新日期：1999-07-01 00:00:00

abstract：:Despite the presence of many studies on the role of mechanistic target of rapamycin (mTOR) in cardiorenal tissues, the definitive role of mTOR in the pathogenesis of renal injury subsequent to ischaemia-reperfusion (IR) remains unclear. The aims of the current study were to characterize the role of mTOR in normal kidn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Alshaman R,Truong L,Oyekan A

更新日期：2016-11-01 00:00:00

abstract：:1. The effects of ATP and some of its more stable analogues have been examined upon preparations of epididymal and prostatic halves of vasa deferentia and of cauda epididymides from rats that had undergone vasectomy by medial transection of the vas deferens. 2. After unilateral vasectomy, the potencies of ATP, beta, g...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ventura S,DeGaris RM,Stead CK,Pennefather JN

更新日期：1990-08-01 00:00:00