Gap junction and tissue invasion: a comparison of tumorigenesis and pregnancy.


:1. Trophoblast invasion during embryo implantation in some aspects resembles tumour cell invasion but, unlike tumour cells, trophoblast cells are able to differentiate and establish a placenta. Because direct cell-cell communication is believed to be involved in growth control and differentiation, we have investigated connexin (cx) gene expression during trophoblast development. 2. Pre-implantation embryos expressed cx43 as well as cx31 proteins from the 8-cell stage onwards. Following implantation, compartmentalization of both connexins occurred: cx31 expression was restricted to the invasive trophoblast cell population, whereas the embryo proper was characterized by cx43. Trophoblast differentiation was indicated by induction of cx26 in the labyrinth and cx43 in the spongiotrophoblast accompanied by a disappearance of cx31. Comparison with trophoblast cell lines revealed that rat trophoblast HRP-1 cells express connexin43, while malignant choriocarcinoma cells express cx31. Treatment with retinoic acid led to a disappearance of cx31 in the choriocarcinoma. Both cell lines reduced their invasion properties after retinoic acid treatment, but growth retardation was only observed in the malignant trophoblast. 3. It seems that the cx31 channel is needed for trophoblast cell populations to maintain the highly proliferative properties but does not alter their invasion properties.


Winterhager E,Reuss B,Hellmann P,Spray DC,Gruemmer R




Has Abstract


1996-12-01 00:00:00












  • Intrarenal oxygen and hypertension.

    abstract::The kidney has a unique environment that results in relatively low tissue oxygen tension (Po2). However, recent studies have shown that renal hypoxia is more severe during hypertension and may reflect changes in the way O2 is used. The present review summarizes studies that explore the relationship between renal oxyge...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Welch WJ

    更新日期:2006-10-01 00:00:00

  • Sample size requirements for clinical trials of isolated systolic hypertension.

    abstract::1. This study investigated components of blood pressure variability in elderly subjects with isolated systolic hypertension (ISH) using both ambulatory blood pressure monitoring (ABPM) and casual clinic blood pressure measurement. These were then used to determine sample size requirements for clinical trials of differ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Silagy CA,McNeil JJ,McGrath BP

    更新日期:1992-05-01 00:00:00

  • Effects of taurine and homocysteine on calcium homeostasis and hydrogen peroxide and superoxide anions in rat myocardial mitochondria.

    abstract::1. Taurine and homocysteine are metabolites of methionine. Hyperhomocysteinaemia is one of the risk factors for cardiovascular disease. Although taurine may be a cardiovascular cytoprotective substance, we hypothesized that it may antagonize the effects of homocysteine on myocardial mitochondrial function. 2. We studi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Chang L,Zhao J,Xu J,Jiang W,Tang CS,Qi YF

    更新日期:2004-04-01 00:00:00

  • Mechanisms of lidocaine actions on normal and abnormal rhythms in canine cardiac tissues in vivo and in vitro.

    abstract::1. The actions of lidocaine on cardiac pacemaker rhythms were studied in anaesthetized dogs and in Purkinje fibres from hearts of the same animals. 2. In vivo, lidocaine (1 mg/kg, intravenously) slowed the sino-atrial (SA) node rhythm (-5.0%), and (during vagal stimulation) prolonged ventricular standstill by +25.1% a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Abete P,Ferrara N,Rengo F,Vassalle M

    更新日期:1991-03-01 00:00:00

  • Pathophysiology of renal tissue damage by iodinated contrast media.

    abstract::1. The present review focuses on the cytotoxic effects of iodinated contrast media (CM) that are shared by all types of CM. 2. Although the clinical nephrotoxicity of CM has been progressively improved, all currently available CM still possess a level of cytotoxicity, which is probably caused by iodine. 3. The toxicit...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Sendeski MM

    更新日期:2011-05-01 00:00:00

  • The anti-diabetic drug miglitol is protective against anginal ischaemia through a mechanism independent of regional myocardial blood flow in the dog.

    abstract::1. In the present study, we attempted to clarify whether the antidiabetic drug miglitol, an alpha-glucosidase inhibitor, has a protective effect against anginal ischaemia. We had reported previously that miglitol reduces myocardial infarct size through inhibition of glycogenolysis during ischaemia in rabbits. However,...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Uno Y,Minatoguchi S,Arai M,Wang N,Chen XH,Hashimoto K,Lu C,Takemura G,Fujiwara H

    更新日期:2005-10-01 00:00:00

  • Angiotensin-converting enzyme inhibitors and atherosclerosis: relevance of animal models to human disease.

    abstract::1. Most studies examining the effect of angiotensin-converting enzyme (ACE) inhibitors on atherosclerosis in experimental animals have used doses well in excess of those given clinically. 2. Using a rabbit model of cholesterol-induced atherosclerosis characterized by subendothelial lipid accumulations ('juvenile fatty...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Fennessy PA,Campbell JH,Mendelsohn FA,Campbell GR

    更新日期:1996-08-01 00:00:00

  • Acute effects of oral glibenclamide on blood pressure and forearm vascular resistance in diabetics.

    abstract::1. To determine the effects of an acute oral dose of glibenclamide on blood pressure (BP), basal forearm vascular resistance (FVR) and FVR responses to the K+(ATP) channel activating vasodilator diazoxide, a placebo-controlled, double-blind cross-over study was performed in eight male volunteers with non-insulin-depen...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,更正并重新发布的文章,杂志文章,随机对照试验


    authors: Sundaresan P,Lykos D,Daher A,Morris R,Diamond T,Howes LG

    更新日期:1998-02-01 00:00:00

  • Glaucocalyxin A inhibits hydrogen peroxide-induced oxidative stress and inflammatory response in coronary artery smooth muscle cells.

    abstract::Atherosclerosis is a complex chronic inflammatory disease that remains one of the leading causes of death and disability worldwide. A previous study reported that glaucocalyxin A (GLA), a natural ent-Kaurane diterpenoid triptolide, exhibits anti-atherosclerotic activity. However, the underlying molecular mechanism has...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhu S,Zhang J,Lv Y

    更新日期:2020-05-01 00:00:00

  • Increased cardiovascular risk without generalized arterial dilating diathesis in persons who do not have abdominal aortic aneurysm but who are first-degree relatives of abdominal aortic aneurysm patients.

    abstract::There is a strong genetic predisposition towards abdominal aortic aneurysm (AAA), but it is unknown whether persons without AAA but with first-degree relatives who are AAA patients have a generalized dilating diathesis, defect arterial wall mechanics, or increased cardiovascular risk. The aim of the study was to inves...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: De Basso R,Sandgren T,Ahlgren ÅR,Länne T

    更新日期:2015-06-01 00:00:00

  • Inhibition of nuclear translocation of transcription factor nuclear factor-kappa B induces FAS- as well as tumour necrosis factor-alpha-mediated apoptosis through downregulation of a conserved family of inhibitor of apoptosis 1.

    abstract::1. In the present study, we examined whether the nuclear transcription factor (NF)-kappaB activity plays a role in the determination of sensitivity to tumour necrosis factor (TNF)-alpha or agonistic Fas antibody (Ab) in human vascular smooth muscle cells (hVSMC). 2. To inhibit agonist-induced NF-kappaB activation in h...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Imanishi T,Hano T,Takarada S,Nishio I

    更新日期:2003-03-01 00:00:00

  • Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodelling induced by chronic volume overload in rats.

    abstract::1. Previous studies have demonstrated progressive ventricular hypertrophy, dilatation and contractile depression in response to chronic volume overload. Whether this decompensation was related to intrinsic myocyte dysfunction was not clear. The present study evaluated ventricular myocyte function at critical times dur...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ding YF,Brower GL,Zhong Q,Murray D,Holland M,Janicki JS,Zhong J

    更新日期:2008-07-01 00:00:00

  • Systemic plasma levels of nitrite/nitrate (NOx) reflect brachial flow-mediated dilation responses in young men and women.

    abstract::1. The aim of the present study was to determine the relationship between plasma levels of nitrite/nitrite (NO(x)) and brachial flow-mediated dilation (FMD) in healthy young men and women. 2. Brachial artery FMD was assessed non-invasively using high-resolution ultrasound in 36 young men and women (21 +/- 3 years; 18 ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Casey DP,Beck DT,Braith RW

    更新日期:2007-12-01 00:00:00

  • Cardiac beta-adrenoceptor changes in experimental hyperthyroidism in dogs.

    abstract::1. Triiodothyronine (T3; 1.0 mg/kg per day subcutaneously) was administered to 10 dogs for 14 days; 10 saline-treated dogs served as controls. T3-treated dogs showed the expected physiological responses of hyperthyroidism; further, chronotropic responses to isoprenaline in vivo were significantly increased in T3-treat...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hoey A,Brown L,Marchant C,Atwell R,Sernia C

    更新日期:1992-11-01 00:00:00

  • Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice.

    abstract::Cannabinoid inverse agonists possess antidepressant-like properties, but the mechanism of this action is unknown. Numerous studies have reported the interaction between opioid and cannabinoid pathways. In this study, acute foot-shock stress was used in mice to investigate the involvement of the opioid pathway in the a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ostadhadi S,Haj-Mirzaian A,Nikoui V,Kordjazy N,Dehpour AR

    更新日期:2016-02-01 00:00:00

  • Beta2-adrenoceptor polymorphisms and obstructive airway diseases: important issues of study design.

    abstract::1. Asthma and chronic obstructive pulmonary disease (COPD) are chronic airway diseases characterized by airflow obstruction. The beta(2)-adrenoceptor mediates bronchodilatation in response to exogenous and endogenous beta-adrenoceptor agonists. 2. Single nucleotide polymorphisms in the beta(2)-adrenoceptor gene (ADRB2...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Yang IA,Ng T,Molenaar P,Fong KM

    更新日期:2007-10-01 00:00:00

  • The macrophage as an initiator of atherosclerosis.

    abstract::1. Heparan sulfate proteoglycan in the basal lamina of smooth muscle cells is important in the maintenance of the 'contractile', high volume fraction of myofilaments (Vvmyo) phenotype. The mechanism by which this occurs may involve the continuous internalization of heparan sulfate by the smooth muscle cells themselves...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Campbell JH,Campbell GR

    更新日期:1991-02-01 00:00:00

  • Species differences in binding of submandibular nuclear proteins to renin promoter DNA.

    abstract::1. Renin is highly expressed in submandibular gland (SMG) of mouse, which has two genes, Ren-1d and Ren-2d, but not at all in rat SMG. Differences in nuclear protein binding to renin promoter DNA were, therefore, explored. 2. Rat -169 to +23 renin DNA formed complexes with both mouse and rat extract, whereas a corresp...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Loudon JA,Fukamizu A,Murakami K,Morris BJ

    更新日期:1993-05-01 00:00:00

  • Effect of low-voltage electrical stimulation on angiogenic growth factors in ischaemic rat skeletal muscle.

    abstract::1. Low-voltage electrical stimulation (LVES) in skeletal muscle at a level far below the threshold of muscle contraction has been reported to promote local angiogenesis. However, the mechanism underlying the promotion of local angiogenesis by LVES has not been fully elucidated. In the present study, we evaluated wheth...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nagasaka M,Kohzuki M,Fujii T,Kanno S,Kawamura T,Onodera H,Itoyama Y,Ichie M,Sato Y

    更新日期:2006-07-01 00:00:00

  • Pharmacodynamics of levodopa in Parkinson's disease.

    abstract::1. Levodopa markedly reduces parkinsonism during the first years of treatment. However, with continued therapy the response to levodopa becomes erratic and is complicated by involuntary movements. To improve the therapy of parkinsonism, the challenge is to understand why fluctuations in response develop and, once deve...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nutt JG

    更新日期:1995-11-01 00:00:00

  • Effects of losartan on the cardiovascular system, renal haemodynamics and function and lung liquid flow in fetal sheep.

    abstract::1. The angiotensin type 1 (AT1) receptor antagonist, losartan (10 mg/kg) was infused intravenously into nine chronically catheterized fetal sheep (125-132 days gestation). Losartan reduced the fetal systolic (P <0.01) and diastolic (P <0.01) pressor response to 5 microg angiotensin II (AngII) i.v. from 27.4 +/- 1.5 to...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Stevenson KM,Gibson KJ,Lumbers ER

    更新日期:1996-02-01 00:00:00

  • Effects of endothelin-1 on arterial pressure: a comparison of intravenous and intra-arterial administration in conscious rabbits.

    abstract::1. Intravenous endothelin-1 releases endothelium-derived relaxing factor (EDRF) and prostacyclin from the lungs, and substantial pulmonary clearance is claimed. Since these vaso-active substances could alter the haemodynamic effects of endothelin-1, the effects of boluses of endothelin-1 injected intravenously and int...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Roberts-Thomson P,McRitchie RJ,Cain MD,Chalmers JP

    更新日期:1994-04-01 00:00:00

  • Increased Ca2+ sensitivity of myofibrillar tension in ischaemic vs dilated cardiomyopathy.

    abstract::1. There is evidence that different aetiologies of heart failure, especially ischaemic vs dilated cardiomyopathy (ICM and DCM, respectively), may influence the prognosis of patients with this disease. Patients with ICM have a worse prognosis than those with DCM; the mechanisms underlying this difference have not yet b...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lee S,Lu R,Müller-Ehmsen J,Schwinger RH,Brixius K

    更新日期:2010-12-01 00:00:00

  • Effect of alcohol on cytochrome p450 arachidonic acid metabolism and blood pressure in rats and its modulation by red wine polyphenolics.

    abstract::Alcohol-induced hypertension is well recognized with clear evidence for a direct pressor effect of chronic alcohol consumption provided by a number of intervention studies in humans. In experimental animals, the effect of alcohol on blood pressure is less consistent; however, in Sprague-Dawley rats, alcohol feeding co...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Cowpland C,Su GM,Murray M,Puddey IB,Croft KD

    更新日期:2006-03-01 00:00:00

  • Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus.

    abstract::Diabetes mellitus and depressive disorders are both common chronic diseases that increase functional disability and social burden. Cognitive impairment is a potentially debilitating feature of depression. Previous evidence indicates that the antidiabetic drug metformin could be suitable for diabetic patients with cogn...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,随机对照试验


    authors: Guo M,Mi J,Jiang QM,Xu JM,Tang YY,Tian G,Wang B

    更新日期:2014-09-01 00:00:00

  • Fixed dose of long-acting erythropoietic stimulating agents at higher frequency improves appetite, reduces inflammation and corrects anaemia in patients on haemodialysis.

    abstract::Anaemia is an important issue in patients undergoing haemodialysis. We aimed to identify a better dosing schedule of a fixed monthly dose of continuous erythropoietin receptor activator (CERA) in patients with chronic kidney disease (CKD) on haemodialysis. The CERA dosing schedule included 100 μg once monthly for 2 mo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Liu WS,Chu DC,Chan HL,Li SY,Liu CK,Yang CY,Chen YW,Lee PC,Lai YT,Lin CC

    更新日期:2016-10-01 00:00:00

  • Unexpected incidence of low blood pressure 2 years after unilateral adrenalectomy for primary aldosteronism.

    abstract::1. Serial observations of blood pressure after unilateral adrenalectomy for aldosterone-producing adenoma revealed an incidence of hypotension (systolic BP less than fifth percentile for age- and sex-matched normal population) of 27% at 2 years, more than 5 times that predicted. 2. Serial observations of volume regula...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gordon RD,Hawkins PG,Hamlet SM,Tunny TJ,Klemm SA,Backmann AW,Finn WL

    更新日期:1989-04-01 00:00:00

  • Possible participation of NMDA and glycine receptors but not GABAA receptors in enflurane-induced opisthotonus in mice.

    abstract::1. We previously reported that volatile anaesthetics produce incidences of a transient opisthotonus in mice, a sign of CNS stimulation. This study was performed to investigate mechanisms by which enflurane-induced opisthotonus (EIO) occurs. 2. The effects of pretreatment of N-methyl-D-aspartate (NMDA) antagonists dizo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Komatsu H,Nogaya J,Ueki M,Yokono S,Ogli K

    更新日期:1994-06-01 00:00:00

  • Stress-induced elevation of the ST segment in the rat electrocardiogram is normalized by an adrenoceptor blocker.

    abstract::1. Emotional stress is one of the aetiologies of cardiac accidents, but the precise mechanisms remain to be elucidated. In the present study we used the immobilization stress model in rats to investigate electrocardiographic (ECG) changes. 2. A rapid elevation of the ST segment at the II, III, aVF and precordial leads...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ueyama T,Yoshida K,Senba E

    更新日期:2000-05-01 00:00:00

  • Effect of enalapril on body sodium and handling of a sodium chloride load in hypertensive and normotensive rats.

    abstract::1. The effect of enalapril on handling of an Na load and on body Na during 96 h of zero Na intake was measured in hypertensive rats (GH and SHR) and their normotensive controls (N and WKY) by a whole body counting method. 2. Enalapril treatment led to a greater fall in body Na in the first 24 h after the Na load (as e...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ledingham JM,Simpson FO

    更新日期:1992-05-01 00:00:00