Reduced adenosine 3',5'-cyclic monophosphate levels in patients with reversible obstructive airways disease.

Abstract:

:1. Patients were grouped into categories of 'no airways disease', 'obstructive airways disease without response to bronchodilator' and 'obstructive airways disease with bronchodilator responsiveness'. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of adenosine 3',5'-cyclic monophosphate (cyclic AMP) were found in pulmonary tissue obtained from patients with reversible obstructive airways disease, lending support to the beta-adrenergic theory of asthma.

authors

Krzanowski JJ,Polson JB,Goldman AL,Ebel TA,Szentivanyi A

doi

10.1111/j.1440-1681.1979.tb00013.x

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

111-5

issue

1

eissn

0305-1870

issn

1440-1681

journal_volume

6

pub_type

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