Spontaneous and agonist-induced contractions and endothelium-dependent relaxation in aortae from SHRSP and WKY rats under various levels of passive force.

abstract：:trans-Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim of the present study was to investigate the effects of resveratrol on cardiac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu Z,Song Y,Zhang X,Liu Z,Zhang W,Mao W,Wang W,Cui W,Zhang X,Jia X,Li N,Han C,Liu C

更新日期：2005-12-01 00:00:00

abstract：:1. It has been proposed that hypertension alters the respiratory and cardiovascular responses to chemoreceptor stimulation. However, in studies of human hypertension or in genetic animal models of hypertension it has been difficult to unequivocally attribute the changes to hypertension per se, rather than to a genetic...

journal_title：Clinical and experimental pharmacology & physiology

authors： Groom AS,Malpas SC

更新日期：1997-03-01 00:00:00

abstract：:1. The role of calcium-activated potassium (KCa) channels in bronchodilation produced by a direct adenylyl cyclase activator, forskolin, was investigated. The involvement of intracellular cyclic AMP (cAMP) in the process was also examined. 2. The isometric tension records from guinea-pig tracheal smooth muscles indica...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hiramatsu T,Kume H,Kotlikoff MI,Takagi K

更新日期：1994-05-01 00:00:00

abstract：:The epithelial sodium channel (ENaC) has long been recognized as playing a vital role in blood pressure (BP) regulation due to its involvement in fluid balance. The genes encoding the three ENaC subunits are likewise important contributors to hypertension, both in rare monogenic diseases and in the general population....

journal_title：Clinical and experimental pharmacology & physiology

authors： Büsst CJ

更新日期：2013-08-01 00:00:00

abstract：:1. We previously reported that volatile anaesthetics produce incidences of a transient opisthotonus in mice, a sign of CNS stimulation. This study was performed to investigate mechanisms by which enflurane-induced opisthotonus (EIO) occurs. 2. The effects of pretreatment of N-methyl-D-aspartate (NMDA) antagonists dizo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Komatsu H,Nogaya J,Ueki M,Yokono S,Ogli K

更新日期：1994-06-01 00:00:00

abstract：:1. Dexamethasone (Dex)-induced hypertension is characterized by endothelial dysfunction associated with nitric oxide (NO) deficiency and increased superoxide (O2-) production. Atorvastatin (Ato) possesses pleiotropic properties that have been reported to improve endothelial function through increased availability of N...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mondo CK,Yang WS,Zhang N,Huang TG

更新日期：2006-11-01 00:00:00

abstract：:1. The haemodynamic and metabolic effects of oral intake of approximately 30 mg/kg per day N-nitro-L-arginine (NOLA) were examined in sham and adrenocorticotrophin (ACTH, 0.5 mg/kg per day) treated conscious Sprague-Dawley rats (n = 33). 2. NOLA administration produced an increase in systolic blood pressure of 24 +/- ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li M,Dusting GJ,Whitworth JA

更新日期：1992-10-01 00:00:00

abstract：:1. Taurine and homocysteine are metabolites of methionine. Hyperhomocysteinaemia is one of the risk factors for cardiovascular disease. Although taurine may be a cardiovascular cytoprotective substance, we hypothesized that it may antagonize the effects of homocysteine on myocardial mitochondrial function. 2. We studi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chang L,Zhao J,Xu J,Jiang W,Tang CS,Qi YF

更新日期：2004-04-01 00:00:00

abstract：:1. The aim of this study was to assess the vagal and sympathetic nerve contribution to the relationship between mean arterial pressure (MAP) and heart rate (HR) at 6, 9, 14 and 20 weeks of age in conscious Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) with methoxamine- and nitroprusside-induced steady-s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head GA,Adams MA

更新日期：1988-04-01 00:00:00

abstract：:This study tested the hypothesis that the initial fall in arterial pressure evoked by lipopolysaccharide (LPS) is mediated by the ventrolateral column of the midbrain periaqueductal gray region (vlPAG). To test this hypothesis, the local anaesthetic lidocaine (2%; 0.1 μL, 0.2 μL or 1.0 μL), the delta opioid receptor a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Millington WR,Yilmaz MS,Feleder C

更新日期：2016-06-01 00:00:00

abstract：:1. Quantitative autoradiography and homogenate radioligand binding of [125I]-Bolton Hunter substance P ([125I]-BHSP) were used to compare brain NK1 receptors in young (2 months) and aged (18-20 months) rats. 2. The autoradiographic distribution and density of [125I]-BHSP binding sites was similar in all cortical regio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Geraghty DP,Maguire CM

更新日期：2002-12-01 00:00:00

abstract：:1. This study investigated the effect of progesterone, which, under certain circumstances, can antagonize both the mineralocorticoid and glucocorticoid activities of steroid hormones, on the development and maintenance of adrenocorticotrophic hormone (ACTH)-induced hypertension in conscious sheep. 2. Progesterone (500...

journal_title：Clinical and experimental pharmacology & physiology

authors： Spence CD,Reid AF,Coghlan JP,Mills EH,Whitworth JA,Scoggins BA

更新日期：1989-08-01 00:00:00

abstract：:1. Pretreatment with intravenous WEB-2086 (0.5 mg/kg; an antagonist of the actions of platelet activating factor; PAF) with or without indomethacin (2 mg/kg) failed to prevent or modify the fall in blood pressure following unclipping of the renal artery of anaesthetized two-kidney, one-clip hypertensive rats. 2. The s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Smith AJ,Gerkens JF,Dosen P

更新日期：1994-05-01 00:00:00

abstract：:1. The aim of the present study was to examine the effect of bacterial lipopolysaccharide (LPS) on the disposition of an organic anion transporting polypeptide and P-glycoprotein substrate in the rat isolated perfused liver. 2. Male Sprague-Dawley rats were divided into four groups. Three of the groups received 1, 2.5...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tong Y,Zhang R,Ngo SN,Davey AK

更新日期：2006-08-01 00:00:00

abstract：:1. The alpha-adrenoceptor antagonist, phentolamine, was administered intravenously, to conscious or anaesthetized rats, before or after the beta-adrenoceptor antagonist, propanolol. 2. The bradycardia which followed the combined administration of propranolol and phentolamine exceeded that induced by propranolol alone,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Oates HF,Stoker LM

更新日期：1980-03-01 00:00:00

abstract：:Afferent splanchnic nerve stimulation with different frequencies in Wistar Kyoto rats caused depressor and pressor responses depending on the frequency employed. Similar visceral afferent activation in spontaneously hypertensive rats caused depressor responses at all frequencies of stimulation. It is suggested that th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Koyama S,Manning JW

更新日期：1985-01-01 00:00:00

abstract：:1. Intravenous endothelin-1 releases endothelium-derived relaxing factor (EDRF) and prostacyclin from the lungs, and substantial pulmonary clearance is claimed. Since these vaso-active substances could alter the haemodynamic effects of endothelin-1, the effects of boluses of endothelin-1 injected intravenously and int...

journal_title：Clinical and experimental pharmacology & physiology

authors： Roberts-Thomson P,McRitchie RJ,Cain MD,Chalmers JP

更新日期：1994-04-01 00:00:00

abstract：:1. The aim of the present study was to investigate the effects of hypoxia on energy metabolism and contraction of rat urinary bladder smooth muscle, thereby gaining insight into the capacity of this smooth muscle to maintain contractile function when rendered hypoxic. 2. Isometric force, oxygen consumption, lactate pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wendt IR,Paul RJ

更新日期：2003-08-01 00:00:00

abstract：:1. Activation of bulbospinal neurons projecting from the C1 area of the rostral ventrolateral medulla evokes a pressor response. The nature of the neurotransmitters involved in mediating this response at spinal cord level has not been established. 2. Amino acid antagonists were introduced into the spinal subarachnoid ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mills EH,Minson JB,Pilowsky PM,Chalmers JP

更新日期：1988-02-01 00:00:00

abstract：:1. The recognition of the role of insulin resistance in disease states and the recent development of new drugs that modify insulin-dependent metabolism has led to increased use of the euglycaemic hyperinsulinaemic clamp to measure in vivo insulin sensitivity, but several key aspects of the technique are poorly documen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris AD,Ueda S,Petrie JR,Connell JM,Elliott HL,Donnelly R

更新日期：1997-07-01 00:00:00

abstract：:Chemotherapy resistance is a major contributor to poor treatment responses and tumour relapse, the development of which has been strongly linked to the action of cancer stem cells (CSCs). Mounting evidence suggests that CSCs are reliant on low oxygen conditions and hypoxia-inducible factors 1α and 2α (HIF1α and HIF2α)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Schöning JP,Monteiro M,Gu W

更新日期：2017-02-01 00:00:00

abstract：:1. Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant numbe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Urakami H,Abe Y,Grisham MB

更新日期：2007-09-01 00:00:00

abstract：:1. The angiotensin type 1 (AT1) receptor antagonist, losartan (10 mg/kg) was infused intravenously into nine chronically catheterized fetal sheep (125-132 days gestation). Losartan reduced the fetal systolic (P <0.01) and diastolic (P <0.01) pressor response to 5 microg angiotensin II (AngII) i.v. from 27.4 +/- 1.5 to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stevenson KM,Gibson KJ,Lumbers ER

更新日期：1996-02-01 00:00:00

abstract：:1. Kynurenine aminotransferase catalyzes the conversion of kynurenine to kynurenic acid, an endogenous antagonist of excitatory amino acid receptors. The kynurenic acid content and kynurenine aminotransferase activity was measured in micro-dissected regions of spontaneously hypertensive rats (SHR) and their normotensi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kapoor V,Kapoor R,Chalmers J

更新日期：1994-11-01 00:00:00

abstract：:1. Although measuring the rate of firing of multi-unit muscle sympathetic nerve activity (MSNA) has provided important information in many aspects of cardiovascular medicine, measuring single-unit vasoconstrictor activity provides a better understanding of the possible mechanisms underlying disturbed sympathetic nervo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lambert E,Dawood T,Schlaich M,Straznicky N,Esler M,Lambert G

更新日期：2008-04-01 00:00:00

abstract：:Aerobic glycolysis plays a crucial role in cancer progression. Ketamine is often used for cancer pain relief in clinical settings. Moreover, ketamine inhibits proliferation and induces apoptosis in many cancer cell types. However, the anti-tumour mechanism of ketamine is still poorly understood. In the present study, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hu J,Duan W,Liu Y

更新日期：2020-05-01 00:00:00

abstract：:1. Low-voltage electrical stimulation (LVES) in skeletal muscle at a level far below the threshold of muscle contraction has been reported to promote local angiogenesis. However, the mechanism underlying the promotion of local angiogenesis by LVES has not been fully elucidated. In the present study, we evaluated wheth...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nagasaka M,Kohzuki M,Fujii T,Kanno S,Kawamura T,Onodera H,Itoyama Y,Ichie M,Sato Y

更新日期：2006-07-01 00:00:00

abstract：:1. Nitric oxide (NO) synthase inhibitors and Paf antagonists abrogate hypotension in septic shock. The latter may act by blocking intracellular transduction mechanisms in vascular smooth muscle cells and inflammatory cells. We examined the effect of Paf antagonists on expression of inducible NO synthase. 2. A murine m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Arthur JF,Shahin S,Dusting GJ

更新日期：1995-06-01 00:00:00

abstract：:1. Erlotinib, a small-molecule epidermal growth factor receptor-tyrosine kinase (EGFR-TK) inhibitor, has been approved for the management of advanced non-small cell lung cancer. The aim of the present study was to investigate whether erlotinib exerts potent antitumour activities through the reactive oxygen species (RO...

journal_title：Clinical and experimental pharmacology & physiology

authors： Qian X,Li J,Ding J,Wang Z,Zhang W,Hu G

更新日期：2009-05-01 00:00:00

abstract：:1. Enzymatic bioremediation is potentially a rapid method of removing environmental pesticide residues. Applications include the treatment of residues resulting from agricultural production and processing industries, such as the treatment of irrigation waters, surface-contaminated fruit and vegetables and spent dip li...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sutherland TD,Horne I,Weir KM,Coppin CW,Williams MR,Selleck M,Russell RJ,Oakeshott JG

更新日期：2004-11-01 00:00:00