Maintenance of pseudopregnancy by prolactin in indomethacin treated rats.

Abstract:

:1. The effects of bromocriptine and indomethacin on prolactin-induced pseudopregnancy were studied in pituitary grafted rats. 2.Administration of bromocriptine (a prolactin suppressant drug) at a total dose of 3 mg/kg body weight, given in 3 divided doses on day 5 of pseudopregnancy, effectively terminated it within 3 days. However, injection of indomethacin (a prostaglandin inhibitor) at a total dose of 6 mg/kg body weight, given in 3 divided doses, on the same day of pseudopregnancy had no significant effect on its duration. 3. It appears unlikely that the luteotrophic effect of prolactin on the corpus luteum is mediated by the stimulation of prostaglandin synthesis.

authors

Tan GJ

doi

10.1111/j.1440-1681.1980.tb00079.x

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

335-8

issue

3

eissn

0305-1870

issn

1440-1681

journal_volume

7

pub_type

杂志文章
  • Pressor responsiveness in steroid-induced hypertension in man.

    abstract::Pressor responsiveness to angiotensin II (AII) and phenylephrine (PE) was examined before and after 5 days of ACTH (1 mg, i.m., daily) or hydrocortisone (200 mg, orally, daily) in six normotensive men. Pulse pressure was higher prior to PE than AII infusion, presumably due to feeding. Systolic blood pressure (SBP) was...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1986.tb00362.x

    authors: Whitworth JA,Connell JM,Lever AF,Fraser R

    更新日期:1986-04-01 00:00:00

  • Unexpected incidence of low blood pressure 2 years after unilateral adrenalectomy for primary aldosteronism.

    abstract::1. Serial observations of blood pressure after unilateral adrenalectomy for aldosterone-producing adenoma revealed an incidence of hypotension (systolic BP less than fifth percentile for age- and sex-matched normal population) of 27% at 2 years, more than 5 times that predicted. 2. Serial observations of volume regula...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1989.tb01558.x

    authors: Gordon RD,Hawkins PG,Hamlet SM,Tunny TJ,Klemm SA,Backmann AW,Finn WL

    更新日期:1989-04-01 00:00:00

  • Cyp2c19 genotype and omeprazole hydroxylation phenotype in Chinese Li population.

    abstract::1. CYP2C19 is a polymorphism of cytochrome P450, which is responsible for the metabolism of many drugs. The genetic polymorphism shows interethnic variation and it has been demonstrated that the frequency of poor metabolizers (PM) and the distribution of alleles of CYP2C19 vary among Chinese ethnic nationalities. The ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04583.x

    authors: Wang JH,Li PQ,Fu QY,Li QX,Cai WW

    更新日期:2007-05-01 00:00:00

  • The inhibition of nitric oxide-mediated relaxations in rat aorta and anococcygeus muscle by diphenylene iodonium.

    abstract::1. The effects of diphenylene iodonium (DPI), an inhibitor of reduced nicotinamide adenine dinucleotide phosphate-dependent oxidases (which generate superoxide anions), were studied on nitric oxide (NO)-mediated responses in isolated preparations of the rat aorta and anococcygeus muscle. 2. In aortic rings, the endoth...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1993.tb01661.x

    authors: Rand MJ,Li CG

    更新日期:1993-03-01 00:00:00

  • Multiple inferences using confidence intervals.

    abstract::1. In a recent review article, the problem of making false-positive inferences as a result of making multiple comparisons between groups of experimental units or between experimental outcomes was addressed. 2. It was concluded that the most universally applicable solution was to use the Ryan-Holm step-down Bonferroni ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2000.03223.x

    authors: Ludbrook J

    更新日期:2000-03-01 00:00:00

  • Dalteparin dose-dependently increases ROTEM(®) thrombelastography parameters only at supratherapeutic anti-factor Xa levels: an in vitro study.

    abstract::1. The low molecular weight heparin (LMWH) dalteparin is used, for example, to prevent primary venous thromboembolism in patients undergoing surgery or in medically ill patients. The anticoagulant activity of dalteparin can be monitored by measuring anti-factor Xa levels and activated partial thromboplastin time (aPTT...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2011.05593.x

    authors: Feuring M,Wehling M,Schultz A

    更新日期:2011-11-01 00:00:00

  • Amelioration of cardiac function in chronic myocardial infarcted rats following administration of vector pcDNA3.1AM.

    abstract::1. The present study was designed to examine the cardiovascular effects of intravenously administered pcDNA3.1AM, a recombinant non-virus vector carrying a rat adrenomedullin (AM) gene translation fragment, in rats with chronic cardiac dysfunction induced by ligation of the left descending coronary artery. 2. Haemodyn...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04678.x

    authors: Wang XF,Shao Y,Chen SW,Tian DZ,Huang GY,Huang Y,Yao T,Lu LM

    更新日期:2007-09-01 00:00:00

  • Role of calcium-activated potassium channels in the relaxation of tracheal smooth muscles by forskolin.

    abstract::1. The role of calcium-activated potassium (KCa) channels in bronchodilation produced by a direct adenylyl cyclase activator, forskolin, was investigated. The involvement of intracellular cyclic AMP (cAMP) in the process was also examined. 2. The isometric tension records from guinea-pig tracheal smooth muscles indica...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1994.tb02529.x

    authors: Hiramatsu T,Kume H,Kotlikoff MI,Takagi K

    更新日期:1994-05-01 00:00:00

  • Acute but not chronic angiotensin-converting enzyme inhibition induces enzyme synthesis in the glomerulus of the spontaneously hypertensive rat.

    abstract::1. Treatment with angiotensin-converting enzyme (ACE) inhibitors slows the rate of progression of nephropathy in the spontaneously hypertensive rat (SHR) with streptozotocin-induced diabetes. Paradoxically, however, chronic ACE inhibitor therapy has been reported to be associated with induction of ACE in the plasma. W...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1997.tb01226.x

    authors: Hodge G,Makarious MM,Charlesworth JA,Duggan KA

    更新日期:1997-06-01 00:00:00

  • Dihydrocyclosporin D in sheep: haemodynamic and renal effects.

    abstract::1. This study was designed to test the haemodynamic and renal effects in sheep of dihydrocyclosporin D (dCyD), an immunosuppressant agent derived from the fungus Tolypocladium inflatum Gams. 2. dCyD was infused for 5 days at 12 mg/kg per day. Mean arterial pressure (MAP) was elevated after 24 h, but thereafter returne...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1988.tb01095.x

    authors: Tresham JJ,Whitworth JA,de Lima JJ,McDougall JG,Scoggins BA

    更新日期:1988-05-01 00:00:00

  • Chronic exercise partially restores the transmural heterogeneity of action potential duration in left ventricular myocytes of spontaneous hypertensive rats.

    abstract::Hypertension leads to electrophysiological changes in the heart. Chronic exercise induced by a treadmill-running programme (TRP) is considered a potential non-pharmacological treatment for hypertension and may have implications in heart remodelling. However, it is not known whether the TRP is able to improve the elect...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2011.05669.x

    authors: Roman-Campos D,Carneiro-Júnior MA,Prímola-Gomes TN,Silva KA,Quintão-Júnior JF,Gondim AN,Duarte HL,Cruz JS,Natali AJ

    更新日期:2012-02-01 00:00:00

  • Single-unit sympathetic discharge pattern in pathological conditions associated with elevated cardiovascular risk.

    abstract::1. Although measuring the rate of firing of multi-unit muscle sympathetic nerve activity (MSNA) has provided important information in many aspects of cardiovascular medicine, measuring single-unit vasoconstrictor activity provides a better understanding of the possible mechanisms underlying disturbed sympathetic nervo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2008.04905.x

    authors: Lambert E,Dawood T,Schlaich M,Straznicky N,Esler M,Lambert G

    更新日期:2008-04-01 00:00:00

  • Generation and propagation of gastric slow waves.

    abstract::1. Mechanisms underlying the generation and propagation of gastrointestinal slow wave depolarizations have long been controversial. The present review aims to collate present knowledge on this subject with specific reference to slow waves in gastric smooth muscle. 2. At present, there is strong agreement that intersti...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2009.05331.x

    authors: van Helden DF,Laver DR,Holdsworth J,Imtiaz MS

    更新日期:2010-04-01 00:00:00

  • β-lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: a structured review.

    abstract::1. Infections and related sepsis are two of the most prevalent issues in the care of critically ill patients, with mortality as high as 70%. Appropriate antibiotic selection, as well as adequate dosing, is important to improve the clinical outcome for these patients. 2. β-Lactams are the most common antibiotic class u...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2012.05715.x

    authors: Sinnollareddy MG,Roberts MS,Lipman J,Roberts JA

    更新日期:2012-06-01 00:00:00

  • Dual nitric oxide mechanisms of cholestasis-induced bradycardia in the rat.

    abstract::1. Cholestatic liver disease is associated with nitric oxide (NO) overproduction and bradycardia. Nitric oxide has a dual effect on sinoatrial node and its effects depend on its concentration. Nitric oxide can increase heart rate by activating hyperpolarization-activated pacemaker current (If) but, at high concentrati...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03748.x

    authors: Mani AR,Nahavandi A,Moosavi M,Safarinejad R,Dehpour AR

    更新日期:2002-10-01 00:00:00

  • Blood volume measurements in the neonatal lamb: validation of a method using [51Cr]-labelled red cells.

    abstract::1. The reproducibility of blood volume measurements, using [51Cr]-labelled red blood cells (RBC) was tested in three lambs, 79-89 days of age, and the accuracy was tested in eight lambs, 83 +/- 0.4 days of age, in which blood volume was measured simultaneously by [51Cr]-RBC and [125I]-gamma globulin plus haematocrit (...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1994.tb02557.x

    authors: Moritz KM,Potocnik SJ,Tangalakis K,Wintour EM

    更新日期:1994-07-01 00:00:00

  • Interaction between epidermal growth factor and arginine vasopressin in renal medullary membranes.

    abstract::1. Epidermal growth factor is a potent mitogen that causes natriuresis, diuresis and inhibition of arginine vasopressin-induced water reabsorption. 2. The aim of this study was to determine any interaction between epidermal growth factor and the V1 (vascular) and/or V2 (antidiuretic) arginine vasopressin receptor subt...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1994.tb02506.x

    authors: Grant SL,Phillips PA,Gow CB

    更新日期:1994-03-01 00:00:00

  • Glycyrrhizin treatment ameliorates post-traumatic stress disorder-like behaviours and restores circadian oscillation of intracranial serotonin.

    abstract::Post-traumatic stress disorder (PTSD) has become a major disease that threatens human health. Neurotransmitters and the amygdala are found to be critical in the development and maintenance of PTSD. We aim to investigate the role of glycyrrhizin in treating PTSD. Contextual fear extinction and elevated plus maze test w...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13173

    authors: Lai S,Shi L,Jiang Z,Lin Z

    更新日期:2020-01-01 00:00:00

  • Characterization of single heart cell contractility by rapid imaging.

    abstract::1. A rapid imaging technique with temporal resolution of about 1 ms was employed to describe cell-length changes during the isotonic contraction cycle of adult rat ventricular myocytes at 22 degrees C. 2. Parameters of cell contraction and relaxation were defined and values obtained under control conditions and after ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1989.tb01542.x

    authors: Delbridge LM,Harris PJ,Morgan TO

    更新日期:1989-03-01 00:00:00

  • Newcastle disease virus: a promising agent for tumour immunotherapy.

    abstract::Malignant tumours are a major cause of mortality in humans. Currently used therapeutic regimens have not improved survival rates of patients suffering from malignant tumours much because of their limited efficacy and side-effects. A therapeutic approach that uses Newcastle disease virus (NDV) represents an attractive ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2011.05662.x

    authors: Zhao L,Liu H

    更新日期:2012-08-01 00:00:00

  • Micropuncture comparison of nephron function during acute and chronic ADH excess in the rat.

    abstract::1. The aim of this study was to compare the effect of acute versus chronic ADH administration on the handling of sodium, potassium and water by the nephron. Simultaneous clearance and free-flow micropuncture experiments were performed on rats, infused with hypotonic Ringer solution, following either 1-3 h ('acute') or...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1989.tb01531.x

    authors: Field MJ,Seow F,Lawrence JR

    更新日期:1989-02-01 00:00:00

  • Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded rats.

    abstract::1. Iron overload contributes to the pathogenesis of various diseases and directly induces tissue injury. In the present study, we investigated the relationship between heart and liver injury induced by iron overload and cellular endoplasmic reticulum (ER) stress to explore the molecular mechanism of iron overload-indu...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2008.05114.x

    authors: Lou LX,Geng B,Chen Y,Yu F,Zhao J,Tang CS

    更新日期:2009-07-01 00:00:00

  • Modelling of frequency-dependent effects of lignocaine homologues on the maximum upstroke velocity of action potentials in guinea-pig papillary muscles.

    abstract::1. The effects of 14 lignocaine homologues on the maximum upstroke velocity (Vmax) of the action potentials (AP) were studied in guinea-pig papillary muscles. These drugs possess one, two or three methyl groups in different positions: an ortho-chloro, -carbomethoxy or -ethyl group instead of an ortho-methyl group; or ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1992.tb00489.x

    authors: Hamamoto T,Ichiyama M,Takahashi Y,Ban T

    更新日期:1992-06-01 00:00:00

  • Activation of peripheral chemoreceptors causes positive inotropic effects in a working heart-brainstem preparation of the rat.

    abstract::1. The aim of the present study was to evaluate the effects of peripheral chemoreceptor activation on myocardial contractility in an anaesthetic-free decerebrated rat preparation. 2. In the decerebrated and retrogradely perfused working heart-brainstem preparation, we recorded phrenic nerve activity, left ventricular ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04699.x

    authors: Braga VA,Zoccal DB,Soriano RN,Antunes VR,Paton JF,Machado BH,Nalivaiko E

    更新日期:2007-11-01 00:00:00

  • Protective effects of magnesium against ischaemia-reperfusion injury through inhibition of P-selectin in rats.

    abstract::1. The leucocyte-mediated inflammatory response plays a pivotal role in ischaemia-reperfusion injury. P-Selectin and CD11b are important mediators for the recruitment of leucocytes into the endothelium. However, the time-course of changes in P-selectin and CD11b expression during reperfusion is not defined. Magnesium ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04697.x

    authors: Ying SQ,Fang L,Xiang MX,Xu G,Shan J,Wang JA

    更新日期:2007-12-01 00:00:00

  • Autonomic control of bronchial circulation in awake sheep during rest and behaviour.

    abstract::1. We tested the hypothesis that the pattern and the intensity of autonomic mechanisms causing vasoconstriction in the resting bronchial circulation of awake dogs also exists in awake sheep. It was also postulated that sighing behaviour and the associated bronchovascular dilatation induced by non-adrenergic, non-choli...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1997.tb02723.x

    authors: McIlveen S,White S,Parsons G

    更新日期:1997-12-01 00:00:00

  • Ca2+-dependent differential development of carbachol-induced desensitization to receptor agonists and high K+ in guinea-pig taenia caeci.

    abstract::1. Carbachol (CCh)-induced desensitization to CCh was interrupted by a transient resensitization during its early stage, with concomitant changes at the muscarinic receptor/G-protein level in smooth muscle of guinea-pig taenia caeci. To assess whether such a peculiar desensitizing process may heterologously regulate s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04530.x

    authors: Hishinuma S,Matsumoto Y,Sato R,Saito M

    更新日期:2007-01-01 00:00:00

  • Transient receptor potential (TRP) channels, vascular tone and autoregulation of cerebral blood flow.

    abstract::Members of the transient receptor potential (TRP) channel superfamily are present in vascular smooth muscle cells and play important roles in the regulation of vascular contractility. The TRPC3 and TRPC6 channels are activated by stimulation of several excitatory receptors in vascular smooth muscle cells. Activation o...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2007.04855.x

    authors: Brayden JE,Earley S,Nelson MT,Reading S

    更新日期:2008-09-01 00:00:00

  • Effects of transthyretin on thyroxine and β-amyloid removal from cerebrospinal fluid in mice.

    abstract::Transthyretin (TTR) is a binding protein for the thyroid hormone thyroxine (T4 ), retinol and β-amyloid peptide. TTR aids the transfer of T4 from the blood to the cerebrospinal fluid (CSF), but also prevents T4 loss from the blood-CSF barrier. It is, however, unclear whether TTR affects the clearance of β-amyloid from...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12598

    authors: Chen R,Chen CP,Preston JE

    更新日期:2016-09-01 00:00:00

  • Wagner-Nelson method for analysing the atypical double-peaked [13CO2] excretion curve in the [13C]-octanoate gastric emptying breath test in humans.

    abstract::1. In the [(13)C]-octanoic acid breath test, the time versus pulmonary [(13)CO(2)] excretion rate curve is analysed using mathematical curve-fitting techniques to calculate gastric emptying parameters. Thus, the goodness-of-fit highly influences the accuracy of the breath test. However, a double-peaked [(13)CO(2)] exc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1440-1681.2005.04235.x

    authors: Sanaka M,Yamamoto T,Tsutsumi H,Abe K,Kuyama Y

    更新日期:2005-07-01 00:00:00