The syndrome of hypertension and hyperkalaemia with normal GFR. A unique pathophysiological mechanism for hypertension?

abstract：:1. Contraction assays and patch clamp methods were used to determine the role of K+ channels in the regulation of contractile tone of human mesangial cells (MC) in culture. 2. MC contraction was induced by vasoconstrictor agents, such as angiotensin II (AngII; 100 nmol/L) and glybenclamide (Glyb), but not by iberiotox...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sansom SC,Stockand JD

更新日期：1996-01-01 00:00:00

abstract：:1. A method is described which allows the determination of liquid junction potentials between biological fluid samples of less than 1 nL with a reproducibility of 10%. This was achieved by use of a micro-method and the use of 3% agarose added to the electrolyte in the measuring electrodes. 2. Validation was performed ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sugo E,Györy AZ

更新日期：1989-07-01 00:00:00

abstract：:1. The present study examined the cytosolic Ca(2+) regulatory machinery involved in the vasorelaxation produced by petasin, a sesquiterpene isolated from Petasites formosanus. 2. Aortic rings isolated from Sprague-Dawley rats were exposed to petasin (0.01-100 micromol/L) to elucidate its vascular effects on isometric ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang GJ,Lin YL,Chen CH,Wu XC,Liao JF,Ren J

更新日期：2010-03-01 00:00:00

abstract：:1. Parathyroidectomy (PTX) lessens the development of hypertension in young spontaneously hypertensive rats (SHR) and the involved mechanisms remain to be elucidated. We have studied here the aortic vascular reactivity to both norepinephrine (NE) and acetylcholine in 10 week old male PTX SHR and Wistar-Kyoto (WKY) rat...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boulebda N,Van Overloop B,Gairard A

更新日期：1993-12-01 00:00:00

abstract：:1. The intravenous administration of nicergoline (5 mg) was followed by a rapid and sustained lowering of blood pressure; less rapid effects were bradycardia and an elevation of cardiac output. These delayed effects are consistent with an indirect action on the alpha-adrenoreceptors of the central nervous system. 2. F...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boismare F,Lefrançois J

更新日期：1980-03-01 00:00:00

abstract：:1. It is known that the alpha(4)-subunit is likely to occur in the brain predominantly in alpha(4)beta(3)delta receptors at extrasynaptic sites. Recent studies have revealed that the alpha(1)-, alpha(4)-, gamma(2)- and delta-subunits may colocalize extrasynaptically in dentate granule cells of the hippocampus. In the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang MD,Rahman M,Johansson IM,Bäckström T

更新日期：2010-07-01 00:00:00

abstract：:1. This study was undertaken to evaluate the preventive effects of locally administered argatroban, a competitive inhibitor of thrombin-induced platelet activation, on restenosis after balloon angioplasty. 2. A hydrogel-coated balloon catheter was immersed three times in argatroban/saline solution (1 mg/mL) for 60 s, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Imanishi T,Arita M,Tomobuchi Y,Hamada M,Hano T,Nishio I

更新日期：1997-11-01 00:00:00

abstract：:Osteosarcoma is the most common non-hematological primary bony malignancy in children and young adults with tumor metastasis being a common event at diagnosis. Understanding the pathogenesis of metastatic osteosarcoma may help identify potential therapeutic targets. In this study, we found that the level of microRNA-6...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiao GJ,Zhang SJ,Li Y,Wu WL,Liu HC

更新日期：2018-12-01 00:00:00

abstract：:The purpose of the present study was to identify the differential proteins that synchronously change in urine and glomeruli and could be used to monitor glomerular lesions of IgA nephropathy (IgAN). The proteomes of urine and glomeruli from four IgAN patients who were graded III/IV according to the grading system of L...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ning X,Yin Z,Li Z,Xu J,Wang L,Shen W,Lu Y,Cai G,Zhang X,Chen X

更新日期：2017-05-01 00:00:00

abstract：:The pharmacological actions of 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP), a putative presynaptic GABA(B) receptor modulator, were examined in electrically stimulated rat neocortical brain slices preloaded with [3H]-GABA or [3H]-glutamic acid. At 10 mmol/L, BSPP inhibited the release of [3H]-GAB...

journal_title：Clinical and experimental pharmacology & physiology

authors： Parker DA,Marino V,Ong J,Puspawati NM,Prager RH

更新日期：2008-09-01 00:00:00

abstract：:1. Kynurenine aminotransferase catalyzes the conversion of kynurenine to kynurenic acid, an endogenous antagonist of excitatory amino acid receptors. The kynurenic acid content and kynurenine aminotransferase activity was measured in micro-dissected regions of spontaneously hypertensive rats (SHR) and their normotensi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kapoor V,Kapoor R,Chalmers J

更新日期：1994-11-01 00:00:00

abstract：:The effect of L-thyroxine on serum angiotensin converting enzyme activity using a sheep model was examined. Following two weeks of L-thyroxine treatment, the activity of serum angiotensin converting enzyme was increased from 6.92 U/ml to 8.65 U/ml (s.e.m. = 0.40, n = 13, P less than 0.01). Discontinuation of L-thyroxi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Verma P,Noble S,Miller R

更新日期：1986-08-01 00:00:00

abstract：:1. The aim of the present study was to evaluate the usefulness and reliability of a portable indirect calorimeter (Metavine; Vine, Tokyo, Japan). 2. We measured energy expenditure (EE) of elderly people (n = 191) at nursing homes using both Metavine and an authorized indirect calorimeter (Deltatrac Metabolic Monitor; ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kato M,Tajika M,Miwa Y,Moriwaki H

更新日期：2002-10-01 00:00:00

abstract：:1. Physical movement is accompanied by coordinated changes in respiratory and cardiovascular activity proportional to the metabolic demands of the locomotor task. Cardiorespiratory changes include increases in ventilation, blood pressure and heart rate, as well as altered regional sympathetic nerve activity and blood ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kramer JM,Beatty JA,Plowey ED,Waldrop TG

更新日期：2002-01-01 00:00:00

abstract：:1. The diffusional permeability of collecting ducts to 22Na+ and 36Cl- was measured in rat papillae in vitro. 2. The permeability of the collecting duct to 36Cl- was 0.72 (s.e.m. = 0.01; n = 356) microns/sec which was significantly higher than the value of 0.51 (s.e.m. = 0.01; n = 356) microns/sec measured for 22Na+. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morgan T,Ray C

更新日期：1982-11-01 00:00:00

abstract：:1. The administration of aldosterone to adrenalectomized rats produces an increase in K+ and decrease in Na+ excretion in the urine. The relationship of the post-aldosterone to the pre-aldosterone urinary sodium and potassium excretion is termed the renal response to aldosterone. 2. The administration of L-dopa enhanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Adam WR

更新日期：1979-01-01 00:00:00

abstract：:Serotonin causes a dose related (0.1-20 micrograms/kg i.v.) increase in mean arterial blood pressure (MAP) and heart rate in conscious sheep. Ketanserin (0.1 mg/kg per h i.v.) causes a decrease in blood pressure, and an increase in heart rate. In the presence of ketanserin, serotonin induced increases in MAP are atten...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nelson MA,Coghlan JP,Denton DA,Mills EH,Spence CD,Whitworth JA,Scoggins BA

更新日期：1984-11-01 00:00:00

abstract：:1. The aims of the present study were to investigate the pharmacological effects of quercetin on wild-type (WT) and mutant (I502A) human (h) Kv1.5 channel currents (I(kur)) and to identify whether mutation in the S6 segment is critical to activation of I(kur) by quercetin. 2. Experiments were performed on WT and site-...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang L,Ma JH,Zhang PH,Zou AR,Tu DN

更新日期：2009-02-01 00:00:00

abstract：:1. We wished to determine whether, during pregnancy, there is reduced renal response to atrial distension, whether secretion of atrial natriuretic factor (ANF) is suppressed and whether neural input from the atrial volume receptors to the central nervous system is altered. 2. Conscious, chronically instrumented female...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kaufman S

更新日期：1995-02-01 00:00:00

abstract：:1. It has been suggested that Na+/K(+)-ATPase and Na(+)-dependent glutamate transport (GluT) are tightly linked in brain tissue. In the present study, we have investigated Na+/K(+)-ATPase activity using Rb+ uptake by 'minislices' (prisms) of the cerebral cortex. This preparation preserves the morphology of neurons, sy...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nanitsos EK,Acosta GB,Saihara Y,Stanton D,Liao LP,Shin JW,Rae C,Balcar VJ

更新日期：2004-11-01 00:00:00

abstract：:1. The aim of the present study was to perform an in vivo estimation of the Michaelis-Menten constants of the major metabolic pathways of paracetamol (APAP). 2. A two-occasion, single-dose cross-over trial was performed using 60 and 90 mg/kg doses of APAP in healthy patients undergoing third molar dental extraction. P...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reith D,Medlicott NJ,Kumara De Silva R,Yang L,Hickling J,Zacharias M

更新日期：2009-01-01 00:00:00

abstract：:1. Signal transducers and activators of transcription (STAT) factors are a family of transcription factors that mediate intracellular signalling initiated at cytokine cell surface receptors and transmitted to the nucleus. In the present study, we determined the global changes in STAT gene expression in the hippocampus...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sun SL,Li TJ,Yang PY,Qiu Y,Rui YC

更新日期：2007-11-01 00:00:00

abstract：:Skeletal muscle is an important site for insulin to regulate blood glucose levels. It is estimated that skeletal muscle is responsible for ~80% of insulin-mediated glucose disposal in the post-prandial period. The classical action of insulin to increase muscle glucose uptake involves insulin binding to insulin recepto...

journal_title：Clinical and experimental pharmacology & physiology

authors： Keske MA,Dwyer RM,Russell RD,Blackwood SJ,Brown AA,Hu D,Premilovac D,Richards SM,Rattigan S

更新日期：2017-01-01 00:00:00

abstract：:1. Telomeres (ends of chromosomes) undergo constant remodelling during cell development, proliferation and differentiation, as well as in neoplastic cell immortalization and transformation. How the cellular microenvironment influences telomere remodelling (lengthening or shortening) remains largely unknown. 2. Recentl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu JP,Nicholls C,Chen SM,Li H,Tao ZZ

更新日期：2010-01-01 00:00:00

abstract：:1. There has been considerable recent interest in the possibility that increased intake of dietary anti-oxidants may protect against cardiovascular disease. This is partly due to the knowledge that oxidative events in vivo may play a role in the pathogenesis of atherosclerosis. 2. While dietary anti-oxidants, such as ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morton LW,Abu-Amsha Caccetta R,Puddey IB,Croft KD

更新日期：2000-03-01 00:00:00

abstract：:1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reid CM,Nelson M,Beckinsale P,Ryan P,Wing LM,Beilin LJ,Brown MA,Jennings GL,Johnston CI,Marley J,McNeil JJ,Morgan TO,Shaw J,Steven ID,West MJ

更新日期：1997-05-01 00:00:00

abstract：:1. The effect of the calcium channel blocker nisoldipine on the myocardial content of lipid peroxidation products (malondialdehyde (MDA), conjugated double bonds (CDB), fluorescent end-products (RF) and mitochondrial adenine nucleotides) was investigated in conscious pigs (n = 14) subjected to 24 h of immobilization s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Herbaczyńska-Cedro K,Lewicki Z,Barcikowski B,Famulski K,Gordon-Majszak W,Kłoś J,Wutzen J,Ceremuzyński L

更新日期：1990-01-01 00:00:00

abstract：:1. The aim of the present study was to characterize the source of plasma catecholamines induced by centrally administered glucagon-like peptide-1 (GLP-1), with regard to brain prostanoids, in urethane-anaesthetized rats. 2. Glucagon-like peptide-1 and other compounds were administered intracerebroventricularly (i.c.v....

journal_title：Clinical and experimental pharmacology & physiology

authors： Arai J,Okada S,Yamaguchi-Shima N,Shimizu T,Sasaki T,Yorimitsu M,Wakiguchi H,Yokotani K

更新日期：2008-08-01 00:00:00

abstract：:1. Angiotensin (Ang)II is involved in responses to hypovolaemia, such as sodium appetite and increase in blood pressure. Target areas subserving these responses for AngII include the cardiovascular system in the periphery and the circumventricular organs in the brain. 2. Conflicting data have been reported for the rol...

journal_title：Clinical and experimental pharmacology & physiology

authors： De Luca LA Jr,Sugawara AM,Menani JV

更新日期：2000-05-01 00:00:00

abstract：:1. Glyceryl trinitrate (GTN) is frequently infused intravenously as a component of the management of acute coronary syndromes (ACS). Abrupt cessation of GTN infusion after periods of more than 24 h administration often induces rebound vasoconstriction reflecting 'pseudotolerance'; this is also the basis of the 'zero h...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kelly EA,Ahmed RM,Horowitz JD

更新日期：2005-04-01 00:00:00