Haemodynamic effects of nicergoline in man at rest and during exercise.

abstract：:1. In the present study we have examined the effects of angiotensin I converting enzyme (ACE) inhibition and nitric oxide (NO) synthesis inhibition on bradykinin (BK) depressor responses in pregnancy in both Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. Ramipril (10 mg/kg, i.v.) significantly reduce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chu ZM,Beilin LJ

更新日期：1995-06-01 00:00:00

abstract：:1. Plasma drug levels and blood pressure changes produced by a single 2 mg oral dose of prazosin were determined in nine hypertensive patients. 2. Regression analysis showed that there was a high degree of correlation between plasma prazosin concentration and change in mean blood pressure. 3. There were marked differe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stokes GS,Monaghan JC,MacCarthy EP,Oates HF

更新日期：1980-03-01 00:00:00

abstract：:Subendocardial viability ratio (SEVR) is a reliable index of myocardial supply-workload balance. This study sought to investigate whether overweight/obese children and adolescents have altered SEVR and to identify which are the associated factors. This cross-sectional study involved 789 individuals. Central haemodynam...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zaniqueli D,Alvim RO,Baldo MP,Luiz SG,Cunha RS,Mill JG

更新日期：2018-05-01 00:00:00

abstract：:1. Neutrophil function was studied in 10 males presenting with acute myocardial infarction (MI) within 6 h of onset and in 10 normal males. Neutrophil production of platelet-activating factor (PAF), determined by bioassay, that of leukotriene B4 by HPLC, and the activity of an enzyme involved in the synthesis of PAF, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Strahan ME,Graham RM,Eccleston DS,Sturm MJ,Taylor RR

更新日期：1995-02-01 00:00:00

abstract：:1. In order to further characterize the adenosine binding sites that we previously purified and termed P3 purinergic receptor-like protein (P3LP), a reliable binding assay method was developed using [3H]-5'-N-ethylcarboxamidoadenosine (NECA) as a radioligand and the newly developed high-affinity selective ligand 9-(6,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yoshioka K,Matsuda A,Nakata H

更新日期：2001-04-01 00:00:00

abstract：:1. Free radical-induced lipid peroxidation and changes in protein and nucleic acid structures can result in various human ailments, including ageing, neurodegenerative disorders and cancer. High body fat or dietary fat further enhances the free radical-mediated pathogenesis of various diseases. 2. In the present study...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ajith TA,Riji T,Anu V

更新日期：2008-05-01 00:00:00

abstract：:1. There has been interest in the suggestion that enzyme-inducing drugs, such as anticonvulsants, may produce beneficial changes in lipoprotein levels, in particular a rise in the ratio of high density lipoprotein cholesterol to total cholesterol. 2. This controlled study observed the effects of diets of charcoal or o...

journal_title：Clinical and experimental pharmacology & physiology

authors： Heller RF,Henry DA,Brent PJ

更新日期：1989-10-01 00:00:00

abstract：:1. The present study was designed to determine the effects of ginkgolide A, ginkgolide B and quercetin on CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes. 2. Hepatocytes were pretreated with ginkgolide A, ginkgolide B and quercetin (at 1, 3, 10 and 30 micromol/L) for 48 h and then...

journal_title：Clinical and experimental pharmacology & physiology

authors： He N,Cai HB,Xie HG,Collins X,Edeki TI,Strom SC

更新日期：2007-07-01 00:00:00

abstract：:Drug-induced phospholipidosis (DIPL) is characterized by phospholipid storage in the lysosomes of affected tissues. Many severe effects and toxicities have been linked to DIPL. The aim of this study was to determine whether the endogenous opioid system is involved in chloroquine-induced phospholipidosis. The effect of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Malek MR,Ahmadian S,Dehpour AR,Ebrahim-Habibi A,Shafizadeh M,Kashani-Amin E

更新日期：2020-09-01 00:00:00

abstract：:In the context of the ongoing debate on the mechanism of blood pressure (BP) regulation and pathophysiology of arterial hypertension ("renocentric" vs "neural" concepts), attention is focused on the putative regulatory role of changes in renal medullary blood flow (MBF). Experimental evidence is analysed with regard t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sadowski J,Bądzyńska B

更新日期：2020-08-01 00:00:00

abstract：:1. To investigate whether the difference in the SA gene expression in the kidneys is causally related to the pathogenesis of hypertension, we reassessed the expression of the SA gene in the kidneys of the spontaneously hypertensive rat (SHR), its stroke-prone substrain (SHRSP) and Wistar-Kyoto (WKY) rat from different...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ishinaga Y,Nabika T,Shimada T,Hiraoka J,Nara Y,Yamori Y

更新日期：1997-01-01 00:00:00

abstract：:1. Hepatic sulphobromophthalein (BSP) transport was studied in guinea-pigs pretreated intraperitoneally with 0.7 ml of diethyl maleate to depress hepatic glutathione levels. 2. Diethyl maleate depressed the hepatic transport of infused conjugated BSP from hepatocytes into bile without influencing hepatic uptake. 3. Un...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whelan G

更新日期：1980-11-01 00:00:00

abstract：:1. Adult soft-shelled turtles were exposed to hyperosmotic and dehydration stresses. 2. Acute treatment for 0.5, 1 or 2 h with sodium chloride (3.6%, single intramuscular injection, 2 mL volume) caused depletion of pineal serotonin contents followed by elevation of norepinephrine and epinephrine levels. In addition, i...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mahapatra MS,Mahata SK,Maiti B

更新日期：1991-10-01 00:00:00

abstract：:1. The effect of pretreatment with nifedipine on naloxone-stimulated corticotrophin-releasing hormone (CRH)-induced adrenocorticotrophin (ACTH) release in humans was investigated. The mean peak plasma ACTH and cortisol levels and the mean peak change in cortisol levels from basal were significantly lower in the nifedi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hockings GI,Grice JE,Walters MM,Jackson RV

更新日期：1991-05-01 00:00:00

abstract：:1. Studies using animal experimental models have suggested that the beta2-adrenoceptor is uncoupled in association with alterations in the expression of G-protein-coupled receptor kinases (GRK) 2/3 in heart failure. However, the functional expression of the components of this pathway in human disease has not been full...

journal_title：Clinical and experimental pharmacology & physiology

authors： Dzimiri N,Basco C,Moorji A,Afrane B,Al-Halees Z

更新日期：2002-03-01 00:00:00

abstract：:1. In the [(13)C]-octanoic acid breath test, the time versus pulmonary [(13)CO(2)] excretion rate curve is analysed using mathematical curve-fitting techniques to calculate gastric emptying parameters. Thus, the goodness-of-fit highly influences the accuracy of the breath test. However, a double-peaked [(13)CO(2)] exc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sanaka M,Yamamoto T,Tsutsumi H,Abe K,Kuyama Y

更新日期：2005-07-01 00:00:00

abstract：:1. Neuropeptide Y (NPY) is colocalized with catecholamines in central regions involved in blood pressure regulation and exerts depressor responses in the nucleus tractus solitarius (NTS). Ageing is accompanied by a decline in baroreflex function and a reduction in NPY concentrations in some brain areas. The present st...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris MJ,Pavia JM

更新日期：1997-02-01 00:00:00

abstract：:1. Levodopa markedly reduces parkinsonism during the first years of treatment. However, with continued therapy the response to levodopa becomes erratic and is complicated by involuntary movements. To improve the therapy of parkinsonism, the challenge is to understand why fluctuations in response develop and, once deve...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nutt JG

更新日期：1995-11-01 00:00:00

abstract：:1. Activation of peripheral chemoreceptors with KCN in the working heart-brainstem preparation from young male Wistar rats (70-90 g) increases phrenic (PNA; +105 +/- 18%) and thoracic (tSNA; +44 +/- 6%) sympathetic nerve activity compared with baseline and reduces heart rate (HR; from 377 +/- 27 to 83 +/- 6 b.p.m.). 2...

journal_title：Clinical and experimental pharmacology & physiology

authors： Antunes VR,Braga VA,Machado BH

更新日期：2005-05-01 00:00:00

abstract：:1. We have tested the effects of 2 month oral treatment with the KATP opener, nitric oxide (NO) donor and anti-oxidant molecule nicorandil (0.1 mg/kg per day) on major physiological parameters and heart function of 4-, 12- and 24-month-old rats. 2. Several methods were used: (i) measurement of blood pressure using a n...

journal_title：Clinical and experimental pharmacology & physiology

authors： Garnier-Raveaud S,Faury G,Mazenot C,Cand F,Godin-Ribuot D,Verdetti J

更新日期：2002-05-01 00:00:00

abstract：:1. Uridine monophosphate was tested in the conscious rat for natriuretic properties and an immunoperoxidase technique was used to localize uridine-containing compounds in the rat kidney. 2. Uridine monophosphate, infused in a moderate pressor dose, caused a significant natriuresis compared to the effect of control inf...

journal_title：Clinical and experimental pharmacology & physiology

authors： Macdonald G,Assef R,Watkins S,Burrell J

更新日期：1987-03-01 00:00:00

abstract：:1. Infusion of salbutamol (3.0 microgram/min after a bolus injection of 100 microgram) produced hypokalaemia in conscious dogs. 2. Measurement of arterial and coronary sinus potassium differences revealed no significant potassium loss from the heart with established hypokalaemia. 3. Shortly after the initial salbutamo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wahlqvist ML,Shanahan EA,Dennis PM,Pullan PT,Wilmshurst EG

更新日期：1978-11-01 00:00:00

abstract：:We evaluated the role of deferasirox therapeutic drug monitoring in order to avoid toxicity or treatment failure. Plasma concentrations, measured between two consecutive liver iron determinations, were determined at the end of dosing interval. Fifty-four β-thalassemic adult patients were enrolled: 50% were males; medi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Allegra S,Massano D,De Francia S,Longo F,Piccione F,Pirro E,Cusato J,D'Avolio A,Piga A

更新日期：2018-02-01 00:00:00

abstract：:1. Activities of acetylcholinesterase (AChE), neuropathy target esterase (NTE), and carboxylesterase (CbxE) were compared in neuroblastoma cells of human origin (SH-SY5Y) and murine origin (NB41A3). 2. Mouse neuroblastoma cells had lower specific activities of NTE and CbxE than did human neuroblastoma cells; specific ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ehrich M,Veronesi B

更新日期：1995-05-01 00:00:00

abstract：:1. Nineteen-day old rats were fed an essential fatty acid deficient diet for 37 weeks, thereby making them essential fatty acid deficient for at least 24 weeks. The weights of their brains were 33% less than those of rats on control diets. 2. When the deficient rats were rehabilitated for ten weeks on a diet containin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Odutuga AA

更新日期：1979-07-01 00:00:00

abstract：:This study investigated if the protective effect of taurine against high fat diet-induced hepatic steatosis involves modulating the hepatic activity of 5' AMP-activated protein kinase (AMPK) and levels/activity of the sterol regulatory element-binding proteins-1/2 (SREBP1/2). Rats were divided into four groups (n = 12...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morsy MD,Aboonq MS,ALsleem MA,Abusham AA

更新日期：2020-07-21 00:00:00

abstract：:1. Na+/H+ exchange, an ethylisopropylamiloride (EIPA)-sensitive Na+ and HCO3- dependent system and a diisothio-cyanatostilbenedisulphonic acid (DIDS)-sensitive Na+ and HCO3- transporter, contribute to sodium influx and intracellular pH (pHi) regulation in vascular smooth muscle. 2. In cultured cells from the human int...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bobik A,Little PJ,Neylon CB

更新日期：1991-02-01 00:00:00

abstract：:1. In the rectum and distal nephron, sodium reabsorption is mediated by the amiloride-sensitive epithelial sodium channel (ENaC). The ENaC-mediated sodium transport is electrogenic and creates an amiloride-sensitive transepithelial potential difference (PD). 2. We have evaluated the salt- and angiotensin (Ang)II-depen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang Q,Horisberger JD,Maillard M,Brunner HR,Rossier BC,Burnier M

更新日期：2000-01-01 00:00:00

abstract：:1. The development of microneurography, in which an insulated tungsten microelectrode is inserted into an accessible peripheral or cranial nerve in awake human subjects, has allowed detailed analyses of the signalling capacities of single mechanoreceptive afferents from the skin, muscles and joints. For example, we kn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Macefield VG

更新日期：2005-01-01 00:00:00

abstract：:1. Neurotensin is released from the intestine into the portal circulation and to exert a systemic effect it must traverse the liver intact. 2. The role of the liver in neurotensin clearance was examined using the isolated perfused rat liver preparation. Two concentrations of neurotensin were used to determine the extr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Brook CW,Shulkes A,Sewell RB,Smallwood RA

更新日期：1987-10-01 00:00:00