Abstract:
:1. The effect of pretreatment with nifedipine on naloxone-stimulated corticotrophin-releasing hormone (CRH)-induced adrenocorticotrophin (ACTH) release in humans was investigated. The mean peak plasma ACTH and cortisol levels and the mean peak change in cortisol levels from basal were significantly lower in the nifedipine/naloxone test than in the naloxone alone test. The integrated areas under the ACTH-time and cortisol-time curves were reduced by 33 and 49%, respectively, in the nifedipine/naloxone test compared with the naloxone alone test. These results correlate well with published in vitro studies. 2. Acute administration of oral nifedipine partially inhibited naloxone-stimulated ACTH and cortisol release, probably by blockade of plasma membrane voltage-dependent L-type calcium channels normally activated following binding of CRH to pituitary corticotroph receptors. 3. Naloxone-induced CRH release may replace insulin hypoglycaemia testing of pituitary ACTH reserve in humans.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Hockings GI,Grice JE,Walters MM,Jackson RVdoi
10.1111/j.1440-1681.1991.tb01451.xkeywords:
subject
Has Abstractpub_date
1991-05-01 00:00:00pages
303-7issue
5eissn
0305-1870issn
1440-1681journal_volume
18pub_type
杂志文章abstract::This study demonstrates the inhibitory effect of anticholinergic drug oxybutynin on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells. Oxybutynin inhibited vascular Kv channels in a concentration-dependent manner, with an IC50 value of 11.51 ± 0.38 μmol/L and a Hill coefficient (n) of ...
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pub_type: 杂志文章,评审
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更新日期:1998-11-01 00:00:00
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doi:10.1111/j.1440-1681.1995.tb02017.x
更新日期:1995-05-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:2015-01-01 00:00:00
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更新日期:1999-07-01 00:00:00
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