In vitro anti-oxidant and DNA protective effects of the novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin.

abstract：:Excessive activation of the sympatho-adrenomedullary system plays a pathogenic role in triggering and sustaining essential hypertension. We previously reported that, in normotensive rats, intracerebroventricularly (i.c.v.) administered neuropeptides, corticotropin-releasing factor and bombesin induced activation of th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shimizu T,Yamamoto M,Zou S,Shimizu S,Higashi Y,Saito M

更新日期：2020-07-01 00:00:00

abstract：:1. Contractions and electrical activity were recorded from isolated segments of longitudinal (L) and circular (C) myometrium from rats on gestation days 16-17 and 21 before and during parturition. 2. The segments were arranged so that the activity of the two layers could be monitored simultaneously and independently. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomiyasu BA,Chen CJ,Marshall JM

更新日期：1988-09-01 00:00:00

abstract：:Posture changes may differ between types of hypertensive disease. The aim is to evaluate the orthostatic response of impedance cardiography (ICG) measurements in uncomplicated and hypertensive pregnancies. Measurements were performed in supine and standing position in 202 women: 41 uncomplicated pregnancies (UP), 59 g...

journal_title：Clinical and experimental pharmacology & physiology

authors： Staelens AS,Vonck S,Mesens T,Tomsin K,Molenberghs G,Gyselaers W

更新日期：2015-10-01 00:00:00

abstract：:1. UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme, and its overexpression has been demonstrated in a variety of malignancies. The aim of the present study is to silence UbcH10 gene by RNA interference (RNAi) and to observe its inhibitory effect on the colorectal cancer cell growth in vitro and in vivo. 2...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen SM,Jiang CY,Wu JY,Liu B,Chen YJ,Hu CJ,Liu XX

更新日期：2010-05-01 00:00:00

abstract：:trans-Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim of the present study was to investigate the effects of resveratrol on cardiac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu Z,Song Y,Zhang X,Liu Z,Zhang W,Mao W,Wang W,Cui W,Zhang X,Jia X,Li N,Han C,Liu C

更新日期：2005-12-01 00:00:00

abstract：:1. Resveratrol (RSV), a polyphenol in red wine, exhibits cardioprotective effects in vitro, such as inhibition of angiotensin II- or phenylephrine-induced cardiomyocyte hypertrophy in rat neonatal myocyte cultures and suppression of cardiac fibroblast proliferation. The aim of the present study was to investigate the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang DL,Zhang HG,Xu YL,Gao YH,Yang XJ,Hao XQ,Li XH

更新日期：2010-02-01 00:00:00

abstract：:Aerobic glycolysis plays a crucial role in cancer progression. Ketamine is often used for cancer pain relief in clinical settings. Moreover, ketamine inhibits proliferation and induces apoptosis in many cancer cell types. However, the anti-tumour mechanism of ketamine is still poorly understood. In the present study, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hu J,Duan W,Liu Y

更新日期：2020-05-01 00:00:00

abstract：:This study investigates the effect of chronic consumption of a high-fat diet rich in corn oil (CO-HFD) on atrial cells ultrastructure, antioxidant levels and markers of intrinsic cell death of both control and type 1 diabetes mellitus (T1DM)-induced rats. Adult male rats (10 rats/group) were divided into four groups: ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Eid RA,Eleawa SM,Alkhateeb MA,Aldera H,Zaki MSA,Al-Shraim M,Saeed MA,El-Kott AF,Alaa Eldeen M,Alassiri M,Alshehri MM,Salem Al-Shudiefat AA,Khalil MA

更新日期：2019-12-01 00:00:00

abstract：:1. In rat isolated tail arteries and atria in which transmitter stores are labelled with (3H)-noradrenaline, isoprenaline in low concentrations facilitates the stimulation-induced efflux of tritium. 2. This effect is dependent on the frequency and duration of electrical stimulation, being observed only at low frequenc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Medgett IC,McCulloch MW,Rand MJ,Story DF

更新日期：1980-09-01 00:00:00

abstract：:1. Pre- and postjunctional effects of endothelin (1-10 nmol/L) have been studied in the rabbit isolated ear artery and in rat isolated atria. 2. Endothelin produced concentration-dependent increases in arterial perfusion pressure, and had positive chronotropic and inotropic effects in rat atria. 3. Vasoconstrictor res...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wong-Dusting HK,Reid JJ,Rand MJ

更新日期：1989-04-01 00:00:00

abstract：:1. Enzymatic bioremediation is potentially a rapid method of removing environmental pesticide residues. Applications include the treatment of residues resulting from agricultural production and processing industries, such as the treatment of irrigation waters, surface-contaminated fruit and vegetables and spent dip li...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sutherland TD,Horne I,Weir KM,Coppin CW,Williams MR,Selleck M,Russell RJ,Oakeshott JG

更新日期：2004-11-01 00:00:00

abstract：:1. The aim of the present study was to explore the effects of CPU0213, a dual endothelin ET(A)/ET(B) receptor antagonist, and nifedipine, a calcium antagonist, in relieving pulmonary hypertension (PH). Both endothelin receptor and calcium antagonists have been reported to be effective in alleviating the remodelling of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui B,Cheng YS,Dai DZ,Li N,Zhang TT,Dai Y

更新日期：2009-02-01 00:00:00

abstract：:1. There was no significant difference between the systolic blood pressure (SBP) of offspring derived from SHRSP mother and WKY father and the SBP of offspring derived from WKY mother and SHRSP father at the developing stage (5-13 weeks of age). 2. The degree of genetic determinations of SBP in stroke-prone spontaneou...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ikeda K,Nara Y,Nabica T,Fujimoto A,Endo J,Ishino H,Yamori Y

更新日期：1991-09-01 00:00:00

abstract：:1. The effects of dietary sodium on blood pressure and levels of sodium, other electrolytes and noradrenaline (NA) in the cerebrospinal fluid (CSF) and blood of 15 patients with essential hypertension were studied. The CSF and blood sampling was carried out after 7 days of a high salt intake (16-18 g/day) and after 7 ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawano Y,Yoshida K,Kawamura M,Yoshimi H,Ashida T,Abe H,Imanishi M,Kimura G,Kojima S,Kuramochi M

更新日期：1992-04-01 00:00:00

abstract：:1. Chronic electrical stimulation of the carotid sinuses has provided unique insight into the mechanisms that cause sustained reductions in blood pressure during chronic suppression of central sympathetic outflow. 2. Because renal denervation does not abolish the sustained fall in arterial pressure in response to baro...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iliescu R,Lohmeier TE

更新日期：2010-02-01 00:00:00

abstract：:1. Inflammation, particularly the pro-inflammatory cytokine tumour necrosis factor (TNF), increases necrosis of skeletal muscle. Depletion of inflammatory cells, such as neutrophils, cromolyn blockade of mast cell degranulation or pharmacological blockade of TNF reduces necrosis of dystrophic myofibres in the mdx mous...

journal_title：Clinical and experimental pharmacology & physiology

authors： Grounds MD,Radley HG,Gebski BL,Bogoyevitch MA,Shavlakadze T

更新日期：2008-07-01 00:00:00

abstract：:1. The aim of the present study was to evaluate the usefulness and reliability of a portable indirect calorimeter (Metavine; Vine, Tokyo, Japan). 2. We measured energy expenditure (EE) of elderly people (n = 191) at nursing homes using both Metavine and an authorized indirect calorimeter (Deltatrac Metabolic Monitor; ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kato M,Tajika M,Miwa Y,Moriwaki H

更新日期：2002-10-01 00:00:00

abstract：:1. The administration of aldosterone to adrenalectomized rats produces an increase in K+ and decrease in Na+ excretion in the urine. The relationship of the post-aldosterone to the pre-aldosterone urinary sodium and potassium excretion is termed the renal response to aldosterone. 2. The administration of L-dopa enhanc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Adam WR

更新日期：1979-01-01 00:00:00

abstract：:1. Changes in renal sympathetic nerve activity (RSNA) were investigated during the development of congestive heart failure (CHF) in rabbits with doxorubicin-induced cardiomyopathy. 2. Controls (saline treated, n = 5) and doxorubicin-treated rabbits (1 mg/kg administered intravenously twice weekly, n = 5) were studied ...

journal_title：Clinical and experimental pharmacology & physiology

authors： McGrath BP,Sano N,Way D

更新日期：1990-04-01 00:00:00

abstract：:1. The distribution of intrarenal blood flow has been measured using the 133Xe-washout technique in thirteen baboons 2 weeks after ligation of the common bile duct. 2. In comparison with eight sham-operated baboons, there was a signifigant decrease in the percentage distribution of blood to the cortex, although the ra...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bloom DS,Bomzon L,Rosendorff C,Kew MC

更新日期：1976-09-01 00:00:00

abstract：:1. Nineteen-day old rats were fed an essential fatty acid deficient diet for 37 weeks, thereby making them essential fatty acid deficient for at least 24 weeks. The weights of their brains were 33% less than those of rats on control diets. 2. When the deficient rats were rehabilitated for ten weeks on a diet containin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Odutuga AA

更新日期：1979-07-01 00:00:00

abstract：:1. Adrenocorticotrophin (ACTH) administration to sheep produces a rapid adrenally dependent hypertension which is maximal after 3 days and associated with increased cardiac output (CO) and heart rate (HR), while calculated total peripheral resistance remains unchanged. 2. This study investigated the proposal that a ce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Spence CD,Mathai M,Mills EH,Coghlan JP,Whitworth JA,Scoggins BA

更新日期：1989-07-01 00:00:00

abstract：:The distribution and binding characteristics of the radioligand (-)-[125I]-cyanopindolol (CYP) have been examined in slide mounted mouse kidney sections, using the technique of in vitro labelling and autoradiography. (-)-[125I]-CYP binding to sections was of high affinity (KD = 55.8 pmol/l, s.e.m. = 8.1, n = 4) to a s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lew R,Summers RJ

更新日期：1986-03-01 00:00:00

abstract：:1. Treatment with angiotensin-converting enzyme (ACE) inhibitors slows the rate of progression of nephropathy in the spontaneously hypertensive rat (SHR) with streptozotocin-induced diabetes. Paradoxically, however, chronic ACE inhibitor therapy has been reported to be associated with induction of ACE in the plasma. W...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hodge G,Makarious MM,Charlesworth JA,Duggan KA

更新日期：1997-06-01 00:00:00

abstract：:1. The effects of ethacrynic acid were studied on relaxations elicited by nitric oxide (NO), the NO-donors sodium nitroprusside (SNP) and glyceryl trinitrate (GTN), nitrergic nerve stimulation and the NO-independent agent papaverine in isolated preparations of rat anococcygeus muscles. 2. Ethacrynic acid (100 mumol/L)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li CG,Brosch SF,Rand MJ

更新日期：1994-04-01 00:00:00

abstract：:1. mu-Opioid receptor agonists mediate their central analgesic effects by actions on neurons within brain regions such as the mid-brain periaqueductal grey (PAG). Within the PAG, mu-opioid receptor-mediated analgesia results from inhibition of GABAergic influences on output projection neurons. We have established that...

journal_title：Clinical and experimental pharmacology & physiology

authors： Christie MJ,Connor M,Vaughan CW,Ingram SL,Bagley EE

更新日期：2000-07-01 00:00:00

abstract：:1. Medullary blood flow (MBF) is important in the long-term control of arterial pressure. However, it is unclear which vascular elements regulate MBF. 2. Exogenous endothelin (ET)-1 decreases cortical more than medullary blood flow. We hypothesized that ET-1 would therefore constrict afferent (AA) and efferent arterio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Denton KM,Shweta A,Finkelstein L,Flower RL,Evans RG

更新日期：2004-08-01 00:00:00

abstract：:Acute kidney injury (AKI) occurs in 5% of hospitalized patients and in 50% of sepsis patients with acute renal dysfunction. However, there have been no safe and effective therapeutic strategies. The hypoxia condition is closely related to renal injury and function under AKI. As hypoxia-inducible factor 1α (HIF-1α) is ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang H,Liu N,Li R,Tian J,Hu W,Zhang J

更新日期：2018-10-01 00:00:00

abstract：:1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 mumol/L prostaglandin F2 alpha and a possible role of K+ channels in mediating the effec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiang F,Li CG,Rand MJ

更新日期：1999-04-01 00:00:00

abstract：:Hantaviruses are enveloped negative (-) single-stranded RNA viruses belongs to Hantaviridae family, hosted by small rodents and entering into the human body through inhalation, causing haemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) also known as hantavirus cardiopulmonary syndrom...

journal_title：Clinical and experimental pharmacology & physiology

authors： Munir N,Jahangeer M,Hussain S,Mahmood Z,Ashiq M,Ehsan F,Akram M,Ali Shah SM,Riaz M,Sana A

更新日期：2020-09-07 00:00:00