Abstract:
:1. Treatment with angiotensin-converting enzyme (ACE) inhibitors slows the rate of progression of nephropathy in the spontaneously hypertensive rat (SHR) with streptozotocin-induced diabetes. Paradoxically, however, chronic ACE inhibitor therapy has been reported to be associated with induction of ACE in the plasma. We sought to determine whether induction also occurred in the glomerulus. 2. Seven days after induction of diabetes rats were randomized to receive perindopril (4 mg/kg per day) in the drinking water or water alone. Blood glucoses were maintained 6-10 mmol/L by daily ultralente insulin. Rats were killed after 1 and 12 weeks of ACE inhibitor therapy and the kidneys were harvested. Angiotensin-converting enzyme activity was determined in isolated glomeruli before and after removal of perindopril and reconstitution with zinc sulphate. 3. After 1 week of ACE inhibitor therapy, glomerular ACE was significantly greater after removal of perindopril than either before its removal (P < 0.025) or in the untreated controls (P < 0.025). After 12 weeks of therapy, ACE activity was significantly lower in the perindopril-treated group than in the untreated controls (P < 0.025). There was no increase in ACE activity following removal of perindopril. 4. These studies suggest that short-term ACE inhibition is associated with induction of ACE in the glomerulus. However, there was no increase in ACE activity after removal of perindopril, suggesting that induction of synthesis of this enzyme in the glomerulus does not occur during chronic ACE inhibition.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Hodge G,Makarious MM,Charlesworth JA,Duggan KAdoi
10.1111/j.1440-1681.1997.tb01226.xsubject
Has Abstractpub_date
1997-06-01 00:00:00pages
460-2issue
6eissn
0305-1870issn
1440-1681journal_volume
24pub_type
杂志文章abstract::Urapidil had blocking activity on alpha 1-adrenoceptors in the rat isolated caudal artery (pA2 congruent to 7) and in the anaesthetized rat. Urapidil had no clonidine like agonistic activity on alpha 2-adrenoceptors in preparations of the guinea-pig ileum (prejunctional) or dog saphenous vein (post-junctional). Urapid...
journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/j.1440-1681.1984.tb00289.x
更新日期:1984-07-01 00:00:00
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doi:10.1111/j.1440-1681.1984.tb00290.x
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1046/j.1440-1681.2000.03241.x
更新日期:2000-04-01 00:00:00
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更新日期:1977-07-01 00:00:00
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更新日期:1999-07-01 00:00:00
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更新日期:2010-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1982.tb00840.x
更新日期:1982-11-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:2011-07-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1046/j.1440-1681.1999.03144.x
更新日期:1999-10-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章,评审
doi:10.1111/j.1440-1681.2007.04587.x
更新日期:2007-04-01 00:00:00
abstract::1. The effects of DL-tetrahydropalmatine (DL-THP) on cardio-vascular function and hypothalamic release of monoamines were assessed in rats under urethane anaesthesia. 2. Intravenous administration of DL-THP (1-10 mg/kg) produced hypotension, bradycardia, a decrease in hypothalamic serotonin and noradrenaline release a...
journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1996.tb01769.x
更新日期:1996-08-01 00:00:00