Comparison of the activity of circular and longitudinal myometrium from pregnant rats: co-ordination between muscle layers.

abstract：:1. Changes in renal sympathetic nerve activity (RSNA) were investigated during the development of congestive heart failure (CHF) in rabbits with doxorubicin-induced cardiomyopathy. 2. Controls (saline treated, n = 5) and doxorubicin-treated rabbits (1 mg/kg administered intravenously twice weekly, n = 5) were studied ...

journal_title：Clinical and experimental pharmacology & physiology

authors： McGrath BP,Sano N,Way D

更新日期：1990-04-01 00:00:00

abstract：:This study hypothesized that different types of anaesthesia management would result in similar postoperative sleep quality. In this prospective single-blind investigation, 219 patients undergoing elective thoracic surgery were randomized into three arms: general anaesthesia, as the control group (group C); general ana...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan WF,Guo B,Ma H,Li XQ,Fang B,Lv HW

更新日期：2016-03-01 00:00:00

abstract：:Afferent splanchnic nerve stimulation with different frequencies in Wistar Kyoto rats caused depressor and pressor responses depending on the frequency employed. Similar visceral afferent activation in spontaneously hypertensive rats caused depressor responses at all frequencies of stimulation. It is suggested that th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Koyama S,Manning JW

更新日期：1985-01-01 00:00:00

abstract：:1. Interactions between autacoids may play important roles in the regulation of blood flow in the foetal placenta. In order to investigate this aspect of placental haemodynamics, human normal-term placentae were perfused in vitro and the responses of the foetal vessels to various combinations of vasoactive agents were...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gude NM,King RG,Brennecke SP

更新日期：1998-09-01 00:00:00

abstract：:The beta-receptor stimulant effects of Sm220Cl, dl-N-(1,1-dimethyl-3-phenylpropyl)-2-hydroxy-2-(3,4-dihydroxy-2-methoxyphenyl)ethylamine, and (-)-isoprenaline have been compared in isolated atrial (beta1) and tracheal (beta2) preparations from guinea-pigs and cats. 2. The compounds were also tested for their ability t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bohmer K,Raper C

更新日期：1977-07-01 00:00:00

abstract：:1. Activation of bulbospinal neurons projecting from the C1 area of the rostral ventrolateral medulla evokes a pressor response. The nature of the neurotransmitters involved in mediating this response at spinal cord level has not been established. 2. Amino acid antagonists were introduced into the spinal subarachnoid ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mills EH,Minson JB,Pilowsky PM,Chalmers JP

更新日期：1988-02-01 00:00:00

abstract：:Ischaemia reperfusion (I/R) is associated with liver injury and impaired regeneration during partial hepatectomy (PH). The aim of this study was to investigate the effect of thymoquinone (TQ), the active compound of essential oil obtained from Nigella sativa seeds, on rat liver after PH. Male Wistar rats were divided ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bouhlel A,Bejaoui M,Ben Mosbah I,Hadj Abdallah N,Ribault C,Viel R,Hentati H,Corlu A,Ben Abdennebi H

更新日期：2018-05-07 00:00:00

abstract：:Skeletal muscle is an important site for insulin to regulate blood glucose levels. It is estimated that skeletal muscle is responsible for ~80% of insulin-mediated glucose disposal in the post-prandial period. The classical action of insulin to increase muscle glucose uptake involves insulin binding to insulin recepto...

journal_title：Clinical and experimental pharmacology & physiology

authors： Keske MA,Dwyer RM,Russell RD,Blackwood SJ,Brown AA,Hu D,Premilovac D,Richards SM,Rattigan S

更新日期：2017-01-01 00:00:00

abstract：:1. Subpressor calcium infusion for 1 h, which raised calcium levels to the upper limit of normal in normal subjects, increased plasma and urinary levels of atrial natriuretic peptide (ANP). 2. Heart rate fell, presumably due to carotid baroreflex stimulation (supported by the fall in noradrenaline) and the resultant f...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finn WL,Gordon RD,Seneviratne BI,Tunny TJ,Klemm SA

更新日期：1992-05-01 00:00:00

abstract：:1. A comparison has been made of the effects of three acetylcholine antagonists--hexamethonium, tubocurarine and pancuronium--on maximal tetani of limb muscles of cats under chloralose anaesthesia. In most experiments, the indirectly stimulated soleus muscle was studied, but observations were also made on the tibialis...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bowman WC,Webb SN

更新日期：1976-11-01 00:00:00

abstract：:1. The reproducibility of blood volume measurements, using [51Cr]-labelled red blood cells (RBC) was tested in three lambs, 79-89 days of age, and the accuracy was tested in eight lambs, 83 +/- 0.4 days of age, in which blood volume was measured simultaneously by [51Cr]-RBC and [125I]-gamma globulin plus haematocrit (...

journal_title：Clinical and experimental pharmacology & physiology

authors： Moritz KM,Potocnik SJ,Tangalakis K,Wintour EM

更新日期：1994-07-01 00:00:00

abstract：:1. Initial unsuccessful attempts to evaluate ventricular function in terms of the 'heart as a pump' led to focusing on the 'heart as a muscle' and to the concept of myocardial contractility. However, no clinically ideal index exists to assess the contractile state. The aim of the present study was to develop a mathema...

journal_title：Clinical and experimental pharmacology & physiology

authors： Curiel R,Perez-Gonzalez J,Torres E,Landaeta R,Cerrolaza M

更新日期：2005-10-01 00:00:00

abstract：:1. Deposition of β-amyloid (Aβ) peptide is a defining pathological hallmark of Alzheimer's disease (AD) and is involved in memory impairment. Evidence suggests that activation of an extracellular signal-regulated kinase (ERK) pathway is related to Aβ accumulation. Thus, the aim of the present study was to investigate ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jin P,Choi DY,Hong JT

更新日期：2012-10-01 00:00:00

abstract：:1. The aim of the present study was to investigate the effects of hypoxia on energy metabolism and contraction of rat urinary bladder smooth muscle, thereby gaining insight into the capacity of this smooth muscle to maintain contractile function when rendered hypoxic. 2. Isometric force, oxygen consumption, lactate pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wendt IR,Paul RJ

更新日期：2003-08-01 00:00:00

abstract：:1. Endogenous polyamines play a key role in mediating cellular growth and differentiation. Hypertension is associated with structural modifications of the circulatory system, a process that may be facilitated by polyamines. In this study, we examined whether there are elevated polyamine concentrations in the cardiovas...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ibrahim J,Hughes AD,Schachter M,Sever PS

更新日期：1996-05-01 00:00:00

abstract：:1. Over the past 50 years considerable evidence has been reported suggesting that endogenous opioids participate in the control of renal function. 2. Exogenous administration of opioids produces profound changes in the renal excretion of water and sodium. 3. Opioids produce changes in urine output and urine sodium exc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kapusta DR

更新日期：1995-12-01 00:00:00

abstract：:1. Glyceryl trinitrate (GTN) is frequently infused intravenously as a component of the management of acute coronary syndromes (ACS). Abrupt cessation of GTN infusion after periods of more than 24 h administration often induces rebound vasoconstriction reflecting 'pseudotolerance'; this is also the basis of the 'zero h...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kelly EA,Ahmed RM,Horowitz JD

更新日期：2005-04-01 00:00:00

abstract：:1. To understand the roles of a putative hypertension gene in the chromosome 1 quantitative trait locus (QTL) region, the response to restraint stress was studied in strains congenic for this QTL. 2. To establish congenic strains, the QTL region was introgressed from stroke-prone spontaneously hypertensive rats (SHRSP...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui ZH,Ikeda K,Kawakami K,Gonda T,Nabika T,Masuda J

更新日期：2003-07-01 00:00:00

abstract：:1. The effects of DL-tetrahydropalmatine (DL-THP) on cardio-vascular function and hypothalamic release of monoamines were assessed in rats under urethane anaesthesia. 2. Intravenous administration of DL-THP (1-10 mg/kg) produced hypotension, bradycardia, a decrease in hypothalamic serotonin and noradrenaline release a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lin MT,Chueh FY,Hsieh MT,Chen CF

更新日期：1996-08-01 00:00:00

abstract：:The aim of this study was to investigate whether enoxaparin (ENX) administration would increase seroma risk and worsen mesh tissue recovery in an experimental rat hernia repair model. Fifty-six adult male Wistar-Albino rats were included in the study. Rats were equally and randomly separated into seven groups: Group 1...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ozkececi ZT,Gonul Y,Karavelioglu A,Bozkurt MF,Kacar E,Bal A,Ozsoy M,Turamanlar O,Celep B

更新日期：2016-07-01 00:00:00

abstract：:Apelin receptors (APJ) cross-talk with other G-protein-coupled receptors. However, the role of APJ interaction with opioid receptors (OPR) on the cardiovascular effects of apelin in hypertension is not clear. Renovascular hypertension was induced by placing a Plexiglas clip on the left kidney of rats. After 16 weeks, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rostamzadeh F,Najafipour H,Yeganeh-Hajahmadi M,Joukar S

更新日期：2018-02-01 00:00:00

abstract：:1. Hepatic sulphobromophthalein (BSP) transport was studied in guinea-pigs pretreated intraperitoneally with 0.7 ml of diethyl maleate to depress hepatic glutathione levels. 2. Diethyl maleate depressed the hepatic transport of infused conjugated BSP from hepatocytes into bile without influencing hepatic uptake. 3. Un...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whelan G

更新日期：1980-11-01 00:00:00

abstract：:Cerebral blood flow (CBF) and cerebral O2 metabolism (CMRO2) changes were measured in these studies during treatment with three reputed cerebral vasodilators: bradykinin, adenosine triphosphate (ATP) and increased arterial PCO2. Intracerebrovascular bradykinin infusions increased CMRO2 and CBF to a similar degree. Int...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hoffman WE,Miletich DJ,Volkman PH,Albrecht RF

更新日期：1983-03-01 00:00:00

abstract：:1. To investigate the pharmacological effects of T-1095, this novel derivative of phlorizin was administered to GK rats for 8 weeks. T-1095 treatment significantly lowered plasma glucose and glycosylated haemoglobin (HbA1c) levels, but did not significantly affect bodyweight. 2. T-1095 treatment did not affect 3.3 mmo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nunoi K,Yasuda K,Adachi T,Okamoto Y,Shihara N,Uno M,Tamon A,Suzuki N,Oku A,Tsuda K

更新日期：2002-05-01 00:00:00

abstract：:Hypoxia-inducible factor-1 alpha (HIF-1α) and nuclear receptor related-1 (Nurr1) play pivotal roles in the development and survival of dopaminergic neurons, and deficiencies in these genes may be involved in Parkinson's disease (PD) pathogenesis. Recently, anthelminthic benzimidazoles were shown to promote HIF-1α tran...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kandil EA,Sayed RH,Ahmed LA,Abd El Fattah MA,El-Sayeh BM

更新日期：2019-12-01 00:00:00

abstract：:This study investigated the effect of muscarinic M1 and M2 receptor antagonists on the rocuronium-induced train of four (TOF) fade and tetanic fade, respectively. Ex-vivo phrenic nerves and diaphragms were obtained from adult Sprague-Dawley rats and stabilized in Krebs buffer; the nerve-stimulated muscle TOF fade was ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kim YB,Lee S,Lee KC,Kim HJ,Ro YJ,Yang HS

更新日期：2017-07-01 00:00:00

abstract：:1. Oestrogen reduces vascular smooth muscle cell proliferation in mouse vascular injury models. Data on the antiproliferative effect of oestrogen in cultured vascular smooth muscle cells (VSMC) are less conclusive than those obtained in whole animal studies. 2. In the present study, we investigated the hypothesis that...

journal_title：Clinical and experimental pharmacology & physiology

authors： Odenlund M,Ekblad E,Nilsson BO

更新日期：2008-03-01 00:00:00

abstract：:1. UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme, and its overexpression has been demonstrated in a variety of malignancies. The aim of the present study is to silence UbcH10 gene by RNA interference (RNAi) and to observe its inhibitory effect on the colorectal cancer cell growth in vitro and in vivo. 2...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen SM,Jiang CY,Wu JY,Liu B,Chen YJ,Hu CJ,Liu XX

更新日期：2010-05-01 00:00:00

abstract：:1. There is mounting evidence that a wide range of antidepressants share the common feature of increasing hippocampal neurogenesis. The specificity of this association has suggested that an ability to increase neurogenesis might be a useful paradigm to screen for compounds with antidepressant activity. 2. The hope of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nandam LS,Jhaveri D,Bartlett P

更新日期：2007-05-01 00:00:00

abstract：:Responses of the toad isolated rectus abdominis muscle to cumulative doses of carbachol were recorded in the absence or presence of varying concentrations of cimetidine or ranitidine. The corresponding cumulative log concentration-response curves for carbachol were then plotted for each antagonist studied. Cimetidine ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gwee MC,Cheah LS,Shoon ML

更新日期：1986-08-01 00:00:00