Enzymatic bioremediation: from enzyme discovery to applications.

Abstract:

:1. Enzymatic bioremediation is potentially a rapid method of removing environmental pesticide residues. Applications include the treatment of residues resulting from agricultural production and processing industries, such as the treatment of irrigation waters, surface-contaminated fruit and vegetables and spent dip liquors. 2. A specific application for some organophosphate-degrading enzymes involves detoxification of nerve agent stockpiles. Effective and affordable remediation requires highly specialized enzymes, so protein engineering techniques are being used to improve properties of various source enzymes to enhance catalytic rates, stability and substrate range. 3. Trials with an optimized organophosphate-degrading enzyme have shown the feasibility of such technology in various applications. 4. The enzymes developed for environmental remediation for specific pesticide classes also have applications as antidotes for high-dose pesticide poisonings and as prophylaxis for people at risk of high pesticide doses.

authors

Sutherland TD,Horne I,Weir KM,Coppin CW,Williams MR,Selleck M,Russell RJ,Oakeshott JG

doi

10.1111/j.1440-1681.2004.04088.x

keywords:

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

817-21

issue

11

eissn

0305-1870

issn

1440-1681

pii

CEP4088

journal_volume

31

pub_type

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    更新日期:2001-12-01 00:00:00

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    abstract::1. Contraction assays and patch clamp methods were used to determine the role of K+ channels in the regulation of contractile tone of human mesangial cells (MC) in culture. 2. MC contraction was induced by vasoconstrictor agents, such as angiotensin II (AngII; 100 nmol/L) and glybenclamide (Glyb), but not by iberiotox...

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    authors: Sansom SC,Stockand JD

    更新日期:1996-01-01 00:00:00

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    更新日期:2007-09-01 00:00:00

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    更新日期:1996-06-01 00:00:00

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    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1991-05-01 00:00:00

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    更新日期:2007-08-01 00:00:00

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    doi:10.1111/j.1440-1681.1993.tb01746.x

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    更新日期:1993-09-01 00:00:00

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    更新日期:1984-07-01 00:00:00

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    更新日期:1983-05-01 00:00:00

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  • Red blood cell ionized calcium concentration in spontaneous hypertension: modulation in vivo by the calcium antagonist PN 200.110.

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  • Renal function in adult rats subjected to prenatal dexamethasone.

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    pub_type: 杂志文章,评审

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    abstract::1. After a severe burn, a marked decrease in myocardial blood flow results in ischaemic and hypoxic injury, which subsequently leads to apoptosis or necrosis. Phosphatidylinositol 3-kinase (PI3-K)/Akt is an important intracellular signal transduction molecule that regulates cell proliferation, differentiation, glucose...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2010.05355.x

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    更新日期:2010-05-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2007.04843.x

    authors: Lu G,Wang Y

    更新日期:2008-02-01 00:00:00