Effects of atropine on the time and frequency domain estimates of blood pressure and heart rate variability in mice.

abstract：:1. Conscious experimental hypertensive rats injected intraventricularly with 5,6-dihydroxytryptamine (50 microgram) responded with a rapid and long-lasting (4 days) fall in blood pressure and this was accompanied by a bradycardia of similar duration. 2. The acute actions of 5,6-dihydroxytryptamine on the cardiovascula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finch L

更新日期：1975-11-01 00:00:00

abstract：:1. There is evidence that different aetiologies of heart failure, especially ischaemic vs dilated cardiomyopathy (ICM and DCM, respectively), may influence the prognosis of patients with this disease. Patients with ICM have a worse prognosis than those with DCM; the mechanisms underlying this difference have not yet b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lee S,Lu R,Müller-Ehmsen J,Schwinger RH,Brixius K

更新日期：2010-12-01 00:00:00

abstract：:trans-Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim of the present study was to investigate the effects of resveratrol on cardiac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liu Z,Song Y,Zhang X,Liu Z,Zhang W,Mao W,Wang W,Cui W,Zhang X,Jia X,Li N,Han C,Liu C

更新日期：2005-12-01 00:00:00

abstract：:1. Congenital long QT syndrome (LQTS) is a genetically heterogeneous disease. The aim of the present study was to identify the gene mutation in a Chinese family with LQTS and investigate the functional changes associated with the mutation. 2. Polymerase chain reaction and DNA sequencing were used to screen for the KCN...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang HT,Sun CF,Cui CC,Xue XL,Zhang AF,Li HB,Wang DQ,Shu J

更新日期：2009-08-01 00:00:00

abstract：:The chemosensitive cardiac vagal and sympathetic afferent reflexes are implicated in driving pathophysiological changes in sympathetic nerve activity (SNA) in cardiovascular disease states. This study investigated the impact of sex and ovarian hormones on the chemosensitive cardiac afferent reflex. Experiments were pe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pinkham MI,Barrett CJ

更新日期：2015-06-01 00:00:00

abstract：:1. The intravenous administration of nicergoline (5 mg) was followed by a rapid and sustained lowering of blood pressure; less rapid effects were bradycardia and an elevation of cardiac output. These delayed effects are consistent with an indirect action on the alpha-adrenoreceptors of the central nervous system. 2. F...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boismare F,Lefrançois J

更新日期：1980-03-01 00:00:00

abstract：:1. We have reported previously that instant coffee contains ligands for opiate receptors with characteristics similar to those of opiate antagonists. 2. A concentrate of receptor-active ligands from instant coffee was prepared by serial treatments involving Amberlite XAD-2, flash chromatography and gel permeation chro...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wynne KN,Familari M,Boublik JH,Drummer OH,Rae ID,Funder JW

更新日期：1987-10-01 00:00:00

abstract：:1. Plasma drug levels and blood pressure changes produced by a single 2 mg oral dose of prazosin were determined in nine hypertensive patients. 2. Regression analysis showed that there was a high degree of correlation between plasma prazosin concentration and change in mean blood pressure. 3. There were marked differe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stokes GS,Monaghan JC,MacCarthy EP,Oates HF

更新日期：1980-03-01 00:00:00

abstract：:1. To assess the effect of dietary phytosterol on stroke and the lifespan of salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP), we investigated the effects of the addition of phytosterol to soybean oil (phytosterol content: 0.3%) on stroke onset, lifespan following onset of stroke and overall lifespan c...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ogawa H,Yamamoto K,Kamisako T,Meguro T

更新日期：2003-12-01 00:00:00

abstract：:The effects of naloxone on contractility and cardiac rhythm were studied in the rat isolated perfused heart during myocardial ischaemia and reperfusion. Pretreatment of the rat isolated perfused heart with naloxone abolished the reduction in left ventricular pressures and attenuated greatly the arrhythmias due to myoc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhan ZY,Lee AY,Wong TM

更新日期：1985-07-01 00:00:00

abstract：:1. The common pathological alteration in virtually every progressive chronic kidney disease (CKD) is renal fibrosis. 2. This review focuses on some growth factors, which are particularly well-established in contributing to fibrosis, such as the profibrotic, transforming growth factor-β, and connective tissue growth fa...

journal_title：Clinical and experimental pharmacology & physiology

authors： Boor P,Floege J

更新日期：2011-07-01 00:00:00

abstract：:1. Although several epidemiological studies have not observed significant independent relationships between physical activity or fitness and blood pressure, others have concluded that blood pressure is lower in individuals who are more fit or active. However, longitudinal intervention studies are more appropriate for ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fagard RH

更新日期：2006-09-01 00:00:00

abstract：:1. We tested the hypothesis that the pattern and the intensity of autonomic mechanisms causing vasoconstriction in the resting bronchial circulation of awake dogs also exists in awake sheep. It was also postulated that sighing behaviour and the associated bronchovascular dilatation induced by non-adrenergic, non-choli...

journal_title：Clinical and experimental pharmacology & physiology

authors： McIlveen S,White S,Parsons G

更新日期：1997-12-01 00:00:00

abstract：:1. Stretch-induced muscle injury results in the damage that causes reduced force and increased membrane permeability. This muscle damage is caused, in part, by ionic entry through stretch-activated channels and blocking these channels with Gd3+ or streptomycin reduces the force deficit associated with damage. 2. Dystr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yeung EW,Allen DG

更新日期：2004-08-01 00:00:00

abstract：:The epithelial sodium channel (ENaC) has long been recognized as playing a vital role in blood pressure (BP) regulation due to its involvement in fluid balance. The genes encoding the three ENaC subunits are likewise important contributors to hypertension, both in rare monogenic diseases and in the general population....

journal_title：Clinical and experimental pharmacology & physiology

authors： Büsst CJ

更新日期：2013-08-01 00:00:00

abstract：:1. Mechanisms underlying the generation and propagation of gastrointestinal slow wave depolarizations have long been controversial. The present review aims to collate present knowledge on this subject with specific reference to slow waves in gastric smooth muscle. 2. At present, there is strong agreement that intersti...

journal_title：Clinical and experimental pharmacology & physiology

authors： van Helden DF,Laver DR,Holdsworth J,Imtiaz MS

更新日期：2010-04-01 00:00:00

abstract：:1. We investigated the effect of exercise on plasma adrenomedullin, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations and studied the relationship between these peptides and haemodynamic parameters in nine patients with old myocardial infarction (MI) and in eight normal subjects. 2. T...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morimoto A,Nishikimi T,Takaki H,Okano Y,Matsuoka H,Takishita S,Kitamura K,Miyata A,Kangawa K,Matsuo H

更新日期：1997-05-01 00:00:00

abstract：:1. The effects of taurine on the development of atherosclerotic lesions were investigated in apolipoprotein (apo) E-deficient mice, an animal model with severe hypercholesterolaemia and extensive atherosclerosis. These mice were fed a normal laboratory chow containing 2% taurine for 12 weeks. 2. Serum total cholestero...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kondo Y,Toda Y,Kitajima H,Oda H,Nagate T,Kameo K,Murakami S

更新日期：2001-10-01 00:00:00

abstract：:This study aimed to evaluate the changes in left and right ventricular functions of children with obstructive sleep apnoea-hypopnoea syndrome (OSAHS) and to determine the efficacy of surgical treatment for OSAHS in children. The subjects included 20 normal controls and 55 children of OSAHS with adenoid and/or tonsil h...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mu H,Liu J,Gong K,Li D,Zhang J

更新日期：2015-06-01 00:00:00

abstract：:1. Hypoxia arises in solid tumour because of inefficient blood supply. While hypoxic cells are resistant to radiotherapy and probably to many chemotherapeutic drugs they can, in principle, be turned to advantage through the development of hypoxia-activated cytotoxic drugs (bioreductive drugs). 2. Three general approac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wilson WR,Pruijn FB

更新日期：1995-11-01 00:00:00

abstract：:1. The present review reports some of the earliest physiological changes that occur in the diabetic retina prior to any clinical or anatomical changes in an animal model of diabetes. 2. Using chemically induced diabetes (by streptozotocin) in rats, retinal blood flow and vitreal and retinal oxygen tension were determi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Alder VA,Su EN,Yu DY,Cringle SJ,Yu PK

更新日期：1997-09-01 00:00:00

abstract：:1. Nitric oxide (NO) is an important mediator of contractile function in the heart. However, isolated papillary muscle preparations appear to lack NO responsiveness in certain animal species. Although cat, guinea-pig and ferret models have been NO responsive, there have been mixed results in the rat papillary muscle. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Worthley MI,Horowitz JD,Zeitz CJ

更新日期：2005-07-01 00:00:00

abstract：:This study tested the hypothesis that the initial fall in arterial pressure evoked by lipopolysaccharide (LPS) is mediated by the ventrolateral column of the midbrain periaqueductal gray region (vlPAG). To test this hypothesis, the local anaesthetic lidocaine (2%; 0.1 μL, 0.2 μL or 1.0 μL), the delta opioid receptor a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Millington WR,Yilmaz MS,Feleder C

更新日期：2016-06-01 00:00:00

abstract：:1. The effects of bromocriptine and indomethacin on prolactin-induced pseudopregnancy were studied in pituitary grafted rats. 2.Administration of bromocriptine (a prolactin suppressant drug) at a total dose of 3 mg/kg body weight, given in 3 divided doses on day 5 of pseudopregnancy, effectively terminated it within 3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan GJ

更新日期：1980-05-01 00:00:00

abstract：:1. The present review focuses on some of the processes producing rhythms in sympathetic nerves influencing cardiovascular functions and considers their potential relevance to nervous integration. 2. Two mechanisms are considered that may account for rhythmic sympathetic discharges. First, neuronal elements of peripher...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gilbey MP

更新日期：2007-04-01 00:00:00

abstract：:The possibility that serotonin (5HT) nerve endings in the dorsomedial medulla oblongata participate in the control of blood pressure was investigated in stroke-prone hypertensive rats and in normotensive rats. 5HT nerves were destroyed by injecting 5,7-dihydroxytryptamine bilaterally into the solitary tract nucleus. I...

journal_title：Clinical and experimental pharmacology & physiology

authors： Howe PR,Rogers PF,King RA,Smith RM

更新日期：1983-05-01 00:00:00

abstract：:1. Pericytes are cells of microvessels (arterioles, capillaries and venules) that wrap around endothelial cells. They are most abundant on venules and are common on capillaries. 2. The pericyte population is highly variable between different tissues and organs, probably in a manner reflecting postarteriolar hydrostati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sims DE

更新日期：2000-10-01 00:00:00

abstract：:Acute kidney injury (AKI) is a rapid loss of kidney function resulting in accumulation of end metabolic products and associated abnormalities in fluid, electrolyte and acid-base homeostasis. The pathophysiology of AKI is complex and multifactorial involving numerous vascular, tubular and inflammatory pathways. Neurohu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hering D,Winklewski PJ

更新日期：2017-02-01 00:00:00

abstract：:1. Renin gene expression was investigated in kidneys from 13 foetal and four adult sheep. 2. The levels of renal renin mRNA in foetuses were greater than those in adult sheep (P < 0.001). 3. There was no significant difference in renin mRNA levels between foetuses aged 91 and 134 days (term 150 days). 4. The levels of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang DY,Lumbers ER,Simonetta G

更新日期：1996-08-01 00:00:00

abstract：:1. The influence of the passive force on the contraction and endothelium-dependent relaxation in aortae of normotensive Wistar Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) were compared. 2. Force changes of endothelium-intact and -removed preparations were measured isometrically by a force...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sekiguchi F,Adachi T,Matsubara H,Matsuda K,Kita K,Shimamura K,Sunano S

更新日期：1996-06-01 00:00:00