Naloxone blocks the cardiac effects of myocardial ischaemia and reperfusion in the rat isolated heart.


:The effects of naloxone on contractility and cardiac rhythm were studied in the rat isolated perfused heart during myocardial ischaemia and reperfusion. Pretreatment of the rat isolated perfused heart with naloxone abolished the reduction in left ventricular pressures and attenuated greatly the arrhythmias due to myocardial ischaemia and reperfusion. Administration of naloxone into the fibrillating rat isolated heart induced by myocardial ischaemia and reperfusion also attenuated the arrhythmias in a dose-dependent manner. The results indicate a possible involvement of the endogenous opioid peptides in the cardiac effects due to myocardial ischaemia and reperfusion. The antiarrhythmic effect of naloxone has great clinical implications.


Zhan ZY,Lee AY,Wong TM




Has Abstract


1985-07-01 00:00:00












  • Hesperidin attenuates altered redox homeostasis in an experimental hyperlipidaemic model of rat.

    abstract::Diets rich in saturated fats and cholesterol contribute to the incidence of hyperlipidaemia. An altered lipid profile is a major factor responsible for the development of CVD. Male Wistar rats were fed with a high-fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) t...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kumar R,Akhtar F,Rizvi SI

    更新日期:2020-04-01 00:00:00

  • Exercise is good for your blood pressure: effects of endurance training and resistance training.

    abstract::1. Although several epidemiological studies have not observed significant independent relationships between physical activity or fitness and blood pressure, others have concluded that blood pressure is lower in individuals who are more fit or active. However, longitudinal intervention studies are more appropriate for ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,meta分析


    authors: Fagard RH

    更新日期:2006-09-01 00:00:00

  • Effect of cold on fetal heart rate and its variability.

    abstract::1. The effects of cold saline (25 mL) injected over the fetal skin on fetal heart rate (HR) and HR variability (HRV), measured as the coefficient of variation (CV) in pulse interval (PI) and by power spectral analysis (PSA), were measured in 10 chronically catheterized fetal sheep aged 140-144 days. To determine the e...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Yu ZY,Lumbers ER

    更新日期:2000-08-01 00:00:00

  • Pharmacodynamics of levodopa in Parkinson's disease.

    abstract::1. Levodopa markedly reduces parkinsonism during the first years of treatment. However, with continued therapy the response to levodopa becomes erratic and is complicated by involuntary movements. To improve the therapy of parkinsonism, the challenge is to understand why fluctuations in response develop and, once deve...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nutt JG

    更新日期:1995-11-01 00:00:00

  • LncRNA XIST promotes chemoresistance of breast cancer cells to doxorubicin by sponging miR-200c-3p to upregulate ANLN.

    abstract::The resistance of breast cancer cells to drugs is a major obstacle to effective cancer chemotherapy. Here, we study the function mechanisms of long non-coding RNA XIST in chemoresistance of breast cancer to doxorubicin. We examined the 50% inhibitive concentration of doxorubicin to MDA-MB-231 and MDA-MB-231/ADM cells,...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Zhang M,Wang F,Xiang Z,Huang T,Zhou WB

    更新日期:2020-08-01 00:00:00

  • Effect of nicorandil on post-ischaemic contractile dysfunction in the heart: roles of its ATP-sensitive K+ channel opening property and nitrate property.

    abstract::1. This study aimed to characterize the effect of nicorandil (NC) on myocardial stunning and the role of ATP-sensitive K+ (KATP) channel opening property in its cardioprotective action. 2. In open-chest anaesthetized rabbits, myocardial stunning was induced by 10 min of coronary occlusion followed by 30 min of reperfu...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Iwamoto T,Miura T,Urabe K,Itoya M,Shimamoto K,Iimura O

    更新日期:1993-09-01 00:00:00

  • Ketamine inhibits aerobic glycolysis in colorectal cancer cells by blocking the NMDA receptor-CaMK II-c-Myc pathway.

    abstract::Aerobic glycolysis plays a crucial role in cancer progression. Ketamine is often used for cancer pain relief in clinical settings. Moreover, ketamine inhibits proliferation and induces apoptosis in many cancer cell types. However, the anti-tumour mechanism of ketamine is still poorly understood. In the present study, ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Hu J,Duan W,Liu Y

    更新日期:2020-05-01 00:00:00

  • Liver alcohol and aldehyde dehydrogenase: inhibition and potentiation by histamine agonists and antagonists.

    abstract::1. The in vitro effects of histamine, some other H1- and H2-receptor agonists and some antagonists were studied on the specific activities and kinetics of rat liver alcohol dehydrogenase (ADH), and cytoplasmic and mitochondrial liver aldehyde dehydrogenase (ALDH). 2. Histamine (H1- and H2-agonist) non-competitively in...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Messiha FS,Hughes MJ

    更新日期:1979-05-01 00:00:00

  • The emerging role of calmodulin regulation of RyR2 in controlling heart rhythm, the progression of heart failure and the antiarrhythmic action of dantrolene.

    abstract::Cardiac output and rhythm depend on the release and the take-up of calcium from the sarcoplasmic reticulum (SR). Excessive diastolic calcium leak from the SR due to dysfunctional calcium release channels (RyR2) contributes to the formation of delayed after-depolarizations, which underlie the fatal arrhythmias that occ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Walweel K,Oo YW,Laver DR

    更新日期:2017-01-01 00:00:00

  • Increase in gastric intramucosal hydrogen ion concentration following endotoxin challenge in the rat and the actions of nitric oxide synthase inhibitors.

    abstract::1. Cardiovascular events and outcome in septic shock may be predicted by monitoring the fall in intramural pH (pHi), as an index of splanchnic perfusion and mucosal ischaemia. In the present study, a small animal model for monitoring the changes of gastric pHi or intramucosal [H+] following challenge with the endotoxi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lamarque D,Whittle BJ

    更新日期:2001-03-01 00:00:00

  • Regulation of axonal growth and guidance by the neurotrophin family of neurotrophic factors.

    abstract::1. The neurotrophins play an important role during development to stimulate and guide axonal growth for the establishment of a correctly wired and functional neural system. Neurotrophins can also regulate adult nervous system plasticity by promoting neuronal survival and stimulating nerve regrowth following injury. 2....

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Gillespie LN

    更新日期:2003-10-01 00:00:00

  • Formation of a ternary complex with serum albumin: an explanation for the effect of alpha-mercapto-beta-(2-furan) acrylic acid on rat plasma zinc clearance.

    abstract::1. Four, six and eight hours after gavage of rats with alpha-mercapto-beta-(2-furan)acrylic acid (MFA) (25 mg/kg) serum zinc concentration was increased ten-fold over control levels and a mean molar ratio of 1 albumin:0-4 zinc:0-8 MFA was found for seventeen sera. 2. At pH 7-5 a maximum of 1 mole of MFA could be bound...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Giroux E,Prakash NJ,Schechter PJ

    更新日期:1977-01-01 00:00:00

  • In Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative.

    abstract::Summary 1. The non-selective K(+) channel blocker 4-aminopyridine (4-AP) has shown clinical efficacy in the treatment of neurological disorders such as multiple sclerosis. The clinical usefulness of 4-AP is hampered by its ability to produce seizures. Nerispirdine, an analogue of 4-AP, is currently under clinical inve...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Smith C,Kongsamut S,Wang H,Ji J,Kang J,Rampe D

    更新日期:2009-11-01 00:00:00

  • Contrasting effects of isoproterenol and phosphodiesterase III inhibitor on intracellular calcium transients in cardiac myocytes from failing hearts.

    abstract::1. Effects of a newly developed phosphodiesterase (PDE) III inhibitor, E-1020, on intracellular calcium transients were compared with those of isoproterenol (ISO) in isolated single myocytes from failing hearts secondary to pulmonary hypertension induced by monocrotaline injection. Myocytes were isolated by enzyme dig...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Honda M,Kuramochi T,Ishinaga Y,Kuzuo H,Tanaka K,Morioka S,Enomoto K,Takabatake T

    更新日期:1994-12-01 00:00:00

  • Both extracellular ATP and shear stress regulate the release of nitric oxide in rat caudal artery.

    abstract::1. To elucidate the physiological role of nitric oxide (NO) in regulating vascular tone, the effects of NG-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, on the vasoconstrictor response to noradrenaline (NA) in rat caudal artery was examined. 2. NG-Nitro-L-arginine methyl ester significantly potenti...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kwon YM,Shinozuka K,Kagota S,Yamaguchi Y,Nakamura K,Kunitomo M

    更新日期:1999-05-01 00:00:00

  • Comparison of the activity of circular and longitudinal myometrium from pregnant rats: co-ordination between muscle layers.

    abstract::1. Contractions and electrical activity were recorded from isolated segments of longitudinal (L) and circular (C) myometrium from rats on gestation days 16-17 and 21 before and during parturition. 2. The segments were arranged so that the activity of the two layers could be monitored simultaneously and independently. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Tomiyasu BA,Chen CJ,Marshall JM

    更新日期:1988-09-01 00:00:00

  • Effect of ethamsylate on carrageenan-induced rat paw oedema: a comparison with indomethacin.

    abstract::1. Ethamsylate (diethylammonium 2,5-dihydroxybenzene sulfonate, Dicynene), a systemic haemostatic agent with an unknown mechanism of action, was tested for anti-inflammatory activity using the carrageenan-induced rat paw oedema test. 2. Ethamsylate was shown to be an effective anti-inflammatory agent with a time cours...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gard PR,Trigger DJ

    更新日期:1990-12-01 00:00:00

  • The role of adenosine A1 receptors in the nucleus accumbens during morphine withdrawal.

    abstract::Opioids are effective analgaesic agents, but serious adverse effects such as tolerance and withdrawal contribute to opioid dependence and limit their use. Opioid withdrawal is a common occurrence in human opiate addicts that is not life-threatening. Studies have shown that the mesocorticolimbic system, especially the ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Jafarova Demirkapu M,Yananlı HR,Kaleli M,Sakalli HE,Gören MZ,Topkara B

    更新日期:2020-04-01 00:00:00

  • Vasoconstrictor responses to polymorphonuclear leucocytes from atherosclerotic rabbits.

    abstract::1. The vascular contractile effects of polymorphonuclear leucocytes (PMN) isolated from control rabbits and from rabbits made atherosclerotic by 1% cholesterol feeding for 8 weeks were examined. 2. Rings of control rabbit thoracic aorta with or without endothelium were mounted at 2 g tension in 10 mL organ baths and w...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Sobey CG,Hart JL,Woodman OL

    更新日期:1994-02-01 00:00:00

  • Characterisation of a rat model of mechanical low back pain at an advanced stage using immunohistochemical methods.

    abstract::Chronic low back pain (LBP) has high prevalence in the adult population which is associated with enormous disability. Hence, our aim was to further characterise our LBP rat model by using immunohistological and immunohistochemical methods at an advanced stage (day 49) of the model. Male Sprague-Dawley rats were anaest...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Park TSW,Khan N,Kuo A,Nicholson JR,Corradini L,Smith MT

    更新日期:2020-09-05 00:00:00

  • Renomedullary interstitial cells: a target for endocrine and paracrine actions of vasoactive peptides in the renal medulla.

    abstract::1. The renal medulla plays an important role in regulating body sodium and fluid balance and blood pressure homeostasis through its unique structural relationships and interactions between renomedullary interstitial cells (RMIC), renal tubules and medullary vasculature. 2. Several endocrine and/or paracrine factors, i...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Zhuo JL

    更新日期:2000-07-01 00:00:00

  • Unexpected incidence of low blood pressure 2 years after unilateral adrenalectomy for primary aldosteronism.

    abstract::1. Serial observations of blood pressure after unilateral adrenalectomy for aldosterone-producing adenoma revealed an incidence of hypotension (systolic BP less than fifth percentile for age- and sex-matched normal population) of 27% at 2 years, more than 5 times that predicted. 2. Serial observations of volume regula...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gordon RD,Hawkins PG,Hamlet SM,Tunny TJ,Klemm SA,Backmann AW,Finn WL

    更新日期:1989-04-01 00:00:00

  • Moderate-to-high normal levels of thyrotropin is a risk factor for urinary incontinence and an unsuitable quality of life in women over 65 years.

    abstract::The present study aimed to investigate the relationship between normal serum concentrations of thyrotropin (TSH) and urinary incontinence (IU), urinary infections, and quality of life in old women. Euthyroid post-menopausal women without sarcopenia, estrogen replacement, emotional illness, and/or cancer were enrolled ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Cuevas-Romero E,Sánchez-Cardiel A,Zamora-Gallegos AM,Cruz-Lumbreras R,Corona-Quintanilla DL,Castelán F,Martínez-Gómez M

    更新日期:2017-12-01 00:00:00

  • A controlled study of the effects of aerobic exercise on antihypertensive drug requirements of essential hypertensive patients in the general practice setting.

    abstract::1. To investigate the effect of an exercise training programme on antihypertensive drug requirements, 19 sedentary subjects (14 men and five women) with mild essential hypertension (systolic blood pressure greater than 140 mmHg but less than 180 mmHg), aged 29-55 years, were randomly assigned to 16 weeks of moderate i...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Allen DH,Puddey IB,Morton AR,Beilin LJ

    更新日期:1991-05-01 00:00:00

  • Rat renomedullary interstitial cells possess bradykinin B2 receptors in vivo and in vitro.

    abstract::1. Renomedullary interstitial cells (RMIC), abundant throughout the medulla of the kidney, have been demonstrated to have binding sites for many vasoactive peptides, including atrial natriuretic peptide, endothelin, angiotensin II and bradykinin (BK). These observations would support the hypothesis that interactions b...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Dean R,Maric C,Aldred GP,Casley D,Zhuo J,Harris P,Alcorn D,Mendelsohn FA

    更新日期:1999-01-01 00:00:00

  • Effect of pregnancy in the rabbit on the pressor response to angiotensin and noradrenaline.

    abstract::The pressor responses to angiotensin II injections of 29, 117 and 468 pmol/kg and infusion at 54 pmol/kg per min were compared in near-term pregnant and matched non-pregnant rabbits. The responses to noradrenaline injections of 652, 2608 and 10 432 pmol/kg and infusion at 1185 pmol/kg per min were similarly compared. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Joels N,Humphreys PW

    更新日期:1985-11-01 00:00:00

  • Functional interaction between DPI 201-106, a drug that mimics congenital long QT syndrome, and sevoflurane on the guinea-pig cardiac action potential.

    abstract::1. Sevoflurane produces QT prolongation on the electrocardiogram, predominantly via inhibition of the slow delayed rectifier K(+) current. DPI 201-106 is an experimental drug that produces QT prolongation by reducing Na(+) channel inactivation, thereby mimicking congenital long QT syndrome type 3 (LQT3). The present s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kang J,Chen XL,Reynolds WP,Rampe D

    更新日期:2007-12-01 00:00:00

  • Cardiac-specific overexpression of catalase prolongs lifespan and attenuates ageing-induced cardiomyocyte contractile dysfunction and protein damage.

    abstract::1. Oxidative stress plays a role in senescence-associated organ deterioration. This is supported by the beneficial effects of anti-oxidants against ageing-related organ damage, although their role in cardiac ageing has not been elucidated. 2. The aim of the present study was to examine the impact of cardiac-specific o...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wu S,Li Q,Du M,Li SY,Ren J

    更新日期:2007-01-01 00:00:00

  • Modulation of the orthostatic blood pressure response by acute nitrate consumption is dependent upon ethnic origin.

    abstract::Orthostatic stress triggers a response to maintain cerebral perfusion and prevent syncope. Given the hypotensive effects of inorganic nitrate this response to orthostasis may be altered by acute supplementation with inorganic nitrate and modified by ethnic origin. Caucasian and SE Asian (n = 30 for both), were recruit...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Allen K,Chuter KM,Fithon K,Marshall L,Hauton D

    更新日期:2018-11-01 00:00:00

  • Hyperoxia confers myocardial protection in mechanically ventilated rats through the generation of free radicals and opening of mitochondrial ATP-sensitive potassium channels.

    abstract::1. One hour exposure to hyperoxia has been shown previously to limit a subsequent ischaemia-reperfusion injury in spontaneously breathing rats. We tested the cardioprotective effect of a shorter period of hyperoxia during mechanical ventilation and the possible contribution of reactive oxygen species (ROS) and mitocho...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Colantuono G,Tiravanti EA,Di Venosa N,Cazzato A,Rastaldo R,Cagiano R,D'Agostino D,Federici A,Fiore T

    更新日期:2008-01-01 00:00:00