Naloxone blocks the cardiac effects of myocardial ischaemia and reperfusion in the rat isolated heart.

abstract：:1. To determine the effects of an acute oral dose of glibenclamide on blood pressure (BP), basal forearm vascular resistance (FVR) and FVR responses to the K+(ATP) channel activating vasodilator diazoxide, a placebo-controlled, double-blind cross-over study was performed in eight male volunteers with non-insulin-depen...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sundaresan P,Lykos D,Daher A,Morris R,Diamond T,Howes LG

更新日期：1998-02-01 00:00:00

abstract：:1. The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, the birds lost about 9% of their bodyweight when on the small ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1989-05-01 00:00:00

abstract：:1. Most studies examining the effect of angiotensin-converting enzyme (ACE) inhibitors on atherosclerosis in experimental animals have used doses well in excess of those given clinically. 2. Using a rabbit model of cholesterol-induced atherosclerosis characterized by subendothelial lipid accumulations ('juvenile fatty...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fennessy PA,Campbell JH,Mendelsohn FA,Campbell GR

更新日期：1996-08-01 00:00:00

abstract：:1. Positive inotropic effect of taurine and improvement of cardiac performance of failing heart are mediated through the modulation of Ca2+ movement through the sarcolemma. 2. Cardioprotection with glutamate and aspartate is related to enhanced anaerobic energy formation in mitochondria coupled with succinate formatio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pisarenko OI

更新日期：1996-08-01 00:00:00

abstract：:This study tested the hypothesis that the initial fall in arterial pressure evoked by lipopolysaccharide (LPS) is mediated by the ventrolateral column of the midbrain periaqueductal gray region (vlPAG). To test this hypothesis, the local anaesthetic lidocaine (2%; 0.1 μL, 0.2 μL or 1.0 μL), the delta opioid receptor a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Millington WR,Yilmaz MS,Feleder C

更新日期：2016-06-01 00:00:00

abstract：:1. Two patients with angiotensin-responsive aldosterone-producing adenoma (APA) and one with adrenal cortical carcinoma demonstrated autonomous secretion of cortisol as well as of aldosterone. 2. The response of cortisol and of aldosterone to ACTH did not differentiate between the two APA which secreted cortisol and t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tunny TJ,Klemm SA,Gordon RD

更新日期：1990-03-01 00:00:00

abstract：:1. We wished to determine whether, during pregnancy, there is reduced renal response to atrial distension, whether secretion of atrial natriuretic factor (ANF) is suppressed and whether neural input from the atrial volume receptors to the central nervous system is altered. 2. Conscious, chronically instrumented female...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kaufman S

更新日期：1995-02-01 00:00:00

abstract：:1. Metformin is one of the most commonly used drugs for the treatment of Type 2 diabetes. Accumulating evidence suggests that metformin also has cardioprotective effects. In the present study, we investigated the cardioprotective effects of metformin and the mechanisms involved. 2. A rat model of chronic heart failure...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang XF,Zhang JY,Li L,Zhao XY,Tao HL,Zhang L

更新日期：2011-02-01 00:00:00

abstract：:1. Iron overload contributes to the pathogenesis of various diseases and directly induces tissue injury. In the present study, we investigated the relationship between heart and liver injury induced by iron overload and cellular endoplasmic reticulum (ER) stress to explore the molecular mechanism of iron overload-indu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lou LX,Geng B,Chen Y,Yu F,Zhao J,Tang CS

更新日期：2009-07-01 00:00:00

abstract：:1. The low molecular weight heparin (LMWH) dalteparin is used, for example, to prevent primary venous thromboembolism in patients undergoing surgery or in medically ill patients. The anticoagulant activity of dalteparin can be monitored by measuring anti-factor Xa levels and activated partial thromboplastin time (aPTT...

journal_title：Clinical and experimental pharmacology & physiology

authors： Feuring M,Wehling M,Schultz A

更新日期：2011-11-01 00:00:00

abstract：:1. In coronary artery disease, the typical atheromatous plaque consists of a lipid core containing various inflammatory cells and a fibrous cap composed mostly of extracellular matrix. Both matrix metalloproteinases (MMPs) and inflammation are involved in the initiation of atherosclerotic plaques and plaque instabilit...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang W,Wang CH,Li F,Zhu WZ

更新日期：2008-03-01 00:00:00

abstract：:1. Strips of rabbit anococcygeus muscle were submaximally contracted by the addition of phenylephrine to the bath fluid. 2. Acetylcholine, dimethylphenylpiperazinium and electrical field stimulation caused relaxation. Relaxation induced by acetylcholine and field stimulation was blocked by tetrodotoxin but only the ac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wai SS,Coupar IM

更新日期：1976-03-01 00:00:00

abstract：:C1q/TNF-related protein 6 (CTRP6) is a member of the CTRP family that has been reported to exhibit a nephroprotective effect. However, the role of CTRP6 in renal ischaemia/reperfusion (I/R) injury (IRI) remains unclear. In the present study, we aimed to explore the protective effect of CTRP6 in renal IRI and the poten...

journal_title：Clinical and experimental pharmacology & physiology

authors： Xiang H,Xue W,Li Y,Zheng J,Ding C,Dou M,Wu X

更新日期：2020-06-01 00:00:00

abstract：:1. The distribution of binding sites for [125I]-labelled endothelin-1 ([125I]-ET-1) and [125I]-labelled sarafotoxin S6B ([125I]-SRT) was visualized in rat tissues using in vitro autoradiography. 2. A high density of endothelin-1 (ET-1) binding was found in the heart. In the kidney, ET-1 binding occurred in association...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kohzuki M,Johnston CI,Abe K,Chai SY,Casley DJ,Yasujima M,Yoshinaga K,Mendelsohn FA

更新日期：1991-07-01 00:00:00

abstract：:1. Intermittent bursts of activity are a robust feature of the discharges of sympathetic nerves. There are at least two major mechanisms producing such discharges: (i) phasic inputs influencing sympathetic circuits; and (ii) oscillators embedded within sympathetic networks. The functional significance of patterned and...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gilbey MP

更新日期：2001-01-01 00:00:00

abstract：:1. During the destruction of articular cartilage, fibrinolytic enzymes and matrix metalloproteinases (MMP) may contribute to the related pathology. The activities, antigens and messenger RNA (mRNA) levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in articular cartilage...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kikuchi H,Shimada W,Nonaka T,Ueshima S,Tanaka S

更新日期：1996-10-01 00:00:00

abstract：:1. In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Falckh PH,Harkin LA,Head RJ

更新日期：1992-08-01 00:00:00

abstract：:1. The effects of taurine on the development of atherosclerotic lesions were investigated in apolipoprotein (apo) E-deficient mice, an animal model with severe hypercholesterolaemia and extensive atherosclerosis. These mice were fed a normal laboratory chow containing 2% taurine for 12 weeks. 2. Serum total cholestero...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kondo Y,Toda Y,Kitajima H,Oda H,Nagate T,Kameo K,Murakami S

更新日期：2001-10-01 00:00:00

abstract：:The activation of inactive renin during incubation of human plasma with puff adder venom at pH 7.4 was found to be a complex process. Gel filtration on Sephacryl S-200 indicated that the venom contains a major peak of caseinolytic and renin-activating activity of low molecular weight. This enzyme was a metalloproteina...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morris BJ,Lawrence CH,Catanzaro DF

更新日期：1980-09-01 00:00:00

abstract：:1. Nitric oxide (NO) plays an important role in the control of glomerular haemodynamics and is synthesized from the amino acid L-arginine by a family of enzymes, NO synthase (NOS). 2. Nitric oxide synthase is present in the endothelium and also in the macula densa, a plaque of specialized tubular epithelial cells. End...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ito S,Carretero OA,Abe K

更新日期：1997-08-01 00:00:00

abstract：:1. Conscious experimental hypertensive rats injected intraventricularly with 5,6-dihydroxytryptamine (50 microgram) responded with a rapid and long-lasting (4 days) fall in blood pressure and this was accompanied by a bradycardia of similar duration. 2. The acute actions of 5,6-dihydroxytryptamine on the cardiovascula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finch L

更新日期：1975-11-01 00:00:00

abstract：:1. Using a nested case-control study of 661 non-institutionalized elderly (> or = 60 years) residents of Dubbo, New South Wales, Australia, the aim of this study is to determine whether the A1166C polymorphism of the angiotensin II type I (AT1) receptor gene is associated with hypertension in the elderly. 2. Individua...

journal_title：Clinical and experimental pharmacology & physiology

authors： Liyou N,Davis D,James K,Simons L,Friedlander Y,Simons J,McCallum J,Johnson A

更新日期：1999-07-01 00:00:00

abstract：:1. There has been interest in the suggestion that enzyme-inducing drugs, such as anticonvulsants, may produce beneficial changes in lipoprotein levels, in particular a rise in the ratio of high density lipoprotein cholesterol to total cholesterol. 2. This controlled study observed the effects of diets of charcoal or o...

journal_title：Clinical and experimental pharmacology & physiology

authors： Heller RF,Henry DA,Brent PJ

更新日期：1989-10-01 00:00:00

abstract：:1. Although several epidemiological studies have not observed significant independent relationships between physical activity or fitness and blood pressure, others have concluded that blood pressure is lower in individuals who are more fit or active. However, longitudinal intervention studies are more appropriate for ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fagard RH

更新日期：2006-09-01 00:00:00

abstract：:1. The role of cardiac reflexes in baroreflex control mechanisms and the changes that occur in chronic hypertension is reviewed. The rapid resetting properties of the arterial baroreceptors ensures its role in short-term rather than long-term control of blood pressure. 2. In hypertensive humans and animals, the barore...

journal_title：Clinical and experimental pharmacology & physiology

authors： Head GA

更新日期：1994-10-01 00:00:00

abstract：:1. Whole-cell patch recordings were made from antidromically identified sympathetic preganglionic neurons (SPN) of immature rat spinal cord slices. Bath application of nociceptin (0.1-1 micromol/L) suppressed excitatory postsynaptic potentials (EPSP) and hyperpolarized a population of SPN; these effects were naloxone ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Brailoiu GC,Lai CC,Chen CT,Hwang LL,Lin HH,Dun NJ

更新日期：2002-03-01 00:00:00

abstract：:1. Oxidative stress is believed to be an important mediator of neuronal cell death but the precise mechanism by which this occurs is unknown. 2. We have developed an in vitro model of neuronal oxidative stress to study the pathways by which free radicals kill neurones. 3. We have shown that oxidative stress, cystine d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ratan RR,Baraban JM

更新日期：1995-04-01 00:00:00

abstract：:1. The present study was designed to determine the effects of ginkgolide A, ginkgolide B and quercetin on CYP3A protein expression and enzyme activity in primary cultures of human hepatocytes. 2. Hepatocytes were pretreated with ginkgolide A, ginkgolide B and quercetin (at 1, 3, 10 and 30 micromol/L) for 48 h and then...

journal_title：Clinical and experimental pharmacology & physiology

authors： He N,Cai HB,Xie HG,Collins X,Edeki TI,Strom SC

更新日期：2007-07-01 00:00:00

abstract：:1. Congenital long QT syndrome (LQTS) is a genetically heterogeneous disease. The aim of the present study was to identify the gene mutation in a Chinese family with LQTS and investigate the functional changes associated with the mutation. 2. Polymerase chain reaction and DNA sequencing were used to screen for the KCN...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang HT,Sun CF,Cui CC,Xue XL,Zhang AF,Li HB,Wang DQ,Shu J

更新日期：2009-08-01 00:00:00

abstract：:1. Insulin-like growth factor (IGF)-I has acute effects on cardiovascular function, including a well-characterized vasodilator response in isolated arteries. In addition to increasing the release of nitric oxide, IGF-I also has effects on a variety of other signalling pathways that affect vascular tone, in particular ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cao N,Lau S,Nguyen TT,White PJ

更新日期：2006-12-01 00:00:00