Enhancement by endothelin-1 of the release of catecholamines from the canine adrenal gland in response to splanchnic nerve stimulation.

Abstract:

:1. The effect of endothelin-1 on the release of adrenal catecholamines was examined in anaesthetized dogs. 2. Splanchnic nerve stimulation (SNS) at 1 and 3 Hz was applied before and after the intravenous injection of endothelin-1. 3. Endothelin-1 (0.1 and 0.3 micrograms/kg) significantly enhanced the release of adrenal catecholamines induced by 3 Hz SNS, but did not affect basal release and the release of adrenal catecholamines induced by 1 Hz SNS. 4. Endothelin-1 produced a slight and short-lasting fall in arterial blood pressure and decreases in adrenal and renal blood flow rates. 5. These results indicate that endothelin-1 enhances the release of adrenal catecholamines from the canine adrenal gland in response to relatively high frequency SNS.

authors

Takeuchi A,Kimura T,Satoh S

doi

10.1111/j.1440-1681.1992.tb00519.x

keywords:

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

663-6

issue

9

eissn

0305-1870

issn

1440-1681

journal_volume

19

pub_type

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