Noradrenaline release from the rat heart during anoxia: effects of changes in extracellular sodium concentration and inhibition of sodium uptake mechanisms.

Abstract:

:1. Anoxic perfusion of the isolated rat heart releases noradrenaline in the absence of sympathetic nerve fibre stimulation. 2. Anoxic noradrenaline release is enhanced by reducing the extracellular Na+ concentration, consistent with the proposal that such release occurs by carrier-mediated efflux. 3. Release is also enhanced by lignocaine but inhibited by amiloride and ethylisopropylamiloride, suggesting that sodium entry into adrenergic nerve terminals during anoxia occurs by Na+/H+ (and possibly Na+/Ca2+) exchange.

authors

Dart AM,Riemersma RA

doi

10.1111/j.1440-1681.1991.tb01375.x

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

43-6

issue

1

eissn

0305-1870

issn

1440-1681

journal_volume

18

pub_type

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