Effect of acute administration of prazosin on blood pressure, heart rate and plasma renin level in the conscious normotensive rat.

abstract：:Angiogenesis is a process through which new capillaries are formed from pre-existing ones, which contributes significantly to the pathogenesis of numerous diseases, such as cancer and chronic inflammatory disorders. The β-D-mannuronic acid (M2000) is a novel non-steroidal anti-inflammatory drug (NSAID) with immunosupp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rastegari-Pouyani M,Mostafaie A,Mansouri K,Mortazavi-Jahromi SS,Mohammadi-Motlagh HR,Mirshafiey A

更新日期：2018-04-01 00:00:00

abstract：:1. Most studies examining the effect of angiotensin-converting enzyme (ACE) inhibitors on atherosclerosis in experimental animals have used doses well in excess of those given clinically. 2. Using a rabbit model of cholesterol-induced atherosclerosis characterized by subendothelial lipid accumulations ('juvenile fatty...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fennessy PA,Campbell JH,Mendelsohn FA,Campbell GR

更新日期：1996-08-01 00:00:00

abstract：:1. Blood pressure (BP) and heart rate (HR) increase 6 and 24 h after sinoaortic baroreceptor denervation (SAD), whereas plasma renin activity (PRA) and renal renin mRNA levels remain unchanged. We postulated that a simultaneous rise in BP could offset the expected activation of renin associated with an increased renal...

journal_title：Clinical and experimental pharmacology & physiology

authors： Krieger MH,Moreira ED,Oliveira EM,Oliveira VL,Krieger EM,Krieger JE

更新日期：2006-05-01 00:00:00

abstract：:Prostaglandin (PG) efflux into ureteral (UE) and venous effluents (VE) of rabbit isolated perfused kidneys was determined by superfusion bioassay and radioimmunoassay (RIA), in response to injections of arginine-vasopressin (AVP), the non-pressor vasopressin analogue 1-deamino-8-D-arginine vasopressin (dDAVP) and arac...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miller MJ,Westlin WF,McNeill H,McGiff JC

更新日期：1986-08-01 00:00:00

abstract：:Rats were prepared with chronic cannulae in the carotid artery, jugular vein and urinary bladder; they were then kept 2 days to allow recovery from surgery. A steady-state continuous saline diuresis was established, then various anaesthetic agents were injected and changes in the urine flow, sodium and potassium excre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen CF,Chapman BJ,Munday KA

更新日期：1985-03-01 00:00:00

abstract：:1. Positive inotropic effect of taurine and improvement of cardiac performance of failing heart are mediated through the modulation of Ca2+ movement through the sarcolemma. 2. Cardioprotection with glutamate and aspartate is related to enhanced anaerobic energy formation in mitochondria coupled with succinate formatio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pisarenko OI

更新日期：1996-08-01 00:00:00

abstract：:Sarcopenia, defined by reduced appendicular skeletal muscle mass (ASM)/height2 (ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI...

journal_title：Clinical and experimental pharmacology & physiology

authors： Figueroa A,Alvarez-Alvarado S,Jaime SJ,Johnson SA,Campbell JC,Feresin RG,Elam ML,Navaei N,Pourafshar S,Arjmandi BH

更新日期：2016-12-01 00:00:00

abstract：:1. It has been proposed that hypertension alters the respiratory and cardiovascular responses to chemoreceptor stimulation. However, in studies of human hypertension or in genetic animal models of hypertension it has been difficult to unequivocally attribute the changes to hypertension per se, rather than to a genetic...

journal_title：Clinical and experimental pharmacology & physiology

authors： Groom AS,Malpas SC

更新日期：1997-03-01 00:00:00

abstract：:1. Calcium regulation has been reported to be associated with the development of diabetic nephropathy. Thus, changes in Ca2+ uptake induced by ATP, an important regulator of Ca2+ uptake, in the diabetic condition and related signal pathways were examined in primary cultures of rabbit renal proximal tubule cells (PTC)....

journal_title：Clinical and experimental pharmacology & physiology

authors： Han HJ,Park SH,Lee YJ,Lee JC,Lee JH

更新日期：2003-09-01 00:00:00

abstract：:1. Adrenocorticotrophin (ACTH) administration to sheep produces a rapid adrenally dependent hypertension which is maximal after 3 days and associated with increased cardiac output (CO) and heart rate (HR), while calculated total peripheral resistance remains unchanged. 2. This study investigated the proposal that a ce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Spence CD,Mathai M,Mills EH,Coghlan JP,Whitworth JA,Scoggins BA

更新日期：1989-07-01 00:00:00

abstract：:This paper attempts to provide a short review of the evidence for: 1. Increased platelet production of thromboxane A2 and reduced vascular production of prostacyclin in the human and also animal models of diabetes. 2. Reduced depressor responsiveness to arachidonic acid of anaesthetized alloxan- and streptozotocin-ind...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hodgson WC,Sikorski BW,King RG

更新日期：1992-01-01 00:00:00

abstract：:Cannabinoid inverse agonists possess antidepressant-like properties, but the mechanism of this action is unknown. Numerous studies have reported the interaction between opioid and cannabinoid pathways. In this study, acute foot-shock stress was used in mice to investigate the involvement of the opioid pathway in the a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ostadhadi S,Haj-Mirzaian A,Nikoui V,Kordjazy N,Dehpour AR

更新日期：2016-02-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a progressively fatal form of cancer originating from the malignant transformation of hepatic biliary cholangiocytes. The present study reports for the first time in vitro growth inhibitory activities of β-eudesmol, the bioactive sesquiterpenoid present in the rhizome of Atractylodes lancea...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mathema VB,Chaijaroenkul W,Karbwang J,Na-Bangchang K

更新日期：2017-11-01 00:00:00

abstract：:1. Anastomosis (vasovasostomy) of epididymal and prostatic halves of vasa deferentia was carried out in rats in which unilateral or bilateral medial transection (vasectomy) had been performed 4 weeks previously. 2. Noradrenaline levels in epididymal halves of vasa deferentia, 8 weeks after anastomosis with prostatic h...

journal_title：Clinical and experimental pharmacology & physiology

authors： DeGaris RM,Pennefather JN

更新日期：1987-05-01 00:00:00

abstract：:1. To characterize the anti-arrhythmic properties of a new calcium antagonist, monatepil [corrected], AJ-2615, the preventive effects of AJ-2615 were compared with those of the existing calcium antagonists, diltiazem and verapamil, in experimental models of arrhythmia. 2. AJ-2615 (0.1-3.0 mg/kg, i.v.) suppressed ventr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yamamoto T,Hosoki K,Karasawa T

更新日期：1993-07-01 00:00:00

abstract：:The resistance of breast cancer cells to drugs is a major obstacle to effective cancer chemotherapy. Here, we study the function mechanisms of long non-coding RNA XIST in chemoresistance of breast cancer to doxorubicin. We examined the 50% inhibitive concentration of doxorubicin to MDA-MB-231 and MDA-MB-231/ADM cells,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang M,Wang F,Xiang Z,Huang T,Zhou WB

更新日期：2020-08-01 00:00:00

abstract：:1. Rabbits were treated with the antiparasitic drug ivermectin at subcutaneous doses of 0.2, 1 and 2.5 mg/kg and blood collected weekly for 4 weeks thereafter for measuring some blood parameters. At a dose of 0.2 or 1 mg/kg the drug had no significant effect on any of the parameters measured. At a dose of 2.5 mg/kg, t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1990-10-01 00:00:00

abstract：:1. Two aspects of cholesterol absorption; (a) the importance of solubilization and (b) the effects of different bile salts on the mucosal metabolism and lymphatic output of cholesterol, have been investigated using two different in vivo techniques. 2. Bile diverted lymph fistula rats were infused intraduodenally at a ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Watt SM,Simmonds WJ

更新日期：1976-07-01 00:00:00

abstract：:The prostaglandin synthesis inhibitor diclofenac sodium has been compared with a placebo in the treatment of primary nocturnal enuresis in a double-blind crossover trial. Twenty patients were entered: 14 female, six male; age range 6-17 years. The results showed that diclofenac sodium was significantly more effective ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Al-Waili NS

更新日期：1986-02-01 00:00:00

abstract：:1. The purpose of the present study was to investigate whether there was a cooperative interaction between substance P (SP) and glutamate (GLU) administered subcutaneously on Adelta and C primary afferent fibre activity in dorsal hairy skin of the rat in vivo. The single unit activities of Adelta and C afferent fibres...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Q,Zhao Y,Guo Y,Cao DY,Tian YL,Yao FR,Wang HS

更新日期：2006-12-01 00:00:00

abstract：:1. There has been considerable recent interest in the possibility that increased intake of dietary anti-oxidants may protect against cardiovascular disease. This is partly due to the knowledge that oxidative events in vivo may play a role in the pathogenesis of atherosclerosis. 2. While dietary anti-oxidants, such as ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morton LW,Abu-Amsha Caccetta R,Puddey IB,Croft KD

更新日期：2000-03-01 00:00:00

abstract：:Glycerophospholipids (GPs) and sphingolipids (SPs) are important lipid components in the body and play biological functions. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are important nutrients, and their supplements are commonly used for preventing some diseases. However, the effect of n-3 PUFAs on the human glyce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yan M,Cai WB,Hua T,Cheng Q,Ai D,Jiang HF,Zhang X

更新日期：2020-07-01 00:00:00

abstract：:Epidemiological studies indicate that poor growth before birth is associated with left ventricular hypertrophy and an increased risk of death from heart disease later in life. In fetal life, the insulin-like growth factor (IGF) system has been implicated in physiological growth of the heart, whereas in postnatal life ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang KC,Botting KJ,Padhee M,Zhang S,McMillen IC,Suter CM,Brooks DA,Morrison JL

更新日期：2012-11-01 00:00:00

abstract：:1. The physiological relevance of cardiac and vascular alpha-adrenoceptors may increase in disease states in which beta-adrenoceptors are altered. To test this, positive inotropic and vasoconstrictor responses to phenylephrine were measured in isolated tissues from rats with experimentally-induced hyperthyroidism, hyp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Brown L,Amos G,Miller B

更新日期：1994-09-01 00:00:00

abstract：:Studies in rats have shown that neomycin administration attenuates certain types of adrenocortical steroid dependent hypertension, including ACTH hypertension. The effects of oral neomycin on ACTH induced hypertension were examined in conscious sheep. Neomycin has no effect on the blood pressure or metabolic responses...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tresham J,Coghlan JP,Denton DA,Scoggins BA,Whitworth JA

更新日期：1984-11-01 00:00:00

abstract：:Preterm birth (PTB) is the single largest cause of death in infants and young children. The rate of PTB is significantly higher in male infants, particularly those that are born very preterm. Here we present evidence to suggest that the decidual renin-angiotensin system may play a role in inhibiting inflammation and m...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pringle KG,Zakar T,Lumbers ER

更新日期：2017-05-01 00:00:00

abstract：:1. The aim of this study was to evaluate the role of endothelium in mediating the response to acetylcholine in the thoracic aorta and coronary vessels of rats exposed to cigarette smoking. Total serum cholesterol was measured at the beginning and end of the experiment. 2. The relaxation response to acetylcholine was s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jorge PA,Ozaki MR,Almeida EA

更新日期：1995-06-01 00:00:00

abstract：:1. It has been demonstrated that blood pressure variability (BPV) is increased in hypertension and related to organ damage. It will be important to lower BPV in the treatment of hypertension. The present study was designed to investigate the effect of ketanserin, a 5-HT2A receptor antagonist with a weak alpha1-adrenoc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miao CY,Xie HH,Yu H,Chu ZX,Su DF

更新日期：2003-03-01 00:00:00

abstract：:1. Resveratrol (RSV), a polyphenol in red wine, exhibits cardioprotective effects in vitro, such as inhibition of angiotensin II- or phenylephrine-induced cardiomyocyte hypertrophy in rat neonatal myocyte cultures and suppression of cardiac fibroblast proliferation. The aim of the present study was to investigate the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yang DL,Zhang HG,Xu YL,Gao YH,Yang XJ,Hao XQ,Li XH

更新日期：2010-02-01 00:00:00

abstract：:1. Irinotecan (also known as CPT-11) is a water soluble, semi-synthetic analogue of 20(S)camptothecin (CPT) with promising activity against a range of tumour types. 2. As with all other active analogues of CPT, irinotecan causes cell toxicity by stabilizing a ternary complex between the nuclear enzyme topoisomerase I ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rivory LP

更新日期：1996-10-01 00:00:00