Effect of acute administration of prazosin on blood pressure, heart rate and plasma renin level in the conscious normotensive rat.


:This study investigated whether the specific alpha-antagonist, prazosin, stimulated basal plasma renin levels and heart rate. Furthermore the beta-adrenergic nervous system was also investigated to ascertain whether it was involved in this effect. Prazosin (0.1 or 1 mg/kg) was injected subcutaneously (s.c.) to conscious normotensive rats, either alone or in combination with the beta-adrenoceptor antagonist, DL-propranolol (1 or 3 mg/kg). Rats bore chronically implanted dorsal aorta cannula for measurement of blood pressure and heart rate and blood sampling for renin determinations. Acute administration of prazosin (1 mg/kg, s.c.) produced a fall in mean arterial pressure accompanied by renin release and tachycardia. A tenfold lower dose of prazosin did not alter blood pressure or heart rate but did stimulate renin release. Acute administration of DL-propranolol, (1 or 3 mg/kg, s.c.) produced falls in blood pressure and heart rate but did not affect plasma renin level. Combinations of prazosin with propranolol gave falls in blood pressure similar to those predicted on the basis of a simple addition of the effects of the two drugs given separately. Prazosin-induced tachycardia and renin release were attenuated by propranolol. It appears that prazosin produces renin release and tachycardia via stimulation of the beta-adrenergic adrenoceptor.


Atkinson J,Luthi P,Sonnay M,Boillat N




Has Abstract


1986-07-01 00:00:00












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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Rastegari-Pouyani M,Mostafaie A,Mansouri K,Mortazavi-Jahromi SS,Mohammadi-Motlagh HR,Mirshafiey A

    更新日期:2018-04-01 00:00:00

  • Angiotensin-converting enzyme inhibitors and atherosclerosis: relevance of animal models to human disease.

    abstract::1. Most studies examining the effect of angiotensin-converting enzyme (ACE) inhibitors on atherosclerosis in experimental animals have used doses well in excess of those given clinically. 2. Using a rabbit model of cholesterol-induced atherosclerosis characterized by subendothelial lipid accumulations ('juvenile fatty...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Fennessy PA,Campbell JH,Mendelsohn FA,Campbell GR

    更新日期:1996-08-01 00:00:00

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    abstract::1. Blood pressure (BP) and heart rate (HR) increase 6 and 24 h after sinoaortic baroreceptor denervation (SAD), whereas plasma renin activity (PRA) and renal renin mRNA levels remain unchanged. We postulated that a simultaneous rise in BP could offset the expected activation of renin associated with an increased renal...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Krieger MH,Moreira ED,Oliveira EM,Oliveira VL,Krieger EM,Krieger JE

    更新日期:2006-05-01 00:00:00

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    journal_title:Clinical and experimental pharmacology & physiology

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    authors: Pisarenko OI

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  • LncRNA XIST promotes chemoresistance of breast cancer cells to doxorubicin by sponging miR-200c-3p to upregulate ANLN.

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    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


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    更新日期:1996-10-01 00:00:00