Stimulation of phosphatidylinositol turnover in adult rat left atria does not involve release of inositol(1,4,5)trisphosphate.

Abstract:

:1. The turnover rate of inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) in noradrenaline-stimulated adult rat left atria was calculated from changes in specific activity and was found to equal 110 ct/min per mg tissue. In contrast, the isomers of inositol mono- and bisphosphates accumulated at a rate of 508 ct/min per mg. 2. Neomycin, which inhibits release of Ins(1,4,5)P3, inhibited the accumulation of inositol phosphates in noradrenaline-stimulated isolated neonatal cardiomyocytes but did not inhibit accumulation in left atria. 3. These data demonstrate that most of the inositol phosphates which accumulate in adult rat left atria do not derive from Ins(1,4,5)P3. 4. These data are best explained by a model in which noradrenaline stimulation results mainly in the breakdown of phosphatidylinositol(4)monophosphate (PtIns(4)P1) to inositol(1,4)bisphosphate (Ins(1,4)P2). Thus, heart tissue avoids the generation of Ins(1,4,5)P3.

authors

Anderson KE,Myers D,Woodcock EA

doi

10.1111/j.1440-1681.1993.tb01698.x

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

335-8

issue

5

eissn

0305-1870

issn

1440-1681

journal_volume

20

pub_type

杂志文章
  • Species difference in the beta1/beta2-adrenoceptor selectivity of SM220CL in the cat and guinea-pig.

    abstract::The beta-receptor stimulant effects of Sm220Cl, dl-N-(1,1-dimethyl-3-phenylpropyl)-2-hydroxy-2-(3,4-dihydroxy-2-methoxyphenyl)ethylamine, and (-)-isoprenaline have been compared in isolated atrial (beta1) and tracheal (beta2) preparations from guinea-pigs and cats. 2. The compounds were also tested for their ability t...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1977.tb02672.x

    authors: Bohmer K,Raper C

    更新日期:1977-07-01 00:00:00

  • Fixed dose of long-acting erythropoietic stimulating agents at higher frequency improves appetite, reduces inflammation and corrects anaemia in patients on haemodialysis.

    abstract::Anaemia is an important issue in patients undergoing haemodialysis. We aimed to identify a better dosing schedule of a fixed monthly dose of continuous erythropoietin receptor activator (CERA) in patients with chronic kidney disease (CKD) on haemodialysis. The CERA dosing schedule included 100 μg once monthly for 2 mo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/1440-1681.12618

    authors: Liu WS,Chu DC,Chan HL,Li SY,Liu CK,Yang CY,Chen YW,Lee PC,Lai YT,Lin CC

    更新日期:2016-10-01 00:00:00

  • Ketamine inhibits aerobic glycolysis in colorectal cancer cells by blocking the NMDA receptor-CaMK II-c-Myc pathway.

    abstract::Aerobic glycolysis plays a crucial role in cancer progression. Ketamine is often used for cancer pain relief in clinical settings. Moreover, ketamine inhibits proliferation and induces apoptosis in many cancer cell types. However, the anti-tumour mechanism of ketamine is still poorly understood. In the present study, ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13248

    authors: Hu J,Duan W,Liu Y

    更新日期:2020-05-01 00:00:00

  • β-lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: a structured review.

    abstract::1. Infections and related sepsis are two of the most prevalent issues in the care of critically ill patients, with mortality as high as 70%. Appropriate antibiotic selection, as well as adequate dosing, is important to improve the clinical outcome for these patients. 2. β-Lactams are the most common antibiotic class u...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2012.05715.x

    authors: Sinnollareddy MG,Roberts MS,Lipman J,Roberts JA

    更新日期:2012-06-01 00:00:00

  • Subsensitivity to ATP and some analogues in preparations of rat cauda epididymis and vas deferens after vasectomy.

    abstract::1. The effects of ATP and some of its more stable analogues have been examined upon preparations of epididymal and prostatic halves of vasa deferentia and of cauda epididymides from rats that had undergone vasectomy by medial transection of the vas deferens. 2. After unilateral vasectomy, the potencies of ATP, beta, g...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1990.tb01358.x

    authors: Ventura S,DeGaris RM,Stead CK,Pennefather JN

    更新日期:1990-08-01 00:00:00

  • Activation of peripheral chemoreceptors causes positive inotropic effects in a working heart-brainstem preparation of the rat.

    abstract::1. The aim of the present study was to evaluate the effects of peripheral chemoreceptor activation on myocardial contractility in an anaesthetic-free decerebrated rat preparation. 2. In the decerebrated and retrogradely perfused working heart-brainstem preparation, we recorded phrenic nerve activity, left ventricular ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04699.x

    authors: Braga VA,Zoccal DB,Soriano RN,Antunes VR,Paton JF,Machado BH,Nalivaiko E

    更新日期:2007-11-01 00:00:00

  • The effects of calcium antagonists on blood pressure and responses to alpha-adrenoceptor agonists in hypertensive rabbits.

    abstract::The effects of the calcium antagonists verapamil and nifedipine on mean arterial blood pressure, heart rate and pressor responses to a range of alpha-adrenoceptor agonists were examined in male normotensive New Zealand white rabbits and in rabbits with perinephritis hypertension. Verapamil and nifedipine caused a grea...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1987.tb00960.x

    authors: Hamilton CA,Jardine E,Sumner DJ,Reid JL

    更新日期:1987-02-01 00:00:00

  • Relative inhibitory potency and plasma drug levels of angiotensin converting enzyme inhibitors in the rat.

    abstract::1. 125I-351A, a tyrosyl derivative of the angiotensin converting enzyme (ACE) inhibitor lisinopril, was used as a radioligand, and radioinhibitor binding and displacement assays have been established. 2. The in vitro potency of a range of ACE inhibitors against rat ACE was determined using the radioinhibitor binding d...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1988.tb01053.x

    authors: Johnston CI,Cubela R,Jackson B

    更新日期:1988-02-01 00:00:00

  • Gender-related differences in the development of atherosclerosis: studies at the cellular level.

    abstract::1. Calcified arteriosclerotic lesions have been recognized early in life as abnormalities in coronary arteries. 2. We examined coronary arterial plaques as an undecalcified tissue and revealed widespread mineralization within the plaque. Non-collagenous proteins that regulate calcification, such as osteopontin, have b...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1996.tb02609.x

    authors: Fitzpatrick LA

    更新日期:1996-03-01 00:00:00

  • 17Beta-oestradiol enhances nitric oxide synthase activity in endothelium-denuded rat aorta.

    abstract::1. It has been suggested that oestrogen-produced vasodilatation is due to induction of endothelial nitric oxide synthase (NOS), but there are many reports of direct effects on vascular smooth muscle. In the present study, these processes were investigated in rat aorta isolated from ovariectomized rats. 2. Short-term t...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1998.tb02188.x

    authors: Binko J,Murphy TV,Majewski H

    更新日期:1998-02-01 00:00:00

  • Interstitial Foxp3-positive T cells may predict renal survival in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis.

    abstract::1. Regulatory T cells (T(reg)) and cytotoxic T cells (CTL) are involved in various immune diseases. However, the prognostic impact of T(reg) and CTL in patients with myeroperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (MPO-ANCA-GN) is not well known. Therefore, in the present study, we e...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2010.05412.x

    authors: Yoshimura J,Fukami K,Koike K,Nagano M,Matsumoto T,Iwatani R,Kusumoto T,Hazama T,Ueda S,Adachi H,Hirai Y,Takasu K,Ohshima K,Yamagishi S,Okuda S

    更新日期:2010-09-01 00:00:00

  • Afferent control of vasopressin and renin release during haemorrhage in normal and autonomically blocked rabbits.

    abstract::1. The role of the arterial and cardiac baroreceptors on the arginine vasopressin (AVP) and plasma renin activity (PRA) responses to haemorrhage was studied in conscious rabbits. They were bled at a rate of approximately 3% of their blood volume (BV)/min, both when the autonomic nervous system (ANS) was intact and dur...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1992.tb00412.x

    authors: Courneya CA,Korner PI,Oliver JR,Woods RL

    更新日期:1992-11-01 00:00:00

  • Anorexic response to rapamycin does not appear to involve a central mechanism.

    abstract::The authors have previously demonstrated that a low and intermittent peripheral dose of rapamycin (1 mg/kg three times/week) to rats inhibited mTORC1 signalling, but avoided the hyperlipidemia and diabetes-like syndrome associated with higher doses of rapamycin. The dosing regimen reduced food intake, body weight, adi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12601

    authors: Toklu HZ,Bruce EB,Sakarya Y,Carter CS,Morgan D,Matheny MK,Kirichenko N,Scarpace PJ,Tümer N

    更新日期:2016-09-01 00:00:00

  • Ca2+-dependent differential development of carbachol-induced desensitization to receptor agonists and high K+ in guinea-pig taenia caeci.

    abstract::1. Carbachol (CCh)-induced desensitization to CCh was interrupted by a transient resensitization during its early stage, with concomitant changes at the muscarinic receptor/G-protein level in smooth muscle of guinea-pig taenia caeci. To assess whether such a peculiar desensitizing process may heterologously regulate s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2007.04530.x

    authors: Hishinuma S,Matsumoto Y,Sato R,Saito M

    更新日期:2007-01-01 00:00:00

  • Endothelin receptor distribution and function in the airways.

    abstract::1. Within the lung, endothelin (ET)-1 is synthesized and released by airway epithelial and vascular endothelial cells, as well as by inflammatory cells, such as macrophages. Following release, ET-1 can modulate the activities of a wide range of different cell types within the lung through the stimulation of specific e...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1681.1999.03010.x

    authors: Henry PJ

    更新日期:1999-02-01 00:00:00

  • The role of adenosine A1 receptors in the nucleus accumbens during morphine withdrawal.

    abstract::Opioids are effective analgaesic agents, but serious adverse effects such as tolerance and withdrawal contribute to opioid dependence and limit their use. Opioid withdrawal is a common occurrence in human opiate addicts that is not life-threatening. Studies have shown that the mesocorticolimbic system, especially the ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13224

    authors: Jafarova Demirkapu M,Yananlı HR,Kaleli M,Sakalli HE,Gören MZ,Topkara B

    更新日期:2020-04-01 00:00:00

  • Activation of plasma prekallikrein and inactive renin by puff adder venom.

    abstract::The activation of inactive renin during incubation of human plasma with puff adder venom at pH 7.4 was found to be a complex process. Gel filtration on Sephacryl S-200 indicated that the venom contains a major peak of caseinolytic and renin-activating activity of low molecular weight. This enzyme was a metalloproteina...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1980.tb00112.x

    authors: Morris BJ,Lawrence CH,Catanzaro DF

    更新日期:1980-09-01 00:00:00

  • Postnatal development of responses to airflow obstruction.

    abstract::1. Obstruction of the upper airway could be an initiating factor in the Sudden Infant Death Syndrome (SIDS). Responses to upper airway obstruction include augmentation of respiratory efforts, active dilation of the upper airway and electrocortical arousal. Vulnerable individuals may fail to mount these responses effec...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1995.tb02063.x

    authors: Harding R,Jakubowska AE,McCrabb GJ

    更新日期:1995-08-01 00:00:00

  • Lipidomics reveals the dynamics of lipid profile altered by omega-3 polyunsaturated fatty acid supplementation in healthy people.

    abstract::Glycerophospholipids (GPs) and sphingolipids (SPs) are important lipid components in the body and play biological functions. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are important nutrients, and their supplements are commonly used for preventing some diseases. However, the effect of n-3 PUFAs on the human glyce...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13285

    authors: Yan M,Cai WB,Hua T,Cheng Q,Ai D,Jiang HF,Zhang X

    更新日期:2020-07-01 00:00:00

  • Identification and evaluation of 2 circulating microRNAs for non-small cell lung cancer diagnosis.

    abstract::The circulating miRNAs are dysregulated in non-small cell lung cancer (NSCLC) and have great promise for clinical diagnosis. The aim of this study was to screen and evaluate the reliability and diagnostic efficiency of candidate serum miRNAs for NSCLC diagnosis. We found that miR-21 and let-7a were significantly dysre...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 信件

    doi:10.1111/1440-1681.12977

    authors: Wang X,Jia Z,Shi H,Pan C

    更新日期:2018-10-01 00:00:00

  • The effect of hypertensive episodes and cardiac hypertrophy on the canine cardiac baroreflex.

    abstract::1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevat...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1994.tb02433.x

    authors: Kingwell BA,Krause L,Julius S

    更新日期:1994-01-01 00:00:00

  • Effects of trans-resveratrol on hypertension-induced cardiac hypertrophy using the partially nephrectomized rat model.

    abstract::trans-Resveratrol (resveratrol) has been shown to have beneficial effects on the cardiovascular system in a number of studies. It is, however, unclear whether this naturally occurring compound can protect against cardiac hypertrophy. The aim of the present study was to investigate the effects of resveratrol on cardiac...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2005.04303.x

    authors: Liu Z,Song Y,Zhang X,Liu Z,Zhang W,Mao W,Wang W,Cui W,Zhang X,Jia X,Li N,Han C,Liu C

    更新日期:2005-12-01 00:00:00

  • Beneficial effect of T-1095, a selective inhibitor of renal Na+-glucose cotransporters, on metabolic index and insulin secretion in spontaneously diabetic GK rats.

    abstract::1. To investigate the pharmacological effects of T-1095, this novel derivative of phlorizin was administered to GK rats for 8 weeks. T-1095 treatment significantly lowered plasma glucose and glycosylated haemoglobin (HbA1c) levels, but did not significantly affect bodyweight. 2. T-1095 treatment did not affect 3.3 mmo...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03671.x

    authors: Nunoi K,Yasuda K,Adachi T,Okamoto Y,Shihara N,Uno M,Tamon A,Suzuki N,Oku A,Tsuda K

    更新日期:2002-05-01 00:00:00

  • Role of CA(2+)-activated K+ channels in the regulation of basilar arterial tone in spontaneously hypertensive rats.

    abstract::1. Ionic channels appear to play an important role in contractile responses of the cerebral arteries and, thereby, contribute to the regulation of cerebral circulation. In the present study, we investigated the role of large-conductance Ca(2+)-activated K+ (BK(Ca)) channels in the regulation of cerebral arterial tone ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03688.x

    authors: Kamouchi M,Kitazono T,Nagao T,Fujishima M,Ibayashi S

    更新日期:2002-07-01 00:00:00

  • Anti-oxidant effects of atorvastatin in dexamethasone-induced hypertension in the rat.

    abstract::1. Dexamethasone (Dex)-induced hypertension is characterized by endothelial dysfunction associated with nitric oxide (NO) deficiency and increased superoxide (O2-) production. Atorvastatin (Ato) possesses pleiotropic properties that have been reported to improve endothelial function through increased availability of N...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04482.x

    authors: Mondo CK,Yang WS,Zhang N,Huang TG

    更新日期:2006-11-01 00:00:00

  • Spermidine prevents high glucose-induced senescence in HT-22 cells by upregulation of CB1 receptor.

    abstract::Hyperglycaemia-induced neurotoxicity involved in the pathogenesis of diabetic encephalopathy and neuronal senescence is one of the worst effects of hyperglyceamic neurotoxicity. Cannabinoid receptor type 1 (CB1) has neuroprotective function in a series of neuropathy. Spermidine (Spd) has anti-aging function in many ti...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12955

    authors: Zhu WW,Xiao F,Tang YY,Zou W,Li X,Zhang P,Wang AP,Tang XQ

    更新日期:2018-08-01 00:00:00

  • Mechanisms underlying biochanin A-induced relaxation of the aorta differ between normotensive and hypertensive rats.

    abstract::1. The aim of the present study was to investigate the mechanism underlying biochanin A-induced relaxation of the aorta in spontaneously hypertensive rats (SHR). 2. The tension in isolated ring preparations of thoracic aortas from normotensive (Wistar-Kyoto (WKY) rats) and SHR at 5 and 10 weeks of age was measured iso...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04443.x

    authors: Wang HP,Gao Q,Mei RH,Zhao MH,Lu Y,Li XY,Bruce IC,Xia Q

    更新日期:2006-09-01 00:00:00

  • Ghrelin gene-related peptides: multifunctional endocrine / autocrine modulators in health and disease.

    abstract::1. Ghrelin is a multifunctional peptide hormone that affects various processes, including growth hormone and insulin release, appetite regulation, gut motility, metabolism and cancer cell proliferation. Ghrelin is produced in the stomach and in other normal and pathological cell types. It may act as an endocrine or au...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2009.05241.x

    authors: Seim I,Amorim L,Walpole C,Carter S,Chopin LK,Herington AC

    更新日期:2010-01-01 00:00:00

  • Calycosin induces apoptosis in adenocarcinoma HT29 cells by inducing cytotoxic autophagy mediated by SIRT1/AMPK-induced inhibition of Akt/mTOR.

    abstract::Autophagy promotes cell survival or induces apoptosis in cancer cells. While SIRT1 and AMPK induce autophagy in both normal and cancer cells, Akt and mTOR can inhibit it. Calycosin, a methoxyisoflavone, protects against several types of solid tumours including colorectal cancer. However, the mechanisms behind the anti...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13133

    authors: El-Kott AF,Al-Kahtani MA,Shati AA

    更新日期:2019-10-01 00:00:00

  • Implications of cross-talk between tumour necrosis factor and insulin-like growth factor-1 signalling in skeletal muscle.

    abstract::1. Inflammation, particularly the pro-inflammatory cytokine tumour necrosis factor (TNF), increases necrosis of skeletal muscle. Depletion of inflammatory cells, such as neutrophils, cromolyn blockade of mast cell degranulation or pharmacological blockade of TNF reduces necrosis of dystrophic myofibres in the mdx mous...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2007.04868.x

    authors: Grounds MD,Radley HG,Gebski BL,Bogoyevitch MA,Shavlakadze T

    更新日期:2008-07-01 00:00:00