Abstract:
:1. Changes in renal sympathetic nerve activity (RSNA) were investigated during the development of congestive heart failure (CHF) in rabbits with doxorubicin-induced cardiomyopathy. 2. Controls (saline treated, n = 5) and doxorubicin-treated rabbits (1 mg/kg administered intravenously twice weekly, n = 5) were studied after 4 and 6 weeks treatment. 3. RSNA was estimated by measuring renal noradrenaline spillover rate under resting conditions and in response to changes in arterial pressure induced by phenylephrine and sodium nitroprusside infusions. 4. In the doxorubicin-treated group, resting renal noradrenaline spillover was increased at 4 weeks (24.2 ng/min, s.e.m. = 2.5, n = 5) compared with controls (15.2 ng/min, s.e.m. = 2.4, n = 5; P less than 0.01) and remained elevated. 5. The baroreceptor-renal noradrenaline spillover curve showed a significant upward shift in the doxorubicin-treated group at 4 weeks. After 6 weeks both heart rate and renal noradrenaline spillover responses to hypotension were significantly blunted. 6. It is suggested that increased RSNA occurs early during the development of CHF in doxorubicin-treated rabbits. The observed changes in the baroreflex responses suggest that different mechanisms may contribute to this increased RSNA at different stages of CHF.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
McGrath BP,Sano N,Way Ddoi
10.1111/j.1440-1681.1990.tb01325.xsubject
Has Abstractpub_date
1990-04-01 00:00:00pages
303-7issue
4eissn
0305-1870issn
1440-1681journal_volume
17pub_type
杂志文章abstract::1. This study investigated the effect of progesterone, which, under certain circumstances, can antagonize both the mineralocorticoid and glucocorticoid activities of steroid hormones, on the development and maintenance of adrenocorticotrophic hormone (ACTH)-induced hypertension in conscious sheep. 2. Progesterone (500...
journal_title:Clinical and experimental pharmacology & physiology
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doi:10.1111/j.1440-1681.1989.tb01618.x
更新日期:1989-08-01 00:00:00
abstract::Despite the presence of many studies on the role of mechanistic target of rapamycin (mTOR) in cardiorenal tissues, the definitive role of mTOR in the pathogenesis of renal injury subsequent to ischaemia-reperfusion (IR) remains unclear. The aims of the current study were to characterize the role of mTOR in normal kidn...
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pub_type: 杂志文章
doi:10.1046/j.1440-1681.2000.03241.x
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pub_type: 杂志文章,评审
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1990.tb01300.x
更新日期:1990-03-01 00:00:00
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更新日期:1984-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1991-02-01 00:00:00
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pub_type: 杂志文章
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