Long-term deficiency of essential fatty acids in rats and its effect on brain recovery.

abstract：:1. It has been suggested that astrocytes prompt the induction of blood-brain barrier (BBB) functions in cerebrovascular endothelial cells. 2. In the present study we have tried to elucidate the genetic differences between astrocytes isolated from Wistar-Kyoto (WKY) control rats and astrocytes isolated from stroke-pron...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yamagata K,Tagami M,Nara Y,Fujino H,Kubota A,Numano F,Kato T,Yamori Y

更新日期：1997-09-01 00:00:00

abstract：:1. The present study aimed to determine the feasibility of conducting a 5 year cardiovascular outcome trial of the treatment of 6000 elderly hypertensive patients in Australian general practices. 2. General practitioners (GPs) were invited to participate by mail and personal follow-up. Patient records were reviewed to...

journal_title：Clinical and experimental pharmacology & physiology

authors： Reid CM,Nelson M,Beckinsale P,Ryan P,Wing LM,Beilin LJ,Brown MA,Jennings GL,Johnston CI,Marley J,McNeil JJ,Morgan TO,Shaw J,Steven ID,West MJ

更新日期：1997-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disorder with an incompletely defined aetiology that is associated with memory and cognitive impairment. Currently available therapeutics only provide temporary assistance with symptoms. In spite of plentiful research in the field and the generation of thousands of studi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zamani E,Parviz M,Roghani M,Mohseni-Moghaddam P

更新日期：2019-01-01 00:00:00

abstract：:1. The transport of taurocholic acid from portal blood to bile was studied in the anaesthetized rat by injecting a radiolabelled pulse of bile acid. 2. The transport process was very rapid, 50% of the dose being secreted within 5 min, and the total dose within 15 min. 3. The transport process had a large capacity. The...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iser JH,Packer JS,Smallwood RA,Hoffman NE

更新日期：1976-01-01 00:00:00

abstract：:1. We wished to determine whether, during pregnancy, there is reduced renal response to atrial distension, whether secretion of atrial natriuretic factor (ANF) is suppressed and whether neural input from the atrial volume receptors to the central nervous system is altered. 2. Conscious, chronically instrumented female...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kaufman S

更新日期：1995-02-01 00:00:00

abstract：:Simultaneous measurements of smooth muscle membrane potential and tension were made from isolated pieces of rat tail artery. A single electrical stimulus to the perivascular nerves produced a transient contraction of the smooth muscle. The amplitude of the contraction was increased after removal of the endothelium. Th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kotecha N,Neild TO

更新日期：1986-03-01 00:00:00

abstract：:1. The present study was designed to examine the cardiovascular effects of intravenously administered pcDNA3.1AM, a recombinant non-virus vector carrying a rat adrenomedullin (AM) gene translation fragment, in rats with chronic cardiac dysfunction induced by ligation of the left descending coronary artery. 2. Haemodyn...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang XF,Shao Y,Chen SW,Tian DZ,Huang GY,Huang Y,Yao T,Lu LM

更新日期：2007-09-01 00:00:00

abstract：:Both opiates and dopamine play important roles in learning and memory. Although synergistic action between these two neurotransmitters has been found, their functional roles remain unclear. Here, low dose morphine (2.5 mg/kg) and low dose dopamine receptor agonists (apomorphine 0.05 mg/kg; SKF38393 0.01 mg/kg; bromocr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen Y,Fu Y,An Y,Cao J,Wang J,Zhang J

更新日期：2018-04-01 00:00:00

abstract：:Receptors for parathyroid hormone (PTH) in the renal tubule are coupled to adenylate cyclase stimulation. PTH causes a rise in urinary cAMP by leakage from adenylate cyclase stimulation. PTH causes a rise in urinary cAMP by leakage from cells of the proximal convoluted tubule. The effects of alpha-adrenergic agonists ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Woodcock EA,McLeod JK,Johnston CI

更新日期：1984-07-01 00:00:00

abstract：:1. Effects of a newly developed phosphodiesterase (PDE) III inhibitor, E-1020, on intracellular calcium transients were compared with those of isoproterenol (ISO) in isolated single myocytes from failing hearts secondary to pulmonary hypertension induced by monocrotaline injection. Myocytes were isolated by enzyme dig...

journal_title：Clinical and experimental pharmacology & physiology

authors： Honda M,Kuramochi T,Ishinaga Y,Kuzuo H,Tanaka K,Morioka S,Enomoto K,Takabatake T

更新日期：1994-12-01 00:00:00

abstract：:1. We have tested the effects of 2 month oral treatment with the KATP opener, nitric oxide (NO) donor and anti-oxidant molecule nicorandil (0.1 mg/kg per day) on major physiological parameters and heart function of 4-, 12- and 24-month-old rats. 2. Several methods were used: (i) measurement of blood pressure using a n...

journal_title：Clinical and experimental pharmacology & physiology

authors： Garnier-Raveaud S,Faury G,Mazenot C,Cand F,Godin-Ribuot D,Verdetti J

更新日期：2002-05-01 00:00:00

abstract：:1. Poor perfusion of the kidneys and gut, and associated functional impairment, are major problems in the first days of life in very preterm infants. These complications can be associated with a substantial mortality and further problems such as reduced kidney growth and chronic renal problems in later childhood. 2. T...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bennet L,Booth L,Malpas SC,Quaedackers JS,Jensen E,Dean J,Gunn AJ

更新日期：2006-04-01 00:00:00

abstract：:1. Atherosclerosis begins with the deposition of cholesterol in arterial tissue that is thought to be derived from circulating lipoproteins. There is considerable evidence implicating low density lipoprotein (LDL) as a primary source of plaque cholesterol and, consequently, there are many articles that deal with vario...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mamo JC,Yu KC,Elsegood CL,Smith D,Vine D,Gennat HC,Voevodin M,Proctor SD

更新日期：1997-03-01 00:00:00

abstract：:1. In the present study, we used a low dose of propofol (5 mg/kg per h) to investigate its effects on the pro-inflammatory cytokines (tumour necrosis factor (TNF)-alpha, interleukin (IL)-1beta and IL-10) and changes in nitric oxide (NO) following lipopolysaccharide (LPS) for a period of 12 h in conscious rats. 2. Expe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hsu BG,Yang FL,Lee RP,Peng TC,Chen HI

更新日期：2005-01-01 00:00:00

abstract：:The chemosensitive cardiac vagal and sympathetic afferent reflexes are implicated in driving pathophysiological changes in sympathetic nerve activity (SNA) in cardiovascular disease states. This study investigated the impact of sex and ovarian hormones on the chemosensitive cardiac afferent reflex. Experiments were pe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pinkham MI,Barrett CJ

更新日期：2015-06-01 00:00:00

abstract：:1. Treatment with angiotensin converting enzyme (ACE) inhibitors ameliorates human and experimental diabetic nephropathy, possibly as a result of changes in angiotensin II (AngII) and/or bradykinin concentrations. However, ACE is an indiscriminate enzyme, which hydrolyses numerous vasoactive peptides at two catalytic ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Duggan KA,Hodge G,Makarious MM,Charlesworth JA

更新日期：1996-06-01 00:00:00

abstract：:1. Mammalian heart muscle is extremely sensitive to the external calcium concentration. It reacts to alterations of the external calcium concentration with an immediate adaptation of contractile force. 2. In mammalian heart there is a network of large transverse tubules throughout the cell. These structures are regula...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lüllmann H,Peters T

更新日期：1977-01-01 00:00:00

abstract：:1. It has been suggested that Na+/K(+)-ATPase and Na(+)-dependent glutamate transport (GluT) are tightly linked in brain tissue. In the present study, we have investigated Na+/K(+)-ATPase activity using Rb+ uptake by 'minislices' (prisms) of the cerebral cortex. This preparation preserves the morphology of neurons, sy...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nanitsos EK,Acosta GB,Saihara Y,Stanton D,Liao LP,Shin JW,Rae C,Balcar VJ

更新日期：2004-11-01 00:00:00

abstract：:Hyperhomocysteine has become a critical risk for atherosclerosis and can stimulate proliferation and migration of vascular smooth muscle cells (VSMCs). N-methyl-D-aspartic acid receptor (NMDAR) is a receptor of homocysteine and mediates the effects of homocysteine on VSMCs. Bioinformatics analysis has shown NMDAR is a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Duan H,Li Y,Yan L,Yang H,Wu J,Qian P,Li B,Wang S

更新日期：2016-10-01 00:00:00

abstract：:Hypertension leads to electrophysiological changes in the heart. Chronic exercise induced by a treadmill-running programme (TRP) is considered a potential non-pharmacological treatment for hypertension and may have implications in heart remodelling. However, it is not known whether the TRP is able to improve the elect...

journal_title：Clinical and experimental pharmacology & physiology

authors： Roman-Campos D,Carneiro-Júnior MA,Prímola-Gomes TN,Silva KA,Quintão-Júnior JF,Gondim AN,Duarte HL,Cruz JS,Natali AJ

更新日期：2012-02-01 00:00:00

abstract：:Diets rich in saturated fats and cholesterol contribute to the incidence of hyperlipidaemia. An altered lipid profile is a major factor responsible for the development of CVD. Male Wistar rats were fed with a high-fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kumar R,Akhtar F,Rizvi SI

更新日期：2020-04-01 00:00:00

abstract：:1. It has been demonstrated that blood pressure variability (BPV) is increased in hypertension and related to organ damage. It will be important to lower BPV in the treatment of hypertension. The present study was designed to investigate the effect of ketanserin, a 5-HT2A receptor antagonist with a weak alpha1-adrenoc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miao CY,Xie HH,Yu H,Chu ZX,Su DF

更新日期：2003-03-01 00:00:00

abstract：:1. Hepatic sulphobromophthalein (BSP) transport was studied in guinea-pigs pretreated intraperitoneally with 0.7 ml of diethyl maleate to depress hepatic glutathione levels. 2. Diethyl maleate depressed the hepatic transport of infused conjugated BSP from hepatocytes into bile without influencing hepatic uptake. 3. Un...

journal_title：Clinical and experimental pharmacology & physiology

authors： Whelan G

更新日期：1980-11-01 00:00:00

abstract：:Melanoma is an aggressive skin malignancy with a high mortality. Astrocyte elevated gene-1 (AEG-1), a downstream target of Ras and c-Myc, has been implicated in the development of multiple tumours, but its role in melanoma remains unclear. In the present study, the role of AEG-1 in melanoma was explored through AEG-1 ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang Y,Peng G,Wang Y,Cui L,Wu W,Wang L,Liu C,Han X

更新日期：2017-07-01 00:00:00

abstract：:1. Calcium regulation has been reported to be associated with the development of diabetic nephropathy. Thus, changes in Ca2+ uptake induced by ATP, an important regulator of Ca2+ uptake, in the diabetic condition and related signal pathways were examined in primary cultures of rabbit renal proximal tubule cells (PTC)....

journal_title：Clinical and experimental pharmacology & physiology

authors： Han HJ,Park SH,Lee YJ,Lee JC,Lee JH

更新日期：2003-09-01 00:00:00

abstract：:The intrarenal renin-angiotensin system (RAS) plays a critical role in the pathogenesis and progression of hypertension and kidney disease. In angiotensin (Ang) II-dependent hypertension, collecting duct renin synthesis and secretion are stimulated despite suppression of juxtaglomerular (JG) renin. This effect is medi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gonzalez AA,Prieto MC

更新日期：2015-01-01 00:00:00

abstract：:Apelin receptors (APJ) cross-talk with other G-protein-coupled receptors. However, the role of APJ interaction with opioid receptors (OPR) on the cardiovascular effects of apelin in hypertension is not clear. Renovascular hypertension was induced by placing a Plexiglas clip on the left kidney of rats. After 16 weeks, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Rostamzadeh F,Najafipour H,Yeganeh-Hajahmadi M,Joukar S

更新日期：2018-02-01 00:00:00

abstract：:This study describes the pharmacodynamic interaction between propofol and remifentanil. Sixty patients who were scheduled for elective surgery under general anaesthesia (30 males/30 females) were enrolled. Patients were randomly allocated to receive one of 15 combinations of drug levels. Baseline electroencephalograms...

journal_title：Clinical and experimental pharmacology & physiology

authors： Choe S,Choi BM,Lee YH,Lee SH,Lee EK,Kim KS,Noh GJ

更新日期：2017-01-01 00:00:00

abstract：:1. Although several epidemiological studies have not observed significant independent relationships between physical activity or fitness and blood pressure, others have concluded that blood pressure is lower in individuals who are more fit or active. However, longitudinal intervention studies are more appropriate for ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fagard RH

更新日期：2006-09-01 00:00:00

abstract：:1. The aim of the present study was to investigate the role of dopamine (DA) in the hypotensive and renal effects of L-arginine during extracellular fluid volume expansion (10% bodyweight). 2. Animals were randomized to non-expanded and expanded groups. Both groups received different treatments: L-arginine (250 mg/kg,...

journal_title：Clinical and experimental pharmacology & physiology

authors： Costa Mde L,Loria A,Marchetti M,Balaszczuk AM,Arranz CT

更新日期：2002-09-01 00:00:00