Acute systemic complications in the preterm fetus after asphyxia: role of cardiovascular and blood flow responses.

Abstract:

:1. Poor perfusion of the kidneys and gut, and associated functional impairment, are major problems in the first days of life in very preterm infants. These complications can be associated with a substantial mortality and further problems such as reduced kidney growth and chronic renal problems in later childhood. 2. There is very little information, and consequently considerable debate, about how or even whether to improve perfusion of the vital organs of this most vulnerable group of babies. Current treatments simply do not consistently improve babies' perfusion generally or kidney and gut perfusion and function in particular. 3. In this review we critically examine clinical and experimental evidence that suggests that exposure to low oxygen levels before and during birth may be a significant contributor to impaired systemic perfusion, and highlight areas requiring further research. 4. This knowledge is essential to develop and refine ways of improving perfusion of the kidneys and other vital organs in premature babies.

authors

Bennet L,Booth L,Malpas SC,Quaedackers JS,Jensen E,Dean J,Gunn AJ

doi

10.1111/j.1440-1681.2006.04364.x

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

291-9

issue

4

eissn

0305-1870

issn

1440-1681

pii

CEP

journal_volume

33

pub_type

杂志文章,评审
  • Endothelial dysfunction in coronary vessels and thoracic aorta of rats exposed to cigarette smoke.

    abstract::1. The aim of this study was to evaluate the role of endothelium in mediating the response to acetylcholine in the thoracic aorta and coronary vessels of rats exposed to cigarette smoking. Total serum cholesterol was measured at the beginning and end of the experiment. 2. The relaxation response to acetylcholine was s...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1995.tb02031.x

    authors: Jorge PA,Ozaki MR,Almeida EA

    更新日期:1995-06-01 00:00:00

  • High-salt diet and responses of the pressurized mesenteric artery of the dog to noradrenaline and acetylcholine.

    abstract::A high-salt diet in rats has been shown to result in enhanced vasoconstrictor and/or reduced vasodilator responses of isolated arteries to agonists. The present experiments were designed to investigate the effects of dietary salt on the responses of the pressurized mesenteric resistance artery of the dog to constricto...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2004.04069.x

    authors: Sofola O,Knill A,Myers D,Hainsworth R,Drinkhill M

    更新日期:2004-10-01 00:00:00

  • Micropuncture comparison of nephron function during acute and chronic ADH excess in the rat.

    abstract::1. The aim of this study was to compare the effect of acute versus chronic ADH administration on the handling of sodium, potassium and water by the nephron. Simultaneous clearance and free-flow micropuncture experiments were performed on rats, infused with hypotonic Ringer solution, following either 1-3 h ('acute') or...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1989.tb01531.x

    authors: Field MJ,Seow F,Lawrence JR

    更新日期:1989-02-01 00:00:00

  • Hypoxia-reoxygenation-induced apoptosis in cultured neonatal rat cardiomyocyets and the protective effect of prostaglandin E.

    abstract::The aim of the present study was to investigate the effect of prostaglandin (PG) E1 on hypoxia/re-oxygenation (H/R) apoptosis and the expression of bcl-2 and bax in cultured neonatal rat cardiomyocytes. The H/R model was made using the first generation of cultured neonatal rat cardiomyocytes. Hypoxia/re-oxygenation ap...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2005.04311.x

    authors: Ma XQ,Fu RF,Feng GQ,Wang ZJ,Ma SG,Weng SA

    更新日期:2005-12-01 00:00:00

  • Chronic kidney disease growth factors in renal fibrosis.

    abstract::1. The common pathological alteration in virtually every progressive chronic kidney disease (CKD) is renal fibrosis. 2. This review focuses on some growth factors, which are particularly well-established in contributing to fibrosis, such as the profibrotic, transforming growth factor-β, and connective tissue growth fa...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2011.05487.x

    authors: Boor P,Floege J

    更新日期:2011-07-01 00:00:00

  • Cerebrovascular and metabolic effects of bradykinin, ATP and hypercapnia in the goat.

    abstract::Cerebral blood flow (CBF) and cerebral O2 metabolism (CMRO2) changes were measured in these studies during treatment with three reputed cerebral vasodilators: bradykinin, adenosine triphosphate (ATP) and increased arterial PCO2. Intracerebrovascular bradykinin infusions increased CMRO2 and CBF to a similar degree. Int...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1983.tb00177.x

    authors: Hoffman WE,Miletich DJ,Volkman PH,Albrecht RF

    更新日期:1983-03-01 00:00:00

  • Docosahexaenoic acid-induced protective effect against impaired learning in amyloid beta-infused rats is associated with increased synaptosomal membrane fluidity.

    abstract::In the present study, we investigated the relationship between the docosahexaenoic acid (DHA)-induced protection of learning deficit of amyloid beta(1-40)-infused Alzheimer's disease (AD) model rats and changes in synaptosomal plasma membrane fluidity of the cerebral cortex. Synaptosomal membrane lateral and rotationa...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04467.x

    authors: Hashimoto M,Hossain S,Shimada T,Shido O

    更新日期:2006-10-01 00:00:00

  • Sympathoinhibitory action of nociceptin in the rat spinal cord.

    abstract::1. Whole-cell patch recordings were made from antidromically identified sympathetic preganglionic neurons (SPN) of immature rat spinal cord slices. Bath application of nociceptin (0.1-1 micromol/L) suppressed excitatory postsynaptic potentials (EPSP) and hyperpolarized a population of SPN; these effects were naloxone ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1681.2002.03635.x

    authors: Brailoiu GC,Lai CC,Chen CT,Hwang LL,Lin HH,Dun NJ

    更新日期:2002-03-01 00:00:00

  • Red blood cell ionized calcium concentration in spontaneous hypertension: modulation in vivo by the calcium antagonist PN 200.110.

    abstract::1. Altered calcium regulation has been observed in experimental and human hypertension. In this study erythrocyte (RBC) intracellular calcium concentration ([Ca2+]i) was compared in conscious spontaneously hypertensive rats (SHR) and their normotensive controls (WKY) at rest and after injection of the dihydropyridine ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1988.tb01068.x

    authors: Morris MJ,David-Dufilho M,Devynck MA

    更新日期:1988-04-01 00:00:00

  • Hypertonicity increases rabbit atrium and pulmonary vein arrhythmogenesis: a potential contributor to the genesis of atrial fibrillation.

    abstract::1. Pulmonary veins are the most important focus for the initiation of atrial fibrillation. Diabetes mellitus may be associated with hypertonicity and increased occurrence of atrial fibrillation. 2. The purpose of the present study was to investigate whether hypertonicity alters the electrophysiological characteristics...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2008.05085.x

    authors: Lee SH,Chen YC,Cheng CC,Higa S,Chen YJ,Chen SA

    更新日期:2009-04-01 00:00:00

  • Hantavirus diseases pathophysiology, their diagnostic strategies and therapeutic approaches: A review.

    abstract::Hantaviruses are enveloped negative (-) single-stranded RNA viruses belongs to Hantaviridae family, hosted by small rodents and entering into the human body through inhalation, causing haemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) also known as hantavirus cardiopulmonary syndrom...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/1440-1681.13403

    authors: Munir N,Jahangeer M,Hussain S,Mahmood Z,Ashiq M,Ehsan F,Akram M,Ali Shah SM,Riaz M,Sana A

    更新日期:2020-09-07 00:00:00

  • HIV infection confers distinct mechanisms in severe drug eruption: Endogenous virus activation with aberrant Th2/Th1 and CD8+ T cells function.

    abstract::Severe drug eruption (SDE), a common skin disease, becomes dangerous when it occurs in patients with human immunodeficiency virus (HIV). However, the molecular mechanisms are poorly understood. Forty patients including HIV+ SDE+ (n = 15), HIV- SDE+ (n = 15) and HIV+ SDE- (n = 10) subjects were enrolled in our study. A...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13266

    authors: Tang JT,Li YY,Zhang Y,Liu J,Guan W,Wang RR,He LP,Zhang JB,Kuang YQ

    更新日期:2020-06-01 00:00:00

  • Unidirectional transfer of D-xylose across the rat placenta.

    abstract::1. The transplacental transfer of D-xylose was investigated in the present study. 2. Umbilical perfusion of the rat term placenta was used to study materno-foetal (M-F) and foetomaternal (F-M) transfer of this compound. 3. D-Xylose was found to cross the rat term placenta very quickly in the M-F direction, with subseq...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1998.tb02144.x

    authors: Staud F,Fendrich Z,Karlícek R,Pávek P

    更新日期:1998-01-01 00:00:00

  • Poly(ADP-ribose)polymerase 1 inhibition protects against age-dependent endothelial dysfunction.

    abstract::Age-related endothelial dysfunction is closely associated with the local production of reactive oxygen species (ROS) within and in the vicinity of the vascular endothelium. Oxidant-induced DNA damage can activate the nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP-1), leading to endothelial dysfunction in various p...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12484

    authors: Zhang GH,Chao M,Hui LH,Xu DL,Cai WL,Zheng J,Gao M,Zhang MX,Wang J,Lu QH

    更新日期:2015-12-01 00:00:00

  • Effects of metronidazole on intestinal transit time and faecal weights of human subjects.

    abstract::The combined administration of metronidazole and ampicillin increased faecal weights by 198% in normal male subjects on controlled diets with constant energy, protein and dietary fibre content. Intestinal transit times were unaltered despite marked increase in faecal weights. ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1984.tb00866.x

    authors: Kurpad AV,Shetty PS

    更新日期:1984-09-01 00:00:00

  • Therapeutic effect of green tea extract on advanced glycation and cross-linking of collagen in the aorta of streptozotocin diabetic rats.

    abstract::1. The therapeutic effect of green tea extract (GTE) on the aortic collagen content and its characteristics were investigated in streptozotocin diabetic rats. 2. Diabetes was induced in rats by a single intra peritoneal injection of streptozotocin (60 mg/kg bodyweight). Six weeks after diabetes induction, GTE was admi...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2006.04374.x

    authors: Babu PV,Sabitha KE,Shyamaladevi CS

    更新日期:2006-04-01 00:00:00

  • C1q/TNF-related protein 6 (CTRP6) attenuates renal ischaemia-reperfusion injury through the activation of PI3K/Akt signalling pathway.

    abstract::C1q/TNF-related protein 6 (CTRP6) is a member of the CTRP family that has been reported to exhibit a nephroprotective effect. However, the role of CTRP6 in renal ischaemia/reperfusion (I/R) injury (IRI) remains unclear. In the present study, we aimed to explore the protective effect of CTRP6 in renal IRI and the poten...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.13274

    authors: Xiang H,Xue W,Li Y,Zheng J,Ding C,Dou M,Wu X

    更新日期:2020-06-01 00:00:00

  • Physiological role of large, Ca2+-activated K+ channels in human glomerular mesangial cells.

    abstract::1. Contraction assays and patch clamp methods were used to determine the role of K+ channels in the regulation of contractile tone of human mesangial cells (MC) in culture. 2. MC contraction was induced by vasoconstrictor agents, such as angiotensin II (AngII; 100 nmol/L) and glybenclamide (Glyb), but not by iberiotox...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1996.tb03066.x

    authors: Sansom SC,Stockand JD

    更新日期:1996-01-01 00:00:00

  • Recombinant human hepatocyte growth factor (HGF), but not rat HGF, elicits glomerular injury and albuminuria in normal rats via an immune complex-dependent mechanism.

    abstract::1. Hepatocyte growth factor (HGF) has the therapeutic potential to improve renal fibrosis and proteinuria in rodents with chronic kidney disease. In contrast, long-term administration of human HGF to normal rats reportedly elicits proteinuria. Thus, the role of HGF during proteinuria remains contentious. The aim of th...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2011.05483.x

    authors: Mizuno S,Ikebuchi F,Fukuta K,Kato T,Matsumoto K,Adachi K,Abe T,Nakamura T

    更新日期:2011-03-01 00:00:00

  • Actions of the anti-oestrogen agent clomiphene on outward K+ currents in rat ventricular myocytes.

    abstract::1. The effects of clomiphene (CLM) on cardiac outward K+ current components from rat isolated ventricular myocytes were investigated using the whole-cell patch-clamp technique. Clomiphene (10 micromol/L) significantly inhibited both peak (Ipeak) and end-pulse (Ilate) outward currents (elicited by a 500 msec voltage st...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.2004.03956.x

    authors: Borg JJ,Hancox JC,Hogg DS,James AF,Kozlowski RZ

    更新日期:2004-01-01 00:00:00

  • The initial fall in arterial pressure evoked by endotoxin is mediated by the ventrolateral periaqueductal gray.

    abstract::This study tested the hypothesis that the initial fall in arterial pressure evoked by lipopolysaccharide (LPS) is mediated by the ventrolateral column of the midbrain periaqueductal gray region (vlPAG). To test this hypothesis, the local anaesthetic lidocaine (2%; 0.1 μL, 0.2 μL or 1.0 μL), the delta opioid receptor a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/1440-1681.12573

    authors: Millington WR,Yilmaz MS,Feleder C

    更新日期:2016-06-01 00:00:00

  • Reduced adenosine 3',5'-cyclic monophosphate levels in patients with reversible obstructive airways disease.

    abstract::1. Patients were grouped into categories of 'no airways disease', 'obstructive airways disease without response to bronchodilator' and 'obstructive airways disease with bronchodilator responsiveness'. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1979.tb00013.x

    authors: Krzanowski JJ,Polson JB,Goldman AL,Ebel TA,Szentivanyi A

    更新日期:1979-01-01 00:00:00

  • Muscarinic receptor differentiation.

    abstract::1. Several selective antagonists are available to differentiate between muscarinic receptors. 2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors. 3. Reasons for differences between affinity constants determined in functional and binding studies a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1989.tb01599.x

    authors: Mitchelson F,Choo LK,Darroch S

    更新日期:1989-06-01 00:00:00

  • Role of calcium-activated potassium channels in the relaxation of tracheal smooth muscles by forskolin.

    abstract::1. The role of calcium-activated potassium (KCa) channels in bronchodilation produced by a direct adenylyl cyclase activator, forskolin, was investigated. The involvement of intracellular cyclic AMP (cAMP) in the process was also examined. 2. The isometric tension records from guinea-pig tracheal smooth muscles indica...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1994.tb02529.x

    authors: Hiramatsu T,Kume H,Kotlikoff MI,Takagi K

    更新日期:1994-05-01 00:00:00

  • 5-HT7, neurogenesis and antidepressants: a promising therapeutic axis for treating depression.

    abstract::1. There is mounting evidence that a wide range of antidepressants share the common feature of increasing hippocampal neurogenesis. The specificity of this association has suggested that an ability to increase neurogenesis might be a useful paradigm to screen for compounds with antidepressant activity. 2. The hope of ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.2007.04608.x

    authors: Nandam LS,Jhaveri D,Bartlett P

    更新日期:2007-05-01 00:00:00

  • Long-term deficiency of essential fatty acids in rats and its effect on brain recovery.

    abstract::1. Nineteen-day old rats were fed an essential fatty acid deficient diet for 37 weeks, thereby making them essential fatty acid deficient for at least 24 weeks. The weights of their brains were 33% less than those of rats on control diets. 2. When the deficient rats were rehabilitated for ten weeks on a diet containin...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1979.tb00022.x

    authors: Odutuga AA

    更新日期:1979-07-01 00:00:00

  • The specificity of bile salts in the intestinal absorption of micellar cholesterol in the rat.

    abstract::1. Two aspects of cholesterol absorption; (a) the importance of solubilization and (b) the effects of different bile salts on the mucosal metabolism and lymphatic output of cholesterol, have been investigated using two different in vivo techniques. 2. Bile diverted lymph fistula rats were infused intraduodenally at a ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1976.tb00607.x

    authors: Watt SM,Simmonds WJ

    更新日期:1976-07-01 00:00:00

  • Plasmalemmal calcium in cardiac excitation-contraction coupling.

    abstract::1. Mammalian heart muscle is extremely sensitive to the external calcium concentration. It reacts to alterations of the external calcium concentration with an immediate adaptation of contractile force. 2. In mammalian heart there is a network of large transverse tubules throughout the cell. These structures are regula...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1681.1977.tb02377.x

    authors: Lüllmann H,Peters T

    更新日期:1977-01-01 00:00:00

  • Cholinergic prejunctional inhibition of nitrergic neurotransmission in the guinea-pig isolated basilar artery.

    abstract::1. The effects of endogenous and exogenous acetylcholine (ACh) on nitrergic relaxations elicited by electrical field stimulation (EFS) were studied in guinea-pig endothelium-denuded basilar artery preparations precontracted with 1 mumol/L prostaglandin F2 alpha and a possible role of K+ channels in mediating the effec...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:

    authors: Jiang F,Li CG,Rand MJ

    更新日期:1999-04-01 00:00:00

  • Acute but not chronic angiotensin-converting enzyme inhibition induces enzyme synthesis in the glomerulus of the spontaneously hypertensive rat.

    abstract::1. Treatment with angiotensin-converting enzyme (ACE) inhibitors slows the rate of progression of nephropathy in the spontaneously hypertensive rat (SHR) with streptozotocin-induced diabetes. Paradoxically, however, chronic ACE inhibitor therapy has been reported to be associated with induction of ACE in the plasma. W...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1681.1997.tb01226.x

    authors: Hodge G,Makarious MM,Charlesworth JA,Duggan KA

    更新日期:1997-06-01 00:00:00