Abstract:
:Alzheimer's disease (AD) is a neurodegenerative disorder with an incompletely defined aetiology that is associated with memory and cognitive impairment. Currently available therapeutics only provide temporary assistance with symptoms. In spite of plentiful research in the field and the generation of thousands of studies, much is still to be clarified on precise mechanisms of pathobiology, prevention modalities, disease course and cure. Netrin-1, a laminin family protein, is said to have anti-inflammatory and anti-apoptotic effects and has a key role in neurogenesis and morphogenesis of neural structures. Accordingly, this study was designed to investigate protective effects of bilateral intrahippocampal fissure microinjections of netrin-1 on memory impairment in rat model of AD. Concomitant administration of netrin-1 with amyloid beta 1-42 (Aβ1-42 ) improved cognitive dysfunction in novel object recognition task (NOR), ameliorated impaired spatial memory in Morris water maze (MWM) setting, increased neuronal density and reduced amyloid aggregation in rat AD model. Netrin-1 was also seen to prevent Aβ1-42 -induced caspase-3, caspase-7 and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation. Therefore, based on the data reported here, netrin-1 may be a promising biologic therapeutic that addresses the memory and neuronal loss associated with AD.
journal_name
Clin Exp Pharmacol Physioljournal_title
Clinical and experimental pharmacology & physiologyauthors
Zamani E,Parviz M,Roghani M,Mohseni-Moghaddam Pdoi
10.1111/1440-1681.13020subject
Has Abstractpub_date
2019-01-01 00:00:00pages
86-93issue
1eissn
0305-1870issn
1440-1681journal_volume
46pub_type
杂志文章abstract::Repaglinide is a short-acting insulin secretagogue, which often results in considerable interindividual variability in therapeutic efficacy when widely used in a clinical setting. Among various reasons under discussion is genetic polymorphism, especially the genes related to insulin secretion and resistance. Recent st...
journal_title:Clinical and experimental pharmacology & physiology
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abstract::1. This study aimed to investigate the protective effects of isosteviol against myocardial ischaemia-reperfusion (IR) injury and its effects on mitochondrial adenosine triphosphate (ATP)-sensitive potassium channel (mitoK(ATP)) activity in vitro. 2. Groups of eight guinea pigs were treated as follows: constant perfusi...
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1988.tb01030.x
更新日期:1988-11-01 00:00:00
abstract::1. The influence of the passive force on the contraction and endothelium-dependent relaxation in aortae of normotensive Wistar Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP) were compared. 2. Force changes of endothelium-intact and -removed preparations were measured isometrically by a force...
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journal_title:Clinical and experimental pharmacology & physiology
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1988.tb01036.x
更新日期:1988-12-01 00:00:00
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doi:10.1111/j.1440-1681.1976.tb00624.x
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更新日期:2006-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
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更新日期:1984-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1440-1681.1976.tb00633.x
更新日期:1976-11-01 00:00:00
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journal_title:Clinical and experimental pharmacology & physiology
pub_type: 杂志文章
doi:10.1111/j.1440-1681.1989.tb01549.x
更新日期:1989-04-01 00:00:00
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更新日期:2010-10-01 00:00:00
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更新日期:1995-05-01 00:00:00
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更新日期:2016-09-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-02-01 00:00:00