Plasmalemmal calcium in cardiac excitation-contraction coupling.

abstract：:1. Subacute administration of dyflos to guinea-pigs (1.2 mg/kg, s.c., daily for 10 days) led to the development of subsensitivity to carbachol in the ileum but not in the electrically stimulated left atrium. 2. Atria from dyflos-pretreated animals became supersensitive to acetylcholine but the ileum became subsensitiv...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mitchelson F,O'Shea RA

更新日期：1977-11-01 00:00:00

abstract：:1. When six female seropositive rheumatoid patients were given placebo therapy for 48 h, their plasma kininogen level, 9.2 +/- 0.7 microgram bradykinin equivalents (bk eq) per ml, was found to be 59% greater than that of a group of eight healthy female volunteers (5.8 +/- 0.5 microgram/ml). 2. When the rheumatoid pati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sharma JN,Zeitlin IJ,Brooks PM,Buchanan WW,Dick WC

更新日期：1980-07-01 00:00:00

abstract：:1. Prenatal dexamethasone leads to low birth weight and compromises organogenesis, but its effects on nephrogenesis in male and female rats have not yet been investigated extensively. Reduced renal mass may be responsible for hypertension and renal haemodynamic and morphological adjustments to maintain the glomerular ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Martins JP,Monteiro JC,Paixão AD

更新日期：2003-01-01 00:00:00

abstract：:1. The present study was performed to test the hypothesis that the reactive oxygen species (ROS)-angiotensinogen (AGT)-renin angiotensin system (RAS) axis is sequentially activated in the development of diabetic nephropathy in Zucker diabetic fatty (ZDF) obese rats. 2. Genetic pairs of male ZDF obese and control ZDF l...

journal_title：Clinical and experimental pharmacology & physiology

authors： Miyata K,Ohashi N,Suzaki Y,Katsurada A,Kobori H

更新日期：2008-08-01 00:00:00

abstract：:1. Over the past 50 years considerable evidence has been reported suggesting that endogenous opioids participate in the control of renal function. 2. Exogenous administration of opioids produces profound changes in the renal excretion of water and sodium. 3. Opioids produce changes in urine output and urine sodium exc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kapusta DR

更新日期：1995-12-01 00:00:00

abstract：:1. The present study was undertaken to elucidate the effects of parecoxib, a novel cyclo-oxygenase (COX)-2 inhibitor, on spontaneous and prostaglandin-induced contractions of uterine smooth muscle. 2. Non-pregnant adult Wistar rats were decapitated and dissected to isolate myometrial strips. The tissue was mounted in ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ayar A

更新日期：2007-08-01 00:00:00

abstract：:1. To elucidate the physiological role of nitric oxide (NO) in regulating vascular tone, the effects of NG-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, on the vasoconstrictor response to noradrenaline (NA) in rat caudal artery was examined. 2. NG-Nitro-L-arginine methyl ester significantly potenti...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kwon YM,Shinozuka K,Kagota S,Yamaguchi Y,Nakamura K,Kunitomo M

更新日期：1999-05-01 00:00:00

abstract：:1. Treatment with angiotensin converting enzyme (ACE) inhibitors ameliorates human and experimental diabetic nephropathy, possibly as a result of changes in angiotensin II (AngII) and/or bradykinin concentrations. However, ACE is an indiscriminate enzyme, which hydrolyses numerous vasoactive peptides at two catalytic ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Duggan KA,Hodge G,Makarious MM,Charlesworth JA

更新日期：1996-06-01 00:00:00

abstract：:1. Direct cortical stimulation of motor and sensory areas of the cortex in experimental animals and some neurosurgical patients has provided much useful physiological information. Some of the benefits of this approach can be provided in awake volunteer subjects using new techniques which activate the motor cortex thor...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gandevia SC

更新日期：1996-10-01 00:00:00

abstract：:1. Aldosterone is a hormone that affects both blood pressure and glucose homeostasis. We studied the association of the aldosterone synthase gene (CYP11B2) polymorphism -344T>C with essential hypertension (EH) and glucose homeostasis in people in China. 2. We investigated the polymorphism -344T>C in CYP11B2 using a ca...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li XM,Ling Y,Lu DR,Lu ZQ,Yi QL,Liu Y,Chen HY,Gao X

更新日期：2011-09-01 00:00:00

abstract：:1. The objectives of the study were to establish that inhibition of neuronal differentiation in culture (assessed by neurite outgrowth) can be used as a broad spectrum in vitro measure of neurotoxicity. 2. To establish whether a rapid measure of neurite outgrowth could be used. Thus the study examined the relationship...

journal_title：Clinical and experimental pharmacology & physiology

authors： Abdulla EM,Calaminici M,Campbell IC

更新日期：1995-05-01 00:00:00

abstract：:The possibility that serotonin (5HT) nerve endings in the dorsomedial medulla oblongata participate in the control of blood pressure was investigated in stroke-prone hypertensive rats and in normotensive rats. 5HT nerves were destroyed by injecting 5,7-dihydroxytryptamine bilaterally into the solitary tract nucleus. I...

journal_title：Clinical and experimental pharmacology & physiology

authors： Howe PR,Rogers PF,King RA,Smith RM

更新日期：1983-05-01 00:00:00

abstract：:1. The most usual form of chronic hypoxia in humans is the intermittent hypoxia resulting from obstructive sleep apnoea (OSA). The OSA syndrome is a highly prevalent sleep breathing disorder that is considered an independent risk factor for hypertension and cardiovascular diseases. Endothelial dysfunction, oxidative s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iturriaga R,Moya EA,Del Rio R

更新日期：2009-12-01 00:00:00

abstract：:1. We have examined the question asked in the title by studying: the carotid baroreceptor reflex in man with a variable-pressure neck chamber; the carotid baroreceptor reflex in conscious rabbits with a variable-pressure capsule around the carotid bifurcation; and the barorecptor-heart rate reflex. 2. At rest, the ass...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ludbrook J,Mancia G,Zanchetti A

更新日期：1980-09-01 00:00:00

abstract：:1. Patients with chronic kidney disease (CKD) demonstrate a high burden of vascular disease. This vascular disease is unusual by way of a preponderance of medial calcification. Further, traditional cardiovascular risk factors fail to fully explain the high cardiovascular event rate in this population. 2. The present r...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kerr PG,Guerin AP

更新日期：2007-07-01 00:00:00

abstract：:1. Infusion of salbutamol (3.0 microgram/min after a bolus injection of 100 microgram) produced hypokalaemia in conscious dogs. 2. Measurement of arterial and coronary sinus potassium differences revealed no significant potassium loss from the heart with established hypokalaemia. 3. Shortly after the initial salbutamo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wahlqvist ML,Shanahan EA,Dennis PM,Pullan PT,Wilmshurst EG

更新日期：1978-11-01 00:00:00

abstract：:1. Intermittent bursts of activity are a robust feature of the discharges of sympathetic nerves. There are at least two major mechanisms producing such discharges: (i) phasic inputs influencing sympathetic circuits; and (ii) oscillators embedded within sympathetic networks. The functional significance of patterned and...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gilbey MP

更新日期：2001-01-01 00:00:00

abstract：:1. We tested the hypothesis that increasing myocardial cyclic GMP levels would reduce myocardial O2 consumption and areas of low O2 supply/consumption balance, using zaprinast, a selective cyclic GMP-phosphodiesterase inhibitor. 2. The study was conducted in three groups (vehicle, 10(-3) and 3 x 10(-3) mol/L zaprinast...

journal_title：Clinical and experimental pharmacology & physiology

authors： Weiss HR,Rodriguez E,Tse J,Scholz PM

更新日期：1994-08-01 00:00:00

abstract：:1. Angiotensin (Ang) II causes growth-related effects on vascular smooth muscle cells in vitro and in vivo. 2. Chronic infusions of AngII systemically, at doses that are initially subpressor, result in slowly progressive increases in arterial pressure ('slow-pressor' hypertension). It has been suggested that the hyper...

journal_title：Clinical and experimental pharmacology & physiology

authors： Edgley A,Kett M,Anderson W

更新日期：2001-12-01 00:00:00

abstract：:Rutaecarpine is a major alkaloid isolated from Evodia rutaecarpa. Here, we investigated the effects of rutaecarpine on osteoclast differentiation induced by macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor κ-B ligand (RANKL) in bone marrow-derived macrophages (BMMs). Treatment with...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fukuma Y,Sakai E,Komaki S,Nishishita K,Okamoto K,Tsukuba T

更新日期：2018-08-01 00:00:00

abstract：:1. Ambulatory monitoring provides a unique opportunity for studying the temporal relationships between lifestyle factors and blood pressure (BP). These include physical activity, mental activity, environmental stressors, substances ingested for pleasure such as smoking, alcohol and caffeine, and nutrition. 2. Changes ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pickering TG,Schwartz JE,James GD

更新日期：1995-03-01 00:00:00

abstract：:1. Contractions and electrical activity were recorded from isolated segments of longitudinal (L) and circular (C) myometrium from rats on gestation days 16-17 and 21 before and during parturition. 2. The segments were arranged so that the activity of the two layers could be monitored simultaneously and independently. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomiyasu BA,Chen CJ,Marshall JM

更新日期：1988-09-01 00:00:00

abstract：:1. Although measuring the rate of firing of multi-unit muscle sympathetic nerve activity (MSNA) has provided important information in many aspects of cardiovascular medicine, measuring single-unit vasoconstrictor activity provides a better understanding of the possible mechanisms underlying disturbed sympathetic nervo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lambert E,Dawood T,Schlaich M,Straznicky N,Esler M,Lambert G

更新日期：2008-04-01 00:00:00

abstract：:1. The aim of the present study was to explore the effects of CPU0213, a dual endothelin ET(A)/ET(B) receptor antagonist, and nifedipine, a calcium antagonist, in relieving pulmonary hypertension (PH). Both endothelin receptor and calcium antagonists have been reported to be effective in alleviating the remodelling of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui B,Cheng YS,Dai DZ,Li N,Zhang TT,Dai Y

更新日期：2009-02-01 00:00:00

abstract：:Diets rich in saturated fats and cholesterol contribute to the incidence of hyperlipidaemia. An altered lipid profile is a major factor responsible for the development of CVD. Male Wistar rats were fed with a high-fat diet (HFD) (suspension (w/v) of 0.5% cholesterol, 3% coconut oil and 0.25% cholic acid for 30 days) t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kumar R,Akhtar F,Rizvi SI

更新日期：2020-04-01 00:00:00

abstract：:1. In the present study, we investigated the associations of nicotinamide phosphoribosyltransferase (NAMPT)-3186 C/T and -948G/T polymorphisms with the risk of Type 2 diabetes mellitus (T2DM) and their impact on the efficacy of repaglinide in Chinese Han T2DM patients. 2. In all, 170 patients with T2DM and 129 healthy...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sheng FF,Dai XP,Qu J,Lei GH,Lu HB,Wu J,Xu XJ,Pei Q,Dong M,Liu YZ,Zhou HH,Liu ZQ

更新日期：2011-08-01 00:00:00

abstract：:Aerobic glycolysis plays a crucial role in cancer progression. Ketamine is often used for cancer pain relief in clinical settings. Moreover, ketamine inhibits proliferation and induces apoptosis in many cancer cell types. However, the anti-tumour mechanism of ketamine is still poorly understood. In the present study, ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hu J,Duan W,Liu Y

更新日期：2020-05-01 00:00:00

abstract：:Cerebral blood flow (CBF) and cerebral O2 metabolism (CMRO2) changes were measured in these studies during treatment with three reputed cerebral vasodilators: bradykinin, adenosine triphosphate (ATP) and increased arterial PCO2. Intracerebrovascular bradykinin infusions increased CMRO2 and CBF to a similar degree. Int...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hoffman WE,Miletich DJ,Volkman PH,Albrecht RF

更新日期：1983-03-01 00:00:00

abstract：:Responses of the toad isolated rectus abdominis muscle to cumulative doses of carbachol were recorded in the absence or presence of varying concentrations of cimetidine or ranitidine. The corresponding cumulative log concentration-response curves for carbachol were then plotted for each antagonist studied. Cimetidine ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Gwee MC,Cheah LS,Shoon ML

更新日期：1986-08-01 00:00:00

abstract：:1. Reactive oxygen species (ROS) are a diverse family of molecules that are produced throughout the vascular wall. Many ROS, such as the superoxide anion (*O2-) and hydrogen peroxide (H2O2), are now known to act as cellular signalling molecules within blood vessels. In particular, these molecules can exert powerful ef...

journal_title：Clinical and experimental pharmacology & physiology

authors： Paravicini TM,Sobey CG

更新日期：2003-11-01 00:00:00