Ionic mechanisms regulating sodium entry into vascular smooth muscle.

abstract：:1. Animal and human studies indicate that female sex hormones are protective against the development of coronary atherosclerosis. 2. Experiments on vascular smooth muscle cells suggest a direct effect of oestrogen on vascular tissue. Although oestrogen receptors (ER) in vascular tissues and an association between ER s...

journal_title：Clinical and experimental pharmacology & physiology

authors： Baysal K,Losordo DW

更新日期：1996-06-01 00:00:00

abstract：:The prostaglandin synthesis inhibitor diclofenac sodium has been compared with a placebo in the treatment of primary nocturnal enuresis in a double-blind crossover trial. Twenty patients were entered: 14 female, six male; age range 6-17 years. The results showed that diclofenac sodium was significantly more effective ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Al-Waili NS

更新日期：1986-02-01 00:00:00

abstract：:The neuropeptide oxytocin (OXT) has been implicated in the pathophysiology of behavioural deficits among patients with autism spectrum disorder (ASD). However, the molecular mechanisms underlying its role in ASD remain unclear. In the present study, a murine model with ASD-like phenotypes was induced by intra-medial a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang Y,Zhao S,Wu Z,Feng Y,Zhao C,Zhang C

更新日期：2015-05-01 00:00:00

abstract：:1. The role of calcium-activated potassium (KCa) channels in bronchodilation produced by a direct adenylyl cyclase activator, forskolin, was investigated. The involvement of intracellular cyclic AMP (cAMP) in the process was also examined. 2. The isometric tension records from guinea-pig tracheal smooth muscles indica...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hiramatsu T,Kume H,Kotlikoff MI,Takagi K

更新日期：1994-05-01 00:00:00

abstract：:1. Blood pressure (BP) and heart rate (HR) increase 6 and 24 h after sinoaortic baroreceptor denervation (SAD), whereas plasma renin activity (PRA) and renal renin mRNA levels remain unchanged. We postulated that a simultaneous rise in BP could offset the expected activation of renin associated with an increased renal...

journal_title：Clinical and experimental pharmacology & physiology

authors： Krieger MH,Moreira ED,Oliveira EM,Oliveira VL,Krieger EM,Krieger JE

更新日期：2006-05-01 00:00:00

abstract：:1. In rat isolated tail arteries and atria in which transmitter stores are labelled with (3H)-noradrenaline, isoprenaline in low concentrations facilitates the stimulation-induced efflux of tritium. 2. This effect is dependent on the frequency and duration of electrical stimulation, being observed only at low frequenc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Medgett IC,McCulloch MW,Rand MJ,Story DF

更新日期：1980-09-01 00:00:00

abstract：:1. Ethionine administered acutely to the adult female rat markedly elevates and then lowers plasma iron concentration over several days. Liver iron undergoes a reverse cycle. 2. Ethionine does not cause changes in the blood parameters, including total plasma iron-binding capacity and plasma iron clearance. Erythrocyte...

journal_title：Clinical and experimental pharmacology & physiology

authors： Loh TT,Archdeacon JW

更新日期：1975-11-01 00:00:00

abstract：:1. The neurotrophins play an important role during development to stimulate and guide axonal growth for the establishment of a correctly wired and functional neural system. Neurotrophins can also regulate adult nervous system plasticity by promoting neuronal survival and stimulating nerve regrowth following injury. 2....

journal_title：Clinical and experimental pharmacology & physiology

authors： Gillespie LN

更新日期：2003-10-01 00:00:00

abstract：:Clinical studies showed that high doses of recombinant human erythropoietin (rHuEPO) used to correct anaemia in chronic kidney disease (CKD) hyporesponsive patients may lead to deleterious effects. The aim of this study was to analyze the effects of rHuEPO in doses usually used to correct CKD-anaemia (100, 200 IU/kg b...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ribeiro S,Garrido P,Fernandes J,Vala H,Rocha-Pereira P,Costa E,Belo L,Reis F,Santos-Silva A

更新日期：2016-03-01 00:00:00

abstract：:1. Inhibiting the renin-angiotensin-aldosterone system prevents left ventricular (LV) remodelling after myocardial infarction (MI). 2. The present study was designed to assess the effects of a combination of perindopril and losartan on LV remodelling, cardiac function and serum procollagen type III amino terminal pept...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li L,Liu RY,Zhao XY,Zhang JY,Jia M,Lu PQ

更新日期：2009-07-01 00:00:00

abstract：:1. The effect of bromocriptine (a prolactin suppressant drug) on the serum levels of calcium was studied in the male rat. The drug was administered subcutaneously at a dosage of 100 microgram per 100 g body weight three times per day. 2. Chronic treatment with bromocriptine had no significant effect on the serum calci...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tan CM,Tan GJ

更新日期：1978-09-01 00:00:00

abstract：:Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body. Plasma renin activity (PRA)...

journal_title：Clinical and experimental pharmacology & physiology

authors： Isbil-Buyukcoskun N,Ilcol YO,Cansev M,Hamurtekin E,Ozluk K,Ulus IH

更新日期：2008-09-01 00:00:00

abstract：:The effects of naloxone on contractility and cardiac rhythm were studied in the rat isolated perfused heart during myocardial ischaemia and reperfusion. Pretreatment of the rat isolated perfused heart with naloxone abolished the reduction in left ventricular pressures and attenuated greatly the arrhythmias due to myoc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhan ZY,Lee AY,Wong TM

更新日期：1985-07-01 00:00:00

abstract：:Summary 1. The non-selective K(+) channel blocker 4-aminopyridine (4-AP) has shown clinical efficacy in the treatment of neurological disorders such as multiple sclerosis. The clinical usefulness of 4-AP is hampered by its ability to produce seizures. Nerispirdine, an analogue of 4-AP, is currently under clinical inve...

journal_title：Clinical and experimental pharmacology & physiology

authors： Smith C,Kongsamut S,Wang H,Ji J,Kang J,Rampe D

更新日期：2009-11-01 00:00:00

abstract：:1. The therapeutic effect of green tea extract (GTE) on the aortic collagen content and its characteristics were investigated in streptozotocin diabetic rats. 2. Diabetes was induced in rats by a single intra peritoneal injection of streptozotocin (60 mg/kg bodyweight). Six weeks after diabetes induction, GTE was admi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Babu PV,Sabitha KE,Shyamaladevi CS

更新日期：2006-04-01 00:00:00

abstract：:1. The present review reports some of the earliest physiological changes that occur in the diabetic retina prior to any clinical or anatomical changes in an animal model of diabetes. 2. Using chemically induced diabetes (by streptozotocin) in rats, retinal blood flow and vitreal and retinal oxygen tension were determi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Alder VA,Su EN,Yu DY,Cringle SJ,Yu PK

更新日期：1997-09-01 00:00:00

abstract：:1. The low molecular weight heparin (LMWH) dalteparin is used, for example, to prevent primary venous thromboembolism in patients undergoing surgery or in medically ill patients. The anticoagulant activity of dalteparin can be monitored by measuring anti-factor Xa levels and activated partial thromboplastin time (aPTT...

journal_title：Clinical and experimental pharmacology & physiology

authors： Feuring M,Wehling M,Schultz A

更新日期：2011-11-01 00:00:00

abstract：:1. Poor perfusion of the kidneys and gut, and associated functional impairment, are major problems in the first days of life in very preterm infants. These complications can be associated with a substantial mortality and further problems such as reduced kidney growth and chronic renal problems in later childhood. 2. T...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bennet L,Booth L,Malpas SC,Quaedackers JS,Jensen E,Dean J,Gunn AJ

更新日期：2006-04-01 00:00:00

abstract：:1. The concentrations of gamma-amino butyric acid (GABA) and glutamate were measured in the brains of chickens which were treated with furazolidone (FZ) or nitrofurazone (NF) at oral doses of 12.5, 25 or 50 mg/kg for 5 days. 2. At the end of the treatment, birds on the small dose of FZ or NF lost about 9% of their bod...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ali BH

更新日期：1988-12-01 00:00:00

abstract：:1. The Type 2C protein phosphatases (PP2C) represent a highly conserved gene family in the mammalian genome. Recent studies have revealed that PP2C isoforms possess unique patterns of tissue and subcellular distribution associated with diverse functionalities. 2. The functional importance of PP2C isoforms has been sho...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lu G,Wang Y

更新日期：2008-02-01 00:00:00

abstract：:1. The concentration of renin and angiotensinogen (Ao) and the activity of angiotensin I-converting enzyme (ACE) was measured in the ascites fluid of nephrotic rats obtained 8 days after puromycin aminonucleoside (PAN) injection. 2. Ascites fluid, serum and urine proteins of these rats were analysed by sodium dodecyl ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cruz C,Correa-Rotter R,Mézquita C,Medina-Campos ON,Pedraza-Chaverrí J

更新日期：1998-07-01 00:00:00

abstract：:1. Mechanisms underlying the generation and propagation of gastrointestinal slow wave depolarizations have long been controversial. The present review aims to collate present knowledge on this subject with specific reference to slow waves in gastric smooth muscle. 2. At present, there is strong agreement that intersti...

journal_title：Clinical and experimental pharmacology & physiology

authors： van Helden DF,Laver DR,Holdsworth J,Imtiaz MS

更新日期：2010-04-01 00:00:00

abstract：:This study demonstrates the inhibitory effect of anticholinergic drug oxybutynin on voltage-dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells. Oxybutynin inhibited vascular Kv channels in a concentration-dependent manner, with an IC50 value of 11.51 ± 0.38 μmol/L and a Hill coefficient (n) of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li H,Seo MS,An JR,Jung HS,Ha KS,Han ET,Hong SH,Bae YM,Ryu DR,Park WS

更新日期：2019-11-01 00:00:00

abstract：:1. Contractions and electrical activity were recorded from isolated segments of longitudinal (L) and circular (C) myometrium from rats on gestation days 16-17 and 21 before and during parturition. 2. The segments were arranged so that the activity of the two layers could be monitored simultaneously and independently. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tomiyasu BA,Chen CJ,Marshall JM

更新日期：1988-09-01 00:00:00

abstract：:The pressor responses to angiotensin II injections of 29, 117 and 468 pmol/kg and infusion at 54 pmol/kg per min were compared in near-term pregnant and matched non-pregnant rabbits. The responses to noradrenaline injections of 652, 2608 and 10 432 pmol/kg and infusion at 1185 pmol/kg per min were similarly compared. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Joels N,Humphreys PW

更新日期：1985-11-01 00:00:00

abstract：:MicroRNA plays an integral role in the development of atherosclerosis. Our study aimed to investigate the roles of miR-599 in lipopolysaccharide (LPS)-induced endothelial damage in human umbilical vein endothelial cells (HUVECs). HUVECs were transfected with a miR-599 mimic and negative control, and then exposed to LP...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang J,Du A,Wang H,Li Y

更新日期：2020-08-01 00:00:00

abstract：:1. Endothelin mediates its effects in a variety of renal cells via a multiplicity of intracellular signalling pathways. 2. Stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC), resulting in the activation of inositol trisphosphate and diacylglycerol, can be detected even at picomolar concentrations of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nord EP

更新日期：1996-04-01 00:00:00

abstract：:Urapidil had blocking activity on alpha 1-adrenoceptors in the rat isolated caudal artery (pA2 congruent to 7) and in the anaesthetized rat. Urapidil had no clonidine like agonistic activity on alpha 2-adrenoceptors in preparations of the guinea-pig ileum (prejunctional) or dog saphenous vein (post-junctional). Urapid...

journal_title：Clinical and experimental pharmacology & physiology

authors： Verberne AJ,Rand MJ

更新日期：1984-07-01 00:00:00

abstract：:1. Left ventricular (LV) hypertrophy has been implicated in the reduction of baroreflex sensitivity present in hypertension. The aim of the current study was to investigate the mean arterial pressure-heart rate reflex (MAP-HR) in a model which induced left ventricular hypertrophy but no sustained blood pressure elevat...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kingwell BA,Krause L,Julius S

更新日期：1994-01-01 00:00:00

abstract：:1. UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme, and its overexpression has been demonstrated in a variety of malignancies. The aim of the present study is to silence UbcH10 gene by RNA interference (RNAi) and to observe its inhibitory effect on the colorectal cancer cell growth in vitro and in vivo. 2...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen SM,Jiang CY,Wu JY,Liu B,Chen YJ,Hu CJ,Liu XX

更新日期：2010-05-01 00:00:00