Plasma and tissue iron changes in the rat after acute administration of ethionine.

Abstract:

:1. Ethionine administered acutely to the adult female rat markedly elevates and then lowers plasma iron concentration over several days. Liver iron undergoes a reverse cycle. 2. Ethionine does not cause changes in the blood parameters, including total plasma iron-binding capacity and plasma iron clearance. Erythrocytes of rats injected with ethionine show altered responses to hypertonicity. 3. Increased reticulo-endothelial activity of the spleen, indicated by increased uptake of 59Fe-labelled erythrocytes by liver and spleen, apparently contributes to plasma iron elevation. Also the liver releases iron which further raises plasma iron.

authors

Loh TT,Archdeacon JW

doi

10.1111/j.1440-1681.1975.tb01851.x

keywords:

subject

Has Abstract

pub_date

1975-11-01 00:00:00

pages

459-67

issue

6

eissn

0305-1870

issn

1440-1681

journal_volume

2

pub_type

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