Plasma and tissue iron changes in the rat after acute administration of ethionine.


:1. Ethionine administered acutely to the adult female rat markedly elevates and then lowers plasma iron concentration over several days. Liver iron undergoes a reverse cycle. 2. Ethionine does not cause changes in the blood parameters, including total plasma iron-binding capacity and plasma iron clearance. Erythrocytes of rats injected with ethionine show altered responses to hypertonicity. 3. Increased reticulo-endothelial activity of the spleen, indicated by increased uptake of 59Fe-labelled erythrocytes by liver and spleen, apparently contributes to plasma iron elevation. Also the liver releases iron which further raises plasma iron.


Loh TT,Archdeacon JW





Has Abstract


1975-11-01 00:00:00












  • Ambulatory blood pressure monitoring for evaluating the relationships between lifestyle, hypertension and cardiovascular risk.

    abstract::1. Ambulatory monitoring provides a unique opportunity for studying the temporal relationships between lifestyle factors and blood pressure (BP). These include physical activity, mental activity, environmental stressors, substances ingested for pleasure such as smoking, alcohol and caffeine, and nutrition. 2. Changes ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Pickering TG,Schwartz JE,James GD

    更新日期:1995-03-01 00:00:00

  • Azithromycin inhibits muscarinic 2 receptor-activated and voltage-activated Ca2+ permeant ion channels and Ca2+ sensitization, relaxing airway smooth muscle contraction.

    abstract::Azithromycin (AZM) has been used for the treatment of asthma and chronic obstructive pulmonary disease (COPD); however, the effects and underlying mechanisms of AZM remain largely unknown. The effects of AZM on airway smooth muscles (ASMs) and the underlying mechanisms were studied using isometric muscle force measure...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang Q,Yu MF,Zhang WJ,Liu BB,Zhao QY,Luo X,Xu H,She YS,Zang DA,Qiu JY,Shen J,Peng YB,Zhao P,Xue L,Chen W,Ma LQ,Nie X,Shen C,Chen S,Chen S,Liu Q,Dai J,Qin G,Zheng YM,Wang YX,ZhuGe R,Chen J,Liu QH

    更新日期:2019-04-01 00:00:00

  • Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease.

    abstract::Peptidyl-prolyl cis/trans isomerases (PPIases) are a conserved group of enzymes that catalyse the conversion between cis and trans conformations of proline imidic peptide bonds. These enzymes play critical roles in regulatory mechanisms of cellular function and pathophysiology of disease. There are three different cla...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Rostam MA,Piva TJ,Rezaei HB,Kamato D,Little PJ,Zheng W,Osman N

    更新日期:2015-02-01 00:00:00

  • Taurine inhibits development of atherosclerotic lesions in apolipoprotein E-deficient mice.

    abstract::1. The effects of taurine on the development of atherosclerotic lesions were investigated in apolipoprotein (apo) E-deficient mice, an animal model with severe hypercholesterolaemia and extensive atherosclerosis. These mice were fed a normal laboratory chow containing 2% taurine for 12 weeks. 2. Serum total cholestero...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kondo Y,Toda Y,Kitajima H,Oda H,Nagate T,Kameo K,Murakami S

    更新日期:2001-10-01 00:00:00

  • Protecting murine hearts from ischaemia-reperfusion using selective inhibitors of adenosine metabolism.

    abstract::1. By selectively modifying adenosine metabolism via adenosine deaminase or adenosine kinase inhibitors, it may be possible to enhance the receptor-mediated protective actions of adenosine in a site- and event-specific fashion. 2. We characterized cardioprotective actions of the adenosine deaminase inhibitor erythro-2...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Willems L,Headrick JP

    更新日期:2005-03-01 00:00:00

  • Hypoxia-inducible factor 1 alpha and nuclear-related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease.

    abstract::Hypoxia-inducible factor-1 alpha (HIF-1α) and nuclear receptor related-1 (Nurr1) play pivotal roles in the development and survival of dopaminergic neurons, and deficiencies in these genes may be involved in Parkinson's disease (PD) pathogenesis. Recently, anthelminthic benzimidazoles were shown to promote HIF-1α tran...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Kandil EA,Sayed RH,Ahmed LA,Abd El Fattah MA,El-Sayeh BM

    更新日期:2019-12-01 00:00:00

  • Exercise and hypertension: a model for central neural plasticity.

    abstract::1. Physical movement is accompanied by coordinated changes in respiratory and cardiovascular activity proportional to the metabolic demands of the locomotor task. Cardiorespiratory changes include increases in ventilation, blood pressure and heart rate, as well as altered regional sympathetic nerve activity and blood ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Kramer JM,Beatty JA,Plowey ED,Waldrop TG

    更新日期:2002-01-01 00:00:00

  • Reduced [125I]-Bolton Hunter substance P binding (NK1 receptors) in the basal forebrain nuclei of aged rats.

    abstract::1. Quantitative autoradiography and homogenate radioligand binding of [125I]-Bolton Hunter substance P ([125I]-BHSP) were used to compare brain NK1 receptors in young (2 months) and aged (18-20 months) rats. 2. The autoradiographic distribution and density of [125I]-BHSP binding sites was similar in all cortical regio...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Geraghty DP,Maguire CM

    更新日期:2002-12-01 00:00:00

  • Agonist function of the recombinant alpha 4 beta 3 delta GABAA receptor is dependent on the human and rat variants of the alpha 4-subunit.

    abstract::1. It is known that the alpha(4)-subunit is likely to occur in the brain predominantly in alpha(4)beta(3)delta receptors at extrasynaptic sites. Recent studies have revealed that the alpha(1)-, alpha(4)-, gamma(2)- and delta-subunits may colocalize extrasynaptically in dentate granule cells of the hippocampus. In the ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wang MD,Rahman M,Johansson IM,Bäckström T

    更新日期:2010-07-01 00:00:00

  • A study of neurokinins and other oedema-inducing mediators and mechanisms in thermal injury.

    abstract::1. Mechanisms involved in the plasma extravasation observed following thermal injury of rat dorsal skin were investigated. 2. Heat applied to the dorsal skin of anaesthetized rats by a temperature-controlled skin heater (1 cm diameter) for 5 min induced temperature-dependent plasma protein extravasation at 48-48.5 deg...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Waller J,Siney L,Hoult JR,Brain SD

    更新日期:1997-11-01 00:00:00

  • Energy cost of contraction in rat urinary bladder smooth muscle during anoxia.

    abstract::1. The aim of the present study was to investigate the effects of hypoxia on energy metabolism and contraction of rat urinary bladder smooth muscle, thereby gaining insight into the capacity of this smooth muscle to maintain contractile function when rendered hypoxic. 2. Isometric force, oxygen consumption, lactate pr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Wendt IR,Paul RJ

    更新日期:2003-08-01 00:00:00

  • Opioid mechanisms controlling renal function.

    abstract::1. Over the past 50 years considerable evidence has been reported suggesting that endogenous opioids participate in the control of renal function. 2. Exogenous administration of opioids produces profound changes in the renal excretion of water and sodium. 3. Opioids produce changes in urine output and urine sodium exc...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Kapusta DR

    更新日期:1995-12-01 00:00:00

  • Down-regulation of microRNA-375 regulates adipokines and inhibits inflammatory cytokines by targeting AdipoR2 in non-alcoholic fatty liver disease.

    abstract::Non-alcoholic fatty liver disease (NAFLD) has been considered as a multi-factorial metabolic syndrome. MicroRNA-375 (MiR-375) was significantly up-regulated in serum of NAFLD patients and the role of miR-375 was addressed as a putative biomarker of NAFLD progression. However, the specific function of miR-375 in the pr...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Lei L,Zhou C,Yang X,Li L

    更新日期:2018-08-01 00:00:00

  • Effect of cold on fetal heart rate and its variability.

    abstract::1. The effects of cold saline (25 mL) injected over the fetal skin on fetal heart rate (HR) and HR variability (HRV), measured as the coefficient of variation (CV) in pulse interval (PI) and by power spectral analysis (PSA), were measured in 10 chronically catheterized fetal sheep aged 140-144 days. To determine the e...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Yu ZY,Lumbers ER

    更新日期:2000-08-01 00:00:00

  • Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation.

    abstract::Cellular senescence is a state of irreversible cell growth arrest. Increasing evidence suggests that cellular senescence contribute to tumour suppression in vivo. However, only a few anti-cancer drugs have been discovered to induce cellular senescence. Searching for new compounds which can inhibit cancer cell growth b...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Shang D,Wu Y,Ding Y,Lu Z,Shen Y,Zhu F,Liu H,Zhu C,Tu Z

    更新日期:2018-05-01 00:00:00

  • Responses of regional kidney perfusion to vasoconstrictors in anaesthetized rabbits: dependence on agent and renal artery pressure.

    abstract::1. We tested the effects of intravenous infusions of angiotensin II (AngII; 300 ng/kg per min) and the vasopressin V1 receptor agonist [Phe2,Ile3,Orn8]-vasopressin (30 ng/kg per min) on regional kidney perfusion in an extracorporeal circuit model in anaesthetized rabbits in which renal artery pressure (RAP) can be set...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Evans RG,Correia AG,Weekes SR,Madden AC

    更新日期:2000-12-01 00:00:00

  • Dalteparin dose-dependently increases ROTEM(®) thrombelastography parameters only at supratherapeutic anti-factor Xa levels: an in vitro study.

    abstract::1. The low molecular weight heparin (LMWH) dalteparin is used, for example, to prevent primary venous thromboembolism in patients undergoing surgery or in medically ill patients. The anticoagulant activity of dalteparin can be monitored by measuring anti-factor Xa levels and activated partial thromboplastin time (aPTT...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Feuring M,Wehling M,Schultz A

    更新日期:2011-11-01 00:00:00

  • Modelling the neural control of intrarenal blood flow.

    abstract::1. The aim of the present study was to produce a mathematical model that describes the way dynamic changes in renal sympathetic nerve activity affect renal, cortical and medullary blood flow. 2. Cortical blood flow (CBF) and medullary blood flow (MBF) were measured using laser-Doppler flowmetry and (total) renal blood...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Navakatikyan MA,Leonard BL,Evans RG,Malpas SC

    更新日期:2000-08-01 00:00:00

  • The effect of spontaneous diabetes mellitus on fatty acid oxidation, beta-hydroxybutyrate dehydrogenase activity and respiratory coupling of hepatic mitochondria in the guinea-pig (Cavia porcellus).

    abstract::1. The purpose of this study was to determine whether hepatic mitochondria of guinea-pigs with spontaneous diabetes mellitus differ from those of non-diabetic guinea-pigs in the oxidation of fatty acids, the activity of beta-hydroxybutyrate dehydrogenase, or respiration-linked oxidative phosphorylation. During the cou...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Nevalainen TO,White WJ,Lang CM,Munger BL

    更新日期:1978-05-01 00:00:00

  • Protective effects of magnesium against ischaemia-reperfusion injury through inhibition of P-selectin in rats.

    abstract::1. The leucocyte-mediated inflammatory response plays a pivotal role in ischaemia-reperfusion injury. P-Selectin and CD11b are important mediators for the recruitment of leucocytes into the endothelium. However, the time-course of changes in P-selectin and CD11b expression during reperfusion is not defined. Magnesium ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ying SQ,Fang L,Xiang MX,Xu G,Shan J,Wang JA

    更新日期:2007-12-01 00:00:00

  • Blunted renal vasoconstriction in patients with subclinical contrast-induced renal injury.

    abstract::Contrast media are considered to cause acute kidney injury by activating various factors that induce renal vasoconstriction. We analysed the renal microvascular haemodynamic response using the Doppler flow wire method. Then changes in urinary liver-type fatty acid-binding protein levels following contrast medium admin...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 信件


    authors: Kurihara O,Seino Y,Shibata Y,Matsushita M,Komiyama H,Kato K,Murakami D,Munakata R,Takano M,Miyauchi Y,Hata N,Shimizu W

    更新日期:2016-11-01 00:00:00

  • MiR-30a-5p ameliorates spinal cord injury-induced inflammatory responses and oxidative stress by targeting Neurod 1 through MAPK/ERK signalling.

    abstract::Spinal cord injury (SCI) is a major disability requiring more effective treatment than is currently available. MicroRNAs have been shown to effectively regulate gene expression at the translational level. The aim of the present study was to explore the potential role of miR-30-5p and possible mechanism in SCI. We foun...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Fu X,Shen Y,Wang W,Li X

    更新日期:2018-01-01 00:00:00

  • Ionic mechanisms regulating sodium entry into vascular smooth muscle.

    abstract::1. Na+/H+ exchange, an ethylisopropylamiloride (EIPA)-sensitive Na+ and HCO3- dependent system and a diisothio-cyanatostilbenedisulphonic acid (DIDS)-sensitive Na+ and HCO3- transporter, contribute to sodium influx and intracellular pH (pHi) regulation in vascular smooth muscle. 2. In cultured cells from the human int...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Bobik A,Little PJ,Neylon CB

    更新日期:1991-02-01 00:00:00

  • Autonomic control of bronchial circulation in awake sheep during rest and behaviour.

    abstract::1. We tested the hypothesis that the pattern and the intensity of autonomic mechanisms causing vasoconstriction in the resting bronchial circulation of awake dogs also exists in awake sheep. It was also postulated that sighing behaviour and the associated bronchovascular dilatation induced by non-adrenergic, non-choli...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: McIlveen S,White S,Parsons G

    更新日期:1997-12-01 00:00:00

  • Cimetidine and ranitidine: a study of competitive and ion-channel blockade in the toad isolated rectus abdominis muscle.

    abstract::Responses of the toad isolated rectus abdominis muscle to cumulative doses of carbachol were recorded in the absence or presence of varying concentrations of cimetidine or ranitidine. The corresponding cumulative log concentration-response curves for carbachol were then plotted for each antagonist studied. Cimetidine ...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Gwee MC,Cheah LS,Shoon ML

    更新日期:1986-08-01 00:00:00

  • Involvement of opioid system in antidepressant-like effect of the cannabinoid CB1 receptor inverse agonist AM-251 after physical stress in mice.

    abstract::Cannabinoid inverse agonists possess antidepressant-like properties, but the mechanism of this action is unknown. Numerous studies have reported the interaction between opioid and cannabinoid pathways. In this study, acute foot-shock stress was used in mice to investigate the involvement of the opioid pathway in the a...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Ostadhadi S,Haj-Mirzaian A,Nikoui V,Kordjazy N,Dehpour AR

    更新日期:2016-02-01 00:00:00

  • Pharmacological activities of the antihypertensive drug urapidil in the rat.

    abstract::Urapidil had blocking activity on alpha 1-adrenoceptors in the rat isolated caudal artery (pA2 congruent to 7) and in the anaesthetized rat. Urapidil had no clonidine like agonistic activity on alpha 2-adrenoceptors in preparations of the guinea-pig ileum (prejunctional) or dog saphenous vein (post-junctional). Urapid...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Verberne AJ,Rand MJ

    更新日期:1984-07-01 00:00:00

  • Inhibition of nuclear translocation of transcription factor nuclear factor-kappa B induces FAS- as well as tumour necrosis factor-alpha-mediated apoptosis through downregulation of a conserved family of inhibitor of apoptosis 1.

    abstract::1. In the present study, we examined whether the nuclear transcription factor (NF)-kappaB activity plays a role in the determination of sensitivity to tumour necrosis factor (TNF)-alpha or agonistic Fas antibody (Ab) in human vascular smooth muscle cells (hVSMC). 2. To inhibit agonist-induced NF-kappaB activation in h...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章


    authors: Imanishi T,Hano T,Takarada S,Nishio I

    更新日期:2003-03-01 00:00:00

  • Postnatal development of responses to airflow obstruction.

    abstract::1. Obstruction of the upper airway could be an initiating factor in the Sudden Infant Death Syndrome (SIDS). Responses to upper airway obstruction include augmentation of respiratory efforts, active dilation of the upper airway and electrocortical arousal. Vulnerable individuals may fail to mount these responses effec...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Harding R,Jakubowska AE,McCrabb GJ

    更新日期:1995-08-01 00:00:00

  • Signalling pathways activated by endothelin stimulation of renal cells.

    abstract::1. Endothelin mediates its effects in a variety of renal cells via a multiplicity of intracellular signalling pathways. 2. Stimulation of phosphatidylinositol-specific phospholipase C (PI-PLC), resulting in the activation of inositol trisphosphate and diacylglycerol, can be detected even at picomolar concentrations of...

    journal_title:Clinical and experimental pharmacology & physiology

    pub_type: 杂志文章,评审


    authors: Nord EP

    更新日期:1996-04-01 00:00:00