Modulation of signal transducers and activators of transcription (STAT) factor pathways during focal cerebral ischaemia: a gene expression array study in rat hippocampus after middle cerebral artery occlusion.

abstract：:MicroRNA plays an integral role in the development of atherosclerosis. Our study aimed to investigate the roles of miR-599 in lipopolysaccharide (LPS)-induced endothelial damage in human umbilical vein endothelial cells (HUVECs). HUVECs were transfected with a miR-599 mimic and negative control, and then exposed to LP...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang J,Du A,Wang H,Li Y

更新日期：2020-08-01 00:00:00

abstract：:1. Ghrelin is a multifunctional peptide hormone that affects various processes, including growth hormone and insulin release, appetite regulation, gut motility, metabolism and cancer cell proliferation. Ghrelin is produced in the stomach and in other normal and pathological cell types. It may act as an endocrine or au...

journal_title：Clinical and experimental pharmacology & physiology

authors： Seim I,Amorim L,Walpole C,Carter S,Chopin LK,Herington AC

更新日期：2010-01-01 00:00:00

abstract：:Nowadays, tramadol hydrochloride is frequently used as a pain reliever, and for the treatment of premature ejaculation. Decreased semen quality was noted in chronic tramadol users. The present study aimed to elucidate the effects of tramadol on the testicular functions of adult male rats. A total of 40 albino adult ma...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ahmed MA,Kurkar A

更新日期：2014-04-01 00:00:00

abstract：:1. In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Falckh PH,Harkin LA,Head RJ

更新日期：1992-08-01 00:00:00

abstract：:1. The aim of the present study was to investigate the effects of hypoxia on energy metabolism and contraction of rat urinary bladder smooth muscle, thereby gaining insight into the capacity of this smooth muscle to maintain contractile function when rendered hypoxic. 2. Isometric force, oxygen consumption, lactate pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wendt IR,Paul RJ

更新日期：2003-08-01 00:00:00

abstract：:1. The effects of the alpha-beta-adrenergic antagonist labetalol on the activation of human platelets by adrenaline and other aggregating stimuli have been investigated. 2. Labetalol inhibited platelet aggregation and secretion induced by collagen and the second phase of aggregation caused by ADP, platelet activating ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Anfossi G,Trovati M,Lanzio M,Mularoni E,Massucco P,Emanuelli G

更新日期：1988-06-01 00:00:00

abstract：:1. We studied the association between the level of the left ventricular ejection fraction and the severity of coronary atherosclerosis. 2. The study population consisted of 850 consecutive patients who underwent coronary angiography for suspected or known coronary atherosclerosis. Anthropometric measurements including...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jia EZ,Xu ZX,Yang ZJ,Zhu TB,Wang LS,Cao KJ,Ma WZ

更新日期：2011-02-01 00:00:00

abstract：:1. Indices quantifying blood pressure (BP) and heart rate (HR) variability have been recently developed and may be used to assess the contribution of the autonomic nervous system to cardiovascular fluctuations. 2. Cardiovascular variables were measured in eight conscious mice equipped with a BP telemetric device. Each...

journal_title：Clinical and experimental pharmacology & physiology

authors： Laude D,Baudrie V,Elghozi JL

更新日期：2008-04-01 00:00:00

abstract：:1. The renal medulla plays an important role in regulating body sodium and fluid balance and blood pressure homeostasis through its unique structural relationships and interactions between renomedullary interstitial cells (RMIC), renal tubules and medullary vasculature. 2. Several endocrine and/or paracrine factors, i...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhuo JL

更新日期：2000-07-01 00:00:00

abstract：:1. The present study was carried out to determine whether rilmenidine, a recently introduced antihypertensive agent which acts on alpha 2-adrenoceptors, has partial agonist activity on prejunctional alpha 2-adrenoceptors in guinea-pig atria. 2. Isolated preparations of guinea-pig atria were incubated with [3H]-noradre...

journal_title：Clinical and experimental pharmacology & physiology

authors： Li CG,Rand MJ

更新日期：1988-10-01 00:00:00

abstract：:Capillary permeability (CP) is elevated in late normal pregnancy, when compared to postpartum values. In women with pregnancy associated hypertension (PAH), pregnancy CP levels are not different from postpartum and are less than in normal pregnancy. These changes in capillary permeability are not explained by alterati...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hunyor SN,McEniery PT,Roberts KA,Bellamy GR,Roffe DJ,Gallery ED,Gyory AZ,Boyce ES

更新日期：1983-05-01 00:00:00

abstract：:1. The lamina terminalis, a region of the brain with a high concentration of angiotensin AT1 receptors, consists of three distinct nuclei, the median preoptic nucleus, the subfornical organ and organum vasculosum of the lamina terminalis (OVLT). These latter two regions lack a blood-brain and detect changes in plasma ...

journal_title：Clinical and experimental pharmacology & physiology

authors： McKinley MJ,Allen AM,May CN,McAllen RM,Oldfield BJ,Sly D,Mendelsohn FA

更新日期：2001-12-01 00:00:00

abstract：:1. The influence of the intact kidney on blood pressure, extracellular fluid volume (ECF, ferrocyanide space) and ECF volume distribution was studied in rats 60 days after constriction of the contralateral renal artery. 2. Renal artery constriction increased both blood pressure and ECF levels. The rise of both variabl...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kunes J,Jelínek J

更新日期：1979-09-01 00:00:00

abstract：:1. Adenosine A(1) receptors (A(1)R) play an important role in cardioprotection against hypoxic damage and the opening of mitochondrial permeability transition pores (MPTP) is central to the regulation of cell apoptosis and necrosis. However, it is still unclear whether A(1)R open MPTP in hypoxic cardiomyocytes. 2. The...

journal_title：Clinical and experimental pharmacology & physiology

authors： Xiang F,Huang YS,Zhang DX,Chu ZG,Zhang JP,Zhang Q

更新日期：2010-03-01 00:00:00

abstract：:1. The diffusional permeability of collecting ducts to 22Na+ and 36Cl- was measured in rat papillae in vitro. 2. The permeability of the collecting duct to 36Cl- was 0.72 (s.e.m. = 0.01; n = 356) microns/sec which was significantly higher than the value of 0.51 (s.e.m. = 0.01; n = 356) microns/sec measured for 22Na+. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morgan T,Ray C

更新日期：1982-11-01 00:00:00

abstract：:1. The aim of the present study was to explore the effects of CPU0213, a dual endothelin ET(A)/ET(B) receptor antagonist, and nifedipine, a calcium antagonist, in relieving pulmonary hypertension (PH). Both endothelin receptor and calcium antagonists have been reported to be effective in alleviating the remodelling of...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cui B,Cheng YS,Dai DZ,Li N,Zhang TT,Dai Y

更新日期：2009-02-01 00:00:00

abstract：:The chemosensitive cardiac vagal and sympathetic afferent reflexes are implicated in driving pathophysiological changes in sympathetic nerve activity (SNA) in cardiovascular disease states. This study investigated the impact of sex and ovarian hormones on the chemosensitive cardiac afferent reflex. Experiments were pe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pinkham MI,Barrett CJ

更新日期：2015-06-01 00:00:00

abstract：:1. Previous studies have demonstrated progressive ventricular hypertrophy, dilatation and contractile depression in response to chronic volume overload. Whether this decompensation was related to intrinsic myocyte dysfunction was not clear. The present study evaluated ventricular myocyte function at critical times dur...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ding YF,Brower GL,Zhong Q,Murray D,Holland M,Janicki JS,Zhong J

更新日期：2008-07-01 00:00:00

abstract：:1. Insulin-like growth factor (IGF)-I has acute effects on cardiovascular function, including a well-characterized vasodilator response in isolated arteries. In addition to increasing the release of nitric oxide, IGF-I also has effects on a variety of other signalling pathways that affect vascular tone, in particular ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Cao N,Lau S,Nguyen TT,White PJ

更新日期：2006-12-01 00:00:00

abstract：:In the present study, we investigated whether mood stabilizer lithium (Li) protects against d-amphetamine (AMP)-induced mania-like behaviours via modulating the novel proinflammatory potential. Repeated treatment with AMP resulted in significant increases in proinflammatory cyclooxygenase-2 (COX-2) and indolemaine-2,3...

journal_title：Clinical and experimental pharmacology & physiology

authors： Phan DH,Shin EJ,Jeong JH,Tran HQ,Sharma N,Nguyen BT,Jung TW,Nah SY,Saito K,Nabeshima T,Kim HC

更新日期：2020-05-01 00:00:00

abstract：:The combined administration of metronidazole and ampicillin increased faecal weights by 198% in normal male subjects on controlled diets with constant energy, protein and dietary fibre content. Intestinal transit times were unaltered despite marked increase in faecal weights. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kurpad AV,Shetty PS

更新日期：1984-09-01 00:00:00

abstract：:1. The present brief review examines some of the new developments in the area of circadian rhythm research. 2. The discovery of the mouse clock and m-per genes and their similarity to other clock genes like per and tim has provided new insight into the control of rhythms in vertebrates. In mice, these genes are expres...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kennaway DJ

更新日期：1998-10-01 00:00:00

abstract：:Short-term salt loading and salt restriction in a group of normal pregnant women produced no changes in lying, sitting or standing blood pressures or heart rates. Home blood pressures showed no trend to change over the periods of altered salt intake. Although plasma volume and plasma renin activity changed with altere...

journal_title：Clinical and experimental pharmacology & physiology

authors： McEniery PJ,Hunyor SN,Cooper KA,Gallery ED,Gyory AZ,Boyce ES

更新日期：1985-05-01 00:00:00

abstract：:1. For the past decade, using radioligand binding, contractility and immunohistochemical techniques, we have been characterizing vascular smooth muscle (VSM) adrenoceptors in four functionally different canine blood vessels, namely the dog aorta (DAO), dog mesenteric artery (DMA), dog mesenteric vein (DMV) and dog sap...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kwan DC

更新日期：1999-10-01 00:00:00

abstract：:The beta-receptor stimulant effects of Sm220Cl, dl-N-(1,1-dimethyl-3-phenylpropyl)-2-hydroxy-2-(3,4-dihydroxy-2-methoxyphenyl)ethylamine, and (-)-isoprenaline have been compared in isolated atrial (beta1) and tracheal (beta2) preparations from guinea-pigs and cats. 2. The compounds were also tested for their ability t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bohmer K,Raper C

更新日期：1977-07-01 00:00:00

abstract：:Age-related endothelial dysfunction is closely associated with the local production of reactive oxygen species (ROS) within and in the vicinity of the vascular endothelium. Oxidant-induced DNA damage can activate the nuclear enzyme poly(ADP-ribose) polymerase 1 (PARP-1), leading to endothelial dysfunction in various p...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhang GH,Chao M,Hui LH,Xu DL,Cai WL,Zheng J,Gao M,Zhang MX,Wang J,Lu QH

更新日期：2015-12-01 00:00:00

abstract：:The effect of indomethacin suppositories on both acute urinary colic and urinary calculus, resistant or refractory to conventional therapy with analgesics and spasmolytics was investigated. Fifty-five patients with acute urinary colic refractory to treatment with repeated injections of antispasmodics and analgesics ha...

journal_title：Clinical and experimental pharmacology & physiology

authors： Al-Waili NS

更新日期：1986-03-01 00:00:00

abstract：:Glycerophospholipids (GPs) and sphingolipids (SPs) are important lipid components in the body and play biological functions. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are important nutrients, and their supplements are commonly used for preventing some diseases. However, the effect of n-3 PUFAs on the human glyce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yan M,Cai WB,Hua T,Cheng Q,Ai D,Jiang HF,Zhang X

更新日期：2020-07-01 00:00:00

abstract：:1. At any one instant, most receptors are now recognized to be able to stimulate multiple signal transduction pathways in a cell when activated by an appropriate hormone. These different signalling pathways appear to allow for distinct cellular responses, such as cell proliferation, differentiation, and shape change. ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Crouch MF,Frew IJ,Simson L,Davy DA

更新日期：1997-08-01 00:00:00

abstract：:1. The turnover rate of inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) in noradrenaline-stimulated adult rat left atria was calculated from changes in specific activity and was found to equal 110 ct/min per mg tissue. In contrast, the isomers of inositol mono- and bisphosphates accumulated at a rate of 508 ct/min per mg....

journal_title：Clinical and experimental pharmacology & physiology

authors： Anderson KE,Myers D,Woodcock EA

更新日期：1993-05-01 00:00:00