The action of aspirin on plasma kininogen and other plasma proteins in rheumatoid patients: relationship to disease activity.

abstract：:1. Na+/H+ exchange, an ethylisopropylamiloride (EIPA)-sensitive Na+ and HCO3- dependent system and a diisothio-cyanatostilbenedisulphonic acid (DIDS)-sensitive Na+ and HCO3- transporter, contribute to sodium influx and intracellular pH (pHi) regulation in vascular smooth muscle. 2. In cultured cells from the human int...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bobik A,Little PJ,Neylon CB

更新日期：1991-02-01 00:00:00

abstract：:1. Most studies examining the effect of angiotensin-converting enzyme (ACE) inhibitors on atherosclerosis in experimental animals have used doses well in excess of those given clinically. 2. Using a rabbit model of cholesterol-induced atherosclerosis characterized by subendothelial lipid accumulations ('juvenile fatty...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fennessy PA,Campbell JH,Mendelsohn FA,Campbell GR

更新日期：1996-08-01 00:00:00

abstract：:Studies in rats have shown that neomycin administration attenuates certain types of adrenocortical steroid dependent hypertension, including ACTH hypertension. The effects of oral neomycin on ACTH induced hypertension were examined in conscious sheep. Neomycin has no effect on the blood pressure or metabolic responses...

journal_title：Clinical and experimental pharmacology & physiology

authors： Tresham J,Coghlan JP,Denton DA,Scoggins BA,Whitworth JA

更新日期：1984-11-01 00:00:00

abstract：:1. Core temperature (Tc), cardiovascular and renal responses to lipopolysaccharide (LPS), as well as the role of endogenously produced prostaglandins (PG) in influencing these responses, were investigated in the present study in conscious, chronically instrumented lambs. 2. Core temperature, mean arterial pressure, he...

journal_title：Clinical and experimental pharmacology & physiology

authors： Smith FG,Fewell JE,Qi W

更新日期：2011-08-01 00:00:00

abstract：:1. Infusion of salbutamol (3.0 microgram/min after a bolus injection of 100 microgram) produced hypokalaemia in conscious dogs. 2. Measurement of arterial and coronary sinus potassium differences revealed no significant potassium loss from the heart with established hypokalaemia. 3. Shortly after the initial salbutamo...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wahlqvist ML,Shanahan EA,Dennis PM,Pullan PT,Wilmshurst EG

更新日期：1978-11-01 00:00:00

abstract：:1. To elucidate the physiological role of nitric oxide (NO) in regulating vascular tone, the effects of NG-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, on the vasoconstrictor response to noradrenaline (NA) in rat caudal artery was examined. 2. NG-Nitro-L-arginine methyl ester significantly potenti...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kwon YM,Shinozuka K,Kagota S,Yamaguchi Y,Nakamura K,Kunitomo M

更新日期：1999-05-01 00:00:00

abstract：:Osteosarcoma is the most common non-hematological primary bony malignancy in children and young adults with tumor metastasis being a common event at diagnosis. Understanding the pathogenesis of metastatic osteosarcoma may help identify potential therapeutic targets. In this study, we found that the level of microRNA-6...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jiao GJ,Zhang SJ,Li Y,Wu WL,Liu HC

更新日期：2018-12-01 00:00:00

abstract：:1. Medullary blood flow (MBF) is important in the long-term control of arterial pressure. However, it is unclear which vascular elements regulate MBF. 2. Exogenous endothelin (ET)-1 decreases cortical more than medullary blood flow. We hypothesized that ET-1 would therefore constrict afferent (AA) and efferent arterio...

journal_title：Clinical and experimental pharmacology & physiology

authors： Denton KM,Shweta A,Finkelstein L,Flower RL,Evans RG

更新日期：2004-08-01 00:00:00

abstract：:1. Plasma drug levels and blood pressure changes produced by a single 2 mg oral dose of prazosin were determined in nine hypertensive patients. 2. Regression analysis showed that there was a high degree of correlation between plasma prazosin concentration and change in mean blood pressure. 3. There were marked differe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Stokes GS,Monaghan JC,MacCarthy EP,Oates HF

更新日期：1980-03-01 00:00:00

abstract：:1. Using the electromagnetic flow probe and the radioactive microsphere technique, systemic and regional haemodynamic variables were measured in conscious normotensive and hypertensive rabbits. The rabbits were made hypertensive by unilateral nephrectomy combined with cellophane-wrapping of the remaining kidney and sy...

journal_title：Clinical and experimental pharmacology & physiology

authors： van Boom M,Saxena PR

更新日期：1981-05-01 00:00:00

abstract：:1. There has been considerable recent interest in the possibility that increased intake of dietary anti-oxidants may protect against cardiovascular disease. This is partly due to the knowledge that oxidative events in vivo may play a role in the pathogenesis of atherosclerosis. 2. While dietary anti-oxidants, such as ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morton LW,Abu-Amsha Caccetta R,Puddey IB,Croft KD

更新日期：2000-03-01 00:00:00

abstract：:1. The concentration of methylguanidine and guanidinosuccinic acid has been measured in normal human plasma and discrepancies between various published methods for measuring methylguanidine have been resolved. Previous methods have been modified to allow these guanidines, together with guanidinoacetic acid and creatin...

journal_title：Clinical and experimental pharmacology & physiology

authors： Lazdins I,Dawborn JK

更新日期：1978-01-01 00:00:00

abstract：:1. Sodium (Na) depletion, due to uncompensated loss of parotid saliva, reduces the pressor responsiveness to angiotensin II (AII) in intact conscious sheep. 2. Inhibition of prostaglandin synthesis by indomethacin restored AII pressor responsiveness in Na-deplete sheep. 3. Indomethacin infusion also increased the pres...

journal_title：Clinical and experimental pharmacology & physiology

authors： Beilby DS,Coghlan JP,Denton DA,Graham WF,Humphery TJ,Scoggins BA,Whitworth JA

更新日期：1981-01-01 00:00:00

abstract：:This study investigated if the protective effect of taurine against high fat diet-induced hepatic steatosis involves modulating the hepatic activity of 5' AMP-activated protein kinase (AMPK) and levels/activity of the sterol regulatory element-binding proteins-1/2 (SREBP1/2). Rats were divided into four groups (n = 12...

journal_title：Clinical and experimental pharmacology & physiology

authors： Morsy MD,Aboonq MS,ALsleem MA,Abusham AA

更新日期：2020-07-21 00:00:00

abstract：:1. There was no significant difference between the systolic blood pressure (SBP) of offspring derived from SHRSP mother and WKY father and the SBP of offspring derived from WKY mother and SHRSP father at the developing stage (5-13 weeks of age). 2. The degree of genetic determinations of SBP in stroke-prone spontaneou...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ikeda K,Nara Y,Nabica T,Fujimoto A,Endo J,Ishino H,Yamori Y

更新日期：1991-09-01 00:00:00

abstract：:1. We tested the hypothesis that increasing myocardial cyclic GMP levels would reduce myocardial O2 consumption and areas of low O2 supply/consumption balance, using zaprinast, a selective cyclic GMP-phosphodiesterase inhibitor. 2. The study was conducted in three groups (vehicle, 10(-3) and 3 x 10(-3) mol/L zaprinast...

journal_title：Clinical and experimental pharmacology & physiology

authors： Weiss HR,Rodriguez E,Tse J,Scholz PM

更新日期：1994-08-01 00:00:00

abstract：:1. The physiological relevance of cardiac and vascular alpha-adrenoceptors may increase in disease states in which beta-adrenoceptors are altered. To test this, positive inotropic and vasoconstrictor responses to phenylephrine were measured in isolated tissues from rats with experimentally-induced hyperthyroidism, hyp...

journal_title：Clinical and experimental pharmacology & physiology

authors： Brown L,Amos G,Miller B

更新日期：1994-09-01 00:00:00

abstract：:1. It is known that the alpha(4)-subunit is likely to occur in the brain predominantly in alpha(4)beta(3)delta receptors at extrasynaptic sites. Recent studies have revealed that the alpha(1)-, alpha(4)-, gamma(2)- and delta-subunits may colocalize extrasynaptically in dentate granule cells of the hippocampus. In the ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang MD,Rahman M,Johansson IM,Bäckström T

更新日期：2010-07-01 00:00:00

abstract：:1. The actions of lidocaine on cardiac pacemaker rhythms were studied in anaesthetized dogs and in Purkinje fibres from hearts of the same animals. 2. In vivo, lidocaine (1 mg/kg, intravenously) slowed the sino-atrial (SA) node rhythm (-5.0%), and (during vagal stimulation) prolonged ventricular standstill by +25.1% a...

journal_title：Clinical and experimental pharmacology & physiology

authors： Abete P,Ferrara N,Rengo F,Vassalle M

更新日期：1991-03-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a progressively fatal form of cancer originating from the malignant transformation of hepatic biliary cholangiocytes. The present study reports for the first time in vitro growth inhibitory activities of β-eudesmol, the bioactive sesquiterpenoid present in the rhizome of Atractylodes lancea...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mathema VB,Chaijaroenkul W,Karbwang J,Na-Bangchang K

更新日期：2017-11-01 00:00:00

abstract：:1. This study aimed to characterize the effect of nicorandil (NC) on myocardial stunning and the role of ATP-sensitive K+ (KATP) channel opening property in its cardioprotective action. 2. In open-chest anaesthetized rabbits, myocardial stunning was induced by 10 min of coronary occlusion followed by 30 min of reperfu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Iwamoto T,Miura T,Urabe K,Itoya M,Shimamoto K,Iimura O

更新日期：1993-09-01 00:00:00

abstract：:1. The leucocyte-mediated inflammatory response plays a pivotal role in ischaemia-reperfusion injury. P-Selectin and CD11b are important mediators for the recruitment of leucocytes into the endothelium. However, the time-course of changes in P-selectin and CD11b expression during reperfusion is not defined. Magnesium ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ying SQ,Fang L,Xiang MX,Xu G,Shan J,Wang JA

更新日期：2007-12-01 00:00:00

abstract：:1. In the present study, we investigated aqueous extracts of Anoectochilus formosanus (AFE) for antihyperglycaemic and anti-oxidant effects in diabetic rats induced by streptozotocin (STZ). 2. Diabetic rats were randomly divided into groups and treated orally by gavage with vehicle (distilled water) or AFE (1 and 2 g/...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shih CC,Wu YW,Lin WC

更新日期：2002-08-01 00:00:00

abstract：:Simultaneous measurements of smooth muscle membrane potential and tension were made from isolated pieces of rat tail artery. A single electrical stimulus to the perivascular nerves produced a transient contraction of the smooth muscle. The amplitude of the contraction was increased after removal of the endothelium. Th...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kotecha N,Neild TO

更新日期：1986-03-01 00:00:00

abstract：:1. 125I-351A, a tyrosyl derivative of the angiotensin converting enzyme (ACE) inhibitor lisinopril, was used as a radioligand, and radioinhibitor binding and displacement assays have been established. 2. The in vitro potency of a range of ACE inhibitors against rat ACE was determined using the radioinhibitor binding d...

journal_title：Clinical and experimental pharmacology & physiology

authors： Johnston CI,Cubela R,Jackson B

更新日期：1988-02-01 00:00:00

abstract：:Placental growth factor (PlGF) is decreased in early gestation of pregnant women who subsequently develop pre-eclampsia. In this study, pre-emptive treatment with PlGF to prevent pre-eclampsia was evaluated in an in vivo rodent model of experimental pre-eclampsia (EPE) induced by TNF-α and in an in vitro model of huma...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chau K,Bobek G,Xu B,Stait-Gardner T,Price W,Hennessy A,Makris A

更新日期：2020-01-01 00:00:00

abstract：:1. Hypertension plays a critical role in the progression of chronic kidney disease (CKD) to end-stage renal disease (ESRD), but it has also been postulated that antihypertensive drugs that block the renin-angiotensin system (RAS) show class-specific renoprotective actions beyond their blood pressure (BP)-lowering effe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kujal P,Chábová VČ,Vernerová Z,Walkowska A,Kompanowska-Jezierska E,Sadowski J,Vaňourková Z,Husková Z,Opočenský M,Skaroupková P,Schejbalová S,Kramer HJ,Rakušan D,Malý J,Netuka I,Vaněčková I,Kopkan L,Cervenka L

更新日期：2010-12-01 00:00:00

abstract：:Hyperglycaemia-induced neurotoxicity involved in the pathogenesis of diabetic encephalopathy and neuronal senescence is one of the worst effects of hyperglyceamic neurotoxicity. Cannabinoid receptor type 1 (CB1) has neuroprotective function in a series of neuropathy. Spermidine (Spd) has anti-aging function in many ti...

journal_title：Clinical and experimental pharmacology & physiology

authors： Zhu WW,Xiao F,Tang YY,Zou W,Li X,Zhang P,Wang AP,Tang XQ

更新日期：2018-08-01 00:00:00

abstract：:1. Infusion of increasing doses of angiotensin II (AII) in normal subjects sequentially increased blood pressure, aldosterone and atrial natriuretic peptide (ANP) levels. 2. The slope of ANP response to AII was positively correlated with basal ANP and with the slope of blood pressure response to AII (pressor slope) bu...

journal_title：Clinical and experimental pharmacology & physiology

authors： Finn WL,Tunny TJ,Klemm SA,Ryan SJ,Gordon RD

更新日期：1993-05-01 00:00:00

abstract：:1. In the [(13)C]-octanoic acid breath test, the time versus pulmonary [(13)CO(2)] excretion rate curve is analysed using mathematical curve-fitting techniques to calculate gastric emptying parameters. Thus, the goodness-of-fit highly influences the accuracy of the breath test. However, a double-peaked [(13)CO(2)] exc...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sanaka M,Yamamoto T,Tsutsumi H,Abe K,Kuyama Y

更新日期：2005-07-01 00:00:00