Low KISS1 expression predicts poor prognosis for patients with colorectal cancer: A meta-analysis.

abstract：:1. In the present study we have examined the effects of angiotensin I converting enzyme (ACE) inhibition and nitric oxide (NO) synthesis inhibition on bradykinin (BK) depressor responses in pregnancy in both Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR). 2. Ramipril (10 mg/kg, i.v.) significantly reduce...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chu ZM,Beilin LJ

更新日期：1995-06-01 00:00:00

abstract：:1. The effects of left ventricular repair (LVR) surgery for ischaemic or dilated cardiomyopathy are not fully understood. The development of a proper animal model will help to resolve this issue. 2. The ischaemic cardiomyopathy (ICM) model used was as follows. Twenty-six rats developed ICM with a large akinetic left v...

journal_title：Clinical and experimental pharmacology & physiology

authors： Nishina T,Miwa S,Yuasa S,Nishimura K,Komeda M

更新日期：2002-08-01 00:00:00

abstract：:1. Patients were grouped into categories of 'no airways disease', 'obstructive airways disease without response to bronchodilator' and 'obstructive airways disease with bronchodilator responsiveness'. 2. Cyclic nucleotides were assayed in specimens of lung tissue that were excised during surgery. 3. Reduced levels of ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Krzanowski JJ,Polson JB,Goldman AL,Ebel TA,Szentivanyi A

更新日期：1979-01-01 00:00:00

abstract：:The antihypertensive agent rilmenidine has threefold higher affinity for I(1) imidazoline receptors compared with alpha(2)-adrenoceptors and acts on the central nervous system by reducing sympathetic activity and in the kidney by inhibiting Na(+)/H(+) exchange activity. In the present study, we examined: (i) the effec...

journal_title：Clinical and experimental pharmacology & physiology

authors： Jovanovska V,Eitle E,Harris PJ

更新日期：2004-05-01 00:00:00

abstract：:1. The present study examined the effects of an aqueous extract of Anoectochilus formosanus (AFE) on both hepatic fibrosis and regeneration in rats. 2. Fibrosis was induced by intraperitoneal injection of dimethylnitrosamine (DMN) for 3 consecutive days per week for 4 weeks. 3. In DMN-treated rats, liver cirrhosis-ass...

journal_title：Clinical and experimental pharmacology & physiology

authors： Shih CC,Wu YW,Hsieh CC,Lin WC

更新日期：2004-09-01 00:00:00

abstract：:1. Currently, there is no satisfactory treatment for pulmonary fibrosis. Emodin, a component in Chinese herbs, has been shown to have an antifibrotic effect on pancreatic fibrosis and liver fibrosis. In the present study, we tested the hypothesis that emodin may attenuate the development of pulmonary fibrosis. 2. Mice...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chen XH,Sun RS,Hu JM,Mo ZY,Yang ZF,Jin GY,Guan WD,Zhong NS

更新日期：2009-02-01 00:00:00

abstract：:1. The effects of cold saline (25 mL) injected over the fetal skin on fetal heart rate (HR) and HR variability (HRV), measured as the coefficient of variation (CV) in pulse interval (PI) and by power spectral analysis (PSA), were measured in 10 chronically catheterized fetal sheep aged 140-144 days. To determine the e...

journal_title：Clinical and experimental pharmacology & physiology

authors： Yu ZY,Lumbers ER

更新日期：2000-08-01 00:00:00

abstract：:1. Plasma concentration and atrial content of atrial natriuretic factor (ANF) were measured in rats with chronic renal failure induced by subtotal nephrectomy. 2. Plasma ANF was higher, and atrial ANF content lower in rats with renal failure when compared with sham-operated controls. 3. Plasma renin activity (PRA) and...

journal_title：Clinical and experimental pharmacology & physiology

authors： Hodsman GP,Jackson B,Debrevi LM,Ogawa K,Johnston CI

更新日期：1987-03-01 00:00:00

abstract：:1. The turnover rate of inositol(1,4,5)trisphosphate (Ins(1,4,5)P3) in noradrenaline-stimulated adult rat left atria was calculated from changes in specific activity and was found to equal 110 ct/min per mg tissue. In contrast, the isomers of inositol mono- and bisphosphates accumulated at a rate of 508 ct/min per mg....

journal_title：Clinical and experimental pharmacology & physiology

authors： Anderson KE,Myers D,Woodcock EA

更新日期：1993-05-01 00:00:00

abstract：:1. The effect of endothelin-1 on the release of adrenal catecholamines was examined in anaesthetized dogs. 2. Splanchnic nerve stimulation (SNS) at 1 and 3 Hz was applied before and after the intravenous injection of endothelin-1. 3. Endothelin-1 (0.1 and 0.3 micrograms/kg) significantly enhanced the release of adrena...

journal_title：Clinical and experimental pharmacology & physiology

authors： Takeuchi A,Kimura T,Satoh S

更新日期：1992-09-01 00:00:00

abstract：:1. It has been suggested that oestrogen-produced vasodilatation is due to induction of endothelial nitric oxide synthase (NOS), but there are many reports of direct effects on vascular smooth muscle. In the present study, these processes were investigated in rat aorta isolated from ovariectomized rats. 2. Short-term t...

journal_title：Clinical and experimental pharmacology & physiology

authors： Binko J,Murphy TV,Majewski H

更新日期：1998-02-01 00:00:00

abstract：:1. The intrinsic sympathomimetic activity of a range of beta-adrenoceptor antagonists and its relationship to beta-adrenoceptor blockade was studied in pentobarbitone-anaesthetized, vagotomized rats which had been depleted of catecholamines by pretreatment with syrosingopine. Dichlorisoprenaline, practolol, oxprenolol...

journal_title：Clinical and experimental pharmacology & physiology

authors： Bilski A,Robertson HH,Wale JL

更新日期：1979-01-01 00:00:00

abstract：:1. Phytoncides are volatile substances released mainly from trees. We studied whether phytoncides can reduce stress responses in stroke-prone spontaneously hypertensive rats (SHRSP). 2. Under the restraint stress, SHRSP exposed to phytoncides showed lower blood pressure than those without the exposure (186.8 +/- 3.9 v...

journal_title：Clinical and experimental pharmacology & physiology

authors： Kawakami K,Kawamoto M,Nomura M,Otani H,Nabika T,Gonda T

更新日期：2004-12-01 00:00:00

abstract：:Spinal cord injury (SCI) is a major disability requiring more effective treatment than is currently available. MicroRNAs have been shown to effectively regulate gene expression at the translational level. The aim of the present study was to explore the potential role of miR-30-5p and possible mechanism in SCI. We foun...

journal_title：Clinical and experimental pharmacology & physiology

authors： Fu X,Shen Y,Wang W,Li X

更新日期：2018-01-01 00:00:00

abstract：:Doxorubicin (DOX) is the most commonly used anticancer drug; however, it has limited use because prolonged administration may result in severe cardiotoxicity. Simvastatin (SIM), generally prescribed for hypercholesterolaemia, has also shown salubrious results in the monotherapy or combinational drug therapy of differe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Alkreathy HM,Alkhatib MH,Al Musaddi SA,Balamash KSA,Osman NN,Ahmad A

更新日期：2019-05-01 00:00:00

abstract：:We evaluated the role of deferasirox therapeutic drug monitoring in order to avoid toxicity or treatment failure. Plasma concentrations, measured between two consecutive liver iron determinations, were determined at the end of dosing interval. Fifty-four β-thalassemic adult patients were enrolled: 50% were males; medi...

journal_title：Clinical and experimental pharmacology & physiology

authors： Allegra S,Massano D,De Francia S,Longo F,Piccione F,Pirro E,Cusato J,D'Avolio A,Piga A

更新日期：2018-02-01 00:00:00

abstract：:1. The aim of the present study was to evaluate the clinical value of colour Doppler application in encircling constriction of the superficial femoral vein in deep vein insufficiency. 2. A total of 87 patients with primary deep venous insufficiency (PDVI) using ascending venography were randomly divided into group A (...

journal_title：Clinical and experimental pharmacology & physiology

authors： Wang T,Wang L,Yi J,Yao Q,Chen JH,Yuan SF,Zhang JL,Yun J,Han ZH,Ren J,Ling R

更新日期：2011-12-01 00:00:00

abstract：:1. Initial unsuccessful attempts to evaluate ventricular function in terms of the 'heart as a pump' led to focusing on the 'heart as a muscle' and to the concept of myocardial contractility. However, no clinically ideal index exists to assess the contractile state. The aim of the present study was to develop a mathema...

journal_title：Clinical and experimental pharmacology & physiology

authors： Curiel R,Perez-Gonzalez J,Torres E,Landaeta R,Cerrolaza M

更新日期：2005-10-01 00:00:00

abstract：:1. Salt intake is not only known to play an important role in determining blood pressure (BP) but has been shown to have other deleterious effects independent of BP. 2. Epidemiological and animal studies have provided evidence that salt intake may have an adverse effect on stroke mortality independent of BP. 3. Signif...

journal_title：Clinical and experimental pharmacology & physiology

authors： Antonios TF,MacGregor GA

更新日期：1995-03-01 00:00:00

abstract：:1. In order to explore the mechanisms responsible for the hypernoradrenergic innervation of the vasculature in the spontaneously hypertensive rat (SHR) the tissue content of nerve growth factor messenger ribonucleic acid (NGFmRNA) was examined. 2. The concentration of NGFmRNA was markedly elevated in mesenteric veins ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Falckh PH,Harkin LA,Head RJ

更新日期：1992-08-01 00:00:00

abstract：:1. Following local vasoconstriction-inducing stimuli, such as the cold pressor test (CPT), significant changes occur in haemodynamics, with a rise in arterial blood pressure and heart rate (HR) due to the activation of the sympathetic nervous system. Among the compensatory mechanisms to local ischaemia, the endogenous...

journal_title：Clinical and experimental pharmacology & physiology

authors： Pasini FL,Capecchi PL,Colafati M,Randisi P,Puccetti L,Di Perri T

更新日期：1999-10-01 00:00:00

abstract：:1. The aim of the present study was to characterize the source of plasma catecholamines induced by centrally administered glucagon-like peptide-1 (GLP-1), with regard to brain prostanoids, in urethane-anaesthetized rats. 2. Glucagon-like peptide-1 and other compounds were administered intracerebroventricularly (i.c.v....

journal_title：Clinical and experimental pharmacology & physiology

authors： Arai J,Okada S,Yamaguchi-Shima N,Shimizu T,Sasaki T,Yorimitsu M,Wakiguchi H,Yokotani K

更新日期：2008-08-01 00:00:00

abstract：:1. Nitric oxide (NO) plays an important role in the control of glomerular haemodynamics and is synthesized from the amino acid L-arginine by a family of enzymes, NO synthase (NOS). 2. Nitric oxide synthase is present in the endothelium and also in the macula densa, a plaque of specialized tubular epithelial cells. End...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ito S,Carretero OA,Abe K

更新日期：1997-08-01 00:00:00

abstract：:1. The leucocyte-mediated inflammatory response plays a pivotal role in ischaemia-reperfusion injury. P-Selectin and CD11b are important mediators for the recruitment of leucocytes into the endothelium. However, the time-course of changes in P-selectin and CD11b expression during reperfusion is not defined. Magnesium ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Ying SQ,Fang L,Xiang MX,Xu G,Shan J,Wang JA

更新日期：2007-12-01 00:00:00

abstract：:1. In infants, promethazine has been implicated in the pathogenesis of sleep apnoea, apparent life threatening events (ALTE) and the Sudden Infant Death syndrome (SIDS). The aim of the present study was to investigate, in a neonatal animal, the effects of a commonly used promethazine-containing medication on airway pr...

journal_title：Clinical and experimental pharmacology & physiology

authors： McKelvey GM,Post EJ,Wood AK,Jeffery HE

更新日期：2001-07-01 00:00:00

abstract：:A high-salt diet in rats has been shown to result in enhanced vasoconstrictor and/or reduced vasodilator responses of isolated arteries to agonists. The present experiments were designed to investigate the effects of dietary salt on the responses of the pressurized mesenteric resistance artery of the dog to constricto...

journal_title：Clinical and experimental pharmacology & physiology

authors： Sofola O,Knill A,Myers D,Hainsworth R,Drinkhill M

更新日期：2004-10-01 00:00:00

abstract：:1. Whole-cell patch recordings were made from antidromically identified sympathetic preganglionic neurons (SPN) of immature rat spinal cord slices. Bath application of nociceptin (0.1-1 micromol/L) suppressed excitatory postsynaptic potentials (EPSP) and hyperpolarized a population of SPN; these effects were naloxone ...

journal_title：Clinical and experimental pharmacology & physiology

authors： Brailoiu GC,Lai CC,Chen CT,Hwang LL,Lin HH,Dun NJ

更新日期：2002-03-01 00:00:00

abstract：:1. Dexamethasone (Dex)-induced hypertension is characterized by endothelial dysfunction associated with nitric oxide (NO) deficiency and increased superoxide (O2-) production. Atorvastatin (Ato) possesses pleiotropic properties that have been reported to improve endothelial function through increased availability of N...

journal_title：Clinical and experimental pharmacology & physiology

authors： Mondo CK,Yang WS,Zhang N,Huang TG

更新日期：2006-11-01 00:00:00

abstract：:1. An antisense oligonucleotide (ASO) is a short strand of deoxyribonucleotide analogue that hybridizes with the complementary mRNA in a sequence-specific manner via Watson-Crick base pairing. Formation of the ASO-mRNA heteroduplex either triggers RNase H activity, leading to mRNA degradation, induces translational ar...

journal_title：Clinical and experimental pharmacology & physiology

authors： Chan JH,Lim S,Wong WS

更新日期：2006-05-01 00:00:00

abstract：:1. Hepatic resection with concomitant periods of ischaemia and reperfusion (I/R) is required to perform reduced-size liver (RSL) transplantation procedures, such as living donor or split liver transplantation. Although a great deal of progress has been made using these types of surgical procedures, a significant numbe...

journal_title：Clinical and experimental pharmacology & physiology

authors： Urakami H,Abe Y,Grisham MB

更新日期：2007-09-01 00:00:00