Primary scrotal malignant melanoma. Report of 2 cases and review of the literature.

abstract：:The effect of malignant tumor growth on host's megakaryocytopoiesis and platelet production was studied in mice bearing transplantable Dalton's lymphoma. Tumor growth was paralleled by thrombocytosis, neutrophilia, and anemia. Platelet 51Cr half-life was normal but incorporation of 75Selenomethionine into circulating ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ray MR

更新日期：2000-12-01 00:00:00

abstract：:p21WAF1,CIP1,SDI 1 is a specific inhibitor of cyclin-dependent kinase and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Cdk1/p34cdc2 plays a crucial role during mitosis. The immunoreactivity of p21 WAF1,CIP1,SDI 1 and cdk1/p34cdc2 was evaluated in adenomas and adenocarcinomas of the hum...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Egilmez R,Elagöz S,Kanik EA

更新日期：2001-12-01 00:00:00

abstract：:This study is aimed at evaluating the inhibitory effects of the association of hematoporphyrin and ultrasound at variable intensities with a fixed frequency of 1.1MHz in tumor nodules. Specifically, the effects were studied both in solid and ascitic S180 tumors transplanted in mice by clinical, cytochemical and ultras...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Quan-hong L,Shi-hui S,Ya-ping X,Hao Q,Jin-xuan Z,Yao-hui R,Meng L,Pan W

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Coiled-Coil Domain Containing 88A (CCDC88A) was identified as a substrate of the serine/threonine kinase Akt that is capable of binding to the actin cytoskeleton. The aim of this study was to investigate the potential role of CCDC88A in the migration and invasiveness of pancreatic ductal adenocarcinoma (PDAC...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tanouchi A,Taniuchi K,Furihata M,Naganuma S,Dabanaka K,Kimura M,Watanabe R,Kohsaki T,Shimizu T,Saito M,Hanazaki K,Saibara T

更新日期：2016-12-05 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the major histological type of liver cancer with high morbidity and mortality worldwide. Long noncoding RNAs (lncRNA) has been proved to be associated with various cancer types, while its regulation in HCC is largely unknown. METHODS:To figure out the specific role of lncRN...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang YG,Wang T,Shi M,Zhai B

更新日期：2019-04-10 00:00:00

abstract：BACKGROUND:Increased serum level of parathyroid hormone (PTH) was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress cell proliferation and to induce apoptosis in parathyroid cells. In this study, we investigated the effect of R-568 on cellular survival of prosta...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li H,Ruan G,Li Z,Liu Z,Zheng X,Zheng H,Cheng G,Li B,Zhan M

更新日期：2009-07-14 00:00:00

abstract：BACKGROUND:The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here, we identified hyperactivated mitophagy is essential for sor...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wu H,Wang T,Liu Y,Li X,Xu S,Wu C,Zou H,Cao M,Jin G,Lang J,Wang B,Liu B,Luo X,Xu C

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Revealing the mechanical role of long non-coding RNAs (lncRNAs) in tumorigenesis can contribute to novel therapeutic target for cancers. The regulatory role of linc01134 in hepatocellular carcinoma (HCC) has not been studied yet. MATERIALS AND METHODS:qRT-PCR and western blot were conducted to measure relev...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rong Z,Wang Z,Wang X,Qin C,Geng W

更新日期：2020-04-09 00:00:00

abstract：:The aim of this study was to assess the nuclear/cytoplasmic (N/C) ratio using computerized image analysis of cervical smears with intraepithelial neoplasia (CIN) grade I to III associated or not with cellular changes of human papillomavirus (HPV) in an attempt to determine if this method is more sensitive for the esti...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Athanassiadou P,Kavantzas N,Gonidi M,Athanassiades P,Liossi A,Nakopoulou L,Petrakakou E,Davaris P

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Human placental development resembles tumorigenesis, due to the invasive and fusogenic potential of trophoblasts. However, these features are tightly controlled in trophoblasts. Disturbance of this spatial and temporal regulation is thought to contribute to the rare formation of choriocarcinomas. Promoter hy...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Huebner H,Strick R,Wachter DL,Kehl S,Strissel PL,Schneider-Stock R,Hartner A,Rascher W,Horn LC,Beckmann MW,Ruebner M,Fahlbusch FB

更新日期：2017-11-23 00:00:00

abstract：:Our previous studies have demonstrated the significant enzymatic activity of glycogen phosphorylase (GP) in the gastric carcinoma and proliferating cells of particular intestinal metaplasia (IM). This paper reviewed the identification of the GP isoform in the gastrointestinal carcinoma, and the investigation on the ro...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shimada S,Tashima S,Yamaguchi K,Matsuzaki H,Ogawa M

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis. MATERIALS AND METHODS:Expression of a putative intestinal stem cell marker LgR5 was analyzed in esophageal can...

journal_title：Journal of experimental & clinical cancer research : CR

authors： von Rahden BH,Kircher S,Lazariotou M,Reiber C,Stuermer L,Otto C,Germer CT,Grimm M

更新日期：2011-02-23 00:00:00

abstract：BACKGROUND:The transcription factor HOXD9 is one of the members of the HOX family, which plays an important role in neoplastic processes. However, the role of HOXD9 in the growth and metastasis of gastric cancer (GC) remains to be elucidated. METHODS:In vitro functional role of HOXD9 and RURY3 in GC cells was determin...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhu H,Dai W,Li J,Xiang L,Wu X,Tang W,Chen Y,Yang Q,Liu M,Xiao Y,Zhang W,Lin J,Wang J,Liu G,Sun Y,Jiang P,Li G,Li A,Liu S,Chen Y,Wang J

更新日期：2019-09-23 00:00:00

abstract：BACKGROUND:Patients with endometrial cancer (EC) and presumably with good prognosis may develop a recurrence indicating that the classification of this tumor is still not definitive and that new markers are needed to identify a subgroup at risk of relapse. The cell adhesion molecule L1CAM is highly expressed in several...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Corrado G,Laquintana V,Loria R,Carosi M,de Salvo L,Sperduti I,Zampa A,Cicchillitti L,Piaggio G,Cutillo G,Falcioni R,Vizza E

更新日期：2018-07-06 00:00:00

abstract：BACKGROUND:Prohibitin (PHB), a pleiotropic protein overexpressed in several tumor types, has been implicated in the regulation of cell proliferation, invasive migration and survival. However, PHB expression and its biological function in gallbladder cancer (GBC) remain largely unknown. METHODS:PHB and p-ERK protein ex...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cao Y,Liang H,Zhang F,Luan Z,Zhao S,Wang XA,Liu S,Bao R,Shu Y,Ma Q,Zhu J,Liu Y

更新日期：2016-04-16 00:00:00

abstract：:Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this success are checkpoint inhibitors (CPIs) and chimeric antigen receptor (CAR) T cells. This review summarizes seminal...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Kruger S,Ilmer M,Kobold S,Cadilha BL,Endres S,Ormanns S,Schuebbe G,Renz BW,D'Haese JG,Schloesser H,Heinemann V,Subklewe M,Boeck S,Werner J,von Bergwelt-Baildon M

更新日期：2019-06-19 00:00:00

abstract：:We evaluated the efficacy and toxicity profile of single-agent docetaxel administered in daily clinical practice at low-dose regimen in 37 pre-treated elderly patients with metastatic breast cancer previously exposed to chemotherapy. Docetaxel was employed by physician's preference according to a weekly (8 patients, 2...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Massacesi C,Marcucci F,Boccetti T,Battelli N,Pilone A,Rocchi MB,Bonsignori M

更新日期：2005-03-01 00:00:00

abstract：:Proliferative activity in 78 glioma specimens was assessed immunohistochemically by determining proliferating index of tumor cells (PTC-PI) and endothelial cells (PEC-PI) using the MIB-1 monoclonal antibody. The PTC-PI of anaplastic astrocytoma (9.0 +/- 5.8: mean + standard deviation) was significantly higher than tha...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Di X,Nishizaki T,Harada K,Kajiwara K,Nakayama H,Ito H

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). Although EGFR and Her-2 are frequently overexpressed in OSCC, few studies evaluated these proteins in saliva and their association with the tumor, which may represent potential useful...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bernardes VF,Gleber-Netto FO,Sousa SF,Silva TA,Aguiar MC

更新日期：2010-04-29 00:00:00

abstract：BACKGROUND:Multinucleated cells are frequently seen in association with a malignant neoplasm. Some of these multinucleated cells are considered to be neoplastic. The mechanism of neoplastic multinucleation remains unknown, but is considered to be induced by either cell-cell fusion or acytokinetic cell division. Myxofib...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ariizumi T,Ogose A,Kawashima H,Hotta T,Umezu H,Endo N

更新日期：2009-03-31 00:00:00

abstract：BACKGROUND:Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene family involved in multiple malignancies. CMTM4 is a member of this family and is located at chromosome 16q22.1, a locus that harbours a number of tumour suppressor genes. It has been defined as a regulator of ce...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li T,Cheng Y,Wang P,Wang W,Hu F,Mo X,Lv H,Xu T,Han W

更新日期：2015-10-16 00:00:00

abstract：:RANKL/RANK/OPG system consists of three essential signaling molecules: i) the receptor activator of nuclear factor (NF)-kB-ligand (RANKL), ii) the receptor activator of NF-kB (RANK), and iii) the soluble decoy receptor osteoprotegerin (OPG). Although this system is critical for the regulation of osteoclast differentia...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Infante M,Fabi A,Cognetti F,Gorini S,Caprio M,Fabbri A

更新日期：2019-01-08 00:00:00

abstract：:Hemangioblastomas of the filum terminale are particularly rare tumors. The authors present the case of a 62-year-old woman with a 6 month history of low-back-pain, who underwent surgery for the removal of an hemangioblastoma affecting the cauda at L2-L3 level. This highly vascularized tumour is tightly adherent to the...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ciappetta P,Occhiogrosso G,Domenicucci M,D'Andrea G,Bastianello S,Frati A

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Metastasis is the primary cause of death in renal cell carcinoma (RCC). Loss of cell-to-cell adhesion, including tight junctions (TJs) is the initial step in the process of metastasis. Claudin-7 (CLDN7) is a major component of TJs. However, the clinical significance and its regulation of kidney tumorigenesis...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li Y,Gong Y,Ning X,Peng D,Liu L,He S,Gong K,Zhang C,Li X,Zhou L

更新日期：2018-11-14 00:00:00

abstract：BACKGROUND:Cancer-associated fibroblasts (CAFs), the primary component of tumor stroma in tumor microenvironments, are well-known contributors to the malignant progression of gallbladder cancer (GBC). Thrombospondins (THBSs or TSPs) comprise a family of five adhesive glycoproteins that are overexpressed in many types o...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shi Y,Sun L,Zhang R,Hu Y,Wu Y,Dong X,Dong D,Chen C,Geng Z,Li E,Fan Y

更新日期：2021-01-06 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. Targeting autophagy has gained interest with multiple preclinical and clinical tri...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yan Y,Chen X,Wang X,Zhao Z,Hu W,Zeng S,Wei J,Yang X,Qian L,Zhou S,Sun L,Gong Z,Xu Z

更新日期：2019-04-23 00:00:00

abstract：:Two-year protocols are commonly used for long-term assay of chemicals for carcinogenicity. However, in some cases, if animals have been exposed to tested agent from the young age and sacrificed at the age of 2, an underestimation of the carcinogenic potential of non-genotoxic agents and tumor promoters is possible. Da...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Anisimov VN

更新日期：1998-09-01 00:00:00

abstract：:The Editor-in-Chief has retracted this article [1] due to concerns about the figures. In Figure 3C, the images from the colony formation assays of all cell lines, excluding the control for the HCCLM9 cell line, contain identical patterns of colonies; this suggests that despite the fact they are supposed to be observat...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang Y,Qin X,Guo T,Liu P,Wu P,Liu Z

更新日期：2019-05-23 00:00:00

abstract：BACKGROUND:Thyroid cancer is one of the most prevalent malignancies in endocrine system. Further understanding and revealing the molecular mechanism underlying thyroid cancer are indispensable for the development of effective diagnosis and treatments. In the present study, we attempted to provide novel basis for target...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu H,Deng H,Zhao Y,Li C,Liang Y

更新日期：2018-11-21 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma is one of the leading causes of cancer-related death worldwide. Immune checkpoint blockade therapy, including anti-PD-1 and anti-PD-L1, is a new therapeutic strategy for cancer treatment but the monotherapy with PD-L1 inhibitors for pancreatic cancer is almost ineffective for...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fan P,Zhao J,Meng Z,Wu H,Wang B,Wu H,Jin X

更新日期：2019-02-01 00:00:00