abstract：BACKGROUND:The oncogenic activity of the high risk human papillomavirus type 16 (HPV16) is fully dependent on the E6 and E7 viral oncoproteins produced during viral infection. The oncoproteins interfere with cellular homeostasis by promoting proliferation, inhibiting apoptosis and blocking epithelial differentiation, d...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Paolini F,Amici C,Carosi M,Bonomo C,Di Bonito P,Venuti A,Accardi L

更新日期：2021-01-23 00:00:00

abstract：BACKGROUND:Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable. Hence, new relevant treatments are urgently needed. The VEGFs core...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Dumond A,Brachet E,Durivault J,Vial V,Puszko AK,Lepelletier Y,Montemagno C,Pagnuzzi-Boncompagni M,Hermine O,Garbay C,Lagarde N,Montes M,Demange L,Grépin R,Pagès G

更新日期：2021-01-18 00:00:00

abstract：:The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progression in a broad landscape of human malignancies. The endothelin-1 (ET-1) receptors (ET-1R), known as ETA recepto...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tocci P,Blandino G,Bagnato A

更新日期：2021-01-09 00:00:00

abstract：BACKGROUND:Tumour-associated macrophages (TAMs) in the tumour microenvironment (TME) can promote the progression of hepatocellular carcinoma (HCC). Some tumours can be suppressed by targeting Wnt2b in tumour cells. However, the role of Wnt2b in HCC is still unknown. In particular, the role of Wnt2b-mediated signal acti...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jiang Y,Han Q,Zhao H,Zhang J

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Cancer-associated fibroblasts (CAFs), the primary component of tumor stroma in tumor microenvironments, are well-known contributors to the malignant progression of gallbladder cancer (GBC). Thrombospondins (THBSs or TSPs) comprise a family of five adhesive glycoproteins that are overexpressed in many types o...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shi Y,Sun L,Zhang R,Hu Y,Wu Y,Dong X,Dong D,Chen C,Geng Z,Li E,Fan Y

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Gastric cancer (GC) is one of the most common malignant tumors worldwide. Currently, the overall survival rate of GC is still unsatisfactory despite progress in diagnosis and treatment. Therefore, studying the molecular mechanisms involved in GC is vital for diagnosis and treatment. CircRNAs, a type of nonco...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cao J,Zhang X,Xu P,Wang H,Wang S,Zhang L,Li Z,Xie L,Sun G,Xia Y,Lv J,Yang J,Xu Z

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND:Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the effect of PGRN on breast cancer tumor immunity and its possible molecular mechanism. METHODS:The changes of macrophage phenotypes after P...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fang W,Zhou T,Shi H,Yao M,Zhang D,Qian H,Zeng Q,Wang Y,Jin F,Chai C,Chen T

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa). Here, we investigated the role of indirect cholinergic activation on PCa progression through inhibition of acetylcholinesterase (AChE) via clinically available ACh...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Pfitzinger PL,Fangmann L,Wang K,Demir E,Gürlevik E,Fleischmann-Mundt B,Brooks J,D'Haese JG,Teller S,Hecker A,Jesinghaus M,Jäger C,Ren L,Istvanffy R,Kühnel F,Friess H,Ceyhan GO,Demir IE

更新日期：2020-12-24 00:00:00

abstract：BACKGROUND:The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here, we identified hyperactivated mitophagy is essential for sor...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wu H,Wang T,Liu Y,Li X,Xu S,Wu C,Zou H,Cao M,Jin G,Lang J,Wang B,Liu B,Luo X,Xu C

更新日期：2020-12-07 00:00:00

abstract：:Accumulating evidence suggests that radiation treatment causes an adaptive response of lung adenocarcinoma (LUAD), which in turn attenuates the lethal effect of the irradiation. Previous microarray assays manifested the change of gene expression profile after irradiation. Bioinformatics analysis of the significantly c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Hao CC,Xu CY,Zhao XY,Luo JN,Wang G,Zhao LH,Ge X,Ge XF

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is one of the frequently occurred malignancies in the world. To date, several onco-microRNAs (miRNAs or miRs), including miR-96, have been identified in the pathogenesis of CRC. In the present study, we aimed to corroborate the oncogenic effect of miR-96 on CRC and to identify the spe...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yue C,Chen J,Li Z,Li L,Chen J,Guo Y

更新日期：2020-11-12 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have made a breakthrough in the treatment of different types of tumors, leading to improvement in survival, even in patients with advanced cancers. Despite the good clinical results, a certain percentage of patients do not respond to this kind of immunotherapy. In addition, in a fra...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Camelliti S,Le Noci V,Bianchi F,Moscheni C,Arnaboldi F,Gagliano N,Balsari A,Garassino MC,Tagliabue E,Sfondrini L,Sommariva M

更新日期：2020-11-09 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yan H,Li H,Li P,Li X,Lin J,Zhu L,Silva MA,Wang X,Wang P,Zhang Z

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Colon cancer represents one of the leading causes of gastrointestinal tumors in industrialized countries, and its incidence appears to be increasing at an alarming rate. Accumulating evidence has unveiled the contributory roles of cancer stem cells (CSCs) in tumorigenicity, recurrence, and metastases. The fu...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang L,Guo J,Zhou J,Wang D,Kang X,Zhou L

更新日期：2020-10-28 00:00:00

abstract：BACKGROUND:Tumor-associated macrophages (TAMs) and tumor cells are important components of the tumor microenvironment. M2 polarization of TAMs, which is a major actor in breast cancer malignancy and metastasis, can be induced by breast cancer cells. However, the potential mechanisms of the interaction between breast ca...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tao S,Chen Q,Lin C,Dong H

更新日期：2020-09-17 00:00:00

abstract：:The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. Through the development of m6A RNA seq...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Geng X,Li Q,Xu J,Tan Y,Xiao M,Song J,Liu F,Fang C,Wang H

更新日期：2020-09-17 00:00:00

abstract：:Recently, the focus of enhancing tumor radiosensitivity has shifted from chemotherapeutics to targeted therapies. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are a novel class of selective cell cycle therapeutics that target the cyclin D-CDK4/6 complex and induce G1 phase arrest. These agents have demonstrated...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Y,Luo J,Chen X,Yang Z,Mei X,Ma J,Zhang Z,Guo X,Yu X

更新日期：2020-09-15 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Sheng W,Shi X,Lin Y,Tang J,Jia C,Cao R,Sun J,Wang G,Zhou L,Dong M

更新日期：2020-08-24 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li Z,Zhang L,Gao M,Han M,Liu K,Zhang Z,Gong Z,Xing L,Shi X,Lu K,Gao H

更新日期：2020-08-19 00:00:00

abstract：BACKGROUND:Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are still largely unclear. METHODS:Use public database to screen the potential lncRNA crucial for metastasi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Huang W,Yuan Y,Li J,Wu J,Yu J,He Y,Wei Z,Zhang C

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Long noncoding RNAs (lncRNAs) are considered critical regulators in cancers; however, the clinical significance and mechanisms of MAPKAPK5-AS1 (hereinafter referred to as MK5-AS1) in colorectal cancer (CRC) remain mostly unknown. METHODS:In this study, quantitative real-time PCR (qPCR) and western blotting ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang T,Chen WC,Shi PC,Liu MR,Jiang T,Song H,Wang JQ,Fan RZ,Pei DS,Song J

更新日期：2020-07-20 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Russano M,Napolitano A,Ribelli G,Iuliani M,Simonetti S,Citarella F,Pantano F,Dell'Aquila E,Anesi C,Silvestris N,Argentiero A,Solimando AG,Vincenzi B,Tonini G,Santini D

更新日期：2020-06-24 00:00:00

abstract：:The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key regulators of cancer gene network. Recently, profiling and sequenci...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Grillone K,Riillo C,Scionti F,Rocca R,Tradigo G,Guzzi PH,Alcaro S,Di Martino MT,Tagliaferri P,Tassone P

更新日期：2020-06-20 00:00:00

abstract：BACKGROUND:Hepatoblastoma (HB) is a common liver malignancy in children. Our previous study has disclosed the crucial role of STAT3 (signal transducer and activator of transcription 3) in HB. AIM OF THE STUDY:Present study was designed to study the circular RNA (circRNA) STAT3 in HB. METHODS:Gel electrophoresis revea...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu Y,Song J,Liu Y,Zhou Z,Wang X

更新日期：2020-06-03 00:00:00

abstract：:Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are able to evade the immune response and establish a very complex balance in which different immune subtypes may drive tumor progression, metastatization and resistance to therapy. New immunotherapeutic approaches aim at restorin...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Galli F,Aguilera JV,Palermo B,Markovic SN,Nisticò P,Signore A

更新日期：2020-05-18 00:00:00

abstract：BACKGROUND:Our previous studies have confirmed that cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells (PGCCs), which is the key to the heterogeneity of solid tumors. PGCC formation is closely related to the abnormal expression of cell cycle-related proteins and cell fusion. In this study,...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu K,Zheng M,Zhao Q,Zhang K,Li Z,Fu F,Zhang H,Du J,Li Y,Zhang S

更新日期：2020-05-11 00:00:00

abstract：:The heterogeneous tumor microenvironment (TME) is highly complex and not entirely understood. These complex configurations lead to the generation of oxygen-deprived conditions within the tumor niche, which modulate several intrinsic TME elements to promote immunosuppressive outcomes. Decoding these communications is n...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bhattacharya S,Calar K,de la Puente P

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Tumor metastasis is one of the main causes of the high mortality of hepatocellular carcinoma (HCC). E-Twenty Six variant gene 6 (ETV6) is a strong transcriptional repressor, associated with the development and progression of tumors. However, the exact role and underlying mechanism of ETV6 in HCC remain uncle...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Guo C,Gao C,Zhao D,Li J,Wang J,Sun X,Liu Q,Hao L,Greenaway FT,Tian Y,Liu S,Sun MZ

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs), which are responsible for AML drug resistance and recurrence, is unclear. In this study, we investi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jang JE,Eom JI,Jeung HK,Chung H,Kim YR,Kim JS,Cheong JW,Min YH

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC). The mechanism regarding how EGFR signaling regulates myeloid cell leukemia sequence 1 (Mcl-1) protein stability and ubiquitination remains undefined. METHODS:MTS ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yu X,Gao F,Li W,Zhou L,Liu W,Li M

更新日期：2020-04-10 00:00:00

abstract：BACKGROUND:Revealing the mechanical role of long non-coding RNAs (lncRNAs) in tumorigenesis can contribute to novel therapeutic target for cancers. The regulatory role of linc01134 in hepatocellular carcinoma (HCC) has not been studied yet. MATERIALS AND METHODS:qRT-PCR and western blot were conducted to measure relev...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rong Z,Wang Z,Wang X,Qin C,Geng W

更新日期：2020-04-09 00:00:00

abstract：:In the original publication of this manuscript [1], Fig. 1 contained a typographical error ('Metabolic' incorrectly written as 'Metabolig'). ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bosco MC,Orazi G,Del Bufalo D

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In this study, we aim to explain this confusing finding and delineate the role of CLDN6 in the breast c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jia Y,Guo Y,Jin Q,Qu H,Qi D,Song P,Zhang X,Wang X,Xu W,Dong Y,Liang Y,Quan C

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme is a CNS cancer characterized by diffuse infiltrative growth, aggressive clinical behavior and very poor prognosis. The state-of-art clinical approach to this disease consists of surgical resection followed by radiotherapy plus concurrent and adjuvant chemotherapy with temozolomide. T...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Abbruzzese C,Matteoni S,Persico M,Villani V,Paggi MG

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Localized C3 deposition is a well-known factor of inflammation. However, its role in oncoprogression of gastric cancer (GC) remains obscured. This study aims to explore the prognostic value of C3 deposition and to elucidate the mechanism of C3-related oncoprogression for GC. METHODS:From August to December ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yuan K,Ye J,Liu Z,Ren Y,He W,Xu J,He Y,Yuan Y

更新日期：2020-01-13 00:00:00

abstract：BACKGROUND:Ovarian cancer (OC) is the most lethal gynecological malignancy and the second leading cause of cancer-related death in women. Treatment with PARP inhibitors (PARPi), such as Olaparib, has been recently introduced for OC patients, but resistance may occur and underlying mechanisms are still poorly understood...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Vescarelli E,Gerini G,Megiorni F,Anastasiadou E,Pontecorvi P,Solito L,De Vitis C,Camero S,Marchetti C,Mancini R,Benedetti Panici P,Dominici C,Romano F,Angeloni A,Marchese C,Ceccarelli S

更新日期：2020-01-02 00:00:00

abstract：BACKGROUND:The deubiquitinase USP7 has been identified as an oncogene with key roles in tumorigenesis and therapeutic resistance for a series of cancer types. Recently small molecular inhibitors have been developed to target USP7. However, the anticancer mechanism of USP7 inhibitors is still elusive. METHODS:Cell viab...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Peng Y,Liu Y,Gao Y,Yuan B,Qi X,Fu Y,Zhu Q,Cao T,Zhang S,Yin L,Li X

更新日期：2019-11-15 00:00:00

abstract：BACKGROUND:Bladder cancer (BC) is a common urothelial malignancy, characterized by a high recurrence rate. The biology of bladder cancer is complex and needs to be deciphered. The latest evidence reveals the critical role of the non-coding RNAs, particularly microRNAs (miRNAs), as vital regulatory elements in cancer. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Braicu C,Buiga R,Cojocneanu R,Buse M,Raduly L,Pop LA,Chira S,Budisan L,Jurj A,Ciocan C,Magdo L,Irimie A,Dobrota F,Petrut B,Berindan-Neagoe I

更新日期：2019-10-29 00:00:00

abstract：BACKGROUND:Glioblastoma is the most common and aggressive brain tumour in adults with a median overall survival of only 14 months after standard therapy with radiation therapy (IR) and temozolomide (TMZ). In a novel multimodal treatment approach we combined the checkpoint kinase 1 (Chk1) inhibitor SAR-020106 (SAR), dis...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Patties I,Kallendrusch S,Böhme L,Kendzia E,Oppermann H,Gaunitz F,Kortmann RD,Glasow A

更新日期：2019-10-21 00:00:00

abstract：BACKGROUND:An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play essential roles in tumor initiation and progression. LncRNAs act as tumor promoters or suppressors by targeting specific genes via epigenetic modifications and competing endogenous RNA (ceRNA) mechanisms. In this study, we exp...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Qiao K,Ning S,Wan L,Wu H,Wang Q,Zhang X,Xu S,Pang D

更新日期：2019-10-17 00:00:00