Clinical significance of EGFR, Her-2 and EGF in oral squamous cell carcinoma: a case control study.

Abstract:

BACKGROUND:The erbB receptors and their ligands are involved in the pathogenesis and progression of oral squamous cell carcinoma (OSCC). Although EGFR and Her-2 are frequently overexpressed in OSCC, few studies evaluated these proteins in saliva and their association with the tumor, which may represent potential usefulness in a clinical setting. METHODS:The levels of EGFR, Her-2, and EGF were evaluated in saliva of 46 patients with OSCC before and after the surgical removal of the lesion, as well as in matched healthy controls. The relationship of salivary levels and EGFR and Her-2 immunoexpression in tumor samples with clinicopathological features was analyzed. RESULTS:EGFR and Her-2 salivary levels did not show difference between to pre-surgery and control groups, however, both demonstrated an increase after surgical removal of the tumor. No association was detectable among receptor salivary levels, tissue expression and clinicopathological features. EGF levels in pre-surgery group were significantly lower when compared to the control group. CONCLUSIONS:EGFR and Her-2 were not considered to be valuable salivary tumor markers in OSCC, however, lower levels of EGF in saliva may suggest a higher susceptibility for OSCC development.

journal_name

J Exp Clin Cancer Res

authors

Bernardes VF,Gleber-Netto FO,Sousa SF,Silva TA,Aguiar MC

doi

10.1186/1756-9966-29-40

subject

Has Abstract

pub_date

2010-04-29 00:00:00

pages

40

eissn

0392-9078

issn

1756-9966

pii

1756-9966-29-40

journal_volume

29

pub_type

杂志文章
  • Challenges and potential of PD-1/PD-L1 checkpoint blockade immunotherapy for glioblastoma.

    abstract::PD-1/PD-L1 checkpoint blockades have achieved significant progress in several kinds of tumours. Pembrolizumab, which targets PD-1, has been approved as a first-line treatment for advanced non-small cell lung cancer (NSCLC) patients with positive PD-L1 expression. However, PD-1/PD-L1 checkpoint blockades have not achie...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,评审

    doi:10.1186/s13046-019-1085-3

    authors: Wang X,Guo G,Guan H,Yu Y,Lu J,Yu J

    更新日期:2019-02-18 00:00:00

  • EZH2 is increased in paediatric T-cell acute lymphoblastic leukemia and is a suitable molecular target in combination treatment approaches.

    abstract:BACKGROUND:T-cell Acute Lymphoblastic Leukemia (ALL) represents about 10-15 % of pediatric ALL cases. EZH2, one of the components of Polycomb group proteins (PRC2) complex, catalyzes the trimethylation of histone H3 lysine 27 that is associated with transcriptional repression and tumor development. METHODS:We examined...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-015-0191-0

    authors: D'Angelo V,Iannotta A,Ramaglia M,Lombardi A,Zarone MR,Desiderio V,Affinita MC,Pecoraro G,Di Martino M,Indolfi P,Casale F,Caraglia M

    更新日期:2015-08-14 00:00:00

  • Estrogen receptor-α-miR-1271-SNAI2 feedback loop regulates transforming growth factor-β-induced breast cancer progression.

    abstract:BACKGROUND:Breast cancer is the most common cancer among women worldwide, and approximately 70% of breast cancers are hormone receptor-positive and express estrogen receptor-α (ERα) or/and progesterone receptor. ERα has been identified to promote the growth of primary breast cancer, however, it can also antagonize sign...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1112-4

    authors: Liu BW,Yu ZH,Chen AX,Chi JR,Ge J,Yu Y,Cao XC

    更新日期:2019-03-01 00:00:00

  • Induction of apoptosis in mouse and human carcinoma cell lines by Emblica officinalis polyphenols and its effect on chemical carcinogenesis.

    abstract::Plant-derived phenolic compounds manifest many beneficial effects and can potentially inhibit several stages of carcinogenesis. In the present study, we investigated the efficacy of Emblica officinalis (E. officinalis) polyphenol fraction (EOP) on the induction of apoptosis in mouse and human carcinoma cell lineses an...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Rajeshkumar NV,Pillai MR,Kuttan R

    更新日期:2003-06-01 00:00:00

  • Phosphatidylserine exposing-platelets and microparticles promote procoagulant activity in colon cancer patients.

    abstract:BACKGROUND:Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored the exposure of PS on platelets and microparticles (MPs), and evaluate its role in procoagulant activ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0328-9

    authors: Zhao L,Bi Y,Kou J,Shi J,Piao D

    更新日期:2016-03-25 00:00:00

  • Magnetic resonance of the breast: correlation between enhancement patterns and microvessel density in malignant tumors.

    abstract::The continuous growth of a solid tumor is contingent upon the induction and formation of new vascular structures (angiogenesis). Several studies have established a close correlation between the microvessel density (MVD) of a tumor and its growth capacity. Therefore, a non-invasive method to accurately assess tumor MVD...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:

    authors: Carriero A,Ambrossini R,Mattei PA,Angelucci D,Bonomo L

    更新日期:2002-09-01 00:00:00

  • Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer.

    abstract:BACKGROUND:Pancreatic ductal adenocarcinoma is one of the leading causes of cancer-related death worldwide. Immune checkpoint blockade therapy, including anti-PD-1 and anti-PD-L1, is a new therapeutic strategy for cancer treatment but the monotherapy with PD-L1 inhibitors for pancreatic cancer is almost ineffective for...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1044-z

    authors: Fan P,Zhao J,Meng Z,Wu H,Wang B,Wu H,Jin X

    更新日期:2019-02-01 00:00:00

  • Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer.

    abstract:BACKGROUND:Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC). The mechanism regarding how EGFR signaling regulates myeloid cell leukemia sequence 1 (Mcl-1) protein stability and ubiquitination remains undefined. METHODS:MTS ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-020-01566-2

    authors: Yu X,Gao F,Li W,Zhou L,Liu W,Li M

    更新日期:2020-04-10 00:00:00

  • Clinical research of Olanzapine for prevention of chemotherapy-induced nausea and vomiting.

    abstract:BACKGROUND:This study was designed to mainly evaluate the activity and safety of olanzapine compared with 5-hydroxytryptamine 3(5-HT3) receptor antagonists for prevention of chemotherapy-induced nausea and vomiting(CINV) in patients receiving highly or moderately emetogenic chemotherapy (HEC or MEC). The second goal wa...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,随机对照试验

    doi:10.1186/1756-9966-28-131

    authors: Tan L,Liu J,Liu X,Chen J,Yan Z,Yang H,Zhang D

    更新日期:2009-09-23 00:00:00

  • miR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop.

    abstract:BACKGROUND:As novel biomarkers for various cancers, microRNAs negatively regulate genes expression via promoting mRNA degradation and suppressing mRNA translation. miR-589 has been reported to be deregulated in several human cancer types. However, its biological role has not been functionally characterized in gastric c...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-018-0821-4

    authors: Zhang F,Li K,Pan M,Li W,Wu J,Li M,Zhao L,Wang H

    更新日期:2018-07-16 00:00:00

  • Epidermal growth factor (EGF) receptor-ligand based molecular staging predicts prognosis in head and neck squamous cell carcinoma partly due to deregulated EGF- induced amphiregulin expression.

    abstract:BACKGROUND:Increased expression of epidermal growth factor receptor (EGFR) and its ligands is associated with poor prognosis and chemoresistance in many carcinoma types, but its role in head and neck squamous cell carcinoma (HNSCC) is unclear. Our aim was to clarify whether mRNA expression of EGFR-ligands was linked to...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0422-z

    authors: Gao J,Ulekleiv CH,Halstensen TS

    更新日期:2016-09-26 00:00:00

  • sE-cadherin serves as a diagnostic and predictive parameter in prostate cancer patients.

    abstract:BACKGROUND:Measurement of prostate-specific antigen (PSA) advanced the diagnostic and prognostic potential for prostate cancer (PCa). However, due to PSA's lack of specificity, novel biomarkers are needed to improve risk assessment and ensure optimal personalized therapy. A set of protein molecules as potential biomark...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-015-0161-6

    authors: Tsaur I,Thurn K,Juengel E,Gust KM,Borgmann H,Mager R,Bartsch G,Oppermann E,Ackermann H,Nelson K,Haferkamp A,Blaheta RA

    更新日期:2015-05-14 00:00:00

  • Demystifying the mechanistic and functional aspects of p21 gene activation with double-stranded RNAs in human cancer cells.

    abstract:BACKGROUND:The recently identified phenomenon of double-stranded RNA (dsRNA)-mediated gene activation (RNAa) has been studied extensively, as it is present in humans, mice, and Caenorhabditis elegans, suggesting that dsRNA-mediated RNAa is an evolutionarily conserved mechanism. Previous studies have shown that dsP21-32...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0423-y

    authors: Wu HL,Li SM,Hu J,Yu X,Xu H,Chen Z,Ye ZQ

    更新日期:2016-09-17 00:00:00

  • Inhibition of oleandrin on the proliferation show and invasion of osteosarcoma cells in vitro by suppressing Wnt/β-catenin signaling pathway.

    abstract:BACKGROUND:Osteosarcoma (OS) is a high-grade bone sarcoma with early metastasis potential, and the clinical chemotherapy drugs that are currently used for its treatment have some limitations. Recently, several studies have reported the selective antitumor effect of oleandrin on various tumor cells. In this study, we ai...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-015-0232-8

    authors: Ma Y,Zhu B,Liu X,Yu H,Yong L,Liu X,Shao J,Liu Z

    更新日期:2015-10-06 00:00:00

  • CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma.

    abstract:BACKGROUND:Chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM) is a gene family involved in multiple malignancies. CMTM4 is a member of this family and is located at chromosome 16q22.1, a locus that harbours a number of tumour suppressor genes. It has been defined as a regulator of ce...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-015-0236-4

    authors: Li T,Cheng Y,Wang P,Wang W,Hu F,Mo X,Lv H,Xu T,Han W

    更新日期:2015-10-16 00:00:00

  • TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling.

    abstract:BACKGROUND:The epithelial-mesenchymal transition (EMT) is crucial for metastasis and positively regulated by calcium-related signaling. The melastatin-related transient receptor potential 7 (TRPM7) regulates a non-selective cation channel and promotes cancer metastasis. However, the mechanisms underlying the action of ...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1061-y

    authors: Liu L,Wu N,Wang Y,Zhang X,Xia B,Tang J,Cai J,Zhao Z,Liao Q,Wang J

    更新日期:2019-02-28 00:00:00

  • Gemcitabine sensitivity-related mRNA expression in endoscopic ultrasound-guided fine-needle aspiration biopsy of unresectable pancreatic cancer.

    abstract:BACKGROUND:The aim of this study was to determine a predictive indicator of gemcitabine (GEM) efficacy in unresectable pancreatic cancer using tissue obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA). METHODS:mRNAs extracted from 35 pancreatic tubular adenocarcinoma tissues obtained by E...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-28-83

    authors: Ashida R,Nakata B,Shigekawa M,Mizuno N,Sawaki A,Hirakawa K,Arakawa T,Yamao K

    更新日期:2009-06-16 00:00:00

  • Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma.

    abstract:BACKGROUND:Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable. Hence, new relevant treatments are urgently needed. The VEGFs core...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-021-01832-x

    authors: Dumond A,Brachet E,Durivault J,Vial V,Puszko AK,Lepelletier Y,Montemagno C,Pagnuzzi-Boncompagni M,Hermine O,Garbay C,Lagarde N,Montes M,Demange L,Grépin R,Pagès G

    更新日期:2021-01-18 00:00:00

  • Transcriptional and post-transcriptional controls of survivin in cancer cells: novel approaches for cancer treatment.

    abstract::Survivin is a novel member of the inhibitor of apoptosis (IAP) protein family, and its aberrant expression in cancer cells has been shown to be associated with tumorigenesis, cancer progression, radiation/drug resistance and shorter patient survival. Survivin is also expressed in certain human adult tissues and cells,...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,评审

    doi:

    authors: Zhang M,Yang J,Li F

    更新日期:2006-09-01 00:00:00

  • Basigin-mediated redistribution of CD98 promotes cell spreading and tumorigenicity in hepatocellular carcinoma.

    abstract:BACKGROUND:Dysregulated endocytosis of membrane proteins contributes significantly to several hallmarks of cancer. Basigin can enhance cancer progression, but its precise mechanism remains unclear. CD98 promotes cell spreading and tumorigenicity by triggering integrin clustering and enhancing cell adhesion to the extra...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-015-0226-6

    authors: Wu B,Wang Y,Yang XM,Xu BQ,Feng F,Wang B,Liang Q,Li Y,Zhou Y,Jiang JL,Chen ZN

    更新日期:2015-10-06 00:00:00

  • HOXD9 promotes the growth, invasion and metastasis of gastric cancer cells by transcriptional activation of RUFY3.

    abstract:BACKGROUND:The transcription factor HOXD9 is one of the members of the HOX family, which plays an important role in neoplastic processes. However, the role of HOXD9 in the growth and metastasis of gastric cancer (GC) remains to be elucidated. METHODS:In vitro functional role of HOXD9 and RURY3 in GC cells was determin...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1399-1

    authors: Zhu H,Dai W,Li J,Xiang L,Wu X,Tang W,Chen Y,Yang Q,Liu M,Xiao Y,Zhang W,Lin J,Wang J,Liu G,Sun Y,Jiang P,Li G,Li A,Liu S,Chen Y,Wang J

    更新日期:2019-09-23 00:00:00

  • MiR-29b/Sp1/FUT4 axis modulates the malignancy of leukemia stem cells by regulating fucosylation via Wnt/β-catenin pathway in acute myeloid leukemia.

    abstract:BACKGROUND:Acute myeloid leukemia (AML) is initiated and maintained by a unique, small subset of leukemia stem cells (LSCs). LSCs are characterized by unrestricted self-renewal and contribute to the malignancy of leukemia. Aberrant protein fucosylation is associated with AML progression. However, it is still less under...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-019-1179-y

    authors: Liu B,Ma H,Liu Q,Xiao Y,Pan S,Zhou H,Jia L

    更新日期:2019-05-16 00:00:00

  • Endoscopic palliative therapy in neoplastic diseases of the esophagus.

    abstract::Over the past 20 years, fiberoptic endoscopy, followed by video-endoscopy, has taken on an increasingly important role in the diagnostics and therapy for digestive tract diseases. Especially in the field of oncology, endoscopy is fundamental not only for the diagnosis and staging of diseases of the gastroenteric tract...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,评审

    doi:

    authors: Casale V,Lapenta R,Gigliozzi A,Villotti G

    更新日期:1999-03-01 00:00:00

  • Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2.

    abstract:BACKGROUND:Hepatoblastoma (HB) is a common liver malignancy in children. Our previous study has disclosed the crucial role of STAT3 (signal transducer and activator of transcription 3) in HB. AIM OF THE STUDY:Present study was designed to study the circular RNA (circRNA) STAT3 in HB. METHODS:Gel electrophoresis revea...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-020-01598-8

    authors: Liu Y,Song J,Liu Y,Zhou Z,Wang X

    更新日期:2020-06-03 00:00:00

  • Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis.

    abstract:BACKGROUND:The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here, we identified hyperactivated mitophagy is essential for sor...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-020-01768-8

    authors: Wu H,Wang T,Liu Y,Li X,Xu S,Wu C,Zou H,Cao M,Jin G,Lang J,Wang B,Liu B,Luo X,Xu C

    更新日期:2020-12-07 00:00:00

  • Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors.

    abstract:BACKGROUND:The oncogenic activity of the high risk human papillomavirus type 16 (HPV16) is fully dependent on the E6 and E7 viral oncoproteins produced during viral infection. The oncoproteins interfere with cellular homeostasis by promoting proliferation, inhibiting apoptosis and blocking epithelial differentiation, d...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-021-01841-w

    authors: Paolini F,Amici C,Carosi M,Bonomo C,Di Bonito P,Venuti A,Accardi L

    更新日期:2021-01-23 00:00:00

  • Clusterin is a potential molecular predictor for ovarian cancer patient's survival: targeting clusterin improves response to paclitaxel.

    abstract:BACKGROUND:Clusterin is a cytoprotective chaperone protein involved in numerous physiological processes, carcinogenesis, tumor growth and tissue remodelling. The purpose of this study was to investigate whether clusterin (CLU), an antiapoptotic molecule, could be a potential predictor molecule for ovarian cancer and wh...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-30-113

    authors: Hassan MK,Watari H,Han Y,Mitamura T,Hosaka M,Wang L,Tanaka S,Sakuragi N

    更新日期:2011-12-20 00:00:00

  • YAP and endothelin-1 signaling: an emerging alliance in cancer.

    abstract::The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progression in a broad landscape of human malignancies. The endothelin-1 (ET-1) receptors (ET-1R), known as ETA recepto...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章,评审

    doi:10.1186/s13046-021-01827-8

    authors: Tocci P,Blandino G,Bagnato A

    更新日期:2021-01-09 00:00:00

  • miR-589-5p inhibits MAP3K8 and suppresses CD90+ cancer stem cells in hepatocellular carcinoma.

    abstract:BACKGROUND:Cancer stem cells (CSCs) are important in the tumorigenesis and progression of hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) play crucial roles regulating CD133+ and EpCAM+ CSCs in HCC, although it is unclear whether miRNAs regulate CD90+ CSCs in HCC. METHODS:The miRNA profiles of CD90+ and CD90- HCC c...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/s13046-016-0452-6

    authors: Zhang X,Jiang P,Shuai L,Chen K,Li Z,Zhang Y,Jiang Y,Li X

    更新日期:2016-11-11 00:00:00

  • Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis.

    abstract:BACKGROUND:The chemokine receptors CXCR4 and CCR7 play an important role in cancer invasion and metastasis. This study investigated the expression of CXCR4, CCR7, CXCL12, CCL21, and EGFR to illustrate the role of these biomarkers in breast cancer metastasis and prognosis. METHODS:The CXCR4, CCR7, CXCL12, CCL21, and EG...

    journal_title:Journal of experimental & clinical cancer research : CR

    pub_type: 杂志文章

    doi:10.1186/1756-9966-29-16

    authors: Liu Y,Ji R,Li J,Gu Q,Zhao X,Sun T,Wang J,Li J,Du Q,Sun B

    更新日期:2010-02-24 00:00:00