Cdk1/P34Cdc2 and P21waf expression in colorectal adenomas and carcinomas.

abstract：:Immunotherapy has become an established pillar of cancer treatment improving the prognosis of many patients with a broad variety of hematological and solid malignancies. The two main drivers behind this success are checkpoint inhibitors (CPIs) and chimeric antigen receptor (CAR) T cells. This review summarizes seminal...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Kruger S,Ilmer M,Kobold S,Cadilha BL,Endres S,Ormanns S,Schuebbe G,Renz BW,D'Haese JG,Schloesser H,Heinemann V,Subklewe M,Boeck S,Werner J,von Bergwelt-Baildon M

更新日期：2019-06-19 00:00:00

abstract：:The cytogenetic characteristics of osteosarcoma (OS) remain controversial. The establishment of a new human OS cell line may improve the characterization. We report the establishment of a new human osteosarcoma cell line, UTOS-1, from a typical osteoblastic OS of an 18-year-old man. Cultured UTOS-1 cells are spindle-s...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yasuda T,Kanamori M,Nogami S,Hori T,Oya T,Suzuki K,Kimura T

更新日期：2009-02-25 00:00:00

abstract：:The authors report one case of cauda equina paraganglioma and review the neurosurgical, radiological and pathological literatureon this rare tumour. Although it is difficult to distinguish preoperatively the paraganglioma from other tumours of the cauda equina, like neurinoma or ependymoma, this neuroendocrine tumour ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Caruso R,Wierzbicki V,Marrocco L,Salvati M

更新日期：2006-06-01 00:00:00

abstract：:In the original publication of this manuscript [1], Fig. 1 contained a typographical error ('Metabolic' incorrectly written as 'Metabolig'). ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bosco MC,Orazi G,Del Bufalo D

更新日期：2020-02-24 00:00:00

abstract：BACKGROUND:Glioma is the most common intracranial neoplasm with vasculogenic mimicry formation as one form of blood supply. Many RNA-binding proteins and long non-coding RNAs are involved in tumorigenesis of glioma. METHODS:The expression of ZRANB2, SNHG20 and FOXK1 in glioma were detected by real-time PCR or western ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li X,Xue Y,Liu X,Zheng J,Shen S,Yang C,Chen J,Li Z,Liu L,Ma J,Ma T,Liu Y

更新日期：2019-02-11 00:00:00

abstract：BACKGROUND:Melanomas are highly malignant and have high metastatic potential; hence, there is a need for new therapeutic strategies to prevent cell metastasis. In the present study, we investigated whether statins inhibit tumor cell migration, invasion, adhesion, and metastasis in the B16BL6 mouse melanoma cell line. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Kidera Y,Tsubaki M,Yamazoe Y,Shoji K,Nakamura H,Ogaki M,Satou T,Itoh T,Isozaki M,Kaneko J,Tanimori Y,Yanae M,Nishida S

更新日期：2010-09-16 00:00:00

abstract：BACKGROUND:When a patient concomitantly uses two or more drugs, a drug-drug interaction (DDI) can possibly occur, potentially leading to an increased or decreased clinical effect of a given treatment. Cancer patients are at high risk of such interactions because they commonly receive multiple medications. Moreover, mos...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ussai S,Petelin R,Giordano A,Malinconico M,Cirillo D,Pentimalli F

更新日期：2015-08-25 00:00:00

abstract：BACKGROUND:Previous meta-analysis suggested that transdermal fentanyl was not inferior to sustained-release oral morphine in treating moderate-severe cancer pain with less adverse effects. Now, we updated the data and performed a systematic review. METHODS:Updated cohort studies on transdermal fentanyl and oral morphi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Q,Xie DR,Jiang ZM,Ma W,Zhang YD,Bi ZF,Chen DL

更新日期：2010-06-09 00:00:00

abstract：:Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in HCC treatment, less than 40% of HCC patients are eligible for potentially curative therapies. Recently, cancer immunotherapy has emerged as ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fu Y,Liu S,Zeng S,Shen H

更新日期：2019-09-09 00:00:00

abstract：BACKGROUND:We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In this study, we aim to explain this confusing finding and delineate the role of CLDN6 in the breast c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jia Y,Guo Y,Jin Q,Qu H,Qi D,Song P,Zhang X,Wang X,Xu W,Dong Y,Liang Y,Quan C

更新日期：2020-02-24 00:00:00

abstract：:Even though it is well established that oxygen-free radicals are the main mechanism responsible for the cytotoxicity produced during radiotherapy, the role of the human antioxidant defense system in clinical radiation oncology is still to be clarified. Changes in the human plasma total peroxyl radical trapping capacit...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Erhola M,Nieminen MM,Ojala A,Metsä-Ketelä T,Kellokumpu-Lehtinen P,Alho H

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:The human epidermal growth factor receptor 2 (HER2) and p53 pathways may be involved in chemotherapy sensitivity and/or resistance. We explore the value of HER2 and p53 status to foretell docetaxel sensitivity in advanced breast cancer. METHODS:HER2 and p53 expression was analysed in 36 (median age 55 yrs; ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Camerini A,Donati S,Viacava P,Siclari O,Puccetti C,Tartarelli G,Valsuani C,De Luca F,Martini L,Cavazzana A,Amoroso D

更新日期：2011-04-11 00:00:00

abstract：BACKGROUND:Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression.We and others find that YAP is up-regulated in human gliomas and associated with worse prognosis of patients. However, the role and mechanism of YAP in glioma pro...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang Y,Pan P,Wang Z,Zhang Y,Xie P,Geng D,Jiang Y,Yu R,Zhou X

更新日期：2017-09-29 00:00:00

abstract：BACKGROUND:Development of resistance to therapy continues to be a serious clinical problem in lung cancer management. We previously identified that Annexin A2 is significantly up-regulated in cisplatin-resistant non-small cell lung cancer (NSCLC) A549/DDP cells. However, the exact function and molecular mechanism of An...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Feng X,Liu H,Zhang Z,Gu Y,Qiu H,He Z

更新日期：2017-09-08 00:00:00

abstract：:This study was carried out to provide extensive information obtained from statistical analysis of laryngeal endocrinomas for the use of investigators working in this particular research field. A total of 278 patients with both typical and atypical varieties of carcinoids, and with small/oat cell carcinomas (SCC/OCC) e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Soga J,Osaka M,Yakuwa Y

更新日期：2002-03-01 00:00:00

abstract：:We previously reported that the expression and the activity of SHP-1, a non-transmembrane protein tyrosine phosphatase (PTPase) increased during myeloid differentiation of an acute promyelocytic leukemia cell line (HT93) induced by all-trans retinoic acid (ATRA). To examine whether inhibition of SHP-1 activity attenua...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Uesugi Y,Fuse I,Toba K,Kishi K,Hashimoto S,Furukawa T,Narita M,Takahashi M,Aizawa Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs), which are responsible for AML drug resistance and recurrence, is unclear. In this study, we investi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jang JE,Eom JI,Jeung HK,Chung H,Kim YR,Kim JS,Cheong JW,Min YH

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Thyroid cancer is one of the most prevalent malignancies in endocrine system. Further understanding and revealing the molecular mechanism underlying thyroid cancer are indispensable for the development of effective diagnosis and treatments. In the present study, we attempted to provide novel basis for target...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu H,Deng H,Zhao Y,Li C,Liang Y

更新日期：2018-11-21 00:00:00

abstract：:Patients with ulcerative colitis (UC) have a higher incidence of colorectal cancer. UC-associated colorectal cancer is thought to develop in patients with preexisting UC-associated dysplasia. It is crucial to diagnose UC-associated dysplasia and early stage of cancer in patients with long-standing UC for the purpose o...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fujii S,Fujimori T,Chiba T

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:Dysregulation of transforming growth factor β (TGF-β) signaling and hypoxic microenvironment have respectively been reported to be involved in disease progression in malignancies of prostate. Emerging evidence indicates that downregulation of TGFBR2, a pivotal regulator of TGF-β signaling, may contribute to ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhou H,Wu G,Ma X,Xiao J,Yu G,Yang C,Xu N,Zhang B,Zhou J,Ye Z,Wang Z

更新日期：2018-04-27 00:00:00

abstract：BACKGROUND:Patients with endometrial cancer (EC) and presumably with good prognosis may develop a recurrence indicating that the classification of this tumor is still not definitive and that new markers are needed to identify a subgroup at risk of relapse. The cell adhesion molecule L1CAM is highly expressed in several...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Corrado G,Laquintana V,Loria R,Carosi M,de Salvo L,Sperduti I,Zampa A,Cicchillitti L,Piaggio G,Cutillo G,Falcioni R,Vizza E

更新日期：2018-07-06 00:00:00

abstract：BACKGROUND:Long non-coding RNA H19 was demonstrated to be significantly correlated with tumor metastasis. However, the specific functions of H19 in colorectal cancer (CRC) metastasis and the underlying mechanism are still largely unclear. METHODS:Use public database to screen the potential lncRNA crucial for metastasi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Huang W,Yuan Y,Li J,Wu J,Yu J,He Y,Wei Z,Zhang C

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Melanoma is a malignant tumor with high misdiagnosis rate and poor prognosis. The bio-targeted therapy is a prevailing method in the treatment of melanoma; however, the accompanying drug resistance is inevitable. SH2 superbinder, a triple-mutant of the Src Homology 2 (SH2) domain, shows potent antitumor abil...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu AD,Xu H,Gao YN,Luo DN,Li ZF,Voss C,Li SSC,Cao X

更新日期：2018-07-05 00:00:00

abstract：BACKGROUND:Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored the exposure of PS on platelets and microparticles (MPs), and evaluate its role in procoagulant activ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhao L,Bi Y,Kou J,Shi J,Piao D

更新日期：2016-03-25 00:00:00

abstract：:Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the specific complex named shelterin and a tight nucleosomal organizati...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cacchione S,Biroccio A,Rizzo A

更新日期：2019-01-17 00:00:00

abstract：PURPOSE:The association between striking life events, an important stress and acute anxiety disorder, and the occurrence of primary breast cancer is unclear. The current meta-analysis was designed to assess the relationship between striking life events and primary breast cancer incidence in women. METHODS:Systematic c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lin Y,Wang C,Zhong Y,Huang X,Peng L,Shan G,Wang K,Sun Q

更新日期：2013-08-13 00:00:00

abstract：BACKGROUND:We conducted multiple microarray datasets analyses from clinical and xenograft tumor tissues to search for disease progression-driving oncogenes in prostate cancer (PCa). Sperm-associated antigen 5 (SPAG5) attracted our attention. SPAG5 was recently identified as an oncogene participating in lung cancer and ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang H,Li S,Yang X,Qiao B,Zhang Z,Xu Y

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Accumulating evidences indicated that lncRNAs play crucial regulatory roles in oncogenesis and progression of cancers. BRAF activated non-coding RNA (BANCR) has been identified to contribute to the progression of some human cancers. However, the relationship between BANCR and bladder cancer (BC) is largely u...

journal_title：Journal of experimental & clinical cancer research : CR

authors： He A,Liu Y,Chen Z,Li J,Chen M,Liu L,Liao X,Lv Z,Zhan Y,Zhuang C,Lin J,Huang W,Mei H

更新日期：2016-08-11 00:00:00

abstract：BACKGROUND:Yes-associated protein (YAP), an essential component of Hippo pathway, was identified as an oncoprotein which participated in the progression of various malignancies. However, its role in chronic myeloid leukemia (CML) remains to be further clarified. METHODS:The expression of YAP in CML cells was determine...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Li H,Huang Z,Gao M,Huang N,Luo Z,Shen H,Wang X,Wang T,Hu J,Feng W

更新日期：2016-09-06 00:00:00

abstract：BACKGROUND:Epilepsy is a frequent symptom in patients with glioma. Although treatment with antiepileptic drugs is generally effective in controlling seizures, drug-resistant patients are not uncommon. Multidrug resistance proteins (MRPs) and P-gp are over-represented in brain tissue of patients with drug-resistant epil...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rizzo A,Donzelli S,Girgenti V,Sacconi A,Vasco C,Salmaggi A,Blandino G,Maschio M,Ciusani E

更新日期：2017-06-06 00:00:00