当前位置： SCI文献检索 > JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH期刊下所有文献 > Multinucleation followed by an acytokinetic cell division in myxofibrosarcoma with giant cell proliferation.

Multinucleation followed by an acytokinetic cell division in myxofibrosarcoma with giant cell proliferation.

Abstract：

BACKGROUND:Multinucleated cells are frequently seen in association with a malignant neoplasm. Some of these multinucleated cells are considered to be neoplastic. The mechanism of neoplastic multinucleation remains unknown, but is considered to be induced by either cell-cell fusion or acytokinetic cell division. Myxofibrosarcoma consists of spindled and pleomorphic tumor cells and bizarre multinucleated giant cells. Some of these multinucleated cells are considered to be neoplastic. METHODS:We studied the mitotic activity of the multinucleated cells by Ki-67 immunohistochemistry, and the dynamics and differentiation by live-cell video microscopy in the two myxofibrosarcoma cell lines to determine whether the mechanism of multinucleation is cell-cell fusion or acytokinetic cell division RESULTS:A Ki-67 immunohistochemical analysis revealed a high positive rate of multinucleated cells, as well as mononuclear cells, and mitotic ability was shown in the multinucleated cells. In live-cell video microscopy, most of the multinucleated cells were induced via the process of acytokinetic cell division. CONCLUSION:The current study indicates that a vulnerability of the cytoskeleton components, such as the contractile ring, causes multinucleation to occur from the telophase to the cytokinesis of the cell cycle.

journal_name

J Exp Clin Cancer Res

journal_title

Journal of experimental & clinical cancer research : CR

authors

Ariizumi T,Ogose A,Kawashima H,Hotta T,Umezu H,Endo N

doi

10.1186/1756-9966-28-44

subject

Has Abstract

pub_date

2009-03-31 00:00:00

pages

44

eissn

0392-9078

issn

1756-9966

pii

1756-9966-28-44

journal_volume

28

pub_type

杂志文章

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