Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer.

abstract：BACKGROUND:Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tumor progression. However, its role in gastric cancer (GC) tumorigenesis and metastasis has not yet been fully elucidated. We determined the significance of CHI3L1 expression in patients with GC. We also explored ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Geng B,Pan J,Zhao T,Ji J,Zhang C,Che Y,Yang J,Shi H,Li J,Zhou H,Mu X,Xu C,Wang C,Xu Y,Liu Z,Wen H,You Q

更新日期：2018-08-30 00:00:00

abstract：:Increased expression of CD44 variants is often observed in differentiated thyroid carcinomas. To establish a method for gene diagnosis of thyroid without any additional invasions to the patients, RNA in leftover cells inside the needle used for fine needle aspiration biopsies (FNABs) was extracted to detect the expres...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Takano T,Sumizaki H,Amino N

更新日期：1997-09-01 00:00:00

abstract：:Insulin-secreting tumors are the commonest hormone-producing neoplasm of the gastrointestinal tract. They occur with an incidence of 4 cases per million per year. About 10% of them are metastatic and malignant insulinomas very rarely observed in children and in elderly. We report a rare case of very large malignant in...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Baldelli R,Ettorre G,Vennarecci G,Pasimeni G,Carboni F,Lorusso R,Barnabei A,Appetecchia M

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Recently, leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1), a negative regulator of EGFR, was discovered is a novel agent for suppressing bladder cancer. The aim of this study was to investigate the impact of LRIG1 on the biological features of aggressive bladder cancer cells and the possible m...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chang L,Shi R,Yang T,Li F,Li G,Guo Y,Lang B,Yang W,Zhuang Q,Xu H

更新日期：2013-12-08 00:00:00

abstract：:The recent studies have evaluated the relationship between BRCA1 expression and clinical outcome of chemotherapy (mainly focused on platinum-based and toxal-based treatment) in NSCLC patients, but the results were inconclusive and controversial. Our aim of this study was to evaluate this association by literature base...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Y,Xie Y,Xian L

更新日期：2013-03-15 00:00:00

abstract：BACKGROUND:The epithelial-to-mesenchymal transition (EMT) has been linked to the regulation of glioma progression. However, the underlying signaling mechanisms that regulate EMT are poorly understood. METHODS:Quantitative real-time PCR (RT-qPCR) and western blot were performed to detect the expression of MeCP2 in glio...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Bian E,Chen X,Xu Y,Ji X,Cheng M,Wang H,Fang Z,Zhao B

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Wnt inhibitory factor-1(WIF-1) acts as a Wnt-antagonists and tumor suppressor, but hypermethylation of WIF-1 gene promoter and low expression activate Wnt signaling aberrantly and induce the development of various human tumors. With this work we intended to investigate the expression and promoter methylation...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Z,Wang Y,Fang J,Chen F,Liu J,Wu J,Wang Y

更新日期：2010-03-24 00:00:00

abstract：BACKGROUND:Colon cancer represents one of the leading causes of gastrointestinal tumors in industrialized countries, and its incidence appears to be increasing at an alarming rate. Accumulating evidence has unveiled the contributory roles of cancer stem cells (CSCs) in tumorigenicity, recurrence, and metastases. The fu...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang L,Guo J,Zhou J,Wang D,Kang X,Zhou L

更新日期：2020-10-28 00:00:00

abstract：BACKGROUND:Cell cycle checkpoint regulation is crucial for prevention of tumor in mammalian cells. Cyclin-dependant kinase 4 (CDK4) is important in cell cycle regulation, as it controls the G1-S phase of the cell cycle. CDK4 has potential mitogenic properties through phosphorylation of target proteins. We aimed at iden...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Meenakshisundaram R,Gragnoli C

更新日期：2009-03-28 00:00:00

abstract：:Antioxidant, antitumor and anticarcinogenic activity of gossypin (3,5,8,3',4'-pentahydroxy-7-O glucosyl flavone) was carried out. The compound needed for 50% inhibition of superoxide, hydroxyl and nitric oxide radicals was 3 microg/ml, 41 microg/ml and 12 microg/ml, respectively. Gossypin also impart 50% inhibition at...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Babu BH,Jayram HN,Nair MG,Ajaikumar KB,Padikkala J

更新日期：2003-12-01 00:00:00

abstract：:Radionuclide therapy with bone seeking radiopharmaceuticals is one of the oldest interventions in nuclear medicine and has been now in use for many years as an effective method of palliating painful bone metastases. Clinical indications have slowly but progressively increased starting from end-stage prostate cancer wi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Maini CL,Sciuto R,Romano L,Bergomi S

更新日期：2003-12-01 00:00:00

abstract：BACKGROUND:Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor with dismal prognosis and high incidence and mortality in Kazakh population. MiR-34a, a direct p53 target gene, possesses tumor-suppressive properties as they mediate apoptosis, cell cycle arrest, and senescence. The reduced expression of miR-3...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cui X,Zhao Z,Liu D,Guo T,Li S,Hu J,Liu C,Yang L,Cao Y,Jiang J,Liang W,Liu W,Li S,Wang L,Wang L,Gu W,Wu C,Chen Y,Li F

更新日期：2014-02-17 00:00:00

abstract：BACKGROUND:Novel therapeutic strategies are urgently needed for the treatment of metastatic Urothelial Bladder Cancer. DNA damaging repair (DDR) targeting has been introduced in cinical trials for bladder cancer patients that carry alterations in homologous DNA repair genes, letting to envisage susceptibility to the Po...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Criscuolo D,Morra F,Giannella R,Visconti R,Cerrato A,Celetti A

更新日期：2019-02-22 00:00:00

abstract：BACKGROUND:Tumour-associated macrophages (TAMs) in the tumour microenvironment (TME) can promote the progression of hepatocellular carcinoma (HCC). Some tumours can be suppressed by targeting Wnt2b in tumour cells. However, the role of Wnt2b in HCC is still unknown. In particular, the role of Wnt2b-mediated signal acti...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jiang Y,Han Q,Zhao H,Zhang J

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is third leading cause of cancer-related death globally. Evidence suggest that long non-coding RNAs (lncRNAs) have emerged as key regulators of tumorigenesis and metastasis in HCC. In this study, we investigated the functional significance of SNHG12 and explored whether SNHG12 ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lan T,Ma W,Hong Z,Wu L,Chen X,Yuan Y

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Cancer and its therapies increase the risk of venous thromboembolism. Compared to patients without cancer, patients with cancer anticoagulated for venous thromboembolism are more likely to develop recurrent thrombotic events and major bleeding. Addressing all important outcomes including harm is of great imp...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Akl EA,Barba M,Rohilla S,Terrenato I,Sperati F,Muti P,Schünemann HJ

更新日期：2008-07-18 00:00:00

abstract：BACKGROUND:The histone methyltransferase G9a has recently been identified as a potential target for epigenetic therapy of acute myeloid leukemia (AML). However, the effect of G9a inhibition on leukemia stem cells (LSCs), which are responsible for AML drug resistance and recurrence, is unclear. In this study, we investi...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jang JE,Eom JI,Jeung HK,Chung H,Kim YR,Kim JS,Cheong JW,Min YH

更新日期：2020-04-15 00:00:00

abstract：:We report the long-term results of a series of patients affected by advanced epithelial ovarian cancer treated with the PEC combination (cisplatin 60 mg/m2, epirubicin 60 mg/m2 and cyclophosphamide 750 mg/m2, all at day 1, every 21 days). Response was evaluated after three cycles, and treatment continued in responsive...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Massacesi C,Bascioni R,Cellerino R,Scartozzi M,Bracci R,Alessandroni P,Antognoli S,Ciavattini A,De Nictolis M,Piga A

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Recent studies have shown dysregulation in TJ structure of several cancers including breast. Claudin-5 is a protein member of the TJ structure expressed in both endothelial and epithelial cells. This study examined the level of expression and distribution of Claudin-5 in human breast cancer tissues and the e...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Escudero-Esparza A,Jiang WG,Martin TA

更新日期：2012-05-04 00:00:00

abstract：BACKGROUND:The disruption of E-cadherin-mediated adhesion is considered an important driver of tumor progression. Nevertheless, numerous studies have demonstrated that E-cadherin promotes growth- or invasion-related signaling, contrary to the prevailing notion. During tumor progression, epithelial ovarian cancer (EOC) ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Rea K,Roggiani F,De Cecco L,Raspagliesi F,Carcangiu ML,Nair-Menon J,Bagnoli M,Bortolomai I,Mezzanzanica D,Canevari S,Kourtidis A,Anastasiadis PZ,Tomassetti A

更新日期：2018-07-11 00:00:00

abstract：:Horseshoe kidney is a congenital anomaly of the upper urinary system frequently associated with atypical vascularization, mostly asymptomatic, usually undetected until the onset of infectious, obstructive or neoplastic complications. Although intravenous pyelography and US are useful tools, the role of CT is of vital ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Maccioni F,Stasolla A,D'Aprile MR,Binda B,Izzo L,Marini M

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:To investigate influencing factors of the metastatic lymph nodes ratio (MLR) and whether it is related to survival in patients with gastric adenocarcinoma. METHODS:We retrospectively evaluated the clinical features of 121 patients with gastric adenocarcinoma enrolled in our hospital between 2000 and 2007. T...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yu JW,Wu JG,Zheng LH,Zhang B,Ni XC,Li XQ,Jiang BJ

更新日期：2009-04-26 00:00:00

abstract：:The rational making the G protein-coupled receptors (GPCR) the centerpiece of targeted therapies is fueled by the awareness that GPCR-initiated signaling acts as pivotal driver of the early stages of progression in a broad landscape of human malignancies. The endothelin-1 (ET-1) receptors (ET-1R), known as ETA recepto...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Tocci P,Blandino G,Bagnato A

更新日期：2021-01-09 00:00:00

abstract：:The aim of this study was to assess the nuclear/cytoplasmic (N/C) ratio using computerized image analysis of cervical smears with intraepithelial neoplasia (CIN) grade I to III associated or not with cellular changes of human papillomavirus (HPV) in an attempt to determine if this method is more sensitive for the esti...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Athanassiadou P,Kavantzas N,Gonidi M,Athanassiades P,Liossi A,Nakopoulou L,Petrakakou E,Davaris P

更新日期：2001-12-01 00:00:00

abstract：:Since the social and financial impact of AML therapy is becoming more and more relevant we analyzed the cost of induction therapy of two different regimens. The first one is part of the widely employed EORTC-GIMEMA AML-10 and consists often days of therapy. The second (FLANG) is a short (three day), Fludarabine, Ara-C...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Clavio M,Quintino S,Masoudi B,Carrara S,Cerri R,Pierri I,Canepa L,Miglino M,Muner P,Damasio E,Gobbi M

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Kidney Renal Clear Cell Carcinoma (KIRC) accounts for 75% of all renal cancers. Previous study had conflict evidences regarding NR1B2 role in cancer, and its expression and biological role in KIRC remained unclear. Our aims were to characterize the role of NR1B2 in KIRC. METHODS:NR1B2 expression in TCGA dat...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yin L,Li W,Wang G,Shi H,Wang K,Yang H,Peng B

更新日期：2019-08-07 00:00:00

abstract：BACKGROUND:DNA methylation has been widely used in classification, early diagnosis, therapy and prediction of metastasis as well as recurrence of cervical cancer. DNMT methyltransferase 1 (DNMT1), which plays a significant role in maintaining DNA methylation status and regulating the expression of tumor suppressor gene...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang Y,Chen FQ,Sun YH,Zhou SY,Li TY,Chen R

更新日期：2011-10-17 00:00:00

abstract：BACKGROUND:We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In this study, we aim to explain this confusing finding and delineate the role of CLDN6 in the breast c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Jia Y,Guo Y,Jin Q,Qu H,Qi D,Song P,Zhang X,Wang X,Xu W,Dong Y,Liang Y,Quan C

更新日期：2020-02-24 00:00:00

abstract：:Tumours involving the scrotum are rare and primary malignant melanoma is among the rarest of these lesions. Between 1949 and 1996 only 7 cases have been reported. We present two cases of scrotal melanoma. The current recommendations and management strategies are discussed on the basis of a review of the literature. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Berkmen F,Tandoğdu R,Ardjçoğlu A

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Anti-HER-2 antibodies targeting distinct epitopes have different biological functions on cancer cells. In a previous study, we demonstrated that anti-HER-2 engineering antibody ChA21 was able to bind to subdomain I of HER-2 extracellular domain. In this study, The effects of ChA21 on growth and apop...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Zhang A,Xue H,Ling X,Gao Y,Yang F,Cheng L,Liu J,Wu Q

更新日期：2010-03-10 00:00:00