当前位置： SCI文献检索 > JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH期刊下所有文献 > Stimulation of megakaryocytopoiesis and platelet production during growth of an experimental lymphoma.

Stimulation of megakaryocytopoiesis and platelet production during growth of an experimental lymphoma.

Abstract：

:The effect of malignant tumor growth on host's megakaryocytopoiesis and platelet production was studied in mice bearing transplantable Dalton's lymphoma. Tumor growth was paralleled by thrombocytosis, neutrophilia, and anemia. Platelet 51Cr half-life was normal but incorporation of 75Selenomethionine into circulating platelets was significantly enhanced in the tumor bearers suggesting stimulated thrombopoiesis while platelet life span remained unchanged. Megakaryocytes and their precursors, the small acetyl cholinesterase positive cells, were found in increased numbers in the bone marrow (BM) and particularly in the spleen where five to eight-fold rise was observed at the log phase of tumor growth. In addition, a remarkable increase in the number of megakaryocyte progenitors (CFU-MK and MK CFU-S) was observed both in the BM and spleen. Stimulation of these progenitors was more pronounced in the spleen than in the marrow, and the change was noticeable even from the third day of tumor bearing. Therefore, the results suggest that thrombocytosis associated with the growth of this experimental lymphoma was due to accelerated platelet production following stimulated megakaryocytopoiesis especially in the spleen.

journal_name

J Exp Clin Cancer Res

journal_title

Journal of experimental & clinical cancer research : CR

authors

Ray MR

keywords:

subject

Has Abstract

pub_date

2000-12-01 00:00:00

pages

505-11

issue

4

eissn

0392-9078

issn

1756-9966

journal_volume

19

pub_type

杂志文章

相关文献

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH文献大全
  • Detection of EGFR mutations in circulating free DNA by PNA-mediated PCR clamping.

    abstract：BACKGROUND:Epidermal growth factor receptor (EGFR)-activating mutations are major determinants in predicting the tumor response to EGFR tyrosine kinase inhibitors in non-small cell lung cancer (NSCLC). Noninvasive test for the detection of EGFR mutations is required, especially in NSCLC patients from whom tissue is not...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,多中心研究

    doi：10.1186/1756-9966-32-50

    authors： Kim HR,Lee SY,Hyun DS,Lee MK,Lee HK,Choi CM,Yang SH,Kim YC,Lee YC,Kim SY,Jang SH,Lee JC,Lee KY

    更新日期：2013-08-09 00:00:00

  • β-catenin-mediated YAP signaling promotes human glioma growth.

    abstract：BACKGROUND:Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression.We and others find that YAP is up-regulated in human gliomas and associated with worse prognosis of patients. However, the role and mechanism of YAP in glioma pro...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-017-0606-1

    authors： Wang Y,Pan P,Wang Z,Zhang Y,Xie P,Geng D,Jiang Y,Yu R,Zhou X

    更新日期：2017-09-29 00:00:00

  • The effects of IL-2, IL-6 and IL-10 levels on prognosis in patients with aggressive Non-Hodgkin's Lymphoma (NHL).

    abstract：:The aim of this study was to investigate serum levels of IL-2, IL-6 and IL-10 in the pretreatment period and to determine if high IL-2, IL-6, IL-10 levels correlate with the outcome in patients with Non-Hodgkin's Lymphoma (NHL) in the post treatment period. Forty-three patients with the diagnosis of aggressive NHL wer...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Ozdemir F,Aydin F,Yilmaz M,Kavgaci H,Bektas O,Yavuz MN,Yavuz AA

    更新日期：2004-09-01 00:00:00

  • Turcot syndrome: case report and nosological aspects.

    abstract：:The Turcot syndrome has been defined as the simultaneous presence of multiple polyposis of the colon and a malignant brain tumor. This association is supposed to be genetically transmitted, even though we still do not exactly know whether this occurs in a dominant or recessive way. The case of a 47-year-old man submit...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Fracasso P,Caviglia R,Grassi A,Lapenta R,Stigliano V,Franco D,Casale V

    更新日期：1997-12-01 00:00:00

  • Clinical research of Olanzapine for prevention of chemotherapy-induced nausea and vomiting.

    abstract：BACKGROUND:This study was designed to mainly evaluate the activity and safety of olanzapine compared with 5-hydroxytryptamine 3(5-HT3) receptor antagonists for prevention of chemotherapy-induced nausea and vomiting(CINV) in patients receiving highly or moderately emetogenic chemotherapy (HEC or MEC). The second goal wa...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,随机对照试验

    doi：10.1186/1756-9966-28-131

    authors： Tan L,Liu J,Liu X,Chen J,Yan Z,Yang H,Zhang D

    更新日期：2009-09-23 00:00:00

  • Oncogene addiction in gliomas: implications for molecular targeted therapy.

    abstract：:Oncogene addiction is a phenomenon that the survival of cancer cells depends on an activated oncogene or inactivation of tumor suppressor gene, and is regarded as the 'Achilles heel' of the successful molecular targeted therapies in cancer. However, the role of oncogene addiction in gliomas has not been elucidated sys...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,评审

    doi：10.1186/1756-9966-30-58

    authors： Yan W,Zhang W,Jiang T

    更新日期：2011-05-17 00:00:00

  • The kinase inhibitor D11 induces caspase-mediated cell death in cancer cells resistant to chemotherapeutic treatment.

    abstract：BACKGROUND:Multi-drug resistance and predisposition to metastasize are major clinical problems in cancer treatment. Malignant primary brain tumor and pancreatic cancer are two well-known examples of malignant tumors resistant to conventional therapies where aberrant EGFR-mediated and NF-κB signal transduction pathways ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-015-0234-6

    authors： Guerra B,Fischer M,Schaefer S,Issinger OG

    更新日期：2015-10-20 00:00:00

  • The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment.

    abstract：BACKGROUND:Glioblastoma is the most common and aggressive brain tumour in adults with a median overall survival of only 14 months after standard therapy with radiation therapy (IR) and temozolomide (TMZ). In a novel multimodal treatment approach we combined the checkpoint kinase 1 (Chk1) inhibitor SAR-020106 (SAR), dis...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-019-1434-2

    authors： Patties I,Kallendrusch S,Böhme L,Kendzia E,Oppermann H,Gaunitz F,Kortmann RD,Glasow A

    更新日期：2019-10-21 00:00:00

  • Toxicity and morbility after isolated lower limb perfusion in 242 chemo-hyperthermal treatments for cutaneous melanoma: the experience of the Tuscan Reference Centre.

    abstract：BACKGROUND:The aim of this retrospective study was to assess the results concerning the regional and systemic toxicity and complications in 242 chemo-hyperthermal treatments (HILPs) for lower limb melanoma. PATIENTS AND METHODS:60 HILPs (G-A) were performed with mild HT plus L-PAM (10 mg/lt) +/- D-actimomycin; 74 HILP...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-27-67

    authors： Pace M,Gattai R,Matteini M,Mascitelli EM,Bechi P

    更新日期：2008-11-12 00:00:00

  • LSH interacts with and stabilizes GINS4 transcript that promotes tumourigenesis in non-small cell lung cancer.

    abstract：BACKGROUND:Elucidating mechanisms in oncogenes and epigenetic modifiers are needed to gain insights into the etiology and treatment of cancer, regulation of oncogene by chromatin modifiers at post-transcriptional level is critical and remains unclear. We have investigated the role of GINS4 in NSCLC. METHODS:The expres...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-019-1276-y

    authors： Yang R,Liu N,Chen L,Jiang Y,Shi Y,Mao C,Liu Y,Wang M,Lai W,Tang H,Gao M,Xiao D,Wang X,Yu F,Cao Y,Yan Q,Liu S,Tao Y

    更新日期：2019-06-28 00:00:00

  • Radionuclide therapy with bone seeking radionuclides in palliation of painful bone metastases.

    abstract：:Radionuclide therapy with bone seeking radiopharmaceuticals is one of the oldest interventions in nuclear medicine and has been now in use for many years as an effective method of palliating painful bone metastases. Clinical indications have slowly but progressively increased starting from end-stage prostate cancer wi...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,评审

    doi：

    authors： Maini CL,Sciuto R,Romano L,Bergomi S

    更新日期：2003-12-01 00:00:00

  • Low-molecular-weight heparins are superior to vitamin K antagonists for the long term treatment of venous thromboembolism in patients with cancer: a cochrane systematic review.

    abstract：BACKGROUND:Cancer and its therapies increase the risk of venous thromboembolism. Compared to patients without cancer, patients with cancer anticoagulated for venous thromboembolism are more likely to develop recurrent thrombotic events and major bleeding. Addressing all important outcomes including harm is of great imp...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,评审

    doi：10.1186/1756-9966-27-21

    authors： Akl EA,Barba M,Rohilla S,Terrenato I,Sperati F,Muti P,Schünemann HJ

    更新日期：2008-07-18 00:00:00

  • Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells.

    abstract：BACKGROUND:One of the most potent costimulatory molecules involved in the recognition and killing of tumor cells is CD80. However, its role and the molecular mechanisms regulating its expression in sporadic colorectal carcinogenesis remain elusive. Here, we provide evidence for CD80 overexpression in human colon epithe...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-019-1205-0

    authors： Marchiori C,Scarpa M,Kotsafti A,Morgan S,Fassan M,Guzzardo V,Porzionato A,Angriman I,Ruffolo C,Sut S,Dall'Acqua S,Bardini R,De Caro R,Castoro C,Scarpa M,Castagliuolo I

    更新日期：2019-05-09 00:00:00

  • Expression of the chemokine receptor CXCR4 in human hepatocellular carcinoma and its role in portal vein tumor thrombus.

    abstract：BACKGROUND:This study was conducted to investigate the expression of CXCR4 in portal vein tumor thrombus (PVTT) tissue and its possible role in the invasiveness of tumor thrombus cells. METHODS:We detected differential expression of CXCR4 between PVTT and hepatocellular carcinoma (HCC) by an immunohistochemical assay....

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-29-156

    authors： Li N,Guo W,Shi J,Xue J,Hu H,Xie D,Wu M,Cheng S

    更新日期：2010-11-27 00:00:00

  • Loss of expression of Kruppel-like factor 6 in primary hepatocellular carcinoma and hepatoma cell lines.

    abstract：:KLF6 (Zf9, COPEB), an ubiquitous transcription factor, maps to chromosome 10p. Recently, KLF6 was found to have a more generalized role in tumorigenesis as a candidate tumor suppressor gene for some tumors. However, results from other published studies seem not to be in agreement with data from previous studies. Gene-...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Wang SP,Zhou HJ,Chen XP,Ren GY,Ruan XX,Zhang Y,Zhang RL,Chen J

    更新日期：2007-03-01 00:00:00

  • Molecular markers associated with outcome and metastasis in human pancreatic cancer.

    abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins to be revealed, genes or pathways that specifically drive tumour progression or metastasis are not ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-31-68

    authors： Van den Broeck A,Vankelecom H,Van Eijsden R,Govaere O,Topal B

    更新日期：2012-08-27 00:00:00

  • Correction to: FAK-ERK activation in cell/matrix adhesion induced by the loss of apolipoprotein E stimulates the malignant progression of ovarian cancer.

    abstract：:In the original publication of this manuscript [1], Fig. 5E lower panel was incorrect due to an error in the preparation of these figures for publication. It was noticed that in the lower panel of Fig. 5E, one mouse image of ApoE-/- + PBS group (upper) was a photograph coming from ApoE-/- + BAPN pre-treatment group (l...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 已发布勘误

    doi：10.1186/s13046-019-1422-6

    authors： Lai H,Zhao X,Qin Y,Ding Y,Chen R,Li G,Labrie M,Ding Z,Zhou J,Hu J,Ma D,Fang Y,Gao Q

    更新日期：2019-10-15 00:00:00

  • Evaluation of skin perfusion after nipple-sparing mastectomy by indocyanine green dye. Preliminary results.

    abstract：:The aim of the study was to investigate the blood supply of the normal nipple areola complex (NAC) and the spared areola complex after a nipple-sparing mastectomy using the analysis of the fluorescence from the indocianine green dye (ICG) injection. Between December 2002 and July 2003 we performed the ICG analysis in ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： De Lorenzi F,Yamaguchi S,Petit JY,Rietjens M,Garusi C,Martella S,Rey PC,Gennari R

    更新日期：2005-09-01 00:00:00

  • SNPs in DNA repair or oxidative stress genes and late subcutaneous fibrosis in patients following single shot partial breast irradiation.

    abstract：BACKGROUND:The aim of this study was to evaluate the potential association between single nucleotide polymorphisms related response to radiotherapy injury, such as genes related to DNA repair or enzymes involved in anti-oxidative activities. The paper aims to identify marker genes able to predict an increased risk of l...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 临床试验,杂志文章

    doi：10.1186/1756-9966-31-7

    authors： Falvo E,Strigari L,Citro G,Giordano C,Boboc G,Fabretti F,Bruzzaniti V,Bellesi L,Muti P,Blandino G,Pinnarò P

    更新日期：2012-01-24 00:00:00

  • Antisense oligonucleotide targeting Livin induces apoptosis of human bladder cancer cell via a mechanism involving caspase 3.

    abstract：BACKGROUND AND AIM:in recent years, Livin, a new member of IAPs family, is found to be a key molecule in cancers. Researchers consider Livin may become a new target for tumor therapy; however, the role of it in bladder cancer is still unclear. The purpose of this article is to investigate Antisense Oligonucleotide (ASO...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/1756-9966-29-63

    authors： Liu C,Wu X,Luo C,Hu Z,Yin Z,He Y,Du H,Zhang W,Jiang Q,Lin Y

    更新日期：2010-06-03 00:00:00

  • LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer.

    abstract：BACKGROUND:Reprogrammed energy metabolism has become an emerging hallmark of cancer in recent years. Transporters have been reported to be amino acid sensors involved in controlling mTOR recruitment and activation, which is crucial for the growth of both normal and tumor cells. L-type amino acid transporter 2 (LAT2), e...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-018-0947-4

    authors： Feng M,Xiong G,Cao Z,Yang G,Zheng S,Qiu J,You L,Zheng L,Zhang T,Zhao Y

    更新日期：2018-11-12 00:00:00

  • Mechanisms of hyperprogressive disease after immune checkpoint inhibitor therapy: what we (don't) know.

    abstract：:Immune checkpoint inhibitors (ICIs) have made a breakthrough in the treatment of different types of tumors, leading to improvement in survival, even in patients with advanced cancers. Despite the good clinical results, a certain percentage of patients do not respond to this kind of immunotherapy. In addition, in a fra...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,评审

    doi：10.1186/s13046-020-01721-9

    authors： Camelliti S,Le Noci V,Bianchi F,Moscheni C,Arnaboldi F,Gagliano N,Balsari A,Garassino MC,Tagliabue E,Sfondrini L,Sommariva M

    更新日期：2020-11-09 00:00:00

  • RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer.

    abstract：BACKGROUND:Retinoic acid-inducible gene-I (Rig-I) is an intracellular viral RNA receptor, which specifically recognizes double-stranded viral RNA initiating antiviral innate immunity. Increasing evidences showed that Rig-I had broader roles in antibacterial immunity and cancer protection. However, the potential roles a...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-016-0471-3

    authors： Zhu H,Xu WY,Hu Z,Zhang H,Shen Y,Lu S,Wei C,Wang ZG

    更新日期：2017-01-05 00:00:00

  • ERβ1 inhibits metastasis of androgen receptor-positive triple-negative breast cancer by suppressing ZEB1.

    abstract：BACKGROUND:Increasing evidence has indicated an important role for estrogen receptor beta 1 (ERβ1) in breast cancer. However, the role of ERβ1 in the metastasis of androgen receptor (AR)-positive triple-negative breast cancer (TNBC) and the underlying mechanisms are still unknown. METHODS:Stable ERβ1-expressing TNBC c...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-017-0545-x

    authors： Song W,Tang L,Xu Y,Sun Q,Yang F,Guan X

    更新日期：2017-06-05 00:00:00

  • Long noncoding RNA AFAP1-AS1 acts as a competing endogenous RNA of miR-423-5p to facilitate nasopharyngeal carcinoma metastasis through regulating the Rho/Rac pathway.

    abstract：BACKGROUND:Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long noncoding RNA, is significantly highly expressed and associated with metastasis and poor prognosis in many cancers, including nasopharyngeal carcinoma (NPC). In this study, we aim to identify the role of AFAP1-AS1 acting as an oncogenic ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-018-0918-9

    authors： Lian Y,Xiong F,Yang L,Bo H,Gong Z,Wang Y,Wei F,Tang Y,Li X,Liao Q,Wang H,Zhou M,Xiang B,Wu X,Li Y,Li X,Chen X,Li G,Guo C,Zeng Z,Xiong W

    更新日期：2018-10-16 00:00:00

  • Detection of t(14;18), P53 and RAS gene mutations and quantification of residual disease in patients with B-cell non-Hodgkin's lymphoma.

    abstract：UNLABELLED:PCR analysis has been demonstrated as a valuable tool for detection of minimal residual disease (MRD) in lymphoid malignancies. However, the finding that patients with evidence of MRD sometimes remain in long-lasting remission directs further investigations toward biology of residual disease and/or quantific...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Cikota BM,Tukić LJ,Tarabar OT,Magić ZM

    更新日期：2007-12-01 00:00:00

  • Formononetin inhibits tumor growth by suppression of EGFR-Akt-Mcl-1 axis in non-small cell lung cancer.

    abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC). The mechanism regarding how EGFR signaling regulates myeloid cell leukemia sequence 1 (Mcl-1) protein stability and ubiquitination remains undefined. METHODS:MTS ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-020-01566-2

    authors： Yu X,Gao F,Li W,Zhou L,Liu W,Li M

    更新日期：2020-04-10 00:00:00

  • miR-539 inhibits prostate cancer progression by directly targeting SPAG5.

    abstract：BACKGROUND:We conducted multiple microarray datasets analyses from clinical and xenograft tumor tissues to search for disease progression-driving oncogenes in prostate cancer (PCa). Sperm-associated antigen 5 (SPAG5) attracted our attention. SPAG5 was recently identified as an oncogene participating in lung cancer and ...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：10.1186/s13046-016-0337-8

    authors： Zhang H,Li S,Yang X,Qiao B,Zhang Z,Xu Y

    更新日期：2016-04-01 00:00:00

  • Modulation of blood circulating immune cells by radiofrequency tumor ablation.

    abstract：:Tumor ablation by radiofrequency (RFA) is an appealing therapeutical strategy for the treatment of liver tumors (hepatocarcinoma and metastatic lesions) to be used as valid alternative to the surgical resection that often is appropriate and feasible in only a minority of patients. RFA induces the localised and control...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章

    doi：

    authors： Rughetti A,Rahimi H,Rossi P,Frati L,Nuti M,Gaspari A,Danza FM,Ercoli L

    更新日期：2003-12-01 00:00:00

  • Molecular genetics of prostate cancer: clinical translational opportunities.

    abstract：:Prostate cancer (PC) development reflects a complex sequence of biologic and molecular events. Several inheritable and somatic genetic changes have been identified. The knowledge of the molecular basis of PC can improve our understanding of the causes of this common cancer and provide information on prognosis and trea...

    journal_title：Journal of experimental & clinical cancer research : CR

    pub_type： 杂志文章,评审

    doi：

    authors： Vecchione A,Gottardo F,Gomella LG,Wildemore B,Fassan Ms,Bragantini E,Pagano F,Baffa R

    更新日期：2007-03-01 00:00:00