Mechanisms of hyperprogressive disease after immune checkpoint inhibitor therapy: what we (don't) know.

abstract：:The incidence of bone metastasis was around 13% in 404 patients with hepatocellular carcinoma (HCC) who underwent treatment at the National Kyushu Cancer Center between 1988-97, which is a high value among various cancers. This is, in part, due to the prolonged survival time of HCC patients in recent years. Serum vasc...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Iguchi H,Yokota M,Fukutomi M,Uchimura K,Yonemasu H,Hachitanda Y,Nakao Y,Tanaka Y,Sumii T,Funakoshi A

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) and sex-determining region Y-box 9 (SOX9), and the...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang L,Yu X,Zhang Z,Pang L,Xu J,Jiang J,Liang W,Chai Y,Hou J,Li F

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:Although significant progress has been made in the treatment of lymphomas, many lymphomas exhibit resistance to cell death, suggesting a defective Fas signaling, which remains poorly understood. We previously reported that cells expressing the K1 protein of human herpesvirus 8 (HHV-8) resist death through th...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Daniluk U,Kerros C,Tao RH,Wise JF,Ao X,Berkova Z,Samaniego F

更新日期：2012-08-28 00:00:00

abstract：BACKGROUND:This study aimed to analyze three-dimensional (3D) dosimetric data of conventional two-dimensional (2D) palliative spinal bone irradiation using different reference points and treatment plans with respect to the International Commission on Radiation Units and Measurements (ICRU) Report 50. METHODS:Forty-fiv...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Andic F,Baz Cifci S,Ors Y,Niang U,Dirier A,Adli M

更新日期：2009-01-07 00:00:00

abstract：BACKGROUND:Ewing's sarcoma is an aggressive bone and soft tissue tumor with a high incidence in children and adolescents. Due to its high malignancy and poor prognosis, identification of novel biomarkers for intervention therapies is necessary to improve outcome. The EWS/FLI1 fusion gene is a characteristic of Ewing's ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ren C,Ren T,Yang K,Wang S,Bao X,Zhang F,Guo W

更新日期：2016-03-11 00:00:00

abstract：:Malignant tumor cells often express embryonic antigens which share the expression with embryonic stem (ES) cells. The embryonic antigens are usually encoded by ES cell-specific genes, a number of which are associated with tumorigenesis and/or tumor progression. We examined the expression of ES cell-specific genes in t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Ehira N,Oshiumi H,Matsumoto M,Kondo T,Asaka M,Seya T

更新日期：2010-10-15 00:00:00

abstract：BACKGROUND:The evasion of cell death is one of the hallmarks of cancer, contributing to both tumor progression and resistance to therapy. Dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to conventional anticancer treatments and patients with these tumors are difficult to...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Broecker-Preuss M,Viehof J,Jastrow H,Becher-Boveleth N,Fuhrer D,Mann K

更新日期：2015-07-22 00:00:00

abstract：BACKGROUND:The third generation Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor (TKI) osimertinib has been initially approved for T790M positive Non-Small Cell Lung Cancer (NSCLC) and more recently for first-line treatment of EGFR-mutant T790M negative NSCLC patients. Similarly to previous generation ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： La Monica S,Minari R,Cretella D,Flammini L,Fumarola C,Bonelli M,Cavazzoni A,Digiacomo G,Galetti M,Madeddu D,Falco A,Lagrasta CA,Squadrilli A,Barocelli E,Romanel A,Quaini F,Petronini PG,Tiseo M,Alfieri R

更新日期：2019-05-28 00:00:00

abstract：BACKGROUND:Pharmacology-based target identification has become a novel strategy leading to the discovery of novel pathological biomarkers. Ellagic acid (EA), a dietary polyphenol compound, exhibits potent anticancer activities; however, the underlying mechanisms remain unclear. The current study sought to determine the...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Wang N,Wang Q,Tang H,Zhang F,Zheng Y,Wang S,Zhang J,Wang Z,Xie X

更新日期：2017-12-02 00:00:00

abstract：BACKGROUND:Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However, the clinical significance and biological roles of MAZ in bone met...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yang Q,Lang C,Wu Z,Dai Y,He S,Guo W,Huang S,Du H,Ren D,Peng X

更新日期：2019-09-05 00:00:00

abstract：BACKGROUND:Investigation of the expression of an intestinal stem cell marker in esophageal adenocarcinomas (EAC) with and without Barrett's Esophagus (BE), with respect to a cancer stem cell (CSC) hypothesis. MATERIALS AND METHODS:Expression of a putative intestinal stem cell marker LgR5 was analyzed in esophageal can...

journal_title：Journal of experimental & clinical cancer research : CR

authors： von Rahden BH,Kircher S,Lazariotou M,Reiber C,Stuermer L,Otto C,Germer CT,Grimm M

更新日期：2011-02-23 00:00:00

abstract：BACKGROUND:Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol synthesis. The inhibition of this key enzyme in the mevalonate pathway leads to suppression of cell proliferation and induction of apoptosis. However, the molecular mechanism of apoptosis induct...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Yanae M,Tsubaki M,Satou T,Itoh T,Imano M,Yamazoe Y,Nishida S

更新日期：2011-08-10 00:00:00

abstract：BACKGROUND:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are being wildly used as target therapy in non-small-cell lung cancer (NSCLC). However, NSCLC patients with wild-type EGFR and KRAS mutation are primary resistant to EGFR-TKIs such as gefitinib. Curcumin has been known as a potential t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chen P,Huang HP,Wang Y,Jin J,Long WG,Chen K,Zhao XH,Chen CG,Li J

更新日期：2019-06-13 00:00:00

abstract：PURPOSE:The association between striking life events, an important stress and acute anxiety disorder, and the occurrence of primary breast cancer is unclear. The current meta-analysis was designed to assess the relationship between striking life events and primary breast cancer incidence in women. METHODS:Systematic c...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Lin Y,Wang C,Zhong Y,Huang X,Peng L,Shan G,Wang K,Sun Q

更新日期：2013-08-13 00:00:00

abstract：BACKGROUND:Osteosarcoma is the most frequent primary malignant bone tumor. Although survival has distinctly increased due to neoadjuvant chemotherapy in the past, patients with metastatic disease and poor response to chemotherapy still have an adverse prognosis. Hence, development of new therapeutic strategies is still...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Kubista B,Schoefl T,Mayr L,van Schoonhoven S,Heffeter P,Windhager R,Keppler BK,Berger W

更新日期：2017-04-12 00:00:00

abstract：:Imatinib mesylate (IM), is a selective and competitive inhibitor of tyrosine kinases, including BCR-ABL, ABL, KIT, and the platelet-derived growth factor receptors (PDGF-R). It binds to the ATP-binding site of the target kinase and prevents the transfer of phosphate from ATP to the tyrosine residues of various substra...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fiorentini G,Rossi S,Lanzanova G,Biancalani M,Palomba A,Bernardeschi P,Dentico P,De Giorgi U

更新日期：2003-12-01 00:00:00

abstract：UNLABELLED:In order to evaluate the influence of time intervals between tumor cell injection and radiotherapy on tumor control and regrowth after surgery, we performed two kinds of experiments on C3D2F1 mice bearing a mammary carcinoma inoculated in the foot or leg. 1st experiment: tumor in foot. END POINT:Tumor Contr...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Cividalli A,Creton G,Ceciarelli F,Strigari L,Tirindelli Danesi D,Benassi M

更新日期：2005-03-01 00:00:00

abstract：:Adenosquamous carcinomas of the colorectum are rare neoplasms. Our experience with two cases is presented in this paper. One patient, who complained of bloody stool, was found to have adenocarcinoma in the sigmoid colon. He received a laparoscopy-assisted sigmoidectomy. The histological examination revealed that the t...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Fukui R,Hata F,Yasoshima T,Furuhata T,Honma T,Nakajima F,Nishimori H,Isomura H,Katsuramaki T,Tanaka H,Kobayashi K,Hirata K

更新日期：2001-06-01 00:00:00

abstract：:Two-year protocols are commonly used for long-term assay of chemicals for carcinogenicity. However, in some cases, if animals have been exposed to tested agent from the young age and sacrificed at the age of 2, an underestimation of the carcinogenic potential of non-genotoxic agents and tumor promoters is possible. Da...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Anisimov VN

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Hepatoblastoma (HB) is a common liver malignancy in children. Our previous study has disclosed the crucial role of STAT3 (signal transducer and activator of transcription 3) in HB. AIM OF THE STUDY:Present study was designed to study the circular RNA (circRNA) STAT3 in HB. METHODS:Gel electrophoresis revea...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu Y,Song J,Liu Y,Zhou Z,Wang X

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Many factors influence breast cancer progression, including the ability of progenitor cells to sustain or increase net tumour cell numbers. Our aim was to define whether alterations in putative progenitor populations could predict clinicopathological factors of prognostic importance for cancer progression. ...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Donatello S,Hudson L,Cottell DC,Blanco A,Aurrekoetxea I,Shelly MJ,Dervan PA,Kell MR,Stokes M,Hill AD,Hopkins AM

更新日期：2011-04-26 00:00:00

abstract：BACKGROUND:Breast cancer is the most common cancer among women worldwide, and approximately 70% of breast cancers are hormone receptor-positive and express estrogen receptor-α (ERα) or/and progesterone receptor. ERα has been identified to promote the growth of primary breast cancer, however, it can also antagonize sign...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Liu BW,Yu ZH,Chen AX,Chi JR,Ge J,Yu Y,Cao XC

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Angiopoietin-like protein 1 (ANGPTL1) has been reported to suppress migration and invasion in lung and breast cancer, acting as a novel tumor suppressor candidate. Nevertheless, its effects on colorectal cancer (CRC) remain poorly defined. In this study, we aim to demonstrate the biological function of ANGPT...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Chen H,Xiao Q,Hu Y,Chen L,Jiang K,Tang Y,Tan Y,Hu W,Wang Z,He J,Liu Y,Cai Y,Yang Q,Ding K

更新日期：2017-06-12 00:00:00

abstract：:The renal oncocytoma is a solid epithelial neoplasm with a generally benign course. The improved image diagnostics with the computerized tomography (CT) and magnetic resonance imaging (MRI) should today permit the identification of these lesions preoperatively so that conservative rather than radical surgery can be em...

journal_title：Journal of experimental & clinical cancer research : CR

authors： De Carli P,Vidiri A,Lamanna L,Cantiani R

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Patients with endometrial cancer (EC) and presumably with good prognosis may develop a recurrence indicating that the classification of this tumor is still not definitive and that new markers are needed to identify a subgroup at risk of relapse. The cell adhesion molecule L1CAM is highly expressed in several...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Corrado G,Laquintana V,Loria R,Carosi M,de Salvo L,Sperduti I,Zampa A,Cicchillitti L,Piaggio G,Cutillo G,Falcioni R,Vizza E

更新日期：2018-07-06 00:00:00

abstract：BACKGROUND:The cisplatin-resistance is still a main course for chemotherapy failure of lung cancer patients. Cisplatin-resistant cancer cells own higher malignance and exhibited increased metastatic ability, but the mechanism is not clear. In this study, we investigated the effects of Ataxia Telangiectasia Mutated (ATM...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Shen M,Xu Z,Xu W,Jiang K,Zhang F,Ding Q,Xu Z,Chen Y

更新日期：2019-04-08 00:00:00

abstract：:Since the social and financial impact of AML therapy is becoming more and more relevant we analyzed the cost of induction therapy of two different regimens. The first one is part of the widely employed EORTC-GIMEMA AML-10 and consists often days of therapy. The second (FLANG) is a short (three day), Fludarabine, Ara-C...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Clavio M,Quintino S,Masoudi B,Carrara S,Cerri R,Pierri I,Canepa L,Miglino M,Muner P,Damasio E,Gobbi M

更新日期：2001-06-01 00:00:00

abstract：:Insulin-secreting tumors are the commonest hormone-producing neoplasm of the gastrointestinal tract. They occur with an incidence of 4 cases per million per year. About 10% of them are metastatic and malignant insulinomas very rarely observed in children and in elderly. We report a rare case of very large malignant in...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Baldelli R,Ettorre G,Vennarecci G,Pasimeni G,Carboni F,Lorusso R,Barnabei A,Appetecchia M

更新日期：2007-12-01 00:00:00

abstract：:Human mammaglobin (hMAM) has recently been recognized as a breast associated glycoprotein. Although the biological role of hMAM is unknown, it has been previously reported that hMAM gene expression is a marker of low biological and clinical aggressiveness of breast cancer (BC). In this study, 148 cases of BC tissues w...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Roncella S,Ferro P,Bacigalupo B,Dessanti P,Giannico A,Gorji N,Moroni M,Tozzini S,Pensa F,Gianquinto D,Fais F,Pronzato P,Fedeli F

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Glucose-6-phospate dehydrogenase (G6PD) is the limiting enzyme of the pentose phosphate pathway (PPP) correlated to cancer progression and drug resistance. We previously showed that G6PD inhibition leads to Endoplasmic Reticulum (ER) stress often associated to autophagy deregulation. The latter can be induce...

journal_title：Journal of experimental & clinical cancer research : CR

authors： Mele L,la Noce M,Paino F,Regad T,Wagner S,Liccardo D,Papaccio G,Lombardi A,Caraglia M,Tirino V,Desiderio V,Papaccio F

更新日期：2019-04-12 00:00:00