Expression of the chemokine receptor CXCR4 in human hepatocellular carcinoma and its role in portal vein tumor thrombus.

Abstract:

BACKGROUND:This study was conducted to investigate the expression of CXCR4 in portal vein tumor thrombus (PVTT) tissue and its possible role in the invasiveness of tumor thrombus cells. METHODS:We detected differential expression of CXCR4 between PVTT and hepatocellular carcinoma (HCC) by an immunohistochemical assay. Lentivirus-mediated RNA interference and a migration assay were performed on human primary cells derived from PVTT to study the impact of CXCR4 on the invasiveness of HCC. RESULTS:The expression of CXCR4 in tumor thrombus tissue was higher than that in HCC tissue. The invasion ratio of PVTT cells was significantly decreased (P < 0.05) after being infected with a CXCR4-targeting siRNA lentivirus, indicating that downregulation of CXCR4 by lentivirus-mediated RNA interference significantly impaired the invasive potential of PVTT. CONCLUSIONS:These results indicate that CXCR4 is an effective curative target for hepatocellular carcinomas with PVTT.

journal_name

J Exp Clin Cancer Res

authors

Li N,Guo W,Shi J,Xue J,Hu H,Xie D,Wu M,Cheng S

doi

10.1186/1756-9966-29-156

subject

Has Abstract

pub_date

2010-11-27 00:00:00

pages

156

eissn

0392-9078

issn

1756-9966

pii

1756-9966-29-156

journal_volume

29

pub_type

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